Abstract:
:Exogenous insulin is the only treatment available for type 1 diabetic patients and is mostly administered by subcutaneous (SC) injection in a basal and bolus scheme using insulin pens (injection) or pumps (preimplanted SC catheter). Some divergence exists between these two modes of administration, since pumps provide better glycaemic control compared to injections in humans. The aim of this study was to compare the impacts of two modes of insulin administration (single injections of long-acting insulin or pump delivery of rapid-acting insulin) at the same dosage (4 IU/200 g/day) on rat metabolism and tissues. The rat weight and blood glucose levels were measured periodically after treatment. Immunostaining for signs of oxidative stress and for macrophages was performed on the liver and omental tissues. The continuous insulin delivery by pumps restored normoglycaemia, which induced the reduction of both reactive oxygen species and macrophage infiltration into the liver and omentum. Injections controlled the glucose levels for only a short period of time and therefore tissue stress and inflammation were elevated. In conclusion, the insulin administration mode has a crucial impact on rat metabolic parameters, which has to be taken into account when studies are designed.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Schaschkow A,Mura C,Dal S,Langlois A,Seyfritz E,Sookhareea C,Bietiger W,Peronet C,Jeandidier N,Pinget M,Sigrist S,Maillard Edoi
10.1155/2016/8310516subject
Has Abstractpub_date
2016-01-01 00:00:00pages
8310516eissn
2314-6745issn
2314-6753journal_volume
2016pub_type
杂志文章abstract:Purpose:We aimed to assess the changes of retinal microvascular parameters using optical coherence tomography angiography (OCTA) between diabetes macular edema (DME) and controls. We assessed the changes between the baseline microvascular parameters and final treatment response in patients with DME, initially treated w...
journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2020-11-16 00:00:00
abstract::Fear of falling (FoF) is known to affect the physical activities and quality of life of older adults with type 2 diabetes mellitus (DM). Many complications of DM, especially ones distressing lower extremity (LE), could lead to increased fall risk and FoF. This study aimed to explore the relationship between FoF, LE mu...
journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2020-06-03 00:00:00
abstract::Introduction. Diabetic Ketoacidosis (DKA) is a serious complication that can be life-threatening. Management of DKA needs admission in a specialized center and imposes major constraints on hospital resources. Aim. We plan to study the impact of adapting a diabetes-educator care model on reducing the frequency of hospi...
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1423191
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abstract::Background. The feasibility of digital health programs to prevent and manage diabetes in low-income patients has not been adequately explored. Methods. Researchers collaborated with a digital health company to adapt a diabetes prevention program for low-income prediabetes patients at a large safety net clinic. We cond...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8472391
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/243518
更新日期:2014-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/237535
更新日期:2014-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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更新日期:2018-10-03 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/7965317
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abstract::Mitogen inducible gene-6 (Mig-6) is a feedback inhibitor of epidermal growth factor receptor (EGFR) signaling pathway. The liver-specific knockout mice of the Mig-6 gene (Mig-6 d/d ) showed hepatomegaly and increased hypercholesterolemia. In this study, the biomarkers of i...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1632061
更新日期:2016-01-01 00:00:00
abstract::T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2D...
journal_title:Journal of diabetes research
pub_type: 杂志文章
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/961732
更新日期:2014-01-01 00:00:00
abstract:Background/Aims:It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes and diabetic nephropathy (DN), so we designed this study to investigate the role of P2X7R and NLRP3 inflammasome in DN pathogenesis and the antagonistic effects of artificially cultivated Ophio...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/1390418
更新日期:2018-11-11 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/7328128
更新日期:2018-03-26 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/4231892
更新日期:2020-03-30 00:00:00
abstract:BACKGROUND:Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a negative regulator of natural and adaptive immunity. The role of TIPE2 in type 2 diabetes mellitus (T2DM) remains unknown, although TIPE2 plays key roles in preserving inflammatory homeostasis. METHODS:TIPE2 expression was measured b...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/4802319
更新日期:2017-01-01 00:00:00
abstract::The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- a...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/2562759
更新日期:2017-01-01 00:00:00
abstract::To compare the efficacy and safety of metformin, glyburide, and insulin in treating gestational diabetes mellitus (GDM), a meta-analysis of randomized controlled trials (RCTs) was conducted. PubMed, Embase, CINAHL, Web of Science, and Cochrane Library to November 13, 2018, were searched for RCT adjusted estimates of t...
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pub_type: 杂志文章,meta分析
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/972073
更新日期:2015-01-01 00:00:00
abstract:Introduction:Diabetes mellitus type 1 and type 2 are linked to higher prevalence and occurrences of depression. Internet-based depression- and diabetes-specific cognitive behavioral therapies (CBT) can be effective in reducing depressive symptom severity and diabetes-related emotional distress. The aim of the study was...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/2634094
更新日期:2019-05-14 00:00:00
abstract::The early growth response- (Egr-) 1 has been found to play a key role in organ fibrosis. Metformin has been shown to be effective in attenuating renal tubular epithelial-to-mesenchymal transition (EMT), which is involved in renal fibrosis. However, it is unknown whether metformin improves EMT via inhibiting Egr-1. In ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/1031367
更新日期:2018-06-27 00:00:00
abstract::The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) a...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/921274
更新日期:2015-01-01 00:00:00
abstract:Objectives:To investigate the risk factors for cognitive impairment in Chinese type 2 diabetes mellitus (T2DM) patients of advanced age and to identify effective biomarkers of mild cognitive impairment (MCI) in these patients. Methods:Chinese T2DM patients (n = 120) aged 50-70 years were divided into groups with impai...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/4591938
更新日期:2020-04-23 00:00:00
abstract::Background/Aims. Subclinical atherosclerosis and long-term glycemic variability have been reported to predict incident chronic kidney disease (CKD) in the general population. However, these associations have not been investigated in patients with type 2 diabetes with preserved kidney function. Methods. We prospectivel...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3295747
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2020-11-24 00:00:00
abstract::Widespread electronic health record (EHR) implementation creates new challenges in the diabetes care of complex and diverse populations, including safe medication prescribing for patients with limited health literacy and limited English proficiency. This review highlights how the EHR electronic prescribing transformat...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/8983237
更新日期:2017-01-01 00:00:00