Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6.

abstract：:Type 2 diabetes increases the risk for all-site cancers including colon cancer. Diabetic patients present typical pathophysiological features including an increased level of advanced glycation end products (AGEs), which comes from a series of nonenzymatic reactions between sugars and biological macromolecules, positiv...

journal_title：Journal of diabetes research

authors： Wang P,Lu YC,Li YF,Wang L,Lee SC

更新日期：2018-09-09 00:00:00

abstract：Aims:To investigate the effect of peer support education model on the levels of glucose and lipids in patients with type 2 diabetes mellitus in China. Methods:120 type 2 diabetes mellitus patients (T2DM) were assigned to two groups randomly from December 2016 to October 2017. Group 1 was trained on basic diabetic medi...

journal_title：Journal of diabetes research

authors： Zhao X,Yu X,Zhang X

更新日期：2019-11-22 00:00:00

abstract：:Advanced glycation end products (AGEs) are major inflammatory mediators in diabetes, affecting atherosclerosis progression via macrophages. Metformin slows diabetic atherosclerosis progression through mechanisms that remain to be fully elucidated. The present study of murine bone marrow derived macrophages showed that...

journal_title：Journal of diabetes research

authors： Zhou Z,Tang Y,Jin X,Chen C,Lu Y,Liu L,Shen C

更新日期：2016-01-01 00:00:00

abstract：:Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascu...

journal_title：Journal of diabetes research

authors： Dahan I,Farber E,Thauho N,Nakhoul N,Francis A,Awawde M,Levy AP,Kim-Shapiro DB,Basu S,Nakhoul F

更新日期：2015-01-01 00:00:00

abstract：:We investigated the correlation between obestatin and metabolic parameters and carotid intima-media thickness (IMT) in plasma of patients with type 2 diabetes mellitus (T2DM). We collected 103 patients aged from 60 to 83 years (69.26 ± 5.83 years) form January, 2007 to May, 2009. All patients were divided into normal ...

journal_title：Journal of diabetes research

authors： Gu PY,Kang DM,Wang WD,Chen Y,Zhao ZH,Zheng H,Ye SD

更新日期：2013-01-01 00:00:00

abstract：:Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a combination of genetic predisposition and environmental and lifestyle factors including lack of physical exercise and poor nutrition habits. The increased risk of type 2 diabetes is molecularly based on defects in insulin signa...

journal_title：Journal of diabetes research

authors： Röhling M,Herder C,Stemper T,Müssig K

更新日期：2016-01-01 00:00:00

abstract：Objectives:To investigate the risk factors for cognitive impairment in Chinese type 2 diabetes mellitus (T2DM) patients of advanced age and to identify effective biomarkers of mild cognitive impairment (MCI) in these patients. Methods:Chinese T2DM patients (n = 120) aged 50-70 years were divided into groups with impai...

journal_title：Journal of diabetes research

authors： Sun L,Diao X,Gang X,Lv Y,Zhao X,Yang S,Gao Y,Wang G

更新日期：2020-04-23 00:00:00

abstract：:Background/Aims. Subclinical atherosclerosis and long-term glycemic variability have been reported to predict incident chronic kidney disease (CKD) in the general population. However, these associations have not been investigated in patients with type 2 diabetes with preserved kidney function. Methods. We prospectivel...

journal_title：Journal of diabetes research

authors： Takenouchi A,Tsuboi A,Kurata M,Fukuo K,Kazumi T

更新日期：2016-01-01 00:00:00

abstract：:Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic β-cells, we investigated their role in the control of insulin secretion and glucose homeostasis. In this study, we conf...

journal_title：Journal of diabetes research

authors： Hivelin C,Béraud-Dufour S,Devader C,Abderrahmani A,Moreno S,Moha Ou Maati H,Djillani A,Heurteaux C,Borsotto M,Mazella J,Coppola T

更新日期：2016-01-01 00:00:00

abstract：:The early growth response- (Egr-) 1 has been found to play a key role in organ fibrosis. Metformin has been shown to be effective in attenuating renal tubular epithelial-to-mesenchymal transition (EMT), which is involved in renal fibrosis. However, it is unknown whether metformin improves EMT via inhibiting Egr-1. In ...

journal_title：Journal of diabetes research

authors： Guan M,Li W,Xu L,Zeng Y,Wang D,Zheng Z,Lyv F,Xue Y

更新日期：2018-06-27 00:00:00

abstract：:We present a post hoc analysis of 17,530 questionnaires collected as part of the 2012 screening for neuropathy using Norfolk Quality of Life tool in patients with diabetes in Romania, to assess the impact on foot complications of time between the onset of symptoms of diabetes/its complications and the physician visit....

journal_title：Journal of diabetes research

authors： Gavan NA,Veresiu IA,Vinik EJ,Vinik AI,Florea B,Bondor CI

更新日期：2016-01-01 00:00:00

abstract：Background and Objectives:Diabetes is one of the most common chronic diseases; it is a debilitating and hard to live with. Diabetes-related distress (DRD) refers to the emotional and behavioral changes caused by diabetes. Our study aims to assess the prevalence of DRD among type 2 diabetes (T2D) patients using Diabetes...

journal_title：Journal of diabetes research

authors： Aljuaid MO,Almutairi AM,Assiri MA,Almalki DM,Alswat K

更新日期：2018-03-26 00:00:00

abstract：:Aims. Dipeptidyl-peptidase IV inhibitors (DPP-4i) are among the most popular oral antidiabetic agents. However, the effects of DPP-4i on diabetic nephropathy are not well-established. The aim of this study was to determine the renoprotective effects of DPP-4i, using albuminuria and glomerular filtration rate (GFR) as ...

journal_title：Journal of diabetes research

authors： Kim YG,Byun J,Yoon D,Jeon JY,Han SJ,Kim DJ,Lee KW,Park RW,Kim HJ

更新日期：2016-01-01 00:00:00

abstract：Objectives:This study is aimed at gaining insights on the changing prevalence, economic burden, and catastrophic costs of diabetes in rural southwest China. Materials and Methods:Data were collected from two cross-sectional health interviews and examination surveys among individuals aged ≥ 35 years in rural Yunnan Pro...

journal_title：Journal of diabetes research

authors： Li HF,Cai L,Golden AR

更新日期：2019-08-01 00:00:00

abstract：:T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2D...

journal_title：Journal of diabetes research

authors： Bloch O,Broide E,Ben-Yehudah G,Cantrell D,Shirin H,Rapoport MJ

更新日期：2015-01-01 00:00:00

abstract：:It is understood that intrauterine hyperglycemia increases the risk of obesity and diabetes in offspring of consecutive generations but its mechanisms remain obscure. This study is aimed at establishing an intrauterine hyperglycemia rat model to investigate the growth and glycolipid metabolic characteristics in transg...

journal_title：Journal of diabetes research

authors： Zhang W,Su R,Feng H,Lin L,Wang C,Yang H

更新日期：2019-09-12 00:00:00

abstract：:Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity ind...

journal_title：Journal of diabetes research

authors： Geragotou T,Jainandunsing S,Özcan B,de Rooij FW,Kokkinos A,Tentolouris N,Sijbrands EJ

更新日期：2016-01-01 00:00:00

abstract：:To evaluate the characteristics and determinants of partial remission (PR) in Belgian children with type 1 diabetes (T1D), we analyzed records of 242 children from our center. Clinical and biological features were collected at diagnosis and during follow-up. PR was defined using the insulin-dose-adjusted A1C definitio...

journal_title：Journal of diabetes research

authors： Pecheur A,Barrea T,Vandooren V,Beauloye V,Robert A,Lysy PA

更新日期：2014-01-01 00:00:00

abstract：:Aims. Prevention of diabetes complications depends on the level of case finding and successful treatment of diabetes, which may differ between ethnicities. Therefore, we studied the prevalence by age, awareness, treatment, and control of type 2 diabetes, among a multiethnic population. Methods. We included 4,541 Dutch...

journal_title：Journal of diabetes research

authors： Snijder MB,Agyemang C,Peters RJ,Stronks K,Ujcic-Voortman JK,van Valkengoed IG

更新日期：2017-01-01 00:00:00

abstract：:The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development of type II diabetes. Aluminum is known to trigger the structural transformation of many amyloid proteins and induce the formation of toxic aggregate species. The (-)-epigallocatechin gallate (EGCG) is considered...

journal_title：Journal of diabetes research

authors： Xu ZX,Zhang Q,Ma GL,Chen CH,He YM,Xu LH,Zhang Y,Zhou GR,Li ZH,Yang HJ,Zhou P

更新日期：2016-01-01 00:00:00

abstract：:Tripterygium glycosides tablet (TGT) is a Chinese traditional medicine that has been shown to protect podocytes from injury and reduce the proteinuria. The aim of this study was to assess the effect of TGT on renal tubulointerstitial fibrosis and its potential mechanism in high-fat diet fed and STZ-induced diabetic ra...

journal_title：Journal of diabetes research

authors： Ma ZJ,Zhang XN,Li L,Yang W,Wang SS,Guo X,Sun P,Chen LM

更新日期：2015-01-01 00:00:00

abstract：:Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in the development of re...

journal_title：Journal of diabetes research

authors： Donate-Correa J,Martín-Núñez E,Muros-de-Fuentes M,Mora-Fernández C,Navarro-González JF

更新日期：2015-01-01 00:00:00

abstract：:Children with type 1 diabetes (T1DM) are the high-risk group of accelerated atherosclerosis. Real-time continuous glucose monitoring (RT-CGM) provides possibilities for the detection of glycaemic variability, newly recognized cardiovascular risk factor. The aim of the study was to assess the usefulness of RT-CGM as an...

journal_title：Journal of diabetes research

authors： Jamiołkowska M,Jamiołkowska I,Łuczyński W,Tołwińska J,Bossowski A,Głowińska Olszewska B

更新日期：2016-01-01 00:00:00

abstract：:This study determined if blocking ligand occupancy of the αVβ3 integrin could inhibit the pathophysiologic changes that occur in the early stages of diabetic nephropathy (DN). Diabetic rats were treated with either vehicle or a monoclonal antibody that binds the β3 subunit of the αVβ3 integrin. After 4 weeks of diabet...

journal_title：Journal of diabetes research

authors： Maile LA,Gollahon K,Wai C,Dunbar P,Busby W,Clemmons D

更新日期：2014-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2018/6239158.]. ...

journal_title：Journal of diabetes research

authors： Abdella NA,Mojiminiyi OA

更新日期：2018-10-22 00:00:00

abstract：Background and Aims:Diabetic foot ulcers (DFUs) are linked to amputations and premature deaths. Negative pressure wound therapy (NPWT) has been used for DFUs. The mechanism of NPWT's action may be associated with its influence on circulating molecules. We assessed NPWT's effect on the plasma levels of angiopoietin-2 (A...

journal_title：Journal of diabetes research

authors： Hohendorff J,Drozdz A,Borys S,Ludwig-Slomczynska AH,Kiec-Wilk B,Stepien EL,Malecki MT

更新日期：2019-10-28 00:00:00

abstract：:Previous studies investigating determinants of changes in glycemic status among individuals with prediabetes mainly focused on glucose-defined prediabetes. In this study, we examined determinants of a regression to normoglycemia or a progression to diabetes among individuals with HbA1c-defined prediabetes. The study i...

journal_title：Journal of diabetes research

authors： Paprott R,Scheidt-Nave C,Heidemann C

更新日期：2018-10-14 00:00:00

abstract：:The complex diagnosis and treatment of diabetes highlight the need for markers to define how to monitor patients correctly during the course of their disease. Different studies demonstrate the existence of patients who cannot be clearly classified. We have previously shown that it is possible to differentiate "atypica...

journal_title：Journal of diabetes research

authors： Fabregat M,Fernandez M,Javiel G,Vitarella G,Mimbacas A

更新日期：2015-01-01 00:00:00

abstract：Background:Diabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide. Due to the increasing prevalence and various complications, diabetes brings about a huge financial burden to DM patients. Nowadays, more and more studies reveal the relationship between diseases and gut microbial c...

journal_title：Journal of diabetes research

authors： Zhao X,Zhang Y,Guo R,Yu W,Zhang F,Wu F,Shang J

更新日期：2020-11-11 00:00:00

abstract：:Partial or complete remission from type 2 diabetes was recently observed after bariatric surgeries. Limited data is available about the possibility of inducing diabetes remission through intensive weight reduction. We retrospectively evaluated diabetes remissions after one year of the Weight Achievement and Intensive ...

journal_title：Journal of diabetes research

authors： Mottalib A,Sakr M,Shehabeldin M,Hamdy O

更新日期：2015-01-01 00:00:00