Abstract:
:Advanced glycation end products (AGEs) are major inflammatory mediators in diabetes, affecting atherosclerosis progression via macrophages. Metformin slows diabetic atherosclerosis progression through mechanisms that remain to be fully elucidated. The present study of murine bone marrow derived macrophages showed that (1) AGEs enhanced proinflammatory cytokines (interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α)) mRNA expression, RAGE expression, and NFκB activation; (2) metformin pretreatment inhibited AGEs effects and AGEs-induced cluster designation 86 (CD86) (M1 marker) expression, while promoting CD206 (M2 marker) surface expression and anti-inflammatory cytokine (IL-10) mRNA expression; and (3) the AMPK inhibitor, Compound C, attenuated metformin effects. In conclusion, metformin inhibits AGEs-induced inflammatory response in murine macrophages partly through AMPK activation and RAGE/NFκB pathway suppression.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Zhou Z,Tang Y,Jin X,Chen C,Lu Y,Liu L,Shen Cdoi
10.1155/2016/4847812subject
Has Abstractpub_date
2016-01-01 00:00:00pages
4847812eissn
2314-6745issn
2314-6753journal_volume
2016pub_type
杂志文章abstract::The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle. However, no significant glycogen stores are detected in normal kidneys, but diabetic subjects present a characteristic renal histopathological feature resulting f...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/5697970
更新日期:2018-05-29 00:00:00
abstract::In bioartificial pancreases (BP), the number of islets needed to restore normoglycaemia in the diabetic patient is critical. However, the confinement of a high quantity of islets in a limited space may impact islet survival, particularly in regard to the low oxygen partial pressure (PO2) in such environments. The aim ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3615286
更新日期:2016-01-01 00:00:00
abstract::Dilated cardiomyopathy (DCM) is characterized by a metabolic shift from fat to carbohydrates and failure to increase myocardial glucose uptake in response to workload increments. We verified whether this pattern is influenced by an abnormal glucose tolerance (AGT). In 10 patients with DCM, 5 with normal glucose tolera...
journal_title:Journal of diabetes research
pub_type: 临床试验,杂志文章
doi:10.1155/2016/3906425
更新日期:2016-01-01 00:00:00
abstract::Methylglyoxal (MG) is a highly reactive glucose metabolic intermediate and a major precursor of advanced glycation end products. MG level is elevated in hyperglycemic disorders such as diabetes mellitus. Substantial evidence has shown that MG is involved in the pathogenesis of diabetes and diabetic complications. We i...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2029854
更新日期:2016-01-01 00:00:00
abstract:Objective:To evaluate (1) the longitudinal relationship between parental well-being and glycemic control in youth with type 1 diabetes and (2) if youth's problem behavior, diabetes parenting behavior, and parental diabetes-distress influence this relationship. Research Design and Methods:Parents of youth 8-15 yrs (at ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1462064
更新日期:2017-01-01 00:00:00
abstract::To evaluate the characteristics and determinants of partial remission (PR) in Belgian children with type 1 diabetes (T1D), we analyzed records of 242 children from our center. Clinical and biological features were collected at diagnosis and during follow-up. PR was defined using the insulin-dose-adjusted A1C definitio...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/851378
更新日期:2014-01-01 00:00:00
abstract::The early growth response- (Egr-) 1 has been found to play a key role in organ fibrosis. Metformin has been shown to be effective in attenuating renal tubular epithelial-to-mesenchymal transition (EMT), which is involved in renal fibrosis. However, it is unknown whether metformin improves EMT via inhibiting Egr-1. In ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/1031367
更新日期:2018-06-27 00:00:00
abstract::Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4 + and CD8 ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2020/4106518
更新日期:2020-07-30 00:00:00
abstract::The role of diabetic nephropathy in the outcome of acute renal injury (AKI) is not well defined. Herein we evaluate the outcome of lipopolysaccharide- (LPS-) induced AKI in streptozotocin-induced diabetes, as well as the potential role of Hypoxia Inducible Factor (HIF-1 α ) in this condition. Although 6 h after LPS in...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/254529
更新日期:2013-01-01 00:00:00
abstract:Objectives:To investigate the risk factors for cognitive impairment in Chinese type 2 diabetes mellitus (T2DM) patients of advanced age and to identify effective biomarkers of mild cognitive impairment (MCI) in these patients. Methods:Chinese T2DM patients (n = 120) aged 50-70 years were divided into groups with impai...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/4591938
更新日期:2020-04-23 00:00:00
abstract::Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β -catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/848679
更新日期:2013-01-01 00:00:00
abstract::Despite recent advances in the understanding and management of diabetes mellitus, the prevalence of the disease is increasing unabatedly with resulting disabling and life-reducing consequences to the global human population. The limitations and side effects associated with current antidiabetic therapies have necessita...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/9737483
更新日期:2016-01-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both environmental and genetic factors contribute to its development. Recent studies have demonstrated that the skeleton realizes systemic regulation of energy metabolism through the secretion of osteocalcin (OCN). Thus, the ass...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/9302636
更新日期:2019-11-27 00:00:00
abstract::This study evaluated the inflammatory markers in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). Inflammatory markers levels were analyzed using one-way analysis of covariance and the association with prediabetes or T2DM risks was examined by logistic regression models. Our data showed increased level...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/7965317
更新日期:2016-01-01 00:00:00
abstract::We investigated the correlation between obestatin and metabolic parameters and carotid intima-media thickness (IMT) in plasma of patients with type 2 diabetes mellitus (T2DM). We collected 103 patients aged from 60 to 83 years (69.26 ± 5.83 years) form January, 2007 to May, 2009. All patients were divided into normal ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/563919
更新日期:2013-01-01 00:00:00
abstract::Tripterygium glycosides tablet (TGT) is a Chinese traditional medicine that has been shown to protect podocytes from injury and reduce the proteinuria. The aim of this study was to assess the effect of TGT on renal tubulointerstitial fibrosis and its potential mechanism in high-fat diet fed and STZ-induced diabetic ra...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/390428
更新日期:2015-01-01 00:00:00
abstract:Purpose:Nontraditional cardiovascular risk factors as apolipoprotein A (ApoA), apolipoprotein B (ApoB), and the proprotein convertase subtilisin/kexin type 9 (PCSK9) increase the prevalence of cardiovascular mortality in chronic kidney disease (CKD) or in end-stage renal disease (ESRD) through quantitative alterations....
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2019/6906278
更新日期:2019-12-14 00:00:00
abstract::Diabetes mellitus is a chronic disease prevalence of which is high and continually growing. Cardiovascular disease continues to be the leading cause of death in patients with T2DM. The prevention of cardiovascular complications and the cardiovascular safety of treatments should be a primary objective when selecting tr...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/4020492
更新日期:2018-04-02 00:00:00
abstract::We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5027356
更新日期:2016-01-01 00:00:00
abstract::Sub-Saharan Africa (SSA) continues to have the highest diabetes-related mortality rate in the world. While there exists a multitude of health system barriers driving poor diabetes control, rural facilities particularly in SSA lack access to proper monitoring of glucose and other key biologic tests. At best, most of th...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/6093595
更新日期:2018-02-26 00:00:00
abstract::Widespread electronic health record (EHR) implementation creates new challenges in the diabetes care of complex and diverse populations, including safe medication prescribing for patients with limited health literacy and limited English proficiency. This review highlights how the EHR electronic prescribing transformat...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/8983237
更新日期:2017-01-01 00:00:00
abstract:Aims:To investigate the effect of peer support education model on the levels of glucose and lipids in patients with type 2 diabetes mellitus in China. Methods:120 type 2 diabetes mellitus patients (T2DM) were assigned to two groups randomly from December 2016 to October 2017. Group 1 was trained on basic diabetic medi...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/5634030
更新日期:2019-11-22 00:00:00
abstract::A growing body of evidence suggests yogic practices may benefit adults with type 2 diabetes (DM2). In this systematic review, we evaluate available evidence from prospective controlled trials regarding the effects of yoga-based programs on specific health outcomes pertinent to DM2 management. To identify qualifying st...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/6979370
更新日期:2016-01-01 00:00:00
abstract::Metabolic inflammatory damage, characterized by Toll-like receptor 4 (TLR4) signaling activation, is a major mechanism underlying lipotoxicity-induced β-cell damage. The present study is aimed at determining whether G protein-coupled receptor 4 (GPR40) agonist can improve β-cell lipotoxicity-induced damage by inhibiti...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/5487962
更新日期:2019-12-17 00:00:00
abstract::Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9648798
更新日期:2016-01-01 00:00:00
abstract::Knowing how to prevent and treat diabetes mellitus (DM) earlier is essential to improving outcomes. Through participating in synthesis and catabolism of glycogen, the liver helps to regulate glucose homeostasis. Viral related liver diseases are associated with glycometabolism disorders, which means effective managemen...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/5625371
更新日期:2017-01-01 00:00:00
abstract::Angiotensin-(1-7) [Ang-(1-7)] may have beneficial effects in diabetes mellitus-induced erectile dysfunction (DMIED) but its molecular actions in the diabetic corpus cavernosum (CC) are not known. We characterized the effects of diabetes and/or chronic in vivo administration of Ang-(1-7) on vascular reactivity in the r...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/142154
更新日期:2014-01-01 00:00:00
abstract::Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity ind...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9286303
更新日期:2016-01-01 00:00:00
abstract:Background:Previous studies showed that probiotics could improve glycemic control and attenuate some of the adverse effects of type 2 diabetes. However, whether the effects are generalizable to gestational diabetes mellitus (GDM) remains uncertain. Objective:We conducted a systematic review and meta-analysis to evalua...
journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析
doi:10.1155/2019/5364730
更新日期:2019-09-05 00:00:00
abstract::The haptoglobin (Hp) genotype (1-1 and 2-2) is a major determinant of nephropathy progression in diabetes mellitus patients. Hp 2-2 diabetic mice have impaired Hb clearance and increased iron deposits and oxidative stress in the proximal tubules (PCT), leading to increased renal injury. However, the precise mechanism ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/7163652
更新日期:2018-09-03 00:00:00