Chronic treatment with Ang-(1-7) reverses abnormal reactivity in the corpus cavernosum and normalizes diabetes-induced changes in the protein levels of ACE, ACE2, ROCK1, ROCK2 and omega-hydroxylase in a rat model of type 1 diabetes.

abstract：:Germinated brown rice (GBR) is rich in bioactive compounds, which confer GBR with many functional properties. Evidence of its hypocholesterolemic effects is emerging, but the exact mechanisms of action and bioactive compounds involved have not been fully documented. Using type 2 diabetic rats, we studied the effects o...

journal_title：Journal of diabetes research

authors： Imam MU,Ismail M,Omar AR,Ithnin H

更新日期：2013-01-01 00:00:00

abstract：:Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy rema...

journal_title：Journal of diabetes research

authors： Ortiz-Avila O,Esquivel-Martínez M,Olmos-Orizaba BE,Saavedra-Molina A,Rodriguez-Orozco AR,Cortés-Rojo C

更新日期：2015-01-01 00:00:00

abstract：Aim:To evaluate the prognostic role of procalcitonin (PCT) in patients with diabetic foot infection (DFI) and critical limb ischemia (CLI). Materials and Methods:The study group was composed of diabetic patients with DFI and CLI. All patients were treated according to a preset limb salvage protocol which includes reva...

journal_title：Journal of diabetes research

authors： Meloni M,Izzo V,Giurato L,Brocco E,Ferrannini M,Gandini R,Uccioli L

更新日期：2019-08-14 00:00:00

abstract：:Aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 isozymes. They are present in various organs and involved in metabolizing aldehydes that are biologically generated. For instance, ALDH2, a cardiac mitochondrial ALDH isozyme, is known to detoxify 4-hydroxy-2-nonenal, a reactive aldehyde produced upon lipid...

journal_title：Journal of diabetes research

authors： Pan G,Deshpande M,Thandavarayan RA,Palaniyandi SS

更新日期：2016-01-01 00:00:00

abstract：:Background. The feasibility of digital health programs to prevent and manage diabetes in low-income patients has not been adequately explored. Methods. Researchers collaborated with a digital health company to adapt a diabetes prevention program for low-income prediabetes patients at a large safety net clinic. We cond...

journal_title：Journal of diabetes research

authors： Fontil V,McDermott K,Tieu L,Rios C,Gibson E,Sweet CC,Payne M,Lyles CR

更新日期：2016-01-01 00:00:00

abstract：:To compare the efficacy and safety of metformin, glyburide, and insulin in treating gestational diabetes mellitus (GDM), a meta-analysis of randomized controlled trials (RCTs) was conducted. PubMed, Embase, CINAHL, Web of Science, and Cochrane Library to November 13, 2018, were searched for RCT adjusted estimates of t...

journal_title：Journal of diabetes research

authors： Guo L,Ma J,Tang J,Hu D,Zhang W,Zhao X

更新日期：2019-11-04 00:00:00

abstract：Objective:To investigate the effects of cod-liver oil on metabolic status and high-sensitivity C-reactive protein (hs-CRP) in patients with gestational diabetes mellitus (GDM). Methods:This study was a randomized, double-blinded, placebo-controlled trial with the allocation ratio of 1 : 1. The contents of EPA and DHA ...

journal_title：Journal of diabetes research

authors： Yang S,Lin R,Si L,Li Z,Jian W,Yu Q,Jia Y

更新日期：2019-12-28 00:00:00

abstract：:Metformin is contraindicated in diabetic patients with declining renal function. This study examined the glycaemic control in diabetic patients with chronic kidney disease when metformin was discontinued. This was a retrospective study. We screened 2032 diabetic patients who attended the Diabetes Clinic at a tertiary ...

journal_title：Journal of diabetes research

authors： Leyco T,Ryanputra D,Peh R,Ponce A,Khoo CM

更新日期：2017-01-01 00:00:00

abstract：Aim:To investigate the association between monocyte CD163 and insulin resistance in patients with type 2 diabetes. Methods:One hundred sixty-six patients with type 2 diabetes without inflammatory or chronic kidney disease were recruited. The monocyte CD163 levels were measured by flow cytometry and soluble CD163 (sCD1...

journal_title：Journal of diabetes research

authors： Kawarabayashi R,Motoyama K,Nakamura M,Yamazaki Y,Morioka T,Mori K,Fukumoto S,Imanishi Y,Shioi A,Shoji T,Emoto M,Inaba M

更新日期：2017-01-01 00:00:00

abstract：AIM:To evaluate an agreement in identifying dysglycemia between fasting plasma glucose (FPG) and the 2 hr postprandial glucose tolerance test (OGTT) in a population with high risk of diabetes. METHODS:A total of 6,884 individuals aged 35-65 years recruited for a community-based diabetes prevention program were tested ...

journal_title：Journal of diabetes research

authors： Aekplakorn W,Tantayotai V,Numsangkul S,Sripho W,Tatsato N,Burapasiriwat T,Pipatsart R,Sansom P,Luckanajantachote P,Chawarokorn P,Thanonghan A,Lakhamkaew W,Mungkung A,Boonkean R,Chantapoon C,Kungsri M,Luanseng K,Chaiyaji

更新日期：2015-01-01 00:00:00

abstract：Background:Maternal dietary patterns play an important role in the progress of gestational diabetes mellitus (GDM). The aim of the present study was to explore this association. Method:A total of 388 pregnant women (122 case and 266 control) were included. Dietary intake were collected using a food frequency questionn...

journal_title：Journal of diabetes research

authors： Sedaghat F,Akhoondan M,Ehteshami M,Aghamohammadi V,Ghanei N,Mirmiran P,Rashidkhani B

更新日期：2017-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2015/723190.]. ...

journal_title：Journal of diabetes research

authors： Yu SH,Chen ST,Li WS,Dubey NK,Chen WH,Chuu JJ,Leu SJ,Deng WP

更新日期：2017-01-01 00:00:00

abstract：:Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM pa...

journal_title：Journal of diabetes research

authors： Zhang X,Sun J,Han W,Jiang Y,Peng S,Shan Z,Teng W

更新日期：2016-01-01 00:00:00

abstract：:Zinc (Zn) is an important nutrient that is involved in various physiological metabolisms. Zn dyshomeostasis is often associated with various pathogeneses of chronic diseases, such as metabolic syndrome, diabetes, and related complications. Zn is present in ocular tissue in high concentrations, particularly in the reti...

journal_title：Journal of diabetes research

authors： Miao X,Sun W,Miao L,Fu Y,Wang Y,Su G,Liu Q

更新日期：2013-01-01 00:00:00

abstract：:Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by progressive glomerular sclerosis and tubulointerstitial fibrosis. However, the underlying mechanisms involved in DN remain to be elucidated. We explored changes in the transcriptional profile in spontaneous type 2 diabetic db/...

journal_title：Journal of diabetes research

authors： Zhang H,Zhao T,Li Z,Yan M,Zhao H,Zhu B,Li P

更新日期：2017-01-01 00:00:00

abstract：Purpose:Nontraditional cardiovascular risk factors as apolipoprotein A (ApoA), apolipoprotein B (ApoB), and the proprotein convertase subtilisin/kexin type 9 (PCSK9) increase the prevalence of cardiovascular mortality in chronic kidney disease (CKD) or in end-stage renal disease (ESRD) through quantitative alterations....

journal_title：Journal of diabetes research

authors： Vlad CE,Foia L,Popescu R,Ivanov I,Luca MC,Delianu C,Toma V,Statescu C,Rezus C,Florea L

更新日期：2019-12-14 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4 + and CD8 ...

journal_title：Journal of diabetes research

authors： Sun L,Xi S,He G,Li Z,Gang X,Sun C,Guo W,Wang G

更新日期：2020-07-30 00:00:00

abstract：Background:Diabetes mellitus is a widely diffused chronic condition which impacts on several aspects of patients' lives. In the current clinical practice, the implementation in the clinical routine of monitoring systems of patients' outcomes has led to an increased generation and use of several measures for the assessm...

journal_title：Journal of diabetes research

authors： Palamenghi L,Carlucci MM,Graffigna G

更新日期：2020-05-20 00:00:00

abstract：:To observe the changes of lung injury when diabetic rats were treated with low concentration of ethanol (EtOH) and analyze the related mechanisms, male Sprague-Dawley (SD) rats were divided into control, diabetic (DM), and EtOH+DM groups. Diabetic rat was mimicked by injection of streptozotocin intraperitoneally. Fast...

journal_title：Journal of diabetes research

authors： Hu JF,Zhang GJ,Wang L,Kang PF,Li J,Wang HJ,Gao Q,Chen YQ

更新日期：2014-01-01 00:00:00

abstract：:The haptoglobin (Hp) genotype (1-1 and 2-2) is a major determinant of nephropathy progression in diabetes mellitus patients. Hp 2-2 diabetic mice have impaired Hb clearance and increased iron deposits and oxidative stress in the proximal tubules (PCT), leading to increased renal injury. However, the precise mechanism ...

journal_title：Journal of diabetes research

authors： Dahan I,Thawho N,Farber E,Nakhoul N,Asleh R,Levy AP,Li YC,Ben-Izhak O,Nakhoul F

更新日期：2018-09-03 00:00:00

abstract：AIMS AND BACKGROUND:Type 2 diabetes is a chronic disease that cannot be treated adequately using the known monotherapies, especially when the disease progresses to an advanced stage. In this study, we explore the possibility of treating the disease with a novel combination approach of oleanolic acid (OA), a glycogen ph...

journal_title：Journal of diabetes research

authors： Wang X,Chen Y,Abdelkader D,Hassan W,Sun H,Liu J

更新日期：2015-01-01 00:00:00

abstract：AIMS:Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. METHODS:Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of ...

journal_title：Journal of diabetes research

authors： Yamada E,Takeuchi M,Kurata M,Kazumi T,Fukuo K

更新日期：2014-01-01 00:00:00

abstract：:South Asians have high prevalence of diabetes, cardiovascular risk, and physical inactivity. Reasons for physical inactivity have not been explored among Asians living within their endogenous environments. During phase 1 of the study, we assessed the physical activity (PA) of the population using a quantitative, descr...

journal_title：Journal of diabetes research

authors： Medagama A,Galgomuwa M

更新日期：2018-03-06 00:00:00

abstract：Background:Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein. Objective:To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D....

journal_title：Journal of diabetes research

authors： Chisalita SI,Ludvigsson J

更新日期：2018-03-20 00:00:00

abstract：:Inflammatory atherosclerosis is increased in subjects with type 1 diabetes mellitus (T1DM). Normally high-density lipoproteins (HDL) protect against atherosclerosis; however, in the presence of serum amyloid-A- (SAA-) related inflammation this property may be reduced. Fasting blood was obtained from fifty subjects wit...

journal_title：Journal of diabetes research

authors： McEneny J,Daniels JA,McGowan A,Gunness A,Moore K,Stevenson M,Young IS,Gibney J

更新日期：2015-01-01 00:00:00

abstract：Aims:To investigate the effect of peer support education model on the levels of glucose and lipids in patients with type 2 diabetes mellitus in China. Methods:120 type 2 diabetes mellitus patients (T2DM) were assigned to two groups randomly from December 2016 to October 2017. Group 1 was trained on basic diabetic medi...

journal_title：Journal of diabetes research

authors： Zhao X,Yu X,Zhang X

更新日期：2019-11-22 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) agonists are used for treating hyperglycemia and type 2 diabetes. However, the mechanism of action of these agonists is still under investigation. The lipid droplet-associated proteins FSP27/CIDEC and LSDP5, regulated directly by PPARγ and PPARα, are associated with he...

journal_title：Journal of diabetes research

authors： Zhu YX,Zhang ML,Zhong Y,Wang C,Jia WP

更新日期：2016-01-01 00:00:00

abstract：Objectives:This study is aimed at gaining insights on the changing prevalence, economic burden, and catastrophic costs of diabetes in rural southwest China. Materials and Methods:Data were collected from two cross-sectional health interviews and examination surveys among individuals aged ≥ 35 years in rural Yunnan Pro...

journal_title：Journal of diabetes research

authors： Li HF,Cai L,Golden AR

更新日期：2019-08-01 00:00:00

abstract：:The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...

journal_title：Journal of diabetes research

authors： Chen GP,Zhang XQ,Wu T,Li L,Han J,Du CQ

更新日期：2015-01-01 00:00:00

abstract：:We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between the control and tene...

journal_title：Journal of diabetes research

authors： Moriya C,Satoh H

更新日期：2016-01-01 00:00:00