Risk Factors for the Requirement of Antenatal Insulin Treatment in Gestational Diabetes Mellitus.

Abstract:

:Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in the pregnant women with GDM. We enrolled 37 pregnant women with GDM and investigated the risk for AIT by comparing the patients with AIT (AIT group; n = 10) and without insulin therapy (Diet group; n = 27). The 1-h and 2-h plasma glucose levels and the number of abnormal values in 75 g OGTT were significantly higher in AIT group compared with Diet group. By logistic regression analysis, plasma glucose level at 1-h was significant predictor for AIT and the odds ratios were 1.115 (1.004-1.239) using forward selection method and 1.192 (1.006-1.413) using backward elimination method. There were no significant differences in obstetrical outcomes and neonatal complications. 1-h plasma glucose levels in 75 g OGTT are useful parameters in predicting the requirement for AIT in GDM. Both maternal and neonatal complications are comparable in GDM patients with and without insulin therapy.

journal_name

J Diabetes Res

authors

Watanabe M,Katayama A,Kagawa H,Ogawa D,Wada J

doi

10.1155/2016/9648798

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

9648798

eissn

2314-6745

issn

2314-6753

journal_volume

2016

pub_type

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