The Genetic Profile from HLA and Non-HLA Loci Allows Identification of Atypical Type 2 Diabetes Patients.

abstract：:Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM pa...

journal_title：Journal of diabetes research

authors： Zhang X,Sun J,Han W,Jiang Y,Peng S,Shan Z,Teng W

更新日期：2016-01-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the incidence of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in 2006-2007 and 2013-2014. METHOD:The study group consisted of 426 children aged 0-18 years with type 1 diabetes onset admitted to our hospital in 2006-2007 (group A) and 2...

journal_title：Journal of diabetes research

authors： Szypowska A,Ramotowska A,Grzechnik-Gryziak M,Szypowski W,Pasierb A,Piechowiak K

更新日期：2016-01-01 00:00:00

abstract：Objective:The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Methods:Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital. ACPR was...

journal_title：Journal of diabetes research

authors： Shen Y,Si Y,Lu J,Ma X,Zhang L,Mo Y,Lu W,Zhu W,Bao Y,Hu G,Zhou J

更新日期：2020-07-21 00:00:00

abstract：:We investigated effects on glucose and lipid metabolism in combination of JTT-130, a novel intestine-specific microsomal triglyceride transfer protein (MTP) inhibitor, and pioglitazone, peroxisome proliferator-activated receptor (PPAR) γ agonist. Male Zucker diabetic fatty rats were divided into 4 groups: control grou...

journal_title：Journal of diabetes research

authors： Sakata S,Mera Y,Kuroki Y,Nashida R,Kakutani M,Ohta T

更新日期：2014-01-01 00:00:00

abstract：:Partial or complete remission from type 2 diabetes was recently observed after bariatric surgeries. Limited data is available about the possibility of inducing diabetes remission through intensive weight reduction. We retrospectively evaluated diabetes remissions after one year of the Weight Achievement and Intensive ...

journal_title：Journal of diabetes research

authors： Mottalib A,Sakr M,Shehabeldin M,Hamdy O

更新日期：2015-01-01 00:00:00

abstract：:The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...

journal_title：Journal of diabetes research

authors： Chen GP,Zhang XQ,Wu T,Li L,Han J,Du CQ

更新日期：2015-01-01 00:00:00

abstract：:Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of evolutionary conserved pathogen-associated molecular patterns or ...

journal_title：Journal of diabetes research

authors： Axelgaard E,Østergaard JA,Thiel S,Hansen TK

更新日期：2017-01-01 00:00:00

abstract：:Aerobic exercise training and weight loss (AEX+WL) improves insulin sensitivity in overweight adults; however, the underlying pathways are incompletely understood. Fetuin-A, a hepatokine that inhibits insulin signaling, may be involved in the salutary effects of AEX+WL. Therefore, we examined the effects of 6-month AE...

journal_title：Journal of diabetes research

authors： Blumenthal JB,Gitterman A,Ryan AS,Prior SJ

更新日期：2017-01-01 00:00:00

abstract：AIMS:This study assesses the impact of using an AP-system at home on fear of hypoglycaemia. In addition, satisfaction and acceptance of the new technology are evaluated. METHODS:In a multicentre, multinational study of 75 patients using the MD-Logic AP during four consecutive nights in home setting 59 of them (aged 10...

journal_title：Journal of diabetes research

authors： Ziegler C,Liberman A,Nimri R,Muller I,Klemenčič S,Bratina N,Bläsig S,Remus K,Phillip M,Battelino T,Kordonouri O,Danne T,Lange K

更新日期：2015-01-01 00:00:00

abstract：:Type 2 diabetes increases the risk for all-site cancers including colon cancer. Diabetic patients present typical pathophysiological features including an increased level of advanced glycation end products (AGEs), which comes from a series of nonenzymatic reactions between sugars and biological macromolecules, positiv...

journal_title：Journal of diabetes research

authors： Wang P,Lu YC,Li YF,Wang L,Lee SC

更新日期：2018-09-09 00:00:00

abstract：:Aims. Dipeptidyl-peptidase IV inhibitors (DPP-4i) are among the most popular oral antidiabetic agents. However, the effects of DPP-4i on diabetic nephropathy are not well-established. The aim of this study was to determine the renoprotective effects of DPP-4i, using albuminuria and glomerular filtration rate (GFR) as ...

journal_title：Journal of diabetes research

authors： Kim YG,Byun J,Yoon D,Jeon JY,Han SJ,Kim DJ,Lee KW,Park RW,Kim HJ

更新日期：2016-01-01 00:00:00

abstract：:Bariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and similarly, it shows great...

journal_title：Journal of diabetes research

authors： Samczuk P,Ciborowski M,Kretowski A

更新日期：2018-03-11 00:00:00

abstract：:To study the relationship between glycosylated hemoglobin (HgbA1c) and myocardial perfusion in type 2 diabetes mellitus (T2DM) patients, we prospectively enrolled 24 patients with known or suspected coronary artery disease (CAD) who underwent adenosine stress by real-time myocardial perfusion echocardiography (RTMPE)....

journal_title：Journal of diabetes research

authors： Huang R,Abdelmoneim SS,Nhola LF,Mulvagh SL

更新日期：2014-01-01 00:00:00

abstract：:Background. The feasibility of digital health programs to prevent and manage diabetes in low-income patients has not been adequately explored. Methods. Researchers collaborated with a digital health company to adapt a diabetes prevention program for low-income prediabetes patients at a large safety net clinic. We cond...

journal_title：Journal of diabetes research

authors： Fontil V,McDermott K,Tieu L,Rios C,Gibson E,Sweet CC,Payne M,Lyles CR

更新日期：2016-01-01 00:00:00

abstract：:Diabetes mellitus is a chronic disease prevalence of which is high and continually growing. Cardiovascular disease continues to be the leading cause of death in patients with T2DM. The prevention of cardiovascular complications and the cardiovascular safety of treatments should be a primary objective when selecting tr...

journal_title：Journal of diabetes research

authors： Del Olmo-Garcia MI,Merino-Torres JF

更新日期：2018-04-02 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4 + and CD8 ...

journal_title：Journal of diabetes research

authors： Sun L,Xi S,He G,Li Z,Gang X,Sun C,Guo W,Wang G

更新日期：2020-07-30 00:00:00

abstract：OBJECTIVE:Puerarin is a natural flavonoid isolated from the TCM lobed kudzuvine root. This study investigated the effect and mechanisms of puerarin on diabetic aorta in rats. METHODS:Streptozotocin- (STZ-) induced diabetic rats were administered with puerarin for 3 weeks. Levels of serum insulin (INS), PGE2, endotheli...

journal_title：Journal of diabetes research

authors： Li W,Zhao W,Wu Q,Lu Y,Shi J,Chen X

更新日期：2016-01-01 00:00:00

abstract：Introduction:Diabetes mellitus type 1 and type 2 are linked to higher prevalence and occurrences of depression. Internet-based depression- and diabetes-specific cognitive behavioral therapies (CBT) can be effective in reducing depressive symptom severity and diabetes-related emotional distress. The aim of the study was...

journal_title：Journal of diabetes research

authors： Schlicker S,Weisel KK,Buntrock C,Berking M,Nobis S,Lehr D,Baumeister H,Snoek FJ,Riper H,Ebert DD

更新日期：2019-05-14 00:00:00

abstract：:Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic β-cells, we investigated their role in the control of insulin secretion and glucose homeostasis. In this study, we conf...

journal_title：Journal of diabetes research

authors： Hivelin C,Béraud-Dufour S,Devader C,Abderrahmani A,Moreno S,Moha Ou Maati H,Djillani A,Heurteaux C,Borsotto M,Mazella J,Coppola T

更新日期：2016-01-01 00:00:00

abstract：:We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between the control and tene...

journal_title：Journal of diabetes research

authors： Moriya C,Satoh H

更新日期：2016-01-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is characterized by a metabolic shift from fat to carbohydrates and failure to increase myocardial glucose uptake in response to workload increments. We verified whether this pattern is influenced by an abnormal glucose tolerance (AGT). In 10 patients with DCM, 5 with normal glucose tolera...

journal_title：Journal of diabetes research

authors： Tricò D,Baldi S,Frascerra S,Venturi E,Marraccini P,Neglia D,Natali A

更新日期：2016-01-01 00:00:00

abstract：:The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development of type II diabetes. Aluminum is known to trigger the structural transformation of many amyloid proteins and induce the formation of toxic aggregate species. The (-)-epigallocatechin gallate (EGCG) is considered...

journal_title：Journal of diabetes research

authors： Xu ZX,Zhang Q,Ma GL,Chen CH,He YM,Xu LH,Zhang Y,Zhou GR,Li ZH,Yang HJ,Zhou P

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats. METHODS:The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ). The rats were randomly divided into 5 groups (ten rats ...

journal_title：Journal of diabetes research

authors： Huang S,Peng W,Jiang X,Shao K,Xia L,Tang Y,Qiu J

更新日期：2014-01-01 00:00:00

abstract：Background:T2DM may cause increased levels of oxidative stress and cardiac apoptosis through elevated blood glucose. The present study investigated the effects of Lactobacillus plantarum (L. plantarum) as a probiotic strain and inulin as a prebiotic supplement on cardiac oxidative stress and apoptotic markers in type 2...

journal_title：Journal of diabetes research

authors： Sefidgari-Abrasi S,Karimi P,Roshangar L,Morshedi M,Bavafa-Valenlia K,Saghafi-Asl M,Mohiti S,Rahimiyan-Heravan M

更新日期：2020-05-15 00:00:00

abstract：Objective:To evaluate diabetic retinopathy (DR) screening via deep learning (DL) and trained human graders (HG) in a longitudinal cohort, as case spectrum shifts based on treatment referral and new-onset DR. Methods:We randomly selected patients with diabetes screened twice, two years apart within a nationwide screeni...

journal_title：Journal of diabetes research

authors： Limwattanayingyong J,Nganthavee V,Seresirikachorn K,Singalavanija T,Soonthornworasiri N,Ruamviboonsuk V,Rao C,Raman R,Grzybowski A,Schaekermann M,Peng LH,Webster DR,Semturs C,Krause J,Sayres R,Hersch F,Tiwari R,Liu Y,

更新日期：2020-12-15 00:00:00

abstract：:Aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 isozymes. They are present in various organs and involved in metabolizing aldehydes that are biologically generated. For instance, ALDH2, a cardiac mitochondrial ALDH isozyme, is known to detoxify 4-hydroxy-2-nonenal, a reactive aldehyde produced upon lipid...

journal_title：Journal of diabetes research

authors： Pan G,Deshpande M,Thandavarayan RA,Palaniyandi SS

更新日期：2016-01-01 00:00:00

abstract：Background:Obesity has been considered as an important factor in the development and progression of chronic kidney diseases (CKD). Perirenal fat, which is surrounding the kidneys, has been reported to be unique in anatomy and biological functions. This study is aimed at assessing the relationship between perirenal fat ...

journal_title：Journal of diabetes research

authors： Fang Y,Xu Y,Yang Y,Liu C,Zhao D,Ke J

更新日期：2020-06-28 00:00:00

abstract：Objective:To examine whether comorbidity with type 2 diabetes (T2D) affects the clinical and hematological parameters of coronavirus disease 2019 (COVID-19) patients. Methods:We retrospectively investigated the clinical, imaging, and laboratory characteristics of patients with confirmed COVID-19 who were hospitalized ...

journal_title：Journal of diabetes research

authors： Sun Y,Zhao R,Hu Z,Wang W,Wang S,Gao L,Fei J,Jian X,Li Y,Zheng H,Hou X,Chen L

更新日期：2020-12-02 00:00:00

abstract：:The objective of this study was to assess the effects of exogenously expressed proinsulin on the biological characters of a hematopoietic stem cell line (HSC) and erythroid myeloid lymphoid (EML) cells and explore new strategies for cell therapy for type I diabetes. EML cells were transduced with lentivirus particles ...

journal_title：Journal of diabetes research

authors： Han Y,Liu T,Zou Y,Ji L,Li Y,Li J,Wang J,Chen G,Chen J,Chen L,Ye Z

更新日期：2017-01-01 00:00:00

abstract：:Insulin resistance, which plays a central role in the pathogenesis of type 2 diabetes (T2D), is an early indicator that heralds the occurrence of T2D. It is imperative to understand the metabolic changes that occur at the cellular level in the early stages of insulin resistance. The objective of this study was to dete...

journal_title：Journal of diabetes research

authors： Berhane F,Fite A,Daboul N,Al-Janabi W,Msallaty Z,Caruso M,Lewis MK,Yi Z,Diamond MP,Abou-Samra AB,Seyoum B

更新日期：2015-01-01 00:00:00