Abstract:
:To study the relationship between glycosylated hemoglobin (HgbA1c) and myocardial perfusion in type 2 diabetes mellitus (T2DM) patients, we prospectively enrolled 24 patients with known or suspected coronary artery disease (CAD) who underwent adenosine stress by real-time myocardial perfusion echocardiography (RTMPE). HgbA1c was measured at time of RTMPE. Microbubble velocity (β min(-1)), myocardial blood flow (MBF, mL/min/g), and myocardial blood flow reserve (MBFR) were quantified. Quantitative MCE analysis was feasible in all patients (272/384 segments, 71%). Those with HgbA1c > 7.1% had significantly lower βreserve and MBFR than those with HgbA1c ≤ 7.1% (P < 0.05). In patients with suspected CAD, there was a significant inverse correlation between MBFR and HgbA1c (r = -0.279, P = 0.01); however, in those with known CAD, this relationship was not significant (r = -0.117, P = 0.129). Using a MBFR cutoff value > 2 as normal, HgbA1c > 7.1% significantly increased the risk for abnormal MBFR, (adjusted odds ratio: 1.92, 95% CI: 1.12-3.35, P = 0.02). Optimal glycemic control is associated with preservation of MBFR as determined by RTMPE, in T2DM patients at risk for CAD.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Huang R,Abdelmoneim SS,Nhola LF,Mulvagh SLdoi
10.1155/2014/243518subject
Has Abstractpub_date
2014-01-01 00:00:00pages
243518eissn
2314-6745issn
2314-6753journal_volume
2014pub_type
杂志文章abstract::To evaluate the characteristics and determinants of partial remission (PR) in Belgian children with type 1 diabetes (T1D), we analyzed records of 242 children from our center. Clinical and biological features were collected at diagnosis and during follow-up. PR was defined using the insulin-dose-adjusted A1C definitio...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/851378
更新日期:2014-01-01 00:00:00
abstract::Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in the development of re...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2015/948417
更新日期:2015-01-01 00:00:00
abstract::Background. The feasibility of digital health programs to prevent and manage diabetes in low-income patients has not been adequately explored. Methods. Researchers collaborated with a digital health company to adapt a diabetes prevention program for low-income prediabetes patients at a large safety net clinic. We cond...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8472391
更新日期:2016-01-01 00:00:00
abstract:Objective:Few studies have examined whether maternal 25(OH)D deficiency and gestational diabetes mellitus (GDM) jointly affect fetal growth. We aimed to examine the separate and combined effects of maternal 25(OH)D deficiency and GDM on trajectories of fetal growth. Methods:We established a birth cohort (2016-2017) wi...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/4231892
更新日期:2020-03-30 00:00:00
abstract::Mitogen inducible gene-6 (Mig-6) is a feedback inhibitor of epidermal growth factor receptor (EGFR) signaling pathway. The liver-specific knockout mice of the Mig-6 gene (Mig-6 d/d ) showed hepatomegaly and increased hypercholesterolemia. In this study, the biomarkers of i...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1632061
更新日期:2016-01-01 00:00:00
abstract::Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic β-cells, we investigated their role in the control of insulin secretion and glucose homeostasis. In this study, we conf...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3142175
更新日期:2016-01-01 00:00:00
abstract:Objective:To evaluate (1) the longitudinal relationship between parental well-being and glycemic control in youth with type 1 diabetes and (2) if youth's problem behavior, diabetes parenting behavior, and parental diabetes-distress influence this relationship. Research Design and Methods:Parents of youth 8-15 yrs (at ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1462064
更新日期:2017-01-01 00:00:00
abstract::Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β -catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/848679
更新日期:2013-01-01 00:00:00
abstract::Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4 + and CD8 ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2020/4106518
更新日期:2020-07-30 00:00:00
abstract::Coupling of the functional stability of rat myocardium and activity of lipid peroxidation processes in combined development of postinfarction remodeling and diabetes mellitus has been studied. The functional stability of myocardium was studied by means of the analysis of inotropic reaction on extrasystolic stimulus, t...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2548689
更新日期:2016-01-01 00:00:00
abstract::Widespread electronic health record (EHR) implementation creates new challenges in the diabetes care of complex and diverse populations, including safe medication prescribing for patients with limited health literacy and limited English proficiency. This review highlights how the EHR electronic prescribing transformat...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/8983237
更新日期:2017-01-01 00:00:00
abstract::Knowing how to prevent and treat diabetes mellitus (DM) earlier is essential to improving outcomes. Through participating in synthesis and catabolism of glycogen, the liver helps to regulate glucose homeostasis. Viral related liver diseases are associated with glycometabolism disorders, which means effective managemen...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/5625371
更新日期:2017-01-01 00:00:00
abstract:Objective:To investigate the effects of cod-liver oil on metabolic status and high-sensitivity C-reactive protein (hs-CRP) in patients with gestational diabetes mellitus (GDM). Methods:This study was a randomized, double-blinded, placebo-controlled trial with the allocation ratio of 1 : 1. The contents of EPA and DHA ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/7074042
更新日期:2019-12-28 00:00:00
abstract:Aims:The purpose of the present research is to investigate the effects of the VHL protein antagonist, VH298, on functional activities of fibroblasts and vascular endothelial cells and the effects on the wound healing process in a streptozotocin-induced hyperglycaemic rat model. Methods:HIF-1α and hydroxy-HIF-1α protei...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/1897174
更新日期:2019-02-17 00:00:00
abstract::The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- a...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/2562759
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to assess the association between OGTT glucose levels and requirement of pharmacotherapy in GDM patients classified by the IADPSG criteria. This study included 203 GDM patients (108 managed with lifestyle modification and 95 requiring pharmacotherapy). Clinical risk factors and OGTT glucose c...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/3243754
更新日期:2018-05-08 00:00:00
abstract::[This corrects the article DOI: 10.1155/2015/723190.]. ...
journal_title:Journal of diabetes research
pub_type: 已发布勘误
doi:10.1155/2017/7947401
更新日期:2017-01-01 00:00:00
abstract::Native Hawaiians and other Pacific Islanders (NH/PI; e.g., Samoan and Chuukese) have higher type 2 diabetes prevalence compared to other groups in Hawai'i. Partners in Care (PIC), a culturally tailored, community-based, diabetes self-management education intervention (DSME), is effective at improving participants' gly...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/7913258
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Experimental and clinical studies suggest a possible association between vitamin D deficiency and both diabetic retinopathy and maculopathy. METHODS:We have performed a cross-sectional study in adults with types 1 and 2 diabetes mellitus. The relationship between the presence and severity of diabetic retino...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/6156217
更新日期:2016-01-01 00:00:00
abstract::The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/379287
更新日期:2015-01-01 00:00:00
abstract::Immune and inflammatory pathways play a central role in the pathogenesis of diabetic liver injury. Celastrol is a potent immunosuppressive and anti-inflammatory agent. So far, there is no evidence regarding the mechanism of innate immune alterations of celastrol on diabetic liver injury in type 2 diabetic animal model...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2641248
更新日期:2016-01-01 00:00:00
abstract:Background:Previous studies showed that probiotics could improve glycemic control and attenuate some of the adverse effects of type 2 diabetes. However, whether the effects are generalizable to gestational diabetes mellitus (GDM) remains uncertain. Objective:We conducted a systematic review and meta-analysis to evalua...
journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析
doi:10.1155/2019/5364730
更新日期:2019-09-05 00:00:00
abstract::The quantitative trait locus (QTL) mapping in segregating crosses of NSY (Nagoya-Shibata-Yasuda) mice, an animal model of type 2 diabetes, with nondiabetic strain C3H/He mice has identified diabetogenic QTLs on multiple chromosomes. The QTL on chromosome 11 (Chr11) (Nidd1n) showing the largest effect on hyperglycemia ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/608923
更新日期:2013-01-01 00:00:00
abstract:Background:The risk factors for acute kidney injury (AKI) development in patients with diabetes hospitalized for COVID-19 have not been fully studied yet. In this study, we aimed to estimate the rate of AKI among the hospitalized population with COVID-19 and to identify the risk factors associated with AKI among patien...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2021/6666086
更新日期:2021-01-06 00:00:00
abstract:Background/Aims:It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes and diabetic nephropathy (DN), so we designed this study to investigate the role of P2X7R and NLRP3 inflammasome in DN pathogenesis and the antagonistic effects of artificially cultivated Ophio...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/1390418
更新日期:2018-11-11 00:00:00
abstract::Gastric emptying and glycemic control pathways are closely interrelated processes. Gastric chyme is transferred into the duodenum with velocities depending on its solid or liquid state, as well as on its caloric and nutritional composition. Once nutrients enter the intestine, the secretion of incretins (hormonal produ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/1736959
更新日期:2018-10-03 00:00:00
abstract::We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between the control and tene...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3201534
更新日期:2016-01-01 00:00:00
abstract::The complex diagnosis and treatment of diabetes highlight the need for markers to define how to monitor patients correctly during the course of their disease. Different studies demonstrate the existence of patients who cannot be clearly classified. We have previously shown that it is possible to differentiate "atypica...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/485132
更新日期:2015-01-01 00:00:00
abstract::Partial or complete remission from type 2 diabetes was recently observed after bariatric surgeries. Limited data is available about the possibility of inducing diabetes remission through intensive weight reduction. We retrospectively evaluated diabetes remissions after one year of the Weight Achievement and Intensive ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/468704
更新日期:2015-01-01 00:00:00
abstract::Background. The aim of this study was to validate the impact of type 2 diabetes (T2D) on the platelet reactivity in patients with acute ST elevation myocardial infarction (STEMI) treated with adenosine diphosphate (ADP) receptor blockers. Methods. A pilot prospective study was performed. Totally 67 patients were enrol...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2909436
更新日期:2016-01-01 00:00:00