Abstract:
:We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between the control and teneligliptin groups under the NCD condition. However, the plasma uric acid level was significantly decreased in the HFD-fed teneligliptin treated rats compared to the HFD-fed control rats. The expression levels of xanthine dehydrogenase (Xdh) mRNA in liver and epididymal adipose tissue of NCD-fed rats were not altered by teneligliptin treatment. On the other hand, Xdh expression was reduced significantly in the epididymal adipose tissue of the HFD-fed teneligliptin treated rats compared with that of HFD-fed control rats, whereas Xdh expression in liver did not change significantly in either group. Furthermore, teneligliptin significantly decreased Xdh expression in 3T3-L1 adipocytes. DPP-4 treatment significantly increased Xdh expression in 3T3-L1 adipocytes. With DPP-4 pretreatment, teneligliptin significantly decreased Xdh mRNA expression compared to the DPP-4-treated 3T3-L1 adipocytes. In conclusion, our studies suggest that teneligliptin reduces uric acid levels by suppressing Xdh expression in epididymal adipose tissue of obese subjects.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Moriya C,Satoh Hdoi
10.1155/2016/3201534subject
Has Abstractpub_date
2016-01-01 00:00:00pages
3201534eissn
2314-6745issn
2314-6753journal_volume
2016pub_type
杂志文章abstract::Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. T...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/6264149
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) a...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/921274
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to investigate the relationship between serum 25-hydroxy vitamin D (25-OHD) and insulin sensitivity and β-cell function in newly diagnosed type 2 diabetes. 395 newly diagnosed type 2 diabetes patients were enrolled in this study. Venous blood samples were collected at 0 min, 30 min, and 120 m...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/636891
更新日期:2015-01-01 00:00:00
abstract::The objective of this study was to assess the effects of exogenously expressed proinsulin on the biological characters of a hematopoietic stem cell line (HSC) and erythroid myeloid lymphoid (EML) cells and explore new strategies for cell therapy for type I diabetes. EML cells were transduced with lentivirus particles ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/5649191
更新日期:2017-01-01 00:00:00
abstract:Background:Diabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide. Due to the increasing prevalence and various complications, diabetes brings about a huge financial burden to DM patients. Nowadays, more and more studies reveal the relationship between diseases and gut microbial c...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8842651
更新日期:2020-11-11 00:00:00
abstract::Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4 + and CD8 ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2020/4106518
更新日期:2020-07-30 00:00:00
abstract:OBJECTIVE:To compare the serum concentration of IL-6, IL-10, TNF, IL-8, resistin, and adiponectin in type 1 diabetic patients with and without metabolic syndrome and to determine the cut-off point of the estimated glucose disposal rate that accurately differentiated these groups. DESIGN:We conducted a cross-sectional ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/972073
更新日期:2015-01-01 00:00:00
abstract::Diabetes mellitus is a chronic disease prevalence of which is high and continually growing. Cardiovascular disease continues to be the leading cause of death in patients with T2DM. The prevention of cardiovascular complications and the cardiovascular safety of treatments should be a primary objective when selecting tr...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/4020492
更新日期:2018-04-02 00:00:00
abstract:Aim:To evaluate the prognostic role of procalcitonin (PCT) in patients with diabetic foot infection (DFI) and critical limb ischemia (CLI). Materials and Methods:The study group was composed of diabetic patients with DFI and CLI. All patients were treated according to a preset limb salvage protocol which includes reva...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/4312737
更新日期:2019-08-14 00:00:00
abstract:Background:In T1DM, delayed pubertal development and reduced final height are associated with inadequate metabolic control. Objective:To assess whether T1DM affects pubertal growth spurt and whether metabolic control during puberty is gender-related. Methods:Using a large multicentre database, longitudinal data from ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/8615769
更新日期:2017-01-01 00:00:00
abstract:Objectives:Tetrahydrobiopterin (BH4) pathway that included generation of neopterin (Neop), biopterin (Biop), and nitric oxide (NO) is altered in type 2 diabetes (T2D). The aim of this study was to assess the biomarkers of BH4 pathway in noninfected DFUs and to relate these levels to the variables of diabetes as well as...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/3426878
更新日期:2019-11-16 00:00:00
abstract::Dilated cardiomyopathy (DCM) is characterized by a metabolic shift from fat to carbohydrates and failure to increase myocardial glucose uptake in response to workload increments. We verified whether this pattern is influenced by an abnormal glucose tolerance (AGT). In 10 patients with DCM, 5 with normal glucose tolera...
journal_title:Journal of diabetes research
pub_type: 临床试验,杂志文章
doi:10.1155/2016/3906425
更新日期:2016-01-01 00:00:00
abstract::A growing body of evidence suggests yogic practices may benefit adults with type 2 diabetes (DM2). In this systematic review, we evaluate available evidence from prospective controlled trials regarding the effects of yoga-based programs on specific health outcomes pertinent to DM2 management. To identify qualifying st...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/6979370
更新日期:2016-01-01 00:00:00
abstract::The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/2974304
更新日期:2018-04-10 00:00:00
abstract:Introduction:The aim of the present study was to examine placental levels of DUSP9 mRNA and protein and to investigate the potential role of DUSP9 in the development of gestational diabetes mellitus (GDM). Methods:Placental tissues from pregnant women with GDM (n = 17) and normal healthy pregnant women (n = 16) were c...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/1963178
更新日期:2019-10-20 00:00:00
abstract::Despite recent advances in the understanding and management of diabetes mellitus, the prevalence of the disease is increasing unabatedly with resulting disabling and life-reducing consequences to the global human population. The limitations and side effects associated with current antidiabetic therapies have necessita...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/9737483
更新日期:2016-01-01 00:00:00
abstract:Objective:The aim of the study was to investigate the independent and combined effects of the cortisol-to-cortisone ratio (F/E) and 11-deoxycortisol on prediabetes and type 2 diabetes mellitus (T2DM) among different genders. Methods:A case-control study was performed including 2676 participants from the Henan Rural Co...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/4693817
更新日期:2019-06-02 00:00:00
abstract::Sodium meta-arsenite (SA) is implicated in the regulation of hepatic gluconeogenesis-related genes in vitro; however, the effects in vivo have not been studied. We investigated whether SA has antidiabetic effects in a type 2 diabetic mouse model. Diabetic db/db mice were orally intubated with SA (10 mg kg(-1) body wei...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/961732
更新日期:2014-01-01 00:00:00
abstract::To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be recapitulated in the mouse, we compared C57BL/6J mice fed a Western-style diet (WD) to weight-matched genetically obese leptin receptor-deficient mice (db/db). All mice were monitored for changes in body composition, glycemia, and t...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/8503754
更新日期:2017-01-01 00:00:00
abstract:Background:Previous studies have examined the role of the KQT-like subfamily Q member1 (KCNQ1) gene polymorphisms on the risk of type 2 diabetes mellitus (T2DM), but the findings are inconclusive. Objective:To examine the association between the KCNQ1 gene polymorphisms and the risk of T2DM using an updated meta-analy...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2020/7145139
更新日期:2020-07-03 00:00:00
abstract::Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries eith...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/8546423
更新日期:2018-04-04 00:00:00
abstract:Introduction:Studies have shown increased urine excretion of vitamin D-binding protein (VDBP) in patients with diabetic nephropathy (DN) resulting from postulated mechanisms linked to renal tubular damage. In this study, we evaluate the utility of VDBP clearance ratio as a novel determinant of glycemic status, DN, and ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/6239158
更新日期:2018-05-20 00:00:00
abstract:AIMS:Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM. METHODS:55 euthyroid patients were enrolle...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/128014
更新日期:2014-01-01 00:00:00
abstract:Background:The effective hemostasis after minor debridement in an outpatient clinic is important and essential. This study is aimed at evaluating the hemostatic efficacy and safety of the kaolin-impregnated dressing for diabetic foot ulcer patient who take an anticoagulant. Methods:A prospective, randomized, clinical ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/9316380
更新日期:2019-11-11 00:00:00
abstract:AIM:The aim of this study was to evaluate the incidence of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in 2006-2007 and 2013-2014. METHOD:The study group consisted of 426 children aged 0-18 years with type 1 diabetes onset admitted to our hospital in 2006-2007 (group A) and 2...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9582793
更新日期:2016-01-01 00:00:00
abstract::Objectives. To compare the prevalence of diabetic peripheral neuropathy (DPN) and that of cardiac autonomic neuropathy (CAN) between South Asians and White Caucasians with type 2 diabetes and to explore reasons for observed differences. Methods. A cross-sectional study of casually selected South Asian and White Caucas...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1273789
更新日期:2017-01-01 00:00:00
abstract::The metabolic syndrome is an escalating worldwide public health concern. Defined by a combination of physiological, metabolic, and biochemical factors, the metabolic syndrome is used as a clinical guideline to identify individuals with a higher risk for type 2 diabetes and cardiovascular disease. Although risk factors...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/8356537
更新日期:2017-01-01 00:00:00
abstract::Insulin resistance, which plays a central role in the pathogenesis of type 2 diabetes (T2D), is an early indicator that heralds the occurrence of T2D. It is imperative to understand the metabolic changes that occur at the cellular level in the early stages of insulin resistance. The objective of this study was to dete...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/102054
更新日期:2015-01-01 00:00:00
abstract::Introduction. Diabetic Ketoacidosis (DKA) is a serious complication that can be life-threatening. Management of DKA needs admission in a specialized center and imposes major constraints on hospital resources. Aim. We plan to study the impact of adapting a diabetes-educator care model on reducing the frequency of hospi...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3917806
更新日期:2016-01-01 00:00:00
abstract::Exogenous insulin is the only treatment available for type 1 diabetic patients and is mostly administered by subcutaneous (SC) injection in a basal and bolus scheme using insulin pens (injection) or pumps (preimplanted SC catheter). Some divergence exists between these two modes of administration, since pumps provide ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8310516
更新日期:2016-01-01 00:00:00