Abstract：
Aim:To evaluate the prognostic role of procalcitonin (PCT) in patients with diabetic foot infection (DFI) and critical limb ischemia (CLI). Materials and Methods:The study group was composed of diabetic patients with DFI and CLI. All patients were treated according to a preset limb salvage protocol which includes revascularization, wound debridement, antibiotic therapy, and offloading. Inflammatory markers, including PCT, were evaluated at admission. Only positive values of PCT, greater than 0.5 ng/ml, were considered. Hospital outcomes were categorized as limb salvage (discharge with preserved limb), major amputation (amputation above the ankle), and mortality. Results:Eighty-six patients were included. The mean age was 67.3 ± 11.4 years, 80.7% were male, 95.1% had type 2 diabetes, and the mean diabetes duration was 20.5 ± 11.1 with a mean HbA1c of 67 ± 16 mmol/mol. 66/86 (76.8%) of patients had limb salvage, 7/86 (8.1%) had major amputation, and 13/86 (15.1%) died. Patients with positive PCT baseline values in comparison to those with normal values showed a lower rate of limb salvage (30.4 versus 93.6%, p = 0.0001), a higher rate of major amputation (13 versus 6.3%, p = 0.3), and a higher rate of hospital mortality (56.5 versus 0%, p < 0.0001). At the multivariate analysis of independent predictors found at univariate analysis, positive PCT was an independent predictor of major amputation [OR 3.3 (CI 95% 2.0-5.3), p = 0.0001] and mortality [OR 4.1 (CI 95% 2.2-8.3), p < 0.0001]. Discussion:Positive PCT at admission increased the risk of major amputation and mortality in hospital patients with DFI and CLI.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Meloni M,Izzo V,Giurato L,Brocco E,Ferrannini M,Gandini R,Uccioli Ldoi
10.1155/2019/4312737subject
Has Abstractpub_date
2019-08-14 00:00:00pages
4312737eissn
2314-6745issn
2314-6753journal_volume
2019pub_type
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journal_title：Journal of diabetes research
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journal_title：Journal of diabetes research
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journal_title：Journal of diabetes research
pub_type： 杂志文章
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更新日期：2018-10-14 00:00:00
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abstract：Aims:The purpose of the present research is to investigate the effects of the VHL protein antagonist, VH298, on functional activities of fibroblasts and vascular endothelial cells and the effects on the wound healing process in a streptozotocin-induced hyperglycaemic rat model. Methods:HIF-1α and hydroxy-HIF-1α protei...
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更新日期：2019-02-17 00:00:00
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pub_type： 杂志文章
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更新日期：2018-07-17 00:00:00
abstract：:Forefoot load (FL) contributes to callus formation, which is one of the pathways to diabetic foot ulcers (DFU). In this study, we hypothesized that excessive FL, which cannot be detected by plantar load measurements within laboratory settings, occurs in daily walks. To demonstrate this, we created a FL estimation algo...
journal_title：Journal of diabetes research
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1155/2018/6807219
更新日期：2018-12-05 00:00:00
abstract：:The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- a...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2017/2562759
更新日期：2017-01-01 00:00:00
abstract：Background and Objectives:Diabetes is one of the most common chronic diseases; it is a debilitating and hard to live with. Diabetes-related distress (DRD) refers to the emotional and behavioral changes caused by diabetes. Our study aims to assess the prevalence of DRD among type 2 diabetes (T2D) patients using Diabetes...
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pub_type： 杂志文章
doi：10.1155/2018/7328128
更新日期：2018-03-26 00:00:00
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journal_title：Journal of diabetes research
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更新日期：2018-05-29 00:00:00
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journal_title：Journal of diabetes research
pub_type： 杂志文章
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journal_title：Journal of diabetes research
pub_type： 杂志文章
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journal_title：Journal of diabetes research
pub_type： 杂志文章
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abstract：:Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in ...
journal_title：Journal of diabetes research
pub_type： 杂志文章
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journal_title：Journal of diabetes research
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Journal of diabetes research
pub_type： 杂志文章
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abstract：:Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of diabetes mellitus (DM). The state of persistent hyperglycemia leads to an increase in the production of cytosolic and mitochondrial reactive oxygen species (ROS) and favors deregulation of the antioxidant defenses that are capable...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
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