High Frequency of Diabetic Ketoacidosis in Children with Newly Diagnosed Type 1 Diabetes.

abstract：:The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development of type II diabetes. Aluminum is known to trigger the structural transformation of many amyloid proteins and induce the formation of toxic aggregate species. The (-)-epigallocatechin gallate (EGCG) is considered...

journal_title：Journal of diabetes research

authors： Xu ZX,Zhang Q,Ma GL,Chen CH,He YM,Xu LH,Zhang Y,Zhou GR,Li ZH,Yang HJ,Zhou P

更新日期：2016-01-01 00:00:00

abstract：Purpose:Because thyroid hormones from the maternal thyroid glands are known to influence the growth, development, and metabolic functioning of offspring, we used a rat model to preliminarily investigate the effects of maternal hypothyroidism on glucose metabolism, pancreas cell proliferation, and insulin production in ...

journal_title：Journal of diabetes research

authors： Liu Z,Chen Y,Chen G,Mao X,Wei X,Li X,Xu Y,Jiang F,Wang K,Liu C

更新日期：2019-02-21 00:00:00

abstract：Background:The effective hemostasis after minor debridement in an outpatient clinic is important and essential. This study is aimed at evaluating the hemostatic efficacy and safety of the kaolin-impregnated dressing for diabetic foot ulcer patient who take an anticoagulant. Methods:A prospective, randomized, clinical ...

journal_title：Journal of diabetes research

authors： Hwang YG,Lee JW,Won EA,Han SH

更新日期：2019-11-11 00:00:00

abstract：Purpose:Pancreatic stone protein/regenerating protein I (PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detec...

journal_title：Journal of diabetes research

authors： Zhu H,Zhu X,Lin H,Liu D,Dai Y,Su X,Li L

更新日期：2020-03-23 00:00:00

abstract：:Aims. To examine whether fibrinogen levels are a valuable biomarker for assessing disease severity and monitoring disease progression in patients with diabetic foot ulcer (DFU). Methods. A retrospective study was designed to examine the utility of fibrinogen in estimating disease severity in patients with DFU admitted...

journal_title：Journal of diabetes research

authors： Li XH,Guan LY,Lin HY,Wang SH,Cao YQ,Jiang XY,Wang YB

更新日期：2016-01-01 00:00:00

abstract：:Previous studies investigating determinants of changes in glycemic status among individuals with prediabetes mainly focused on glucose-defined prediabetes. In this study, we examined determinants of a regression to normoglycemia or a progression to diabetes among individuals with HbA1c-defined prediabetes. The study i...

journal_title：Journal of diabetes research

authors： Paprott R,Scheidt-Nave C,Heidemann C

更新日期：2018-10-14 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4 + and CD8 ...

journal_title：Journal of diabetes research

authors： Sun L,Xi S,He G,Li Z,Gang X,Sun C,Guo W,Wang G

更新日期：2020-07-30 00:00:00

abstract：AIMS:Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM. METHODS:55 euthyroid patients were enrolle...

journal_title：Journal of diabetes research

authors： Liu F,Yang Q,Gao N,Liu F,Chen S

更新日期：2014-01-01 00:00:00

abstract：Objective:Few studies have examined whether maternal 25(OH)D deficiency and gestational diabetes mellitus (GDM) jointly affect fetal growth. We aimed to examine the separate and combined effects of maternal 25(OH)D deficiency and GDM on trajectories of fetal growth. Methods:We established a birth cohort (2016-2017) wi...

journal_title：Journal of diabetes research

authors： Liu Z,Liu H,Xu X,Luo S,Liu J,Jin C,Han N,Wang HJ

更新日期：2020-03-30 00:00:00

abstract：AIMS AND BACKGROUND:Type 2 diabetes is a chronic disease that cannot be treated adequately using the known monotherapies, especially when the disease progresses to an advanced stage. In this study, we explore the possibility of treating the disease with a novel combination approach of oleanolic acid (OA), a glycogen ph...

journal_title：Journal of diabetes research

authors： Wang X,Chen Y,Abdelkader D,Hassan W,Sun H,Liu J

更新日期：2015-01-01 00:00:00

abstract：:Inflammatory atherosclerosis is increased in subjects with type 1 diabetes mellitus (T1DM). Normally high-density lipoproteins (HDL) protect against atherosclerosis; however, in the presence of serum amyloid-A- (SAA-) related inflammation this property may be reduced. Fasting blood was obtained from fifty subjects wit...

journal_title：Journal of diabetes research

authors： McEneny J,Daniels JA,McGowan A,Gunness A,Moore K,Stevenson M,Young IS,Gibney J

更新日期：2015-01-01 00:00:00

abstract：:Glucokinase (GK) plays a critical role in the control of whole-body glucose homeostasis. We investigated the possible effects of a novel glucokinase activator (GKA), HMS5552, to the GK in rats with type 2 diabetes mellitus (T2DM). Male Sprague-Dawley (SD) rats were divided into four groups: control group, diabetic gro...

journal_title：Journal of diabetes research

authors： Wang P,Liu H,Chen L,Duan Y,Chen Q,Xi S

更新日期：2017-01-01 00:00:00

abstract：Background:Diabetic foot ulcers are one disabling complication of diabetes mellitus. Pirfenidone (PFD) is a potent modulator of extracellular matrix. Modified diallyl disulfide oxide (M-DDO) is an antimicrobial and antiseptic agent. Aim:To evaluate efficacy of topical PFD + M-DDO in a randomized, double-blind trial ve...

journal_title：Journal of diabetes research

authors： Gasca-Lozano LE,Lucano-Landeros S,Ruiz-Mercado H,Salazar-Montes A,Sandoval-Rodríguez A,Garcia-Bañuelos J,Santos-Garcia A,Davila-Rodriguez JR,Navarro-Partida J,Bojórquez-Sepúlveda H,Castañeda-Gomez J,Domínguez-Rosales J,Ruiz-Arcos

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to investigate the relationship between serum 25-hydroxy vitamin D (25-OHD) and insulin sensitivity and β-cell function in newly diagnosed type 2 diabetes. 395 newly diagnosed type 2 diabetes patients were enrolled in this study. Venous blood samples were collected at 0 min, 30 min, and 120 m...

journal_title：Journal of diabetes research

authors： Gao Y,Wu X,Fu Q,Li Y,Yang T,Tang W

更新日期：2015-01-01 00:00:00

abstract：:Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness. The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight...

journal_title：Journal of diabetes research

authors： Simó-Servat O,Simó R,Hernández C

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to assess the association between OGTT glucose levels and requirement of pharmacotherapy in GDM patients classified by the IADPSG criteria. This study included 203 GDM patients (108 managed with lifestyle modification and 95 requiring pharmacotherapy). Clinical risk factors and OGTT glucose c...

journal_title：Journal of diabetes research

authors： Yerlikaya G,Falcone V,Stopp T,Mittlböck M,Tura A,Husslein P,Eppel W,Göbl CS

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:Experimental and clinical studies suggest a possible association between vitamin D deficiency and both diabetic retinopathy and maculopathy. METHODS:We have performed a cross-sectional study in adults with types 1 and 2 diabetes mellitus. The relationship between the presence and severity of diabetic retino...

journal_title：Journal of diabetes research

authors： Alam U,Amjad Y,Chan AW,Asghar O,Petropoulos IN,Malik RA

更新日期：2016-01-01 00:00:00

abstract：:Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactio...

journal_title：Journal of diabetes research

authors： Haghvirdizadeh P,Mohamed Z,Abdullah NA,Haghvirdizadeh P,Haerian MS,Haerian BS

更新日期：2015-01-01 00:00:00

abstract：:The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...

journal_title：Journal of diabetes research

authors： Chen GP,Zhang XQ,Wu T,Li L,Han J,Du CQ

更新日期：2015-01-01 00:00:00

abstract：:miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 ex...

journal_title：Journal of diabetes research

authors： Huang X,Gong S,Ma Y,Cai X,Zhou L,Luo Y,Li M,Liu W,Zhang S,Zhang X,Ren Q,Zhu Y,Zhou X,Zhang R,Chen L,Gao X,Zhang F,Wang Y,Han X,Ji L

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. METHODS:A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nond...

journal_title：Journal of diabetes research

authors： Li S,Liu D,Li L,Li Y,Li Q,An Z,Sun X,Tian H

更新日期：2016-01-01 00:00:00

abstract：:Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats. Here we investigated the mechanisms of such effects of CRT. Diabetes was induced by a single injection of 40 mg/kg of STZ. CRT was poured into the stomach by gastric lavage o...

journal_title：Journal of diabetes research

authors： Sha H,Zhao D,Tong X,Gregersen H,Zhao J

更新日期：2016-01-01 00:00:00

abstract：Background:Chronic overnutrition leads to cardiac dysfunction and insulin (INS) resistance. Dipeptidyl peptidase-4 (DPP-4) improves glucose metabolism and insulin sensitivity in both human and animal models. In this study, we explored whether DPP-4 inhibitor sitagliptin (SIT) is involved in the protection of cardiac fu...

journal_title：Journal of diabetes research

authors： Qiao S,Mao G,Li H,Ma Z,Hong L,Zhang H,Wang C,An J

更新日期：2018-07-17 00:00:00

abstract：Background:In vivo experiments in Goto-Kakizaki (GK) type 2 diabetic rats have demonstrated reductions in heart rate from a young age. The expression of genes encoding more than 70 proteins that are associated with the generation and conduction of electrical activity in the GK sinoatrial node (SAN) have been evaluated ...

journal_title：Journal of diabetes research

authors： Howarth FC,Qureshi MA,Jayaprakash P,Parekh K,Oz M,Dobrzynski H,Adrian TE

更新日期：2018-09-02 00:00:00

abstract：Objective:To evaluate diabetic retinopathy (DR) screening via deep learning (DL) and trained human graders (HG) in a longitudinal cohort, as case spectrum shifts based on treatment referral and new-onset DR. Methods:We randomly selected patients with diabetes screened twice, two years apart within a nationwide screeni...

journal_title：Journal of diabetes research

authors： Limwattanayingyong J,Nganthavee V,Seresirikachorn K,Singalavanija T,Soonthornworasiri N,Ruamviboonsuk V,Rao C,Raman R,Grzybowski A,Schaekermann M,Peng LH,Webster DR,Semturs C,Krause J,Sayres R,Hersch F,Tiwari R,Liu Y,

更新日期：2020-12-15 00:00:00

abstract：Background:Gestational diabetes mellitus (GDM) contributes to adverse pregnancy and birth outcomes. In recent decades, extensive research has been devoted to the early prediction of GDM by various methods. Machine learning methods are flexible prediction algorithms with potential advantages over conventional regression...

journal_title：Journal of diabetes research

authors： Ye Y,Xiong Y,Zhou Q,Wu J,Li X,Xiao X

更新日期：2020-06-12 00:00:00

abstract：Objective:The aim of the study was to investigate the independent and combined effects of the cortisol-to-cortisone ratio (F/E) and 11-deoxycortisol on prediabetes and type 2 diabetes mellitus (T2DM) among different genders. Methods:A case-control study was performed including 2676 participants from the Henan Rural Co...

journal_title：Journal of diabetes research

authors： Liu X,Jiang J,Liu X,Luo Z,Wang Y,Dong X,Wei D,Huo W,Yu S,Li L,Jin S,Wang C,Mao Z

更新日期：2019-06-02 00:00:00

abstract：Objective:To examine whether comorbidity with type 2 diabetes (T2D) affects the clinical and hematological parameters of coronavirus disease 2019 (COVID-19) patients. Methods:We retrospectively investigated the clinical, imaging, and laboratory characteristics of patients with confirmed COVID-19 who were hospitalized ...

journal_title：Journal of diabetes research

authors： Sun Y,Zhao R,Hu Z,Wang W,Wang S,Gao L,Fei J,Jian X,Li Y,Zheng H,Hou X,Chen L

更新日期：2020-12-02 00:00:00

abstract：:The haptoglobin (Hp) genotype (1-1 and 2-2) is a major determinant of nephropathy progression in diabetes mellitus patients. Hp 2-2 diabetic mice have impaired Hb clearance and increased iron deposits and oxidative stress in the proximal tubules (PCT), leading to increased renal injury. However, the precise mechanism ...

journal_title：Journal of diabetes research

authors： Dahan I,Thawho N,Farber E,Nakhoul N,Asleh R,Levy AP,Li YC,Ben-Izhak O,Nakhoul F

更新日期：2018-09-03 00:00:00

abstract：:The quantitative trait locus (QTL) mapping in segregating crosses of NSY (Nagoya-Shibata-Yasuda) mice, an animal model of type 2 diabetes, with nondiabetic strain C3H/He mice has identified diabetogenic QTLs on multiple chromosomes. The QTL on chromosome 11 (Chr11) (Nidd1n) showing the largest effect on hyperglycemia ...

journal_title：Journal of diabetes research

authors： Babaya N,Ueda H,Noso S,Hiromine Y,Nojima K,Itoi-Babaya M,Kobayashi M,Fujisawa T,Ikegami H

更新日期：2013-01-01 00:00:00