Abstract：
:Background. The feasibility of digital health programs to prevent and manage diabetes in low-income patients has not been adequately explored. Methods. Researchers collaborated with a digital health company to adapt a diabetes prevention program for low-income prediabetes patients at a large safety net clinic. We conducted focus groups to assess patient perspectives, revised lessons for improved readability and cultural relevance to low-income and Hispanic patients, conducted a feasibility study of the adapted program in English and Spanish speaking cohorts, and implemented real-time adaptations to the program for commercial use and for a larger trial of in multiple safety net clinics. Results. The majority of focus group participants were receptive to the program. We modified the curriculum to a 5th-grade reading level and adapted content based on patient feedback. In the feasibility study, 54% of eligible contacted patients expressed interest in enrolling (n = 23). Although some participants' computer access and literacy made registration challenging, they were highly satisfied and engaged (80% logged in at least once/week). Conclusions. Underserved prediabetic patients displayed high engagement and satisfaction with a digital diabetes prevention program despite lower digital literacy skills. The collaboration between researchers and a digital health company enabled iterative improvements in technology implementation to address challenges in low-income populations.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Fontil V,McDermott K,Tieu L,Rios C,Gibson E,Sweet CC,Payne M,Lyles CRdoi
10.1155/2016/8472391subject
Has Abstractpub_date
2016-01-01 00:00:00pages
8472391eissn
2314-6745issn
2314-6753journal_volume
2016pub_type
杂志文章abstract：AIMS:This study assesses the impact of using an AP-system at home on fear of hypoglycaemia. In addition, satisfaction and acceptance of the new technology are evaluated. METHODS:In a multicentre, multinational study of 75 patients using the MD-Logic AP during four consecutive nights in home setting 59 of them (aged 10...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2015/590308
更新日期：2015-01-01 00:00:00
abstract：:Aims. Dipeptidyl-peptidase IV inhibitors (DPP-4i) are among the most popular oral antidiabetic agents. However, the effects of DPP-4i on diabetic nephropathy are not well-established. The aim of this study was to determine the renoprotective effects of DPP-4i, using albuminuria and glomerular filtration rate (GFR) as ...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/1423191
更新日期：2016-01-01 00:00:00
abstract：:The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) a...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2015/921274
更新日期：2015-01-01 00:00:00
abstract：Objectives:This study is aimed at gaining insights on the changing prevalence, economic burden, and catastrophic costs of diabetes in rural southwest China. Materials and Methods:Data were collected from two cross-sectional health interviews and examination surveys among individuals aged ≥ 35 years in rural Yunnan Pro...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2019/9626413
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. METHODS:A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nond...
journal_title：Journal of diabetes research
pub_type： 杂志文章,meta分析
doi：10.1155/2016/6194750
更新日期：2016-01-01 00:00:00
abstract：:Gastric emptying and glycemic control pathways are closely interrelated processes. Gastric chyme is transferred into the duodenum with velocities depending on its solid or liquid state, as well as on its caloric and nutritional composition. Once nutrients enter the intestine, the secretion of incretins (hormonal produ...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2018/1736959
更新日期：2018-10-03 00:00:00
abstract：:The aim of this study was to investigate the relationship between serum 25-hydroxy vitamin D (25-OHD) and insulin sensitivity and β-cell function in newly diagnosed type 2 diabetes. 395 newly diagnosed type 2 diabetes patients were enrolled in this study. Venous blood samples were collected at 0 min, 30 min, and 120 m...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2015/636891
更新日期：2015-01-01 00:00:00
abstract：:We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health ...
journal_title：Journal of diabetes research
pub_type： 杂志文章,随机对照试验
doi：10.1155/2016/5027356
更新日期：2016-01-01 00:00:00
abstract：:To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be recapitulated in the mouse, we compared C57BL/6J mice fed a Western-style diet (WD) to weight-matched genetically obese leptin receptor-deficient mice (db/db). All mice were monitored for changes in body composition, glycemia, and t...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2017/8503754
更新日期：2017-01-01 00:00:00
abstract：Objective:The objective of this study is to investigate the relationship between time in range (TIR), a new metric of continuous glucose monitoring (CGM) and cardiovascular autonomic neuropathy (CAN) in individuals with type 2 diabetes mellitus (T2DM). Methods:A total of 349 individuals with T2DM were enrolled in this...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2020/5817074
更新日期：2020-02-06 00:00:00
abstract：:The aim of this study was to assess the association between OGTT glucose levels and requirement of pharmacotherapy in GDM patients classified by the IADPSG criteria. This study included 203 GDM patients (108 managed with lifestyle modification and 95 requiring pharmacotherapy). Clinical risk factors and OGTT glucose c...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2018/3243754
更新日期：2018-05-08 00:00:00
abstract：Objective:To evaluate the role of CCAAT/enhancer-binding protein β (C/EBP β (C/EBP. Methods:Rats with OIR were exposed to alternating hypoxic and hyperopic conditions for 14 days. Then, the rats with OIR were assigned randomly to groups that received intravitreal injections of either shRNA lentiviral particles targeti...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2020/2789209
更新日期：2020-03-09 00:00:00
abstract：BACKGROUND:Intestinal dysfunction in the ob/ob mouse model of diabetes mimics that seen clinically. METHODS:We determined the effects of a 4-week genistein diet (600 mg genistein/kg food) on intestinal function (contractility, morphology, AChR, and motility) in female ob/ob and lean mice. RESULTS:Contractility of the...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2017/3568146
更新日期：2017-01-01 00:00:00
abstract：:Despite recent advances in the understanding and management of diabetes mellitus, the prevalence of the disease is increasing unabatedly with resulting disabling and life-reducing consequences to the global human population. The limitations and side effects associated with current antidiabetic therapies have necessita...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2016/9737483
更新日期：2016-01-01 00:00:00
abstract：:Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy rema...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2015/485759
更新日期：2015-01-01 00:00:00
abstract：:Diabetes mellitus is a metabolic disorder which is characterized by multiple long-term complications that affect almost every system in the body. Foot ulcers are one of the main complications of diabetes mellitus. However, there is limited evidence on the occurrence of foot ulcer and influencing factors in Ethiopia. A...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2017/2879249
更新日期：2017-01-01 00:00:00
abstract：:This study determined if blocking ligand occupancy of the αVβ3 integrin could inhibit the pathophysiologic changes that occur in the early stages of diabetic nephropathy (DN). Diabetic rats were treated with either vehicle or a monoclonal antibody that binds the β3 subunit of the αVβ3 integrin. After 4 weeks of diabet...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2014/421827
更新日期：2014-01-01 00:00:00
abstract：:We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between the control and tene...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/3201534
更新日期：2016-01-01 00:00:00
abstract：:Statin therapy improves lipid profiles and reduces vascular inflammation, but its effects on central arterial stiffness in type 2 diabetes are unclear. The aim of this study was to determine whether statin therapy reduces central arterial stiffness, in a dose-dependent manner, in male patients with type 2 diabetes. Fi...
journal_title：Journal of diabetes research
pub_type： 杂志文章,随机对照试验
doi：10.1155/2015/846807
更新日期：2015-01-01 00:00:00
abstract：:Type 2 diabetes increases the risk for all-site cancers including colon cancer. Diabetic patients present typical pathophysiological features including an increased level of advanced glycation end products (AGEs), which comes from a series of nonenzymatic reactions between sugars and biological macromolecules, positiv...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2018/3274084
更新日期：2018-09-09 00:00:00
abstract：Introduction:Studies have shown increased urine excretion of vitamin D-binding protein (VDBP) in patients with diabetic nephropathy (DN) resulting from postulated mechanisms linked to renal tubular damage. In this study, we evaluate the utility of VDBP clearance ratio as a novel determinant of glycemic status, DN, and ...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2018/6239158
更新日期：2018-05-20 00:00:00
abstract：:Metabolic memory (MM) is defined as the persistence of diabetic (DM) complications even after glycemic control is pharmacologically achieved. Using a zebrafish diabetic model that induces a MM state, we previously reported that, in this model, tissue dysfunction was of a heritable nature based on cell proliferation st...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/2860780
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Intensive transfusion schedule and iron-chelating therapy prolonged and improved quality of life in patients with β-thalassemia (β-T) major. However, this led to an increased risk of developing impaired glucose tolerance or diabetes. In this study we analyzed variables associated with the occurrence of impai...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/1401829
更新日期：2016-01-01 00:00:00
abstract：:Aim. To investigate corneal endothelial cell morphological in children with type 1 diabetes and to determine the systemic and local factors that contribute to these changes. Methods. One hundred sixty eyes of 80 children with type 1 diabetes and 80 eyes of 40 normal children as a control during the period from July 20...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/7319047
更新日期：2016-01-01 00:00:00
abstract：Background:Diabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide. Due to the increasing prevalence and various complications, diabetes brings about a huge financial burden to DM patients. Nowadays, more and more studies reveal the relationship between diseases and gut microbial c...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2020/8842651
更新日期：2020-11-11 00:00:00
abstract：:The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development of type II diabetes. Aluminum is known to trigger the structural transformation of many amyloid proteins and induce the formation of toxic aggregate species. The (-)-epigallocatechin gallate (EGCG) is considered...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/1867059
更新日期：2016-01-01 00:00:00
abstract：:Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in the development of re...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2015/948417
更新日期：2015-01-01 00:00:00
abstract：:We investigated the correlation between obestatin and metabolic parameters and carotid intima-media thickness (IMT) in plasma of patients with type 2 diabetes mellitus (T2DM). We collected 103 patients aged from 60 to 83 years (69.26 ± 5.83 years) form January, 2007 to May, 2009. All patients were divided into normal ...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2013/563919
更新日期：2013-01-01 00:00:00
abstract：:Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of diabetes mellitus (DM). The state of persistent hyperglycemia leads to an increase in the production of cytosolic and mitochondrial reactive oxygen species (ROS) and favors deregulation of the antioxidant defenses that are capable...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2017/1673081
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. METHODS:A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3. RESULTS:The incidenc...
journal_title：Journal of diabetes research
pub_type： 杂志文章,多中心研究
doi：10.1155/2017/6924637
更新日期：2017-01-01 00:00:00
