The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy.

abstract：:To study the relationship between glycosylated hemoglobin (HgbA1c) and myocardial perfusion in type 2 diabetes mellitus (T2DM) patients, we prospectively enrolled 24 patients with known or suspected coronary artery disease (CAD) who underwent adenosine stress by real-time myocardial perfusion echocardiography (RTMPE)....

journal_title：Journal of diabetes research

authors： Huang R,Abdelmoneim SS,Nhola LF,Mulvagh SL

更新日期：2014-01-01 00:00:00

abstract：:Knowing how to prevent and treat diabetes mellitus (DM) earlier is essential to improving outcomes. Through participating in synthesis and catabolism of glycogen, the liver helps to regulate glucose homeostasis. Viral related liver diseases are associated with glycometabolism disorders, which means effective managemen...

journal_title：Journal of diabetes research

authors： Zhao Y,Xing H

更新日期：2017-01-01 00:00:00

abstract：:Coupling of the functional stability of rat myocardium and activity of lipid peroxidation processes in combined development of postinfarction remodeling and diabetes mellitus has been studied. The functional stability of myocardium was studied by means of the analysis of inotropic reaction on extrasystolic stimulus, t...

journal_title：Journal of diabetes research

authors： Afanasiev SA,Kondratieva DS,Rebrova TY,Batalov RE,Popov SV

更新日期：2016-01-01 00:00:00

abstract：Objective:Few studies have examined whether maternal 25(OH)D deficiency and gestational diabetes mellitus (GDM) jointly affect fetal growth. We aimed to examine the separate and combined effects of maternal 25(OH)D deficiency and GDM on trajectories of fetal growth. Methods:We established a birth cohort (2016-2017) wi...

journal_title：Journal of diabetes research

authors： Liu Z,Liu H,Xu X,Luo S,Liu J,Jin C,Han N,Wang HJ

更新日期：2020-03-30 00:00:00

abstract：:More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, f...

journal_title：Journal of diabetes research

authors： da Silva Xavier G,Bellomo EA,McGinty JA,French PM,Rutter GA

更新日期：2013-01-01 00:00:00

abstract：:Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. T...

journal_title：Journal of diabetes research

authors： Aravindhan V,Madhumitha H

更新日期：2016-01-01 00:00:00

abstract：:The hypoalbuminuric effect of sulodexide (SDX) on diabetic kidney disease (DKD) was suggested by some clinical trials but was denied by the Collaborative Study Group. In this study, the diabetic rats were treated with SDX either from week 0 to 24 or from week 13 to 24. We found that 24-week treatment significantly dec...

journal_title：Journal of diabetes research

authors： Liu YN,Zhou J,Li T,Wu J,Xie SH,Liu HF,Liu Z,Park TS,Wang Y,Liu WJ

更新日期：2017-01-01 00:00:00

abstract：:The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- a...

journal_title：Journal of diabetes research

authors： Blindbæk SL,Torp TL,Lundberg K,Soelberg K,Vergmann AS,Poulsen CD,Frydkjaer-Olsen U,Broe R,Rasmussen ML,Wied J,Lind M,Vestergaard AH,Peto T,Grauslund J

更新日期：2017-01-01 00:00:00

abstract：:The complex diagnosis and treatment of diabetes highlight the need for markers to define how to monitor patients correctly during the course of their disease. Different studies demonstrate the existence of patients who cannot be clearly classified. We have previously shown that it is possible to differentiate "atypica...

journal_title：Journal of diabetes research

authors： Fabregat M,Fernandez M,Javiel G,Vitarella G,Mimbacas A

更新日期：2015-01-01 00:00:00

abstract：:The rapid rise of type II diabetes mellitus and its accompanying vascular complications call for novel approaches in unravelling its pathophysiological mechanisms and designing new treatment modalities. Noncoding RNAs represent a class of previously unknown molecular modulators of this disease. The most important feat...

journal_title：Journal of diabetes research

authors： Eken SM,Jin H,Chernogubova E,Maegdefessel L

更新日期：2013-01-01 00:00:00

abstract：:miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 ex...

journal_title：Journal of diabetes research

authors： Huang X,Gong S,Ma Y,Cai X,Zhou L,Luo Y,Li M,Liu W,Zhang S,Zhang X,Ren Q,Zhu Y,Zhou X,Zhang R,Chen L,Gao X,Zhang F,Wang Y,Han X,Ji L

更新日期：2018-08-01 00:00:00

abstract：:Methylglyoxal (MG) is a highly reactive glucose metabolic intermediate and a major precursor of advanced glycation end products. MG level is elevated in hyperglycemic disorders such as diabetes mellitus. Substantial evidence has shown that MG is involved in the pathogenesis of diabetes and diabetic complications. We i...

journal_title：Journal of diabetes research

authors： Bo J,Xie S,Guo Y,Zhang C,Guan Y,Li C,Lu J,Meng QH

更新日期：2016-01-01 00:00:00

abstract：Aim:To evaluate the prognostic role of procalcitonin (PCT) in patients with diabetic foot infection (DFI) and critical limb ischemia (CLI). Materials and Methods:The study group was composed of diabetic patients with DFI and CLI. All patients were treated according to a preset limb salvage protocol which includes reva...

journal_title：Journal of diabetes research

authors： Meloni M,Izzo V,Giurato L,Brocco E,Ferrannini M,Gandini R,Uccioli L

更新日期：2019-08-14 00:00:00

abstract：Background:Diabetic retinopathy (DR) is a severe complication of diabetes mellitus. DR is considered as a neurovascular disease. Retinal ganglion cell (RGC) loss plays an important role in the vision function disorder of diabetic patients. Histone deacetylase3 (HDAC3) is closely related to injury repair and nerve regen...

journal_title：Journal of diabetes research

authors： Fu Y,Wang Y,Gao X,Li H,Yuan Y

更新日期：2020-03-01 00:00:00

abstract：:Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats. Here we investigated the mechanisms of such effects of CRT. Diabetes was induced by a single injection of 40 mg/kg of STZ. CRT was poured into the stomach by gastric lavage o...

journal_title：Journal of diabetes research

authors： Sha H,Zhao D,Tong X,Gregersen H,Zhao J

更新日期：2016-01-01 00:00:00

abstract：:Aims. Prevention of diabetes complications depends on the level of case finding and successful treatment of diabetes, which may differ between ethnicities. Therefore, we studied the prevalence by age, awareness, treatment, and control of type 2 diabetes, among a multiethnic population. Methods. We included 4,541 Dutch...

journal_title：Journal of diabetes research

authors： Snijder MB,Agyemang C,Peters RJ,Stronks K,Ujcic-Voortman JK,van Valkengoed IG

更新日期：2017-01-01 00:00:00

abstract：:The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle. However, no significant glycogen stores are detected in normal kidneys, but diabetic subjects present a characteristic renal histopathological feature resulting f...

journal_title：Journal of diabetes research

authors： Bertinat R,Westermeier F,Silva P,Gatica R,Oliveira JM,Nualart F,Gomis R,Yáñez AJ

更新日期：2018-05-29 00:00:00

abstract：AIMS:Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM. METHODS:55 euthyroid patients were enrolle...

journal_title：Journal of diabetes research

authors： Liu F,Yang Q,Gao N,Liu F,Chen S

更新日期：2014-01-01 00:00:00

abstract：Objective:To examine whether comorbidity with type 2 diabetes (T2D) affects the clinical and hematological parameters of coronavirus disease 2019 (COVID-19) patients. Methods:We retrospectively investigated the clinical, imaging, and laboratory characteristics of patients with confirmed COVID-19 who were hospitalized ...

journal_title：Journal of diabetes research

authors： Sun Y,Zhao R,Hu Z,Wang W,Wang S,Gao L,Fei J,Jian X,Li Y,Zheng H,Hou X,Chen L

更新日期：2020-12-02 00:00:00

abstract：Background:The risk factors for acute kidney injury (AKI) development in patients with diabetes hospitalized for COVID-19 have not been fully studied yet. In this study, we aimed to estimate the rate of AKI among the hospitalized population with COVID-19 and to identify the risk factors associated with AKI among patien...

journal_title：Journal of diabetes research

authors： Khalili S,Sabaghian T,Sedaghat M,Soroureddin Z,Askari E,Khalili N

更新日期：2021-01-06 00:00:00

abstract：:In bioartificial pancreases (BP), the number of islets needed to restore normoglycaemia in the diabetic patient is critical. However, the confinement of a high quantity of islets in a limited space may impact islet survival, particularly in regard to the low oxygen partial pressure (PO2) in such environments. The aim ...

journal_title：Journal of diabetes research

authors： Rodriguez-Brotons A,Bietiger W,Peronet C,Magisson J,Sookhareea C,Langlois A,Mura C,Jeandidier N,Pinget M,Sigrist S,Maillard E

更新日期：2016-01-01 00:00:00

abstract：:Mannan-binding lectin (MBL) has been reported to be involved in the pathophysiology of diabetic nephropathy. MBL is a pattern-recognition molecule of the innate immune system that initiates the lectin pathway of the complement system upon recognition of evolutionary conserved pathogen-associated molecular patterns or ...

journal_title：Journal of diabetes research

authors： Axelgaard E,Østergaard JA,Thiel S,Hansen TK

更新日期：2017-01-01 00:00:00

abstract：:Many studies have assessed the association between eNOS-4b/a polymorphism and the risk of diabetic retinopathy (DR) among type 2 diabetic subjects. However, the results are inconsistent. In order to derive a more precise estimation of the association, a meta-analysis was conducted. Fifteen studies with 3, 183 cases an...

journal_title：Journal of diabetes research

authors： Ma ZJ,Chen R,Ren HZ,Guo X,Guo J,Chen LM

更新日期：2014-01-01 00:00:00

abstract：:Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM pa...

journal_title：Journal of diabetes research

authors： Zhang X,Sun J,Han W,Jiang Y,Peng S,Shan Z,Teng W

更新日期：2016-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and in...

journal_title：Journal of diabetes research

authors： Tanase DM,Gosav EM,Costea CF,Ciocoiu M,Lacatusu CM,Maranduca MA,Ouatu A,Floria M

更新日期：2020-07-31 00:00:00

abstract：:Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactio...

journal_title：Journal of diabetes research

authors： Haghvirdizadeh P,Mohamed Z,Abdullah NA,Haghvirdizadeh P,Haerian MS,Haerian BS

更新日期：2015-01-01 00:00:00

abstract：:Despite recent advances in the understanding and management of diabetes mellitus, the prevalence of the disease is increasing unabatedly with resulting disabling and life-reducing consequences to the global human population. The limitations and side effects associated with current antidiabetic therapies have necessita...

journal_title：Journal of diabetes research

authors： Oyenihi OR,Oyenihi AB,Adeyanju AA,Oguntibeju OO

更新日期：2016-01-01 00:00:00

abstract：Background:In vivo experiments in Goto-Kakizaki (GK) type 2 diabetic rats have demonstrated reductions in heart rate from a young age. The expression of genes encoding more than 70 proteins that are associated with the generation and conduction of electrical activity in the GK sinoatrial node (SAN) have been evaluated ...

journal_title：Journal of diabetes research

authors： Howarth FC,Qureshi MA,Jayaprakash P,Parekh K,Oz M,Dobrzynski H,Adrian TE

更新日期：2018-09-02 00:00:00

abstract：:To compare the efficacy and safety of metformin, glyburide, and insulin in treating gestational diabetes mellitus (GDM), a meta-analysis of randomized controlled trials (RCTs) was conducted. PubMed, Embase, CINAHL, Web of Science, and Cochrane Library to November 13, 2018, were searched for RCT adjusted estimates of t...

journal_title：Journal of diabetes research

authors： Guo L,Ma J,Tang J,Hu D,Zhang W,Zhao X

更新日期：2019-11-04 00:00:00

abstract：:According to the American Diabetes Association (ADA), the side effects of diabetes mellitus have recently increased the global health expenditure each year. Of these, the early diagnostic can contribute to the decrease on renal, cardiovascular, and nervous systems complications. However, the diagnostic criteria, which...

journal_title：Journal of diabetes research

authors： Arroyo-Carmona RE,López-Serrano AL,Albarado-Ibañez A,Mendoza-Lucero FM,Medel-Cajica D,López-Mayorga RM,Torres-Jácome J

更新日期：2016-01-01 00:00:00