Abstract:
Purpose:We aimed to assess the changes of retinal microvascular parameters using optical coherence tomography angiography (OCTA) between diabetes macular edema (DME) and controls. We assessed the changes between the baseline microvascular parameters and final treatment response in patients with DME, initially treated with intravitreal dexamethasone (DEX) implant followed by antivascular endothelial growth factor (VEGF) injections on an as-needed basis. Methods:This retrospective study included 90 DME patients and 24 healthy control subjects. All subjects had their best-corrected visual acuity (BCVA) and central macular thickness (CMT) measured at baseline and after 12 months. Vessel density (VD) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) and the deep/superficial flow ratio at baseline were analyzed. A subgroup analysis was used to compare the treatment response. A poor-response group was defined by five or more retreatments at 12 months. Results:BCVA and CMT showed a significant improvement at 12 months (all p < 0.001). The VD in the whole and parafoveal areas of the DCP was significantly reduced in DME patients compared to that in controls (all p < 0.05). The DCP/SCP flow ratio was also significantly reduced in the DME group (1.08 ± 0.03 vs. 1.05 ± 0.02, p = 0.001). In the subgroup analysis, the VD in the foveal and whole DCP areas was significantly lower in the poor-response group than that in the good-response group (p = 0.043 and p = 0.048, respectively). The DCP/SCP flow ratio was also significantly lower in the poor-response group (p = 0.011). Conclusion:DME correlated with significant retinal microvascular impairment in the DCP. A decreased DCP/SCP flow ratio was observed in patients with DME that exhibited a poor treatment response. Retinal microvascular parameters could predict the treatment response in DME and help optimize clinical outcomes.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Park YG,Park YHdoi
10.1155/2020/2132037subject
Has Abstractpub_date
2020-11-16 00:00:00pages
2132037eissn
2314-6745issn
2314-6753journal_volume
2020pub_type
杂志文章abstract::The purpose of this study was to investigate the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on the progression of diabetic retinopathy (DR) in patients with type 2 diabetes. The medical records of 21 type 2 diabetic patients who used a SGLT2i and 71 patients with sulfonylurea (control) were reviewed...
journal_title:Journal of diabetes research
pub_type: 杂志文章
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journal_title:Journal of diabetes research
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journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8839376
更新日期:2020-12-15 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/5703652
更新日期:2018-10-14 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/4650906
更新日期:2019-04-17 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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更新日期:2018-04-10 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1867059
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/6264149
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/4989847
更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,多中心研究
doi:10.1155/2017/6924637
更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2029854
更新日期:2016-01-01 00:00:00
abstract::Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats. Here we investigated the mechanisms of such effects of CRT. Diabetes was induced by a single injection of 40 mg/kg of STZ. CRT was poured into the stomach by gastric lavage o...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1826281
更新日期:2016-01-01 00:00:00
abstract::Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactio...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8842651
更新日期:2020-11-11 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/8454078
更新日期:2018-09-02 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1401829
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5027356
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8310516
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8541520
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/1963178
更新日期:2019-10-20 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2020/3920196
更新日期:2020-07-31 00:00:00