Differences in the Clinical and Hematological Characteristics of COVID-19 Patients with and without Type 2 Diabetes.

Abstract:

Objective:To examine whether comorbidity with type 2 diabetes (T2D) affects the clinical and hematological parameters of coronavirus disease 2019 (COVID-19) patients. Methods:We retrospectively investigated the clinical, imaging, and laboratory characteristics of patients with confirmed COVID-19 who were hospitalized from January 30, 2020 to March 17, 2020, at the Renmin Hospital of Wuhan University. A detailed clinical record was kept for each subject, including the medical history of COVID-19 and physical and laboratory examinations. A total of 164 subjects were eligible for the study, among which 40 patients were comorbid with T2D. Further analysis was conducted in two subcohorts of sex- and age-matched patients with and without T2D to identify hematological and biochemical differences. The laboratory tests, including routine blood tests, serum biochemistry, and coagulation function, were performed upon admission. Results:The two groups showed no significant differences in baseline parameters, including age, sex, chest X-ray, or computed tomography (CT) findings, upon admission. However, patients with T2D showed an increased incidence of diarrhea. T2D patients required more recovery time from pneumonia, as shown by follow-up CT findings, which might contribute to the prolonged hospitalization. Comorbidity with T2D also increased risk of secondary bacterial infection during COVID-19. The T2D group had significantly higher white blood cell and neutrophil counts compared with the nondiabetic group, but T2D patients suffered from more severe lymphocytopenia and inflammation (P < 0.05). Most biochemical parameters showed no significant differences between the two groups (P > 0.05). However, patients with T2D seemed to have a significantly higher risk of developing hyperlactatemia, hyponatremia, and hypocalcemia. Conclusions:COVID-19 patients comorbid with T2D demonstrated distinguishing clinical features and hematological parameters during the infection. It is necessary to develop a different clinical severity scoring system for COVID-19 patients with T2D. This study may provide helpful clues for the assessment and management of COVID-19 in T2D patients.

journal_name

J Diabetes Res

authors

Sun Y,Zhao R,Hu Z,Wang W,Wang S,Gao L,Fei J,Jian X,Li Y,Zheng H,Hou X,Chen L

doi

10.1155/2020/1038585

subject

Has Abstract

pub_date

2020-12-02 00:00:00

pages

1038585

eissn

2314-6745

issn

2314-6753

journal_volume

2020

pub_type

杂志文章
  • Effects of Exercise Training and Weight Loss on Plasma Fetuin-A Levels and Insulin Sensitivity in Overweight Older Men.

    abstract::Aerobic exercise training and weight loss (AEX+WL) improves insulin sensitivity in overweight adults; however, the underlying pathways are incompletely understood. Fetuin-A, a hepatokine that inhibits insulin signaling, may be involved in the salutary effects of AEX+WL. Therefore, we examined the effects of 6-month AE...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2017/1492581

    authors: Blumenthal JB,Gitterman A,Ryan AS,Prior SJ

    更新日期:2017-01-01 00:00:00

  • Fibrinogen: A Marker in Predicting Diabetic Foot Ulcer Severity.

    abstract::Aims. To examine whether fibrinogen levels are a valuable biomarker for assessing disease severity and monitoring disease progression in patients with diabetic foot ulcer (DFU). Methods. A retrospective study was designed to examine the utility of fibrinogen in estimating disease severity in patients with DFU admitted...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/2358321

    authors: Li XH,Guan LY,Lin HY,Wang SH,Cao YQ,Jiang XY,Wang YB

    更新日期:2016-01-01 00:00:00

  • Ethanol at low concentration attenuates diabetes induced lung injury in rats model.

    abstract::To observe the changes of lung injury when diabetic rats were treated with low concentration of ethanol (EtOH) and analyze the related mechanisms, male Sprague-Dawley (SD) rats were divided into control, diabetic (DM), and EtOH+DM groups. Diabetic rat was mimicked by injection of streptozotocin intraperitoneally. Fast...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2014/107152

    authors: Hu JF,Zhang GJ,Wang L,Kang PF,Li J,Wang HJ,Gao Q,Chen YQ

    更新日期:2014-01-01 00:00:00

  • Alteration of mevalonate pathway in proliferated vascular smooth muscle from diabetic mice: possible role in high-glucose-induced atherogenic process.

    abstract::The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2015/379287

    authors: Chen GP,Zhang XQ,Wu T,Li L,Han J,Du CQ

    更新日期:2015-01-01 00:00:00

  • The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart.

    abstract:Background:In vivo experiments in Goto-Kakizaki (GK) type 2 diabetic rats have demonstrated reductions in heart rate from a young age. The expression of genes encoding more than 70 proteins that are associated with the generation and conduction of electrical activity in the GK sinoatrial node (SAN) have been evaluated ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2018/8454078

    authors: Howarth FC,Qureshi MA,Jayaprakash P,Parekh K,Oz M,Dobrzynski H,Adrian TE

    更新日期:2018-09-02 00:00:00

  • Case Finding and Medical Treatment of Type 2 Diabetes among Different Ethnic Minority Groups: The HELIUS Study.

    abstract::Aims. Prevention of diabetes complications depends on the level of case finding and successful treatment of diabetes, which may differ between ethnicities. Therefore, we studied the prevalence by age, awareness, treatment, and control of type 2 diabetes, among a multiethnic population. Methods. We included 4,541 Dutch...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2017/9896849

    authors: Snijder MB,Agyemang C,Peters RJ,Stronks K,Ujcic-Voortman JK,van Valkengoed IG

    更新日期:2017-01-01 00:00:00

  • Risk Factors for Cognitive Impairment in Patients with Type 2 Diabetes.

    abstract:Objectives:To investigate the risk factors for cognitive impairment in Chinese type 2 diabetes mellitus (T2DM) patients of advanced age and to identify effective biomarkers of mild cognitive impairment (MCI) in these patients. Methods:Chinese T2DM patients (n = 120) aged 50-70 years were divided into groups with impai...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/4591938

    authors: Sun L,Diao X,Gang X,Lv Y,Zhao X,Yang S,Gao Y,Wang G

    更新日期:2020-04-23 00:00:00

  • Short-Term Trends in Economic Burden and Catastrophic Costs of Type 2 Diabetes Mellitus in Rural Southwest China.

    abstract:Objectives:This study is aimed at gaining insights on the changing prevalence, economic burden, and catastrophic costs of diabetes in rural southwest China. Materials and Methods:Data were collected from two cross-sectional health interviews and examination surveys among individuals aged ≥ 35 years in rural Yunnan Pro...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2019/9626413

    authors: Li HF,Cai L,Golden AR

    更新日期:2019-08-01 00:00:00

  • Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling.

    abstract:Aims:The purpose of the present research is to investigate the effects of the VHL protein antagonist, VH298, on functional activities of fibroblasts and vascular endothelial cells and the effects on the wound healing process in a streptozotocin-induced hyperglycaemic rat model. Methods:HIF-1α and hydroxy-HIF-1α protei...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2019/1897174

    authors: Qiu S,Jia Y,Sun Y,Han P,Xu J,Wen G,Chai Y

    更新日期:2019-02-17 00:00:00

  • The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice.

    abstract::The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle. However, no significant glycogen stores are detected in normal kidneys, but diabetic subjects present a characteristic renal histopathological feature resulting f...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2018/5697970

    authors: Bertinat R,Westermeier F,Silva P,Gatica R,Oliveira JM,Nualart F,Gomis R,Yáñez AJ

    更新日期:2018-05-29 00:00:00

  • Determinants of Change in Glycemic Status in Individuals with Prediabetes: Results from a Nationwide Cohort Study in Germany.

    abstract::Previous studies investigating determinants of changes in glycemic status among individuals with prediabetes mainly focused on glucose-defined prediabetes. In this study, we examined determinants of a regression to normoglycemia or a progression to diabetes among individuals with HbA1c-defined prediabetes. The study i...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2018/5703652

    authors: Paprott R,Scheidt-Nave C,Heidemann C

    更新日期:2018-10-14 00:00:00

  • The Impact of Type 2 Diabetes on the Efficacy of ADP Receptor Blockers in Patients with Acute ST Elevation Myocardial Infarction: A Pilot Prospective Study.

    abstract::Background. The aim of this study was to validate the impact of type 2 diabetes (T2D) on the platelet reactivity in patients with acute ST elevation myocardial infarction (STEMI) treated with adenosine diphosphate (ADP) receptor blockers. Methods. A pilot prospective study was performed. Totally 67 patients were enrol...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/2909436

    authors: Samoš M,Fedor M,Kovář F,Galajda P,Bolek T,Stančiaková L,Fedorová J,Staško J,Kubisz P,Mokáň M

    更新日期:2016-01-01 00:00:00

  • High Frequency of Diabetic Ketoacidosis in Children with Newly Diagnosed Type 1 Diabetes.

    abstract:AIM:The aim of this study was to evaluate the incidence of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in 2006-2007 and 2013-2014. METHOD:The study group consisted of 426 children aged 0-18 years with type 1 diabetes onset admitted to our hospital in 2006-2007 (group A) and 2...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/9582793

    authors: Szypowska A,Ramotowska A,Grzechnik-Gryziak M,Szypowski W,Pasierb A,Piechowiak K

    更新日期:2016-01-01 00:00:00

  • Transcriptional Profile of Kidney from Type 2 Diabetic db/db Mice.

    abstract::Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by progressive glomerular sclerosis and tubulointerstitial fibrosis. However, the underlying mechanisms involved in DN remain to be elucidated. We explored changes in the transcriptional profile in spontaneous type 2 diabetic db/...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2017/8391253

    authors: Zhang H,Zhao T,Li Z,Yan M,Zhao H,Zhu B,Li P

    更新日期:2017-01-01 00:00:00

  • Heart Rate Variability as Early Biomarker for the Evaluation of Diabetes Mellitus Progress.

    abstract::According to the American Diabetes Association (ADA), the side effects of diabetes mellitus have recently increased the global health expenditure each year. Of these, the early diagnostic can contribute to the decrease on renal, cardiovascular, and nervous systems complications. However, the diagnostic criteria, which...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/8483537

    authors: Arroyo-Carmona RE,López-Serrano AL,Albarado-Ibañez A,Mendoza-Lucero FM,Medel-Cajica D,López-Mayorga RM,Torres-Jácome J

    更新日期:2016-01-01 00:00:00

  • Fear of Falling, Lower Extremity Strength, and Physical and Balance Performance in Older Adults with Diabetes Mellitus.

    abstract::Fear of falling (FoF) is known to affect the physical activities and quality of life of older adults with type 2 diabetes mellitus (DM). Many complications of DM, especially ones distressing lower extremity (LE), could lead to increased fall risk and FoF. This study aimed to explore the relationship between FoF, LE mu...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/8573817

    authors: Vongsirinavarat M,Mathiyakom W,Kraiwong R,Hiengkaew V

    更新日期:2020-06-03 00:00:00

  • Relevance of plasma obestatin and early arteriosclerosis in patients with type 2 diabetes mellitus.

    abstract::We investigated the correlation between obestatin and metabolic parameters and carotid intima-media thickness (IMT) in plasma of patients with type 2 diabetes mellitus (T2DM). We collected 103 patients aged from 60 to 83 years (69.26 ± 5.83 years) form January, 2007 to May, 2009. All patients were divided into normal ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2013/563919

    authors: Gu PY,Kang DM,Wang WD,Chen Y,Zhao ZH,Zheng H,Ye SD

    更新日期:2013-01-01 00:00:00

  • Early-Stage Diabetic Neuropathy Reduces Foot Strength and Intrinsic but Not Extrinsic Foot Muscle Size.

    abstract:Background:Tracking progression of diabetic peripheral polyneuropathy (DPN) is usually focused on sensory nerves and subjective testing methods. Recent studies have suggested that distal muscle atrophy may precede sensation loss. Methods to objectively measure distal muscle size and strength are needed to help understa...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/9536362

    authors: Henderson AD,Johnson AW,Rasmussen LG,Peine WP,Symons SH,Scoresby KA,Ridge ST,Bruening DA

    更新日期:2020-03-12 00:00:00

  • The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

    abstract::Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM pa...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2016/5928726

    authors: Zhang X,Sun J,Han W,Jiang Y,Peng S,Shan Z,Teng W

    更新日期:2016-01-01 00:00:00

  • Novel Association of WNK4 Gene, Ala589Ser Polymorphism in Essential Hypertension, and Type 2 Diabetes Mellitus in Malaysia.

    abstract::With-no-lysine (K) Kinase-4 (WNK4) consisted of unique serine and threonine protein kinases, genetically associated with an autosomal dominant form of hypertension. Argumentative consequences have lately arisen on the association of specific single nucleotide polymorphisms of WNK4 gene and essential hypertension (EHT)...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/8219543

    authors: Ghodsian N,Ismail P,Ahmadloo S,Heidari F,Haghvirdizadeh P,Ataollahi Eshkoor S,Etemad A

    更新日期:2016-01-01 00:00:00

  • Diabetes Remission after Nonsurgical Intensive Lifestyle Intervention in Obese Patients with Type 2 Diabetes.

    abstract::Partial or complete remission from type 2 diabetes was recently observed after bariatric surgeries. Limited data is available about the possibility of inducing diabetes remission through intensive weight reduction. We retrospectively evaluated diabetes remissions after one year of the Weight Achievement and Intensive ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2015/468704

    authors: Mottalib A,Sakr M,Shehabeldin M,Hamdy O

    更新日期:2015-01-01 00:00:00

  • Nutrient induced type 2 and chemical induced type 1 experimental diabetes differently modulate gastric GLP-1 receptor expression.

    abstract::T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2D...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2015/561353

    authors: Bloch O,Broide E,Ben-Yehudah G,Cantrell D,Shirin H,Rapoport MJ

    更新日期:2015-01-01 00:00:00

  • The Genetic Profile from HLA and Non-HLA Loci Allows Identification of Atypical Type 2 Diabetes Patients.

    abstract::The complex diagnosis and treatment of diabetes highlight the need for markers to define how to monitor patients correctly during the course of their disease. Different studies demonstrate the existence of patients who cannot be clearly classified. We have previously shown that it is possible to differentiate "atypica...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2015/485132

    authors: Fabregat M,Fernandez M,Javiel G,Vitarella G,Mimbacas A

    更新日期:2015-01-01 00:00:00

  • Longitudinal Screening for Diabetic Retinopathy in a Nationwide Screening Program: Comparing Deep Learning and Human Graders.

    abstract:Objective:To evaluate diabetic retinopathy (DR) screening via deep learning (DL) and trained human graders (HG) in a longitudinal cohort, as case spectrum shifts based on treatment referral and new-onset DR. Methods:We randomly selected patients with diabetes screened twice, two years apart within a nationwide screeni...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/8839376

    authors: Limwattanayingyong J,Nganthavee V,Seresirikachorn K,Singalavanija T,Soonthornworasiri N,Ruamviboonsuk V,Rao C,Raman R,Grzybowski A,Schaekermann M,Peng LH,Webster DR,Semturs C,Krause J,Sayres R,Hersch F,Tiwari R,Liu Y,

    更新日期:2020-12-15 00:00:00

  • Renal Protective Effect of DPP-4 Inhibitors in Type 2 Diabetes Mellitus Patients: A Cohort Study.

    abstract::Aims. Dipeptidyl-peptidase IV inhibitors (DPP-4i) are among the most popular oral antidiabetic agents. However, the effects of DPP-4i on diabetic nephropathy are not well-established. The aim of this study was to determine the renoprotective effects of DPP-4i, using albuminuria and glomerular filtration rate (GFR) as ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/1423191

    authors: Kim YG,Byun J,Yoon D,Jeon JY,Han SJ,Kim DJ,Lee KW,Park RW,Kim HJ

    更新日期:2016-01-01 00:00:00

  • Poor Control of Plasma Triglycerides Is Associated with Early Decline of Estimated Glomerular Filtration Rates in New-Onset Type 2 Diabetes in China: Results from a 3-Year Follow-Up Study.

    abstract:Objective:Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease (ESRD). Even after strict control of obesity, hyperglycemia, and hypertension, some patients still progress rapidly. Previous studies suggested diabetic dyslipidemia might be one of the factors responsible for this high residual...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/3613041

    authors: Wang C,Wang L,Liang K,Yan F,Hou X,Liu F,Chen L

    更新日期:2020-09-28 00:00:00

  • Diabetes-Related Distress Assessment among Type 2 Diabetes Patients.

    abstract:Background and Objectives:Diabetes is one of the most common chronic diseases; it is a debilitating and hard to live with. Diabetes-related distress (DRD) refers to the emotional and behavioral changes caused by diabetes. Our study aims to assess the prevalence of DRD among type 2 diabetes (T2D) patients using Diabetes...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2018/7328128

    authors: Aljuaid MO,Almutairi AM,Assiri MA,Almalki DM,Alswat K

    更新日期:2018-03-26 00:00:00

  • Delay between Onset of Symptoms and Seeking Physician Intervention Increases Risk of Diabetic Foot Complications: Results of a Cross-Sectional Population-Based Survey.

    abstract::We present a post hoc analysis of 17,530 questionnaires collected as part of the 2012 screening for neuropathy using Norfolk Quality of Life tool in patients with diabetes in Romania, to assess the impact on foot complications of time between the onset of symptoms of diabetes/its complications and the physician visit....

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/1567405

    authors: Gavan NA,Veresiu IA,Vinik EJ,Vinik AI,Florea B,Bondor CI

    更新日期:2016-01-01 00:00:00

  • Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes.

    abstract::Metabolic memory (MM) is defined as the persistence of diabetic (DM) complications even after glycemic control is pharmacologically achieved. Using a zebrafish diabetic model that induces a MM state, we previously reported that, in this model, tissue dysfunction was of a heritable nature based on cell proliferation st...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/2860780

    authors: Leontovich AA,Intine RV,Sarras MP Jr

    更新日期:2016-01-01 00:00:00

  • Quantitative Analysis of Retinal Microvascular Perfusion and Novel Biomarkers of the Treatment Response in Diabetic Macular Edema.

    abstract:Purpose:We aimed to assess the changes of retinal microvascular parameters using optical coherence tomography angiography (OCTA) between diabetes macular edema (DME) and controls. We assessed the changes between the baseline microvascular parameters and final treatment response in patients with DME, initially treated w...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/2132037

    authors: Park YG,Park YH

    更新日期:2020-11-16 00:00:00