Abstract:
Objective:To examine whether comorbidity with type 2 diabetes (T2D) affects the clinical and hematological parameters of coronavirus disease 2019 (COVID-19) patients. Methods:We retrospectively investigated the clinical, imaging, and laboratory characteristics of patients with confirmed COVID-19 who were hospitalized from January 30, 2020 to March 17, 2020, at the Renmin Hospital of Wuhan University. A detailed clinical record was kept for each subject, including the medical history of COVID-19 and physical and laboratory examinations. A total of 164 subjects were eligible for the study, among which 40 patients were comorbid with T2D. Further analysis was conducted in two subcohorts of sex- and age-matched patients with and without T2D to identify hematological and biochemical differences. The laboratory tests, including routine blood tests, serum biochemistry, and coagulation function, were performed upon admission. Results:The two groups showed no significant differences in baseline parameters, including age, sex, chest X-ray, or computed tomography (CT) findings, upon admission. However, patients with T2D showed an increased incidence of diarrhea. T2D patients required more recovery time from pneumonia, as shown by follow-up CT findings, which might contribute to the prolonged hospitalization. Comorbidity with T2D also increased risk of secondary bacterial infection during COVID-19. The T2D group had significantly higher white blood cell and neutrophil counts compared with the nondiabetic group, but T2D patients suffered from more severe lymphocytopenia and inflammation (P < 0.05). Most biochemical parameters showed no significant differences between the two groups (P > 0.05). However, patients with T2D seemed to have a significantly higher risk of developing hyperlactatemia, hyponatremia, and hypocalcemia. Conclusions:COVID-19 patients comorbid with T2D demonstrated distinguishing clinical features and hematological parameters during the infection. It is necessary to develop a different clinical severity scoring system for COVID-19 patients with T2D. This study may provide helpful clues for the assessment and management of COVID-19 in T2D patients.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Sun Y,Zhao R,Hu Z,Wang W,Wang S,Gao L,Fei J,Jian X,Li Y,Zheng H,Hou X,Chen Ldoi
10.1155/2020/1038585subject
Has Abstractpub_date
2020-12-02 00:00:00pages
1038585eissn
2314-6745issn
2314-6753journal_volume
2020pub_type
杂志文章abstract:BACKGROUND:To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. METHODS:A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3. RESULTS:The incidenc...
journal_title:Journal of diabetes research
pub_type: 杂志文章,多中心研究
doi:10.1155/2017/6924637
更新日期:2017-01-01 00:00:00
abstract::The metabolic syndrome is an escalating worldwide public health concern. Defined by a combination of physiological, metabolic, and biochemical factors, the metabolic syndrome is used as a clinical guideline to identify individuals with a higher risk for type 2 diabetes and cardiovascular disease. Although risk factors...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/8356537
更新日期:2017-01-01 00:00:00
abstract::Background. The feasibility of digital health programs to prevent and manage diabetes in low-income patients has not been adequately explored. Methods. Researchers collaborated with a digital health company to adapt a diabetes prevention program for low-income prediabetes patients at a large safety net clinic. We cond...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8472391
更新日期:2016-01-01 00:00:00
abstract:Objective:To investigate the effects of cod-liver oil on metabolic status and high-sensitivity C-reactive protein (hs-CRP) in patients with gestational diabetes mellitus (GDM). Methods:This study was a randomized, double-blinded, placebo-controlled trial with the allocation ratio of 1 : 1. The contents of EPA and DHA ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/7074042
更新日期:2019-12-28 00:00:00
abstract::Aims. To examine whether fibrinogen levels are a valuable biomarker for assessing disease severity and monitoring disease progression in patients with diabetic foot ulcer (DFU). Methods. A retrospective study was designed to examine the utility of fibrinogen in estimating disease severity in patients with DFU admitted...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2358321
更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2015/723190.]. ...
journal_title:Journal of diabetes research
pub_type: 已发布勘误
doi:10.1155/2017/7947401
更新日期:2017-01-01 00:00:00
abstract:Background:Previous studies have examined the role of the KQT-like subfamily Q member1 (KCNQ1) gene polymorphisms on the risk of type 2 diabetes mellitus (T2DM), but the findings are inconclusive. Objective:To examine the association between the KCNQ1 gene polymorphisms and the risk of T2DM using an updated meta-analy...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2020/7145139
更新日期:2020-07-03 00:00:00
abstract::Most patients with type 2 diabetes (T2D) have suboptimal adherence to recommended diet, physical activity, and/or medication. Current approaches to improve health behaviors in T2D have been variably effective, and successful interventions are often complex and intensive. It is therefore vital to develop interventions ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2015/428349
更新日期:2015-01-01 00:00:00
abstract::The aim of this study is to evaluate the effects of regular moderate exercise training initiated previously or after induction of diabetes mellitus on renal oxidative stress and inflammation in STZ-induced diabetic female rats. For this purpose, Wistar rats were divided into five groups: sedentary control (SC), traine...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/6170352
更新日期:2018-03-29 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/4713906
更新日期:2019-02-21 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/3613041
更新日期:2020-09-28 00:00:00
abstract::The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/2974304
更新日期:2018-04-10 00:00:00
abstract::Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats. Here we investigated the mechanisms of such effects of CRT. Diabetes was induced by a single injection of 40 mg/kg of STZ. CRT was poured into the stomach by gastric lavage o...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1826281
更新日期:2016-01-01 00:00:00
abstract::Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of diabetes mellitus (DM). The state of persistent hyperglycemia leads to an increase in the production of cytosolic and mitochondrial reactive oxygen species (ROS) and favors deregulation of the antioxidant defenses that are capable...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/1673081
更新日期:2017-01-01 00:00:00
abstract:Objective:To evaluate diabetic retinopathy (DR) screening via deep learning (DL) and trained human graders (HG) in a longitudinal cohort, as case spectrum shifts based on treatment referral and new-onset DR. Methods:We randomly selected patients with diabetes screened twice, two years apart within a nationwide screeni...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8839376
更新日期:2020-12-15 00:00:00
abstract::To study the relationship between glycosylated hemoglobin (HgbA1c) and myocardial perfusion in type 2 diabetes mellitus (T2DM) patients, we prospectively enrolled 24 patients with known or suspected coronary artery disease (CAD) who underwent adenosine stress by real-time myocardial perfusion echocardiography (RTMPE)....
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/243518
更新日期:2014-01-01 00:00:00
abstract::The role of diabetic nephropathy in the outcome of acute renal injury (AKI) is not well defined. Herein we evaluate the outcome of lipopolysaccharide- (LPS-) induced AKI in streptozotocin-induced diabetes, as well as the potential role of Hypoxia Inducible Factor (HIF-1 α ) in this condition. Although 6 h after LPS in...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/254529
更新日期:2013-01-01 00:00:00
abstract::We present a post hoc analysis of 17,530 questionnaires collected as part of the 2012 screening for neuropathy using Norfolk Quality of Life tool in patients with diabetes in Romania, to assess the impact on foot complications of time between the onset of symptoms of diabetes/its complications and the physician visit....
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1567405
更新日期:2016-01-01 00:00:00
abstract:Background:T2DM may cause increased levels of oxidative stress and cardiac apoptosis through elevated blood glucose. The present study investigated the effects of Lactobacillus plantarum (L. plantarum) as a probiotic strain and inulin as a prebiotic supplement on cardiac oxidative stress and apoptotic markers in type 2...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/4745389
更新日期:2020-05-15 00:00:00
abstract:Aim:To evaluate the prognostic role of procalcitonin (PCT) in patients with diabetic foot infection (DFI) and critical limb ischemia (CLI). Materials and Methods:The study group was composed of diabetic patients with DFI and CLI. All patients were treated according to a preset limb salvage protocol which includes reva...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/4312737
更新日期:2019-08-14 00:00:00
abstract::Metformin is contraindicated in diabetic patients with declining renal function. This study examined the glycaemic control in diabetic patients with chronic kidney disease when metformin was discontinued. This was a retrospective study. We screened 2032 diabetic patients who attended the Diabetes Clinic at a tertiary ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/2769819
更新日期:2017-01-01 00:00:00
abstract:Objective:To evaluate (1) the longitudinal relationship between parental well-being and glycemic control in youth with type 1 diabetes and (2) if youth's problem behavior, diabetes parenting behavior, and parental diabetes-distress influence this relationship. Research Design and Methods:Parents of youth 8-15 yrs (at ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1462064
更新日期:2017-01-01 00:00:00
abstract::Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy rema...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/485759
更新日期:2015-01-01 00:00:00
abstract::Proliferative diabetic retinopathy (PDR) is the leading cause of blindness in working age Americans. We demonstrated that diabetes disturbs the homeostasis of nerve growth factor (NGF) resulting in accumulation of its precursor proNGF. Increases in proNGF were positively correlated with progression of diabetic retinop...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/432659
更新日期:2013-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor (PPAR) agonists are used for treating hyperglycemia and type 2 diabetes. However, the mechanism of action of these agonists is still under investigation. The lipid droplet-associated proteins FSP27/CIDEC and LSDP5, regulated directly by PPARγ and PPARα, are associated with he...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8315454
更新日期:2016-01-01 00:00:00
abstract:Objectives:To investigate the risk factors for cognitive impairment in Chinese type 2 diabetes mellitus (T2DM) patients of advanced age and to identify effective biomarkers of mild cognitive impairment (MCI) in these patients. Methods:Chinese T2DM patients (n = 120) aged 50-70 years were divided into groups with impai...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/4591938
更新日期:2020-04-23 00:00:00
abstract::Aims. Dipeptidyl-peptidase IV inhibitors (DPP-4i) are among the most popular oral antidiabetic agents. However, the effects of DPP-4i on diabetic nephropathy are not well-established. The aim of this study was to determine the renoprotective effects of DPP-4i, using albuminuria and glomerular filtration rate (GFR) as ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1423191
更新日期:2016-01-01 00:00:00
abstract::More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, f...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2013/906590
更新日期:2013-01-01 00:00:00
abstract::The complex diagnosis and treatment of diabetes highlight the need for markers to define how to monitor patients correctly during the course of their disease. Different studies demonstrate the existence of patients who cannot be clearly classified. We have previously shown that it is possible to differentiate "atypica...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/485132
更新日期:2015-01-01 00:00:00
abstract::miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 ex...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/7842064
更新日期:2018-08-01 00:00:00