Abstract:
:Many studies have assessed the association between eNOS-4b/a polymorphism and the risk of diabetic retinopathy (DR) among type 2 diabetic subjects. However, the results are inconsistent. In order to derive a more precise estimation of the association, a meta-analysis was conducted. Fifteen studies with 3, 183 cases and 3, 410 controls were enrolled by searching the databases of Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Chinese Wanfang Database. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. The main analysis indicated no significant association between eNOS-4b/a polymorphism and the risk of DR in overall population [allelic model: OR = 0.94 (0.79-1.11); additive model: OR = 0.91 (0.73-1.14); recessive model: OR = 1.01 (0.81-1.25); dominant model: OR = 0.91 (0.75-1.09)]. Subgroup analysis by ethnicity also indicated no significant association. In conclusion, the current meta-analysis did not observe any association between the polymorphism of eNOS 4b/a and the risk of DR among type 2 diabetic subjects. However, larger well-designed studies are required to confirm this finding.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Ma ZJ,Chen R,Ren HZ,Guo X,Guo J,Chen LMdoi
10.1155/2014/549747subject
Has Abstractpub_date
2014-01-01 00:00:00pages
549747eissn
2314-6745issn
2314-6753journal_volume
2014pub_type
杂志文章,meta分析,评审abstract::The complex diagnosis and treatment of diabetes highlight the need for markers to define how to monitor patients correctly during the course of their disease. Different studies demonstrate the existence of patients who cannot be clearly classified. We have previously shown that it is possible to differentiate "atypica...
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abstract::[This corrects the article DOI: 10.1155/2018/6239158.]. ...
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pub_type: 杂志文章,已发布勘误
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abstract:Background:Previous studies have examined the role of the KQT-like subfamily Q member1 (KCNQ1) gene polymorphisms on the risk of type 2 diabetes mellitus (T2DM), but the findings are inconclusive. Objective:To examine the association between the KCNQ1 gene polymorphisms and the risk of T2DM using an updated meta-analy...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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abstract::Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness. The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Journal of diabetes research
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析
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更新日期:2019-09-05 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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更新日期:2018-03-11 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/6076145
更新日期:2020-06-28 00:00:00
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journal_title:Journal of diabetes research
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
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更新日期:2020-11-18 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/807209
更新日期:2014-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
abstract:Purpose:Because thyroid hormones from the maternal thyroid glands are known to influence the growth, development, and metabolic functioning of offspring, we used a rat model to preliminarily investigate the effects of maternal hypothyroidism on glucose metabolism, pancreas cell proliferation, and insulin production in ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2019-02-21 00:00:00
abstract::To study the relationship between glycosylated hemoglobin (HgbA1c) and myocardial perfusion in type 2 diabetes mellitus (T2DM) patients, we prospectively enrolled 24 patients with known or suspected coronary artery disease (CAD) who underwent adenosine stress by real-time myocardial perfusion echocardiography (RTMPE)....
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/243518
更新日期:2014-01-01 00:00:00
abstract:AIMS:This study assesses the impact of using an AP-system at home on fear of hypoglycaemia. In addition, satisfaction and acceptance of the new technology are evaluated. METHODS:In a multicentre, multinational study of 75 patients using the MD-Logic AP during four consecutive nights in home setting 59 of them (aged 10...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/590308
更新日期:2015-01-01 00:00:00
abstract::The metabolic syndrome is an escalating worldwide public health concern. Defined by a combination of physiological, metabolic, and biochemical factors, the metabolic syndrome is used as a clinical guideline to identify individuals with a higher risk for type 2 diabetes and cardiovascular disease. Although risk factors...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/8356537
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Intestinal dysfunction in the ob/ob mouse model of diabetes mimics that seen clinically. METHODS:We determined the effects of a 4-week genistein diet (600 mg genistein/kg food) on intestinal function (contractility, morphology, AChR, and motility) in female ob/ob and lean mice. RESULTS:Contractility of the...
journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
abstract:Background/Aims:It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes and diabetic nephropathy (DN), so we designed this study to investigate the role of P2X7R and NLRP3 inflammasome in DN pathogenesis and the antagonistic effects of artificially cultivated Ophio...
journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2018-11-11 00:00:00
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pub_type: 杂志文章
doi:10.1155/2017/4802319
更新日期:2017-01-01 00:00:00
abstract:Background:The effective hemostasis after minor debridement in an outpatient clinic is important and essential. This study is aimed at evaluating the hemostatic efficacy and safety of the kaolin-impregnated dressing for diabetic foot ulcer patient who take an anticoagulant. Methods:A prospective, randomized, clinical ...
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-11-11 00:00:00
abstract::To evaluate the characteristics and determinants of partial remission (PR) in Belgian children with type 1 diabetes (T1D), we analyzed records of 242 children from our center. Clinical and biological features were collected at diagnosis and during follow-up. PR was defined using the insulin-dose-adjusted A1C definitio...
journal_title:Journal of diabetes research
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5027356
更新日期:2016-01-01 00:00:00