Abstract：
:Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness. The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight control of the risk factors for DR. Therefore, new pharmacological treatments for these early stages of the disease are required. In order to develop therapeutic strategies for early stages of DR new diagnostic tools are urgently needed. In this regard, circulating biomarkers could be useful to detect early disease, to identify those diabetic patients most prone to progressive worsening who ought to be followed up more often and who could obtain the most benefit from these therapies, and to monitor the effectiveness of new drugs for DR before more advanced DR stages have been reached. Research of biomarkers for DR has been mainly based on the pathogenic mechanism involved in the development of DR (i.e., AGEs, oxidative stress, endothelial dysfunction, inflammation, and proangiogenic factors). This review focuses on circulating biomarkers at both early and advanced stages that could be relevant for the prediction or detection of DR.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Simó-Servat O,Simó R,Hernández Cdoi
10.1155/2016/5263798subject
Has Abstractpub_date
2016-01-01 00:00:00pages
5263798eissn
2314-6745issn
2314-6753journal_volume
2016pub_type
杂志文章,评审abstract：Objective:To evaluate diabetic retinopathy (DR) screening via deep learning (DL) and trained human graders (HG) in a longitudinal cohort, as case spectrum shifts based on treatment referral and new-onset DR. Methods:We randomly selected patients with diabetes screened twice, two years apart within a nationwide screeni...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2020/8839376
更新日期：2020-12-15 00:00:00
abstract：Objective:The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Methods:Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital. ACPR was...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2020/4243053
更新日期：2020-07-21 00:00:00
abstract：:Mitogen inducible gene-6 (Mig-6) is a feedback inhibitor of epidermal growth factor receptor (EGFR) signaling pathway. The liver-specific knockout mice of the Mig-6 gene (Mig-6 d/d ) showed hepatomegaly and increased hypercholesterolemia. In this study, the biomarkers of i...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/1632061
更新日期：2016-01-01 00:00:00
abstract：:The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2015/379287
更新日期：2015-01-01 00:00:00
abstract：:The metabolic syndrome is an escalating worldwide public health concern. Defined by a combination of physiological, metabolic, and biochemical factors, the metabolic syndrome is used as a clinical guideline to identify individuals with a higher risk for type 2 diabetes and cardiovascular disease. Although risk factors...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2017/8356537
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. METHODS:A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nond...
journal_title：Journal of diabetes research
pub_type： 杂志文章,meta分析
doi：10.1155/2016/6194750
更新日期：2016-01-01 00:00:00
abstract：:The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- a...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2017/2562759
更新日期：2017-01-01 00:00:00
abstract：:Coupling of the functional stability of rat myocardium and activity of lipid peroxidation processes in combined development of postinfarction remodeling and diabetes mellitus has been studied. The functional stability of myocardium was studied by means of the analysis of inotropic reaction on extrasystolic stimulus, t...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/2548689
更新日期：2016-01-01 00:00:00
abstract：Objectives:Tetrahydrobiopterin (BH4) pathway that included generation of neopterin (Neop), biopterin (Biop), and nitric oxide (NO) is altered in type 2 diabetes (T2D). The aim of this study was to assess the biomarkers of BH4 pathway in noninfected DFUs and to relate these levels to the variables of diabetes as well as...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2019/3426878
更新日期：2019-11-16 00:00:00
abstract：AIM:The aim of this study was to evaluate the incidence of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in 2006-2007 and 2013-2014. METHOD:The study group consisted of 426 children aged 0-18 years with type 1 diabetes onset admitted to our hospital in 2006-2007 (group A) and 2...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/9582793
更新日期：2016-01-01 00:00:00
abstract：Background:Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein. Objective:To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D....
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2018/8623560
更新日期：2018-03-20 00:00:00
abstract：:According to the American Diabetes Association (ADA), the side effects of diabetes mellitus have recently increased the global health expenditure each year. Of these, the early diagnostic can contribute to the decrease on renal, cardiovascular, and nervous systems complications. However, the diagnostic criteria, which...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/8483537
更新日期：2016-01-01 00:00:00
abstract：:This study evaluated the inflammatory markers in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). Inflammatory markers levels were analyzed using one-way analysis of covariance and the association with prediabetes or T2DM risks was examined by logistic regression models. Our data showed increased level...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/7965317
更新日期：2016-01-01 00:00:00
abstract：:Objectives. To compare the prevalence of diabetic peripheral neuropathy (DPN) and that of cardiac autonomic neuropathy (CAN) between South Asians and White Caucasians with type 2 diabetes and to explore reasons for observed differences. Methods. A cross-sectional study of casually selected South Asian and White Caucas...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2017/1273789
更新日期：2017-01-01 00:00:00
abstract：:Glucokinase (GK) plays a critical role in the control of whole-body glucose homeostasis. We investigated the possible effects of a novel glucokinase activator (GKA), HMS5552, to the GK in rats with type 2 diabetes mellitus (T2DM). Male Sprague-Dawley (SD) rats were divided into four groups: control group, diabetic gro...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2017/5812607
更新日期：2017-01-01 00:00:00
abstract：:Metabolic memory (MM) is defined as the persistence of diabetic (DM) complications even after glycemic control is pharmacologically achieved. Using a zebrafish diabetic model that induces a MM state, we previously reported that, in this model, tissue dysfunction was of a heritable nature based on cell proliferation st...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/2860780
更新日期：2016-01-01 00:00:00
abstract：:Inflammatory atherosclerosis is increased in subjects with type 1 diabetes mellitus (T1DM). Normally high-density lipoproteins (HDL) protect against atherosclerosis; however, in the presence of serum amyloid-A- (SAA-) related inflammation this property may be reduced. Fasting blood was obtained from fifty subjects wit...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2015/351601
更新日期：2015-01-01 00:00:00
abstract：:Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM pa...
journal_title：Journal of diabetes research
pub_type： 杂志文章,meta分析,评审
doi：10.1155/2016/5928726
更新日期：2016-01-01 00:00:00
abstract：Purpose:We aimed to assess the changes of retinal microvascular parameters using optical coherence tomography angiography (OCTA) between diabetes macular edema (DME) and controls. We assessed the changes between the baseline microvascular parameters and final treatment response in patients with DME, initially treated w...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2020/2132037
更新日期：2020-11-16 00:00:00
abstract：Background:Diabetic retinopathy (DR) is a severe complication of diabetes mellitus. DR is considered as a neurovascular disease. Retinal ganglion cell (RGC) loss plays an important role in the vision function disorder of diabetic patients. Histone deacetylase3 (HDAC3) is closely related to injury repair and nerve regen...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2020/6086780
更新日期：2020-03-01 00:00:00
abstract：:More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, f...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2013/906590
更新日期：2013-01-01 00:00:00
abstract：Aim:To evaluate the effect of an inhibitor of sodium-glucose cotransporter 2 (SGLT-2 inhibitor, dapagliflozin) on glycemic variability in type 2 diabetes mellitus (T2D) under insulin glargine combined with oral hypoglycemic drugs, using a continuous glucose monitoring system (CGMS). Methods:This prospective, self-cont...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2020/6666403
更新日期：2020-11-24 00:00:00
abstract：Background and Aims:Diabetic foot ulcers (DFUs) are linked to amputations and premature deaths. Negative pressure wound therapy (NPWT) has been used for DFUs. The mechanism of NPWT's action may be associated with its influence on circulating molecules. We assessed NPWT's effect on the plasma levels of angiopoietin-2 (A...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2019/1756798
更新日期：2019-10-28 00:00:00
abstract：:We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels (P < 0.001), higher prevalence of hy...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2014/807209
更新日期：2014-01-01 00:00:00
abstract：:Type 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both environmental and genetic factors contribute to its development. Recent studies have demonstrated that the skeleton realizes systemic regulation of energy metabolism through the secretion of osteocalcin (OCN). Thus, the ass...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2019/9302636
更新日期：2019-11-27 00:00:00
abstract：:We present a post hoc analysis of 17,530 questionnaires collected as part of the 2012 screening for neuropathy using Norfolk Quality of Life tool in patients with diabetes in Romania, to assess the impact on foot complications of time between the onset of symptoms of diabetes/its complications and the physician visit....
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2016/1567405
更新日期：2016-01-01 00:00:00
abstract：Objective:The aim of the study was to investigate the independent and combined effects of the cortisol-to-cortisone ratio (F/E) and 11-deoxycortisol on prediabetes and type 2 diabetes mellitus (T2DM) among different genders. Methods:A case-control study was performed including 2676 participants from the Henan Rural Co...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2019/4693817
更新日期：2019-06-02 00:00:00
abstract：:Widespread electronic health record (EHR) implementation creates new challenges in the diabetes care of complex and diverse populations, including safe medication prescribing for patients with limited health literacy and limited English proficiency. This review highlights how the EHR electronic prescribing transformat...
journal_title：Journal of diabetes research
pub_type： 杂志文章,评审
doi：10.1155/2017/8983237
更新日期：2017-01-01 00:00:00
abstract：Background:Type 2 diabetes mellitus (T2DM) has become a chronic disease, serious harm to human health. Complications of the blood pipe are the main cause of disability and death in diabetic patients, including vascular lesions that directly affects the prognosis of patients with diabetes and survival. This study was to...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2019/4650906
更新日期：2019-04-17 00:00:00
abstract：:Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries eith...
journal_title：Journal of diabetes research
pub_type： 杂志文章
doi：10.1155/2018/8546423
更新日期：2018-04-04 00:00:00
