Heart Rate Variability as Early Biomarker for the Evaluation of Diabetes Mellitus Progress.

abstract：:The haptoglobin (Hp) genotype (1-1 and 2-2) is a major determinant of nephropathy progression in diabetes mellitus patients. Hp 2-2 diabetic mice have impaired Hb clearance and increased iron deposits and oxidative stress in the proximal tubules (PCT), leading to increased renal injury. However, the precise mechanism ...

journal_title：Journal of diabetes research

authors： Dahan I,Thawho N,Farber E,Nakhoul N,Asleh R,Levy AP,Li YC,Ben-Izhak O,Nakhoul F

更新日期：2018-09-03 00:00:00

abstract：:Gastric emptying and glycemic control pathways are closely interrelated processes. Gastric chyme is transferred into the duodenum with velocities depending on its solid or liquid state, as well as on its caloric and nutritional composition. Once nutrients enter the intestine, the secretion of incretins (hormonal produ...

journal_title：Journal of diabetes research

authors： Mihai BM,Mihai C,Cijevschi-Prelipcean C,Grigorescu ED,Dranga M,Drug V,Sporea I,Lăcătușu CM

更新日期：2018-10-03 00:00:00

abstract：:The rapid rise of type II diabetes mellitus and its accompanying vascular complications call for novel approaches in unravelling its pathophysiological mechanisms and designing new treatment modalities. Noncoding RNAs represent a class of previously unknown molecular modulators of this disease. The most important feat...

journal_title：Journal of diabetes research

authors： Eken SM,Jin H,Chernogubova E,Maegdefessel L

更新日期：2013-01-01 00:00:00

abstract：Objective:The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Methods:Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital. ACPR was...

journal_title：Journal of diabetes research

authors： Shen Y,Si Y,Lu J,Ma X,Zhang L,Mo Y,Lu W,Zhu W,Bao Y,Hu G,Zhou J

更新日期：2020-07-21 00:00:00

abstract：AIMS:Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. METHODS:Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of ...

journal_title：Journal of diabetes research

authors： Yamada E,Takeuchi M,Kurata M,Kazumi T,Fukuo K

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Intensive transfusion schedule and iron-chelating therapy prolonged and improved quality of life in patients with β-thalassemia (β-T) major. However, this led to an increased risk of developing impaired glucose tolerance or diabetes. In this study we analyzed variables associated with the occurrence of impai...

journal_title：Journal of diabetes research

authors： Pes GM,Tolu F,Dore MP

更新日期：2016-01-01 00:00:00

abstract：:Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy rema...

journal_title：Journal of diabetes research

authors： Ortiz-Avila O,Esquivel-Martínez M,Olmos-Orizaba BE,Saavedra-Molina A,Rodriguez-Orozco AR,Cortés-Rojo C

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) a...

journal_title：Journal of diabetes research

authors： Cheema AK,Li T,Liuzzi JP,Zarini GG,Dorak MT,Huffman FG

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats. METHODS:The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ). The rats were randomly divided into 5 groups (ten rats ...

journal_title：Journal of diabetes research

authors： Huang S,Peng W,Jiang X,Shao K,Xia L,Tang Y,Qiu J

更新日期：2014-01-01 00:00:00

abstract：:Angiotensin-(1-7) [Ang-(1-7)] may have beneficial effects in diabetes mellitus-induced erectile dysfunction (DMIED) but its molecular actions in the diabetic corpus cavernosum (CC) are not known. We characterized the effects of diabetes and/or chronic in vivo administration of Ang-(1-7) on vascular reactivity in the r...

journal_title：Journal of diabetes research

authors： Yousif MH,Makki B,El-Hashim AZ,Akhtar S,Benter IF

更新日期：2014-01-01 00:00:00

abstract：:Aims. Prevention of diabetes complications depends on the level of case finding and successful treatment of diabetes, which may differ between ethnicities. Therefore, we studied the prevalence by age, awareness, treatment, and control of type 2 diabetes, among a multiethnic population. Methods. We included 4,541 Dutch...

journal_title：Journal of diabetes research

authors： Snijder MB,Agyemang C,Peters RJ,Stronks K,Ujcic-Voortman JK,van Valkengoed IG

更新日期：2017-01-01 00:00:00

abstract：:Aims. Dipeptidyl-peptidase IV inhibitors (DPP-4i) are among the most popular oral antidiabetic agents. However, the effects of DPP-4i on diabetic nephropathy are not well-established. The aim of this study was to determine the renoprotective effects of DPP-4i, using albuminuria and glomerular filtration rate (GFR) as ...

journal_title：Journal of diabetes research

authors： Kim YG,Byun J,Yoon D,Jeon JY,Han SJ,Kim DJ,Lee KW,Park RW,Kim HJ

更新日期：2016-01-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both environmental and genetic factors contribute to its development. Recent studies have demonstrated that the skeleton realizes systemic regulation of energy metabolism through the secretion of osteocalcin (OCN). Thus, the ass...

journal_title：Journal of diabetes research

authors： Chumachenko YD,Harbuzova VY,Ataman AV

更新日期：2019-11-27 00:00:00

abstract：:Coupling of the functional stability of rat myocardium and activity of lipid peroxidation processes in combined development of postinfarction remodeling and diabetes mellitus has been studied. The functional stability of myocardium was studied by means of the analysis of inotropic reaction on extrasystolic stimulus, t...

journal_title：Journal of diabetes research

authors： Afanasiev SA,Kondratieva DS,Rebrova TY,Batalov RE,Popov SV

更新日期：2016-01-01 00:00:00

abstract：:The quantitative trait locus (QTL) mapping in segregating crosses of NSY (Nagoya-Shibata-Yasuda) mice, an animal model of type 2 diabetes, with nondiabetic strain C3H/He mice has identified diabetogenic QTLs on multiple chromosomes. The QTL on chromosome 11 (Chr11) (Nidd1n) showing the largest effect on hyperglycemia ...

journal_title：Journal of diabetes research

authors： Babaya N,Ueda H,Noso S,Hiromine Y,Nojima K,Itoi-Babaya M,Kobayashi M,Fujisawa T,Ikegami H

更新日期：2013-01-01 00:00:00

abstract：:Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic β-cells, we investigated their role in the control of insulin secretion and glucose homeostasis. In this study, we conf...

journal_title：Journal of diabetes research

authors： Hivelin C,Béraud-Dufour S,Devader C,Abderrahmani A,Moreno S,Moha Ou Maati H,Djillani A,Heurteaux C,Borsotto M,Mazella J,Coppola T

更新日期：2016-01-01 00:00:00

abstract：:Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a combination of genetic predisposition and environmental and lifestyle factors including lack of physical exercise and poor nutrition habits. The increased risk of type 2 diabetes is molecularly based on defects in insulin signa...

journal_title：Journal of diabetes research

authors： Röhling M,Herder C,Stemper T,Müssig K

更新日期：2016-01-01 00:00:00

abstract：:Sodium meta-arsenite (SA) is implicated in the regulation of hepatic gluconeogenesis-related genes in vitro; however, the effects in vivo have not been studied. We investigated whether SA has antidiabetic effects in a type 2 diabetic mouse model. Diabetic db/db mice were orally intubated with SA (10 mg kg(-1) body wei...

journal_title：Journal of diabetes research

authors： Lee YS,Lee EK,Oh HH,Choi CS,Kim S,Jun HS

更新日期：2014-01-01 00:00:00

abstract：:Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. T...

journal_title：Journal of diabetes research

authors： Aravindhan V,Madhumitha H

更新日期：2016-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and in...

journal_title：Journal of diabetes research

authors： Tanase DM,Gosav EM,Costea CF,Ciocoiu M,Lacatusu CM,Maranduca MA,Ouatu A,Floria M

更新日期：2020-07-31 00:00:00

abstract：:In bioartificial pancreases (BP), the number of islets needed to restore normoglycaemia in the diabetic patient is critical. However, the confinement of a high quantity of islets in a limited space may impact islet survival, particularly in regard to the low oxygen partial pressure (PO2) in such environments. The aim ...

journal_title：Journal of diabetes research

authors： Rodriguez-Brotons A,Bietiger W,Peronet C,Magisson J,Sookhareea C,Langlois A,Mura C,Jeandidier N,Pinget M,Sigrist S,Maillard E

更新日期：2016-01-01 00:00:00

abstract：:miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 ex...

journal_title：Journal of diabetes research

authors： Huang X,Gong S,Ma Y,Cai X,Zhou L,Luo Y,Li M,Liu W,Zhang S,Zhang X,Ren Q,Zhu Y,Zhou X,Zhang R,Chen L,Gao X,Zhang F,Wang Y,Han X,Ji L

更新日期：2018-08-01 00:00:00

abstract：:The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...

journal_title：Journal of diabetes research

authors： Chen GP,Zhang XQ,Wu T,Li L,Han J,Du CQ

更新日期：2015-01-01 00:00:00

abstract：:Oxidative stress is enhanced by various mechanisms. Serum oxidized low-density lipoprotein (LDL) is a useful prognostic marker in diabetic patients with coronary artery disease. To examine the effects of Theracurmin®, a highly absorbable curcumin preparation, on glucose tolerance, adipocytokines, and oxidized LDL, we ...

journal_title：Journal of diabetes research

authors： Funamoto M,Shimizu K,Sunagawa Y,Katanasaka Y,Miyazaki Y,Kakeya H,Yamakage H,Satoh-Asahara N,Wada H,Hasegawa K,Morimoto T

更新日期：2019-11-23 00:00:00

abstract：Objective:To evaluate the role of CCAAT/enhancer-binding protein β (C/EBP β (C/EBP. Methods:Rats with OIR were exposed to alternating hypoxic and hyperopic conditions for 14 days. Then, the rats with OIR were assigned randomly to groups that received intravitreal injections of either shRNA lentiviral particles targeti...

journal_title：Journal of diabetes research

authors： Li T,Cai X,Wang X,Zhang X,Zhang H,Xu B,Li S,Hu J,Wu Q

更新日期：2020-03-09 00:00:00

abstract：:The aim of this study is to evaluate the effects of regular moderate exercise training initiated previously or after induction of diabetes mellitus on renal oxidative stress and inflammation in STZ-induced diabetic female rats. For this purpose, Wistar rats were divided into five groups: sedentary control (SC), traine...

journal_title：Journal of diabetes research

authors： Amaral LSB,Souza CS,Volpini RA,Shimizu MHM,de Bragança AC,Canale D,Seguro AC,Coimbra TM,de Magalhães ACM,Soares TJ

更新日期：2018-03-29 00:00:00

abstract：:The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development of type II diabetes. Aluminum is known to trigger the structural transformation of many amyloid proteins and induce the formation of toxic aggregate species. The (-)-epigallocatechin gallate (EGCG) is considered...

journal_title：Journal of diabetes research

authors： Xu ZX,Zhang Q,Ma GL,Chen CH,He YM,Xu LH,Zhang Y,Zhou GR,Li ZH,Yang HJ,Zhou P

更新日期：2016-01-01 00:00:00

abstract：Objective:This study adopts the method of retrospective analysis to collect general information and laboratory results of physical examination population, hoping to clarify the correlation between uric acid and thyroid hormone. Methods:The subjects of the study were healthy subjects who underwent physical examination ...

journal_title：Journal of diabetes research

authors： Chao G,Zhu Y,Fang L

更新日期：2019-07-07 00:00:00

abstract：:Metformin is contraindicated in diabetic patients with declining renal function. This study examined the glycaemic control in diabetic patients with chronic kidney disease when metformin was discontinued. This was a retrospective study. We screened 2032 diabetic patients who attended the Diabetes Clinic at a tertiary ...

journal_title：Journal of diabetes research

authors： Leyco T,Ryanputra D,Peh R,Ponce A,Khoo CM

更新日期：2017-01-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is characterized by a metabolic shift from fat to carbohydrates and failure to increase myocardial glucose uptake in response to workload increments. We verified whether this pattern is influenced by an abnormal glucose tolerance (AGT). In 10 patients with DCM, 5 with normal glucose tolera...

journal_title：Journal of diabetes research

authors： Tricò D,Baldi S,Frascerra S,Venturi E,Marraccini P,Neglia D,Natali A

更新日期：2016-01-01 00:00:00