Vitamin status as a determinant of serum homocysteine concentration in type 2 diabetic retinopathy.

abstract：:It is understood that intrauterine hyperglycemia increases the risk of obesity and diabetes in offspring of consecutive generations but its mechanisms remain obscure. This study is aimed at establishing an intrauterine hyperglycemia rat model to investigate the growth and glycolipid metabolic characteristics in transg...

journal_title：Journal of diabetes research

authors： Zhang W,Su R,Feng H,Lin L,Wang C,Yang H

更新日期：2019-09-12 00:00:00

abstract：:Bariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and similarly, it shows great...

journal_title：Journal of diabetes research

authors： Samczuk P,Ciborowski M,Kretowski A

更新日期：2018-03-11 00:00:00

abstract：:Immune and inflammatory pathways play a central role in the pathogenesis of diabetic liver injury. Celastrol is a potent immunosuppressive and anti-inflammatory agent. So far, there is no evidence regarding the mechanism of innate immune alterations of celastrol on diabetic liver injury in type 2 diabetic animal model...

journal_title：Journal of diabetes research

authors： Han LP,Li CJ,Sun B,Xie Y,Guan Y,Ma ZJ,Chen LM

更新日期：2016-01-01 00:00:00

abstract：:Aim. To investigate corneal endothelial cell morphological in children with type 1 diabetes and to determine the systemic and local factors that contribute to these changes. Methods. One hundred sixty eyes of 80 children with type 1 diabetes and 80 eyes of 40 normal children as a control during the period from July 20...

journal_title：Journal of diabetes research

authors： Anbar M,Ammar H,Mahmoud RA

更新日期：2016-01-01 00:00:00

abstract：:T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2D...

journal_title：Journal of diabetes research

authors： Bloch O,Broide E,Ben-Yehudah G,Cantrell D,Shirin H,Rapoport MJ

更新日期：2015-01-01 00:00:00

abstract：:The haptoglobin (Hp) genotype (1-1 and 2-2) is a major determinant of nephropathy progression in diabetes mellitus patients. Hp 2-2 diabetic mice have impaired Hb clearance and increased iron deposits and oxidative stress in the proximal tubules (PCT), leading to increased renal injury. However, the precise mechanism ...

journal_title：Journal of diabetes research

authors： Dahan I,Thawho N,Farber E,Nakhoul N,Asleh R,Levy AP,Li YC,Ben-Izhak O,Nakhoul F

更新日期：2018-09-03 00:00:00

abstract：Background and Aims:Diabetic foot ulcers (DFUs) are linked to amputations and premature deaths. Negative pressure wound therapy (NPWT) has been used for DFUs. The mechanism of NPWT's action may be associated with its influence on circulating molecules. We assessed NPWT's effect on the plasma levels of angiopoietin-2 (A...

journal_title：Journal of diabetes research

authors： Hohendorff J,Drozdz A,Borys S,Ludwig-Slomczynska AH,Kiec-Wilk B,Stepien EL,Malecki MT

更新日期：2019-10-28 00:00:00

abstract：:The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development of type II diabetes. Aluminum is known to trigger the structural transformation of many amyloid proteins and induce the formation of toxic aggregate species. The (-)-epigallocatechin gallate (EGCG) is considered...

journal_title：Journal of diabetes research

authors： Xu ZX,Zhang Q,Ma GL,Chen CH,He YM,Xu LH,Zhang Y,Zhou GR,Li ZH,Yang HJ,Zhou P

更新日期：2016-01-01 00:00:00

abstract：Background:Diabetes mellitus is a widely diffused chronic condition which impacts on several aspects of patients' lives. In the current clinical practice, the implementation in the clinical routine of monitoring systems of patients' outcomes has led to an increased generation and use of several measures for the assessm...

journal_title：Journal of diabetes research

authors： Palamenghi L,Carlucci MM,Graffigna G

更新日期：2020-05-20 00:00:00

abstract：:This study determined if blocking ligand occupancy of the αVβ3 integrin could inhibit the pathophysiologic changes that occur in the early stages of diabetic nephropathy (DN). Diabetic rats were treated with either vehicle or a monoclonal antibody that binds the β3 subunit of the αVβ3 integrin. After 4 weeks of diabet...

journal_title：Journal of diabetes research

authors： Maile LA,Gollahon K,Wai C,Dunbar P,Busby W,Clemmons D

更新日期：2014-01-01 00:00:00

abstract：:Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactio...

journal_title：Journal of diabetes research

authors： Haghvirdizadeh P,Mohamed Z,Abdullah NA,Haghvirdizadeh P,Haerian MS,Haerian BS

更新日期：2015-01-01 00:00:00

abstract：:Exogenous insulin is the only treatment available for type 1 diabetic patients and is mostly administered by subcutaneous (SC) injection in a basal and bolus scheme using insulin pens (injection) or pumps (preimplanted SC catheter). Some divergence exists between these two modes of administration, since pumps provide ...

journal_title：Journal of diabetes research

authors： Schaschkow A,Mura C,Dal S,Langlois A,Seyfritz E,Sookhareea C,Bietiger W,Peronet C,Jeandidier N,Pinget M,Sigrist S,Maillard E

更新日期：2016-01-01 00:00:00

abstract：:Macrophage migration inhibitory factor (Mif) is highly expressed in type 1 diabetes mellitus (T1DM). However, there is limited information about how Mif influences the activation of macrophages (Mφ) and dendritic cells (DC) in T1DM. To address this issue, we induced T1DM by administering multiple low doses of streptoz...

journal_title：Journal of diabetes research

authors： Sánchez-Zamora YI,Juarez-Avelar I,Vazquez-Mendoza A,Hiriart M,Rodriguez-Sosa M

更新日期：2016-01-01 00:00:00

abstract：:Tripterygium glycosides tablet (TGT) is a Chinese traditional medicine that has been shown to protect podocytes from injury and reduce the proteinuria. The aim of this study was to assess the effect of TGT on renal tubulointerstitial fibrosis and its potential mechanism in high-fat diet fed and STZ-induced diabetic ra...

journal_title：Journal of diabetes research

authors： Ma ZJ,Zhang XN,Li L,Yang W,Wang SS,Guo X,Sun P,Chen LM

更新日期：2015-01-01 00:00:00

abstract：:Sub-Saharan Africa (SSA) continues to have the highest diabetes-related mortality rate in the world. While there exists a multitude of health system barriers driving poor diabetes control, rural facilities particularly in SSA lack access to proper monitoring of glucose and other key biologic tests. At best, most of th...

journal_title：Journal of diabetes research

authors： Park PH,Pastakia SD

更新日期：2018-02-26 00:00:00

abstract：AIMS:Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM. METHODS:55 euthyroid patients were enrolle...

journal_title：Journal of diabetes research

authors： Liu F,Yang Q,Gao N,Liu F,Chen S

更新日期：2014-01-01 00:00:00

abstract：:Statin therapy improves lipid profiles and reduces vascular inflammation, but its effects on central arterial stiffness in type 2 diabetes are unclear. The aim of this study was to determine whether statin therapy reduces central arterial stiffness, in a dose-dependent manner, in male patients with type 2 diabetes. Fi...

journal_title：Journal of diabetes research

authors： Davenport C,Ashley DT,O'Sullivan EP,McHenry CM,Agha A,Thompson CJ,O'Gorman DJ,Smith D

更新日期：2015-01-01 00:00:00

abstract：:Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in ...

journal_title：Journal of diabetes research

authors： Watanabe M,Katayama A,Kagawa H,Ogawa D,Wada J

更新日期：2016-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) agonists are used for treating hyperglycemia and type 2 diabetes. However, the mechanism of action of these agonists is still under investigation. The lipid droplet-associated proteins FSP27/CIDEC and LSDP5, regulated directly by PPARγ and PPARα, are associated with he...

journal_title：Journal of diabetes research

authors： Zhu YX,Zhang ML,Zhong Y,Wang C,Jia WP

更新日期：2016-01-01 00:00:00

abstract：:Metabolic memory (MM) is defined as the persistence of diabetic (DM) complications even after glycemic control is pharmacologically achieved. Using a zebrafish diabetic model that induces a MM state, we previously reported that, in this model, tissue dysfunction was of a heritable nature based on cell proliferation st...

journal_title：Journal of diabetes research

authors： Leontovich AA,Intine RV,Sarras MP Jr

更新日期：2016-01-01 00:00:00

abstract：:Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness. The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight...

journal_title：Journal of diabetes research

authors： Simó-Servat O,Simó R,Hernández C

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to assess the association between OGTT glucose levels and requirement of pharmacotherapy in GDM patients classified by the IADPSG criteria. This study included 203 GDM patients (108 managed with lifestyle modification and 95 requiring pharmacotherapy). Clinical risk factors and OGTT glucose c...

journal_title：Journal of diabetes research

authors： Yerlikaya G,Falcone V,Stopp T,Mittlböck M,Tura A,Husslein P,Eppel W,Göbl CS

更新日期：2018-05-08 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both environmental and genetic factors contribute to its development. Recent studies have demonstrated that the skeleton realizes systemic regulation of energy metabolism through the secretion of osteocalcin (OCN). Thus, the ass...

journal_title：Journal of diabetes research

authors： Chumachenko YD,Harbuzova VY,Ataman AV

更新日期：2019-11-27 00:00:00

abstract：Objectives:To investigate the risk factors for cognitive impairment in Chinese type 2 diabetes mellitus (T2DM) patients of advanced age and to identify effective biomarkers of mild cognitive impairment (MCI) in these patients. Methods:Chinese T2DM patients (n = 120) aged 50-70 years were divided into groups with impai...

journal_title：Journal of diabetes research

authors： Sun L,Diao X,Gang X,Lv Y,Zhao X,Yang S,Gao Y,Wang G

更新日期：2020-04-23 00:00:00

abstract：:We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between the control and tene...

journal_title：Journal of diabetes research

authors： Moriya C,Satoh H

更新日期：2016-01-01 00:00:00

abstract：:According to the American Diabetes Association (ADA), the side effects of diabetes mellitus have recently increased the global health expenditure each year. Of these, the early diagnostic can contribute to the decrease on renal, cardiovascular, and nervous systems complications. However, the diagnostic criteria, which...

journal_title：Journal of diabetes research

authors： Arroyo-Carmona RE,López-Serrano AL,Albarado-Ibañez A,Mendoza-Lucero FM,Medel-Cajica D,López-Mayorga RM,Torres-Jácome J

更新日期：2016-01-01 00:00:00

abstract：:Clopidogrel (INN), an oral antiplatelet drug, has been revealed to have a number of biological properties, for instance, anti-inflammation and antioxidation. Oxidative stress plays an imperative role in inflammation, diabetes mellitus, atherosclerosis, and cancer. In the present study, human aortic endothelial cells (...

journal_title：Journal of diabetes research

authors： Yang H,Zhao P,Tian S

更新日期：2016-01-01 00:00:00

abstract：:Forefoot load (FL) contributes to callus formation, which is one of the pathways to diabetic foot ulcers (DFU). In this study, we hypothesized that excessive FL, which cannot be detected by plantar load measurements within laboratory settings, occurs in daily walks. To demonstrate this, we created a FL estimation algo...

journal_title：Journal of diabetes research

authors： Watanabe A,Noguchi H,Oe M,Sanada H,Mori T

更新日期：2017-01-01 00:00:00

abstract：:Diabetes mellitus is a chronic disease prevalence of which is high and continually growing. Cardiovascular disease continues to be the leading cause of death in patients with T2DM. The prevention of cardiovascular complications and the cardiovascular safety of treatments should be a primary objective when selecting tr...

journal_title：Journal of diabetes research

authors： Del Olmo-Garcia MI,Merino-Torres JF

更新日期：2018-04-02 00:00:00

abstract：Objective:This study adopts the method of retrospective analysis to collect general information and laboratory results of physical examination population, hoping to clarify the correlation between uric acid and thyroid hormone. Methods:The subjects of the study were healthy subjects who underwent physical examination ...

journal_title：Journal of diabetes research

authors： Chao G,Zhu Y,Fang L

更新日期：2019-07-07 00:00:00