KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus.

abstract：AIMS:Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM. METHODS:55 euthyroid patients were enrolle...

journal_title：Journal of diabetes research

authors： Liu F,Yang Q,Gao N,Liu F,Chen S

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. METHODS:A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nond...

journal_title：Journal of diabetes research

authors： Li S,Liu D,Li L,Li Y,Li Q,An Z,Sun X,Tian H

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study is to evaluate the effects of regular moderate exercise training initiated previously or after induction of diabetes mellitus on renal oxidative stress and inflammation in STZ-induced diabetic female rats. For this purpose, Wistar rats were divided into five groups: sedentary control (SC), traine...

journal_title：Journal of diabetes research

authors： Amaral LSB,Souza CS,Volpini RA,Shimizu MHM,de Bragança AC,Canale D,Seguro AC,Coimbra TM,de Magalhães ACM,Soares TJ

更新日期：2018-03-29 00:00:00

abstract：:Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a combination of genetic predisposition and environmental and lifestyle factors including lack of physical exercise and poor nutrition habits. The increased risk of type 2 diabetes is molecularly based on defects in insulin signa...

journal_title：Journal of diabetes research

authors： Röhling M,Herder C,Stemper T,Müssig K

更新日期：2016-01-01 00:00:00

abstract：:Fear of falling (FoF) is known to affect the physical activities and quality of life of older adults with type 2 diabetes mellitus (DM). Many complications of DM, especially ones distressing lower extremity (LE), could lead to increased fall risk and FoF. This study aimed to explore the relationship between FoF, LE mu...

journal_title：Journal of diabetes research

authors： Vongsirinavarat M,Mathiyakom W,Kraiwong R,Hiengkaew V

更新日期：2020-06-03 00:00:00

abstract：Background/Aims:It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes and diabetic nephropathy (DN), so we designed this study to investigate the role of P2X7R and NLRP3 inflammasome in DN pathogenesis and the antagonistic effects of artificially cultivated Ophio...

journal_title：Journal of diabetes research

authors： Wang C,Hou XX,Rui HL,Li LJ,Zhao J,Yang M,Sun LJ,Dong HR,Cheng H,Chen YP

更新日期：2018-11-11 00:00:00

abstract：:Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in the development of re...

journal_title：Journal of diabetes research

authors： Donate-Correa J,Martín-Núñez E,Muros-de-Fuentes M,Mora-Fernández C,Navarro-González JF

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. METHODS:A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3. RESULTS:The incidenc...

journal_title：Journal of diabetes research

authors： Gu Y,Wang Y,Li P,Wei H,Chen L,Liu Q,Liu Y,Yang Q,Cheng X,He L,Wei L,Zhu Z,Chen Y,Wang F,Shi X,Cheng Y,Wei Y,Yu J,Gong C

更新日期：2017-01-01 00:00:00

abstract：Objective:The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Methods:Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital. ACPR was...

journal_title：Journal of diabetes research

authors： Shen Y,Si Y,Lu J,Ma X,Zhang L,Mo Y,Lu W,Zhu W,Bao Y,Hu G,Zhou J

更新日期：2020-07-21 00:00:00

abstract：Objective:Few studies have examined whether maternal 25(OH)D deficiency and gestational diabetes mellitus (GDM) jointly affect fetal growth. We aimed to examine the separate and combined effects of maternal 25(OH)D deficiency and GDM on trajectories of fetal growth. Methods:We established a birth cohort (2016-2017) wi...

journal_title：Journal of diabetes research

authors： Liu Z,Liu H,Xu X,Luo S,Liu J,Jin C,Han N,Wang HJ

更新日期：2020-03-30 00:00:00

abstract：:Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity ind...

journal_title：Journal of diabetes research

authors： Geragotou T,Jainandunsing S,Özcan B,de Rooij FW,Kokkinos A,Tentolouris N,Sijbrands EJ

更新日期：2016-01-01 00:00:00

abstract：:In bioartificial pancreases (BP), the number of islets needed to restore normoglycaemia in the diabetic patient is critical. However, the confinement of a high quantity of islets in a limited space may impact islet survival, particularly in regard to the low oxygen partial pressure (PO2) in such environments. The aim ...

journal_title：Journal of diabetes research

authors： Rodriguez-Brotons A,Bietiger W,Peronet C,Magisson J,Sookhareea C,Langlois A,Mura C,Jeandidier N,Pinget M,Sigrist S,Maillard E

更新日期：2016-01-01 00:00:00

abstract：Objective:To examine whether comorbidity with type 2 diabetes (T2D) affects the clinical and hematological parameters of coronavirus disease 2019 (COVID-19) patients. Methods:We retrospectively investigated the clinical, imaging, and laboratory characteristics of patients with confirmed COVID-19 who were hospitalized ...

journal_title：Journal of diabetes research

authors： Sun Y,Zhao R,Hu Z,Wang W,Wang S,Gao L,Fei J,Jian X,Li Y,Zheng H,Hou X,Chen L

更新日期：2020-12-02 00:00:00

abstract：:Aims. Dipeptidyl-peptidase IV inhibitors (DPP-4i) are among the most popular oral antidiabetic agents. However, the effects of DPP-4i on diabetic nephropathy are not well-established. The aim of this study was to determine the renoprotective effects of DPP-4i, using albuminuria and glomerular filtration rate (GFR) as ...

journal_title：Journal of diabetes research

authors： Kim YG,Byun J,Yoon D,Jeon JY,Han SJ,Kim DJ,Lee KW,Park RW,Kim HJ

更新日期：2016-01-01 00:00:00

abstract：Background:The risk factors for acute kidney injury (AKI) development in patients with diabetes hospitalized for COVID-19 have not been fully studied yet. In this study, we aimed to estimate the rate of AKI among the hospitalized population with COVID-19 and to identify the risk factors associated with AKI among patien...

journal_title：Journal of diabetes research

authors： Khalili S,Sabaghian T,Sedaghat M,Soroureddin Z,Askari E,Khalili N

更新日期：2021-01-06 00:00:00

abstract：Introduction:Studies have shown increased urine excretion of vitamin D-binding protein (VDBP) in patients with diabetic nephropathy (DN) resulting from postulated mechanisms linked to renal tubular damage. In this study, we evaluate the utility of VDBP clearance ratio as a novel determinant of glycemic status, DN, and ...

journal_title：Journal of diabetes research

authors： Abdella NA,Mojiminiyi OA

更新日期：2018-05-20 00:00:00

abstract：OBJECTIVE:Puerarin is a natural flavonoid isolated from the TCM lobed kudzuvine root. This study investigated the effect and mechanisms of puerarin on diabetic aorta in rats. METHODS:Streptozotocin- (STZ-) induced diabetic rats were administered with puerarin for 3 weeks. Levels of serum insulin (INS), PGE2, endotheli...

journal_title：Journal of diabetes research

authors： Li W,Zhao W,Wu Q,Lu Y,Shi J,Chen X

更新日期：2016-01-01 00:00:00

abstract：:Gastric emptying and glycemic control pathways are closely interrelated processes. Gastric chyme is transferred into the duodenum with velocities depending on its solid or liquid state, as well as on its caloric and nutritional composition. Once nutrients enter the intestine, the secretion of incretins (hormonal produ...

journal_title：Journal of diabetes research

authors： Mihai BM,Mihai C,Cijevschi-Prelipcean C,Grigorescu ED,Dranga M,Drug V,Sporea I,Lăcătușu CM

更新日期：2018-10-03 00:00:00

abstract：:Sodium meta-arsenite (SA) is implicated in the regulation of hepatic gluconeogenesis-related genes in vitro; however, the effects in vivo have not been studied. We investigated whether SA has antidiabetic effects in a type 2 diabetic mouse model. Diabetic db/db mice were orally intubated with SA (10 mg kg(-1) body wei...

journal_title：Journal of diabetes research

authors： Lee YS,Lee EK,Oh HH,Choi CS,Kim S,Jun HS

更新日期：2014-01-01 00:00:00

abstract：:Metabolic inflammatory damage, characterized by Toll-like receptor 4 (TLR4) signaling activation, is a major mechanism underlying lipotoxicity-induced β-cell damage. The present study is aimed at determining whether G protein-coupled receptor 4 (GPR40) agonist can improve β-cell lipotoxicity-induced damage by inhibiti...

journal_title：Journal of diabetes research

authors： Chen X,Yan Y,Weng Z,Chen C,Lv M,Lin Q,Du Q,Shen X,Yang L

更新日期：2019-12-17 00:00:00

abstract：:The hypoalbuminuric effect of sulodexide (SDX) on diabetic kidney disease (DKD) was suggested by some clinical trials but was denied by the Collaborative Study Group. In this study, the diabetic rats were treated with SDX either from week 0 to 24 or from week 13 to 24. We found that 24-week treatment significantly dec...

journal_title：Journal of diabetes research

authors： Liu YN,Zhou J,Li T,Wu J,Xie SH,Liu HF,Liu Z,Park TS,Wang Y,Liu WJ

更新日期：2017-01-01 00:00:00

abstract：:Tripterygium glycosides tablet (TGT) is a Chinese traditional medicine that has been shown to protect podocytes from injury and reduce the proteinuria. The aim of this study was to assess the effect of TGT on renal tubulointerstitial fibrosis and its potential mechanism in high-fat diet fed and STZ-induced diabetic ra...

journal_title：Journal of diabetes research

authors： Ma ZJ,Zhang XN,Li L,Yang W,Wang SS,Guo X,Sun P,Chen LM

更新日期：2015-01-01 00:00:00

abstract：:Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in ...

journal_title：Journal of diabetes research

authors： Watanabe M,Katayama A,Kagawa H,Ogawa D,Wada J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a negative regulator of natural and adaptive immunity. The role of TIPE2 in type 2 diabetes mellitus (T2DM) remains unknown, although TIPE2 plays key roles in preserving inflammatory homeostasis. METHODS:TIPE2 expression was measured b...

journal_title：Journal of diabetes research

authors： Liu Y,Wang X,Zhao Y,Zhao P,Wang L,Zhai Q,Zhang X,Tian W,Xiang X,Li T

更新日期：2017-01-01 00:00:00

abstract：Aim:To evaluate the prognostic role of procalcitonin (PCT) in patients with diabetic foot infection (DFI) and critical limb ischemia (CLI). Materials and Methods:The study group was composed of diabetic patients with DFI and CLI. All patients were treated according to a preset limb salvage protocol which includes reva...

journal_title：Journal of diabetes research

authors： Meloni M,Izzo V,Giurato L,Brocco E,Ferrannini M,Gandini R,Uccioli L

更新日期：2019-08-14 00:00:00

abstract：PURPOSE:The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats. METHODS:The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ). The rats were randomly divided into 5 groups (ten rats ...

journal_title：Journal of diabetes research

authors： Huang S,Peng W,Jiang X,Shao K,Xia L,Tang Y,Qiu J

更新日期：2014-01-01 00:00:00

abstract：Background:Type 2 diabetes mellitus (T2DM) has become a chronic disease, serious harm to human health. Complications of the blood pipe are the main cause of disability and death in diabetic patients, including vascular lesions that directly affects the prognosis of patients with diabetes and survival. This study was to...

journal_title：Journal of diabetes research

authors： Gao JR,Qin XJ,Fang ZH,Li-Shan,Han LP,Hui-Jiang,Guo MF,Jiang NN

更新日期：2019-04-17 00:00:00

abstract：:The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- a...

journal_title：Journal of diabetes research

authors： Blindbæk SL,Torp TL,Lundberg K,Soelberg K,Vergmann AS,Poulsen CD,Frydkjaer-Olsen U,Broe R,Rasmussen ML,Wied J,Lind M,Vestergaard AH,Peto T,Grauslund J

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to assess the association between OGTT glucose levels and requirement of pharmacotherapy in GDM patients classified by the IADPSG criteria. This study included 203 GDM patients (108 managed with lifestyle modification and 95 requiring pharmacotherapy). Clinical risk factors and OGTT glucose c...

journal_title：Journal of diabetes research

authors： Yerlikaya G,Falcone V,Stopp T,Mittlböck M,Tura A,Husslein P,Eppel W,Göbl CS

更新日期：2018-05-08 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4 + and CD8 ...

journal_title：Journal of diabetes research

authors： Sun L,Xi S,He G,Li Z,Gang X,Sun C,Guo W,Wang G

更新日期：2020-07-30 00:00:00