Abstract:
:Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM patients as marked by the HbA1C levels. Design and Methods. The terms "rs225014," "thr92ala," "T92A," or "dio2 a/g" were used to search for eligible studies in the PubMed, Embase, and Cochrane databases and Google Scholar. A systematic review and meta-analysis of studies including both polymorphism testing and glycated hemoglobin (HbA1C) assays were performed. Results. Four studies were selected, totaling 2190 subjects. The pooled mean difference of the studies was 0.48% (95% CI, 0.18-0.77%), indicating that type 2 diabetics homozygous for the Dio2 Thr92Ala polymorphism had higher HbA1C levels. Conclusions. Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in T2DM patients. To confirm this conclusion, more studies of larger populations are needed.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Zhang X,Sun J,Han W,Jiang Y,Peng S,Shan Z,Teng Wdoi
10.1155/2016/5928726subject
Has Abstractpub_date
2016-01-01 00:00:00pages
5928726eissn
2314-6745issn
2314-6753journal_volume
2016pub_type
杂志文章,meta分析,评审abstract::Introduction. Diabetic Ketoacidosis (DKA) is a serious complication that can be life-threatening. Management of DKA needs admission in a specialized center and imposes major constraints on hospital resources. Aim. We plan to study the impact of adapting a diabetes-educator care model on reducing the frequency of hospi...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3917806
更新日期:2016-01-01 00:00:00
abstract:Background:In T1DM, delayed pubertal development and reduced final height are associated with inadequate metabolic control. Objective:To assess whether T1DM affects pubertal growth spurt and whether metabolic control during puberty is gender-related. Methods:Using a large multicentre database, longitudinal data from ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/8615769
更新日期:2017-01-01 00:00:00
abstract::Metabolic memory (MM) is defined as the persistence of diabetic (DM) complications even after glycemic control is pharmacologically achieved. Using a zebrafish diabetic model that induces a MM state, we previously reported that, in this model, tissue dysfunction was of a heritable nature based on cell proliferation st...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2860780
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To compare the serum concentration of IL-6, IL-10, TNF, IL-8, resistin, and adiponectin in type 1 diabetic patients with and without metabolic syndrome and to determine the cut-off point of the estimated glucose disposal rate that accurately differentiated these groups. DESIGN:We conducted a cross-sectional ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/972073
更新日期:2015-01-01 00:00:00
abstract:Purpose:Pancreatic stone protein/regenerating protein I (PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detec...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/9787839
更新日期:2020-03-23 00:00:00
abstract::Diabetes mellitus is a chronic disease prevalence of which is high and continually growing. Cardiovascular disease continues to be the leading cause of death in patients with T2DM. The prevention of cardiovascular complications and the cardiovascular safety of treatments should be a primary objective when selecting tr...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/4020492
更新日期:2018-04-02 00:00:00
abstract:Background:The risk factors for acute kidney injury (AKI) development in patients with diabetes hospitalized for COVID-19 have not been fully studied yet. In this study, we aimed to estimate the rate of AKI among the hospitalized population with COVID-19 and to identify the risk factors associated with AKI among patien...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2021/6666086
更新日期:2021-01-06 00:00:00
abstract:AIMS:Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatina...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/7526919
更新日期:2017-01-01 00:00:00
abstract:Background and Aims:Diabetic foot ulcers (DFUs) are linked to amputations and premature deaths. Negative pressure wound therapy (NPWT) has been used for DFUs. The mechanism of NPWT's action may be associated with its influence on circulating molecules. We assessed NPWT's effect on the plasma levels of angiopoietin-2 (A...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/1756798
更新日期:2019-10-28 00:00:00
abstract::Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness. The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/5263798
更新日期:2016-01-01 00:00:00
abstract:Objective:To evaluate diabetic retinopathy (DR) screening via deep learning (DL) and trained human graders (HG) in a longitudinal cohort, as case spectrum shifts based on treatment referral and new-onset DR. Methods:We randomly selected patients with diabetes screened twice, two years apart within a nationwide screeni...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8839376
更新日期:2020-12-15 00:00:00
abstract::Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a combination of genetic predisposition and environmental and lifestyle factors including lack of physical exercise and poor nutrition habits. The increased risk of type 2 diabetes is molecularly based on defects in insulin signa...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/2868652
更新日期:2016-01-01 00:00:00
abstract::Aerobic exercise training and weight loss (AEX+WL) improves insulin sensitivity in overweight adults; however, the underlying pathways are incompletely understood. Fetuin-A, a hepatokine that inhibits insulin signaling, may be involved in the salutary effects of AEX+WL. Therefore, we examined the effects of 6-month AE...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1492581
更新日期:2017-01-01 00:00:00
abstract::Glucokinase (GK) plays a critical role in the control of whole-body glucose homeostasis. We investigated the possible effects of a novel glucokinase activator (GKA), HMS5552, to the GK in rats with type 2 diabetes mellitus (T2DM). Male Sprague-Dawley (SD) rats were divided into four groups: control group, diabetic gro...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/5812607
更新日期:2017-01-01 00:00:00
abstract:Introduction:Studies have shown increased urine excretion of vitamin D-binding protein (VDBP) in patients with diabetic nephropathy (DN) resulting from postulated mechanisms linked to renal tubular damage. In this study, we evaluate the utility of VDBP clearance ratio as a novel determinant of glycemic status, DN, and ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/6239158
更新日期:2018-05-20 00:00:00
abstract::The haptoglobin (Hp) genotype (1-1 and 2-2) is a major determinant of nephropathy progression in diabetes mellitus patients. Hp 2-2 diabetic mice have impaired Hb clearance and increased iron deposits and oxidative stress in the proximal tubules (PCT), leading to increased renal injury. However, the precise mechanism ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/7163652
更新日期:2018-09-03 00:00:00
abstract:Aim:To investigate the association between monocyte CD163 and insulin resistance in patients with type 2 diabetes. Methods:One hundred sixty-six patients with type 2 diabetes without inflammatory or chronic kidney disease were recruited. The monocyte CD163 levels were measured by flow cytometry and soluble CD163 (sCD1...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/6549242
更新日期:2017-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor (PPAR) agonists are used for treating hyperglycemia and type 2 diabetes. However, the mechanism of action of these agonists is still under investigation. The lipid droplet-associated proteins FSP27/CIDEC and LSDP5, regulated directly by PPARγ and PPARα, are associated with he...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8315454
更新日期:2016-01-01 00:00:00
abstract::Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactio...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2015/908152
更新日期:2015-01-01 00:00:00
abstract::To observe the changes of lung injury when diabetic rats were treated with low concentration of ethanol (EtOH) and analyze the related mechanisms, male Sprague-Dawley (SD) rats were divided into control, diabetic (DM), and EtOH+DM groups. Diabetic rat was mimicked by injection of streptozotocin intraperitoneally. Fast...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/107152
更新日期:2014-01-01 00:00:00
abstract::Aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 isozymes. They are present in various organs and involved in metabolizing aldehydes that are biologically generated. For instance, ALDH2, a cardiac mitochondrial ALDH isozyme, is known to detoxify 4-hydroxy-2-nonenal, a reactive aldehyde produced upon lipid...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1390861
更新日期:2016-01-01 00:00:00
abstract::This study evaluated the inflammatory markers in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). Inflammatory markers levels were analyzed using one-way analysis of covariance and the association with prediabetes or T2DM risks was examined by logistic regression models. Our data showed increased level...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/7965317
更新日期:2016-01-01 00:00:00
abstract::Zinc (Zn) is an important nutrient that is involved in various physiological metabolisms. Zn dyshomeostasis is often associated with various pathogeneses of chronic diseases, such as metabolic syndrome, diabetes, and related complications. Zn is present in ocular tissue in high concentrations, particularly in the reti...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/425854
更新日期:2013-01-01 00:00:00
abstract::Methylglyoxal (MG) is a highly reactive glucose metabolic intermediate and a major precursor of advanced glycation end products. MG level is elevated in hyperglycemic disorders such as diabetes mellitus. Substantial evidence has shown that MG is involved in the pathogenesis of diabetes and diabetic complications. We i...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2029854
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. METHODS:A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nond...
journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析
doi:10.1155/2016/6194750
更新日期:2016-01-01 00:00:00
abstract:Background:Obesity has been considered as an important factor in the development and progression of chronic kidney diseases (CKD). Perirenal fat, which is surrounding the kidneys, has been reported to be unique in anatomy and biological functions. This study is aimed at assessing the relationship between perirenal fat ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/6076145
更新日期:2020-06-28 00:00:00
abstract:Aims:The purpose of the present research is to investigate the effects of the VHL protein antagonist, VH298, on functional activities of fibroblasts and vascular endothelial cells and the effects on the wound healing process in a streptozotocin-induced hyperglycaemic rat model. Methods:HIF-1α and hydroxy-HIF-1α protei...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/1897174
更新日期:2019-02-17 00:00:00
abstract::Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries eith...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/8546423
更新日期:2018-04-04 00:00:00
abstract::Children with type 1 diabetes (T1DM) are the high-risk group of accelerated atherosclerosis. Real-time continuous glucose monitoring (RT-CGM) provides possibilities for the detection of glycaemic variability, newly recognized cardiovascular risk factor. The aim of the study was to assess the usefulness of RT-CGM as an...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/4385312
更新日期:2016-01-01 00:00:00
abstract:Background:T2DM may cause increased levels of oxidative stress and cardiac apoptosis through elevated blood glucose. The present study investigated the effects of Lactobacillus plantarum (L. plantarum) as a probiotic strain and inulin as a prebiotic supplement on cardiac oxidative stress and apoptotic markers in type 2...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/4745389
更新日期:2020-05-15 00:00:00