Abstract:
:Zinc (Zn) is an important nutrient that is involved in various physiological metabolisms. Zn dyshomeostasis is often associated with various pathogeneses of chronic diseases, such as metabolic syndrome, diabetes, and related complications. Zn is present in ocular tissue in high concentrations, particularly in the retina and choroid. Zn deficiencies have been shown to affect ocular development, cataracts, age-related macular degeneration, and even diabetic retinopathy. However, the mechanism by which Zn deficiency increases the prevalence of diabetic retinopathy remains unclear. In addition, due to the negative effect of Zn deficiency on the eye, Zn supplementation should prevent diabetic retinopathy; however, limited available data do not always support this notion. Therefore, the goal of this paper was to summarize these pieces of available information regarding Zn prevention of diabetic retinopathy. Current theories and possible mechanisms underlying the role of Zn in the eye-related diseases are discussed. The possible factors that affect the preventive effect of Zn supplementation on diabetic retinopathy were also discussed.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Miao X,Sun W,Miao L,Fu Y,Wang Y,Su G,Liu Qdoi
10.1155/2013/425854subject
Has Abstractpub_date
2013-01-01 00:00:00pages
425854eissn
2314-6745issn
2314-6753journal_volume
2013pub_type
杂志文章abstract:Background:Obesity has been considered as an important factor in the development and progression of chronic kidney diseases (CKD). Perirenal fat, which is surrounding the kidneys, has been reported to be unique in anatomy and biological functions. This study is aimed at assessing the relationship between perirenal fat ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/6076145
更新日期:2020-06-28 00:00:00
abstract::Objectives. To compare the prevalence of diabetic peripheral neuropathy (DPN) and that of cardiac autonomic neuropathy (CAN) between South Asians and White Caucasians with type 2 diabetes and to explore reasons for observed differences. Methods. A cross-sectional study of casually selected South Asian and White Caucas...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1273789
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) a...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/921274
更新日期:2015-01-01 00:00:00
abstract::The aim of this study is to evaluate the effects of regular moderate exercise training initiated previously or after induction of diabetes mellitus on renal oxidative stress and inflammation in STZ-induced diabetic female rats. For this purpose, Wistar rats were divided into five groups: sedentary control (SC), traine...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/6170352
更新日期:2018-03-29 00:00:00
abstract::The metabolic syndrome is an escalating worldwide public health concern. Defined by a combination of physiological, metabolic, and biochemical factors, the metabolic syndrome is used as a clinical guideline to identify individuals with a higher risk for type 2 diabetes and cardiovascular disease. Although risk factors...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/8356537
更新日期:2017-01-01 00:00:00
abstract::Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients. A multifaceted treatment approach can include nutritional supplements with antioxidant properties such as 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC). This prospective, randomized, sing...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/8294805
更新日期:2016-01-01 00:00:00
abstract::Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats. Here we investigated the mechanisms of such effects of CRT. Diabetes was induced by a single injection of 40 mg/kg of STZ. CRT was poured into the stomach by gastric lavage o...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1826281
更新日期:2016-01-01 00:00:00
abstract::The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/379287
更新日期:2015-01-01 00:00:00
abstract::To evaluate the characteristics and determinants of partial remission (PR) in Belgian children with type 1 diabetes (T1D), we analyzed records of 242 children from our center. Clinical and biological features were collected at diagnosis and during follow-up. PR was defined using the insulin-dose-adjusted A1C definitio...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/851378
更新日期:2014-01-01 00:00:00
abstract::Native Hawaiians and other Pacific Islanders (NH/PI; e.g., Samoan and Chuukese) have higher type 2 diabetes prevalence compared to other groups in Hawai'i. Partners in Care (PIC), a culturally tailored, community-based, diabetes self-management education intervention (DSME), is effective at improving participants' gly...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/7913258
更新日期:2016-01-01 00:00:00
abstract::Children with type 1 diabetes (T1DM) are the high-risk group of accelerated atherosclerosis. Real-time continuous glucose monitoring (RT-CGM) provides possibilities for the detection of glycaemic variability, newly recognized cardiovascular risk factor. The aim of the study was to assess the usefulness of RT-CGM as an...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/4385312
更新日期:2016-01-01 00:00:00
abstract::Germinated brown rice (GBR) is rich in bioactive compounds, which confer GBR with many functional properties. Evidence of its hypocholesterolemic effects is emerging, but the exact mechanisms of action and bioactive compounds involved have not been fully documented. Using type 2 diabetic rats, we studied the effects o...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/134694
更新日期:2013-01-01 00:00:00
abstract::Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten. Aims. To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring. Methods. Nonobese diabetic mice were divided into 7 groups to receive c...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3047574
更新日期:2016-01-01 00:00:00
abstract::Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β -catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/848679
更新日期:2013-01-01 00:00:00
abstract::To observe the changes of lung injury when diabetic rats were treated with low concentration of ethanol (EtOH) and analyze the related mechanisms, male Sprague-Dawley (SD) rats were divided into control, diabetic (DM), and EtOH+DM groups. Diabetic rat was mimicked by injection of streptozotocin intraperitoneally. Fast...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/107152
更新日期:2014-01-01 00:00:00
abstract:Aim:To evaluate the prognostic role of procalcitonin (PCT) in patients with diabetic foot infection (DFI) and critical limb ischemia (CLI). Materials and Methods:The study group was composed of diabetic patients with DFI and CLI. All patients were treated according to a preset limb salvage protocol which includes reva...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/4312737
更新日期:2019-08-14 00:00:00
abstract:Aim:To evaluate the effect of an inhibitor of sodium-glucose cotransporter 2 (SGLT-2 inhibitor, dapagliflozin) on glycemic variability in type 2 diabetes mellitus (T2D) under insulin glargine combined with oral hypoglycemic drugs, using a continuous glucose monitoring system (CGMS). Methods:This prospective, self-cont...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/6666403
更新日期:2020-11-24 00:00:00
abstract:Objective:To evaluate (1) the longitudinal relationship between parental well-being and glycemic control in youth with type 1 diabetes and (2) if youth's problem behavior, diabetes parenting behavior, and parental diabetes-distress influence this relationship. Research Design and Methods:Parents of youth 8-15 yrs (at ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1462064
更新日期:2017-01-01 00:00:00
abstract::Introduction. Diabetic Ketoacidosis (DKA) is a serious complication that can be life-threatening. Management of DKA needs admission in a specialized center and imposes major constraints on hospital resources. Aim. We plan to study the impact of adapting a diabetes-educator care model on reducing the frequency of hospi...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3917806
更新日期:2016-01-01 00:00:00
abstract:Background:In vivo experiments in Goto-Kakizaki (GK) type 2 diabetic rats have demonstrated reductions in heart rate from a young age. The expression of genes encoding more than 70 proteins that are associated with the generation and conduction of electrical activity in the GK sinoatrial node (SAN) have been evaluated ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/8454078
更新日期:2018-09-02 00:00:00
abstract:Background:Maternal dietary patterns play an important role in the progress of gestational diabetes mellitus (GDM). The aim of the present study was to explore this association. Method:A total of 388 pregnant women (122 case and 266 control) were included. Dietary intake were collected using a food frequency questionn...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/5173926
更新日期:2017-01-01 00:00:00
abstract:Background:The effective hemostasis after minor debridement in an outpatient clinic is important and essential. This study is aimed at evaluating the hemostatic efficacy and safety of the kaolin-impregnated dressing for diabetic foot ulcer patient who take an anticoagulant. Methods:A prospective, randomized, clinical ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/9316380
更新日期:2019-11-11 00:00:00
abstract::We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels (P < 0.001), higher prevalence of hy...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/807209
更新日期:2014-01-01 00:00:00
abstract::Clopidogrel (INN), an oral antiplatelet drug, has been revealed to have a number of biological properties, for instance, anti-inflammation and antioxidation. Oxidative stress plays an imperative role in inflammation, diabetes mellitus, atherosclerosis, and cancer. In the present study, human aortic endothelial cells (...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9128050
更新日期:2016-01-01 00:00:00
abstract::Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by progressive glomerular sclerosis and tubulointerstitial fibrosis. However, the underlying mechanisms involved in DN remain to be elucidated. We explored changes in the transcriptional profile in spontaneous type 2 diabetic db/...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/8391253
更新日期:2017-01-01 00:00:00
abstract::We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between the control and tene...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3201534
更新日期:2016-01-01 00:00:00
abstract::Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a combination of genetic predisposition and environmental and lifestyle factors including lack of physical exercise and poor nutrition habits. The increased risk of type 2 diabetes is molecularly based on defects in insulin signa...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/2868652
更新日期:2016-01-01 00:00:00
abstract::Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4 + and CD8 ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2020/4106518
更新日期:2020-07-30 00:00:00
abstract:BACKGROUND:Intestinal dysfunction in the ob/ob mouse model of diabetes mimics that seen clinically. METHODS:We determined the effects of a 4-week genistein diet (600 mg genistein/kg food) on intestinal function (contractility, morphology, AChR, and motility) in female ob/ob and lean mice. RESULTS:Contractility of the...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/3568146
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to investigate the relationship between serum 25-hydroxy vitamin D (25-OHD) and insulin sensitivity and β-cell function in newly diagnosed type 2 diabetes. 395 newly diagnosed type 2 diabetes patients were enrolled in this study. Venous blood samples were collected at 0 min, 30 min, and 120 m...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/636891
更新日期:2015-01-01 00:00:00