Abstract:
:Germinated brown rice (GBR) is rich in bioactive compounds, which confer GBR with many functional properties. Evidence of its hypocholesterolemic effects is emerging, but the exact mechanisms of action and bioactive compounds involved have not been fully documented. Using type 2 diabetic rats, we studied the effects of white rice, GBR, and brown rice (BR) on lipid profile and on the regulation of selected genes involved in cholesterol metabolism. Our results showed that the upregulation of apolipoprotein A1 and low-density lipoprotein receptor genes was involved in the hypocholesterolemic effects of GBR. Additionally, in vitro studies using HEPG2 cells showed that acylated steryl glycoside, gamma amino butyric acid, and oryzanol and phenolic extracts of GBR contribute to the nutrigenomic regulation of these genes. Transcriptional and nontranscriptional mechanisms are likely involved in the overall hypocholesterolemic effects of GBR suggesting that it may have an impact on the prevention and/or management of hypercholesterolemia due to a wide variety of metabolic perturbations. However, there is need to conduct long-term clinical trials to determine the clinical relevance of the hypocholesterolemic effects of GBR determined through animal studies.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Imam MU,Ismail M,Omar AR,Ithnin Hdoi
10.1155/2013/134694subject
Has Abstractpub_date
2013-01-01 00:00:00pages
134694eissn
2314-6745issn
2314-6753journal_volume
2013pub_type
杂志文章abstract:Aims:To investigate the effect of peer support education model on the levels of glucose and lipids in patients with type 2 diabetes mellitus in China. Methods:120 type 2 diabetes mellitus patients (T2DM) were assigned to two groups randomly from December 2016 to October 2017. Group 1 was trained on basic diabetic medi...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/5634030
更新日期:2019-11-22 00:00:00
abstract::Native Hawaiians and other Pacific Islanders (NH/PI; e.g., Samoan and Chuukese) have higher type 2 diabetes prevalence compared to other groups in Hawai'i. Partners in Care (PIC), a culturally tailored, community-based, diabetes self-management education intervention (DSME), is effective at improving participants' gly...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/7913258
更新日期:2016-01-01 00:00:00
abstract::Macrophage migration inhibitory factor (Mif) is highly expressed in type 1 diabetes mellitus (T1DM). However, there is limited information about how Mif influences the activation of macrophages (Mφ) and dendritic cells (DC) in T1DM. To address this issue, we induced T1DM by administering multiple low doses of streptoz...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/7053963
更新日期:2016-01-01 00:00:00
abstract:Aim:To evaluate the effect of an inhibitor of sodium-glucose cotransporter 2 (SGLT-2 inhibitor, dapagliflozin) on glycemic variability in type 2 diabetes mellitus (T2D) under insulin glargine combined with oral hypoglycemic drugs, using a continuous glucose monitoring system (CGMS). Methods:This prospective, self-cont...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/6666403
更新日期:2020-11-24 00:00:00
abstract::The aim of the current study was to provide updated time-path equations for risk factors of type-2-diabetes-related cardiovascular complications for application in risk calculators and health economic models. Observational data from the Swedish National Diabetes Register were analysed using Generalized Method of Momen...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/241347
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Intensive transfusion schedule and iron-chelating therapy prolonged and improved quality of life in patients with β-thalassemia (β-T) major. However, this led to an increased risk of developing impaired glucose tolerance or diabetes. In this study we analyzed variables associated with the occurrence of impai...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1401829
更新日期:2016-01-01 00:00:00
abstract::Proliferative diabetic retinopathy (PDR) is the leading cause of blindness in working age Americans. We demonstrated that diabetes disturbs the homeostasis of nerve growth factor (NGF) resulting in accumulation of its precursor proNGF. Increases in proNGF were positively correlated with progression of diabetic retinop...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/432659
更新日期:2013-01-01 00:00:00
abstract::Advanced glycation end products (AGEs) are major inflammatory mediators in diabetes, affecting atherosclerosis progression via macrophages. Metformin slows diabetic atherosclerosis progression through mechanisms that remain to be fully elucidated. The present study of murine bone marrow derived macrophages showed that...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/4847812
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of onsite screening with a nonmydriatic, digital fundus camera for diabetic retinopathy (DR) at a diabetes outpatient clinic. RESEARCH DESIGN AND METHODS:This cross-sectional study included 502 patients, 112 with type 1 and 390 with type 2 diabetes. Patients attended screenings for mic...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/4101890
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. METHODS:A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3. RESULTS:The incidenc...
journal_title:Journal of diabetes research
pub_type: 杂志文章,多中心研究
doi:10.1155/2017/6924637
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) a...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/921274
更新日期:2015-01-01 00:00:00
abstract::Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactio...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2015/908152
更新日期:2015-01-01 00:00:00
abstract::Mitogen inducible gene-6 (Mig-6) is a feedback inhibitor of epidermal growth factor receptor (EGFR) signaling pathway. The liver-specific knockout mice of the Mig-6 gene (Mig-6 d/d ) showed hepatomegaly and increased hypercholesterolemia. In this study, the biomarkers of i...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1632061
更新日期:2016-01-01 00:00:00
abstract:Objective:The objective of this study is to investigate the relationship between time in range (TIR), a new metric of continuous glucose monitoring (CGM) and cardiovascular autonomic neuropathy (CAN) in individuals with type 2 diabetes mellitus (T2DM). Methods:A total of 349 individuals with T2DM were enrolled in this...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/5817074
更新日期:2020-02-06 00:00:00
abstract::Objectives. To compare the prevalence of diabetic peripheral neuropathy (DPN) and that of cardiac autonomic neuropathy (CAN) between South Asians and White Caucasians with type 2 diabetes and to explore reasons for observed differences. Methods. A cross-sectional study of casually selected South Asian and White Caucas...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1273789
更新日期:2017-01-01 00:00:00
abstract::Previous studies investigating determinants of changes in glycemic status among individuals with prediabetes mainly focused on glucose-defined prediabetes. In this study, we examined determinants of a regression to normoglycemia or a progression to diabetes among individuals with HbA1c-defined prediabetes. The study i...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/5703652
更新日期:2018-10-14 00:00:00
abstract::Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9648798
更新日期:2016-01-01 00:00:00
abstract::The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle. However, no significant glycogen stores are detected in normal kidneys, but diabetic subjects present a characteristic renal histopathological feature resulting f...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/5697970
更新日期:2018-05-29 00:00:00
abstract:Objective:This study adopts the method of retrospective analysis to collect general information and laboratory results of physical examination population, hoping to clarify the correlation between uric acid and thyroid hormone. Methods:The subjects of the study were healthy subjects who underwent physical examination ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/5904264
更新日期:2019-07-07 00:00:00
abstract::Bariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and similarly, it shows great...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/6270875
更新日期:2018-03-11 00:00:00
abstract::Methylglyoxal (MG) is a highly reactive glucose metabolic intermediate and a major precursor of advanced glycation end products. MG level is elevated in hyperglycemic disorders such as diabetes mellitus. Substantial evidence has shown that MG is involved in the pathogenesis of diabetes and diabetic complications. We i...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2029854
更新日期:2016-01-01 00:00:00
abstract::The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/2974304
更新日期:2018-04-10 00:00:00
abstract::To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be recapitulated in the mouse, we compared C57BL/6J mice fed a Western-style diet (WD) to weight-matched genetically obese leptin receptor-deficient mice (db/db). All mice were monitored for changes in body composition, glycemia, and t...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/8503754
更新日期:2017-01-01 00:00:00
abstract:Background:T2DM may cause increased levels of oxidative stress and cardiac apoptosis through elevated blood glucose. The present study investigated the effects of Lactobacillus plantarum (L. plantarum) as a probiotic strain and inulin as a prebiotic supplement on cardiac oxidative stress and apoptotic markers in type 2...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/4745389
更新日期:2020-05-15 00:00:00
abstract::More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, f...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2013/906590
更新日期:2013-01-01 00:00:00
abstract:Aim:To investigate the association between monocyte CD163 and insulin resistance in patients with type 2 diabetes. Methods:One hundred sixty-six patients with type 2 diabetes without inflammatory or chronic kidney disease were recruited. The monocyte CD163 levels were measured by flow cytometry and soluble CD163 (sCD1...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/6549242
更新日期:2017-01-01 00:00:00
abstract::Many studies have assessed the association between eNOS-4b/a polymorphism and the risk of diabetic retinopathy (DR) among type 2 diabetic subjects. However, the results are inconsistent. In order to derive a more precise estimation of the association, a meta-analysis was conducted. Fifteen studies with 3, 183 cases an...
journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2014/549747
更新日期:2014-01-01 00:00:00
abstract:Objectives:Tetrahydrobiopterin (BH4) pathway that included generation of neopterin (Neop), biopterin (Biop), and nitric oxide (NO) is altered in type 2 diabetes (T2D). The aim of this study was to assess the biomarkers of BH4 pathway in noninfected DFUs and to relate these levels to the variables of diabetes as well as...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/3426878
更新日期:2019-11-16 00:00:00
abstract::Knowing how to prevent and treat diabetes mellitus (DM) earlier is essential to improving outcomes. Through participating in synthesis and catabolism of glycogen, the liver helps to regulate glucose homeostasis. Viral related liver diseases are associated with glycometabolism disorders, which means effective managemen...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/5625371
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats. METHODS:The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ). The rats were randomly divided into 5 groups (ten rats ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/717219
更新日期:2014-01-01 00:00:00