Abstract:
AIMS:Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatinase-associated lipocalin (NGAL) in unravelling early cardio-renal dysfunction in T1D. METHODS:Two T1D patient groups participating in two-centre prospective cohorts were studied. Group A consisted of 57 participants aged 13.9 years (SD: 3.1) and group B consisted of 59 patients aged 28.0 years (SD: 4.4). Forty-nine healthy children [age: 10.5 years (SD: 6.6)] and 18 healthy adults [age 27.7 years (SD: 4.2)] served as controls. Serum concentrations of NGAL (ELISA) were determined, and SAP and DAP were examined (SAP and DAP also expressed as z-scores in the younger group). RESULTS:NGAL correlated positively with SAP in both patient groups (P = 0.020 and P = 0.031, resp.) and SAP z-score (P = 0.009) (group A) and negatively with eGFR in both groups (P < 0.001 and P < 0.001, resp.). CONCLUSIONS:NGAL may be proposed as a biomarker of early renal dysfunction even in nonalbuminuric T1D patients, since it was strongly associated with renal function decline and increasing systolic arterial pressure even at prehypertensive range in people with T1D, in a broad age range.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Papadopoulou-Marketou N,Margeli A,Papassotiriou I,Chrousos GP,Kanaka-Gantenbein C,Wahlberg Jdoi
10.1155/2017/7526919subject
Has Abstractpub_date
2017-01-01 00:00:00pages
7526919eissn
2314-6745issn
2314-6753journal_volume
2017pub_type
杂志文章abstract::Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9648798
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. METHODS:A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nond...
journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析
doi:10.1155/2016/6194750
更新日期:2016-01-01 00:00:00
abstract:Background:Tracking progression of diabetic peripheral polyneuropathy (DPN) is usually focused on sensory nerves and subjective testing methods. Recent studies have suggested that distal muscle atrophy may precede sensation loss. Methods to objectively measure distal muscle size and strength are needed to help understa...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/9536362
更新日期:2020-03-12 00:00:00
abstract::It is understood that intrauterine hyperglycemia increases the risk of obesity and diabetes in offspring of consecutive generations but its mechanisms remain obscure. This study is aimed at establishing an intrauterine hyperglycemia rat model to investigate the growth and glycolipid metabolic characteristics in transg...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/6320839
更新日期:2019-09-12 00:00:00
abstract::Persons with type 2 diabetes mellitus (T2DM) have an elevated risk of atherosclerosis. High-density lipoproteins (HDL) normally protect against cardiovascular disease (CVD), but this may be attenuated by serum amyloid A (SAA). In a case-control study of young females, blood samples were compared between subjects with ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1314864
更新日期:2017-01-01 00:00:00
abstract::Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries eith...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/8546423
更新日期:2018-04-04 00:00:00
abstract:Purpose:Because thyroid hormones from the maternal thyroid glands are known to influence the growth, development, and metabolic functioning of offspring, we used a rat model to preliminarily investigate the effects of maternal hypothyroidism on glucose metabolism, pancreas cell proliferation, and insulin production in ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/4713906
更新日期:2019-02-21 00:00:00
abstract::Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in the development of re...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2015/948417
更新日期:2015-01-01 00:00:00
abstract::Mitogen inducible gene-6 (Mig-6) is a feedback inhibitor of epidermal growth factor receptor (EGFR) signaling pathway. The liver-specific knockout mice of the Mig-6 gene (Mig-6 d/d ) showed hepatomegaly and increased hypercholesterolemia. In this study, the biomarkers of i...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1632061
更新日期:2016-01-01 00:00:00
abstract::Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity ind...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9286303
更新日期:2016-01-01 00:00:00
abstract:Objective:To evaluate (1) the longitudinal relationship between parental well-being and glycemic control in youth with type 1 diabetes and (2) if youth's problem behavior, diabetes parenting behavior, and parental diabetes-distress influence this relationship. Research Design and Methods:Parents of youth 8-15 yrs (at ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/1462064
更新日期:2017-01-01 00:00:00
abstract:AIMS:Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM. METHODS:55 euthyroid patients were enrolle...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/128014
更新日期:2014-01-01 00:00:00
abstract::Many studies have assessed the association between eNOS-4b/a polymorphism and the risk of diabetic retinopathy (DR) among type 2 diabetic subjects. However, the results are inconsistent. In order to derive a more precise estimation of the association, a meta-analysis was conducted. Fifteen studies with 3, 183 cases an...
journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2014/549747
更新日期:2014-01-01 00:00:00
abstract::We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels (P < 0.001), higher prevalence of hy...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/807209
更新日期:2014-01-01 00:00:00
abstract:Background:Diabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide. Due to the increasing prevalence and various complications, diabetes brings about a huge financial burden to DM patients. Nowadays, more and more studies reveal the relationship between diseases and gut microbial c...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8842651
更新日期:2020-11-11 00:00:00
abstract::The role of diabetic nephropathy in the outcome of acute renal injury (AKI) is not well defined. Herein we evaluate the outcome of lipopolysaccharide- (LPS-) induced AKI in streptozotocin-induced diabetes, as well as the potential role of Hypoxia Inducible Factor (HIF-1 α ) in this condition. Although 6 h after LPS in...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/254529
更新日期:2013-01-01 00:00:00
abstract::The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- a...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/2562759
更新日期:2017-01-01 00:00:00
abstract:Aim:To evaluate the prognostic role of procalcitonin (PCT) in patients with diabetic foot infection (DFI) and critical limb ischemia (CLI). Materials and Methods:The study group was composed of diabetic patients with DFI and CLI. All patients were treated according to a preset limb salvage protocol which includes reva...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/4312737
更新日期:2019-08-14 00:00:00
abstract::Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. T...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/6264149
更新日期:2016-01-01 00:00:00
abstract::Inflammatory atherosclerosis is increased in subjects with type 1 diabetes mellitus (T1DM). Normally high-density lipoproteins (HDL) protect against atherosclerosis; however, in the presence of serum amyloid-A- (SAA-) related inflammation this property may be reduced. Fasting blood was obtained from fifty subjects wit...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/351601
更新日期:2015-01-01 00:00:00
abstract::The aim of this study is to evaluate the effects of regular moderate exercise training initiated previously or after induction of diabetes mellitus on renal oxidative stress and inflammation in STZ-induced diabetic female rats. For this purpose, Wistar rats were divided into five groups: sedentary control (SC), traine...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/6170352
更新日期:2018-03-29 00:00:00
abstract::Objective. Diabetic nephropathy is a life-threatening complication in patients with long-standing diabetes. Hemodynamic, inflammatory, and metabolic factors are considered as developmental factors for diabetic nephropathy. In this study, we evaluated whether pharmacological interventions with salicylate, compared to p...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1786789
更新日期:2016-01-01 00:00:00
abstract::We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5027356
更新日期:2016-01-01 00:00:00
abstract::Dilated cardiomyopathy (DCM) is characterized by a metabolic shift from fat to carbohydrates and failure to increase myocardial glucose uptake in response to workload increments. We verified whether this pattern is influenced by an abnormal glucose tolerance (AGT). In 10 patients with DCM, 5 with normal glucose tolera...
journal_title:Journal of diabetes research
pub_type: 临床试验,杂志文章
doi:10.1155/2016/3906425
更新日期:2016-01-01 00:00:00
abstract:Background and Objectives:Diabetes is one of the most common chronic diseases; it is a debilitating and hard to live with. Diabetes-related distress (DRD) refers to the emotional and behavioral changes caused by diabetes. Our study aims to assess the prevalence of DRD among type 2 diabetes (T2D) patients using Diabetes...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/7328128
更新日期:2018-03-26 00:00:00
abstract::We investigated effects on glucose and lipid metabolism in combination of JTT-130, a novel intestine-specific microsomal triglyceride transfer protein (MTP) inhibitor, and pioglitazone, peroxisome proliferator-activated receptor (PPAR) γ agonist. Male Zucker diabetic fatty rats were divided into 4 groups: control grou...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/890639
更新日期:2014-01-01 00:00:00
abstract:Background:Maternal dietary patterns play an important role in the progress of gestational diabetes mellitus (GDM). The aim of the present study was to explore this association. Method:A total of 388 pregnant women (122 case and 266 control) were included. Dietary intake were collected using a food frequency questionn...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/5173926
更新日期:2017-01-01 00:00:00
abstract:Background:Chronic overnutrition leads to cardiac dysfunction and insulin (INS) resistance. Dipeptidyl peptidase-4 (DPP-4) improves glucose metabolism and insulin sensitivity in both human and animal models. In this study, we explored whether DPP-4 inhibitor sitagliptin (SIT) is involved in the protection of cardiac fu...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/3641516
更新日期:2018-07-17 00:00:00
abstract::Bariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and similarly, it shows great...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/6270875
更新日期:2018-03-11 00:00:00
abstract:BACKGROUND:To investigate the hospital-based incidence of FT1D in Chinese children and compare the clinical feature with classical T1DM. METHODS:A cross-sectional study with sixteen hospitals involved. We obtained 23 FT1D cases as group 1, acute-onset T1DM as group 2, and typical T1DM as group 3. RESULTS:The incidenc...
journal_title:Journal of diabetes research
pub_type: 杂志文章,多中心研究
doi:10.1155/2017/6924637
更新日期:2017-01-01 00:00:00