Abstract:
:With-no-lysine (K) Kinase-4 (WNK4) consisted of unique serine and threonine protein kinases, genetically associated with an autosomal dominant form of hypertension. Argumentative consequences have lately arisen on the association of specific single nucleotide polymorphisms of WNK4 gene and essential hypertension (EHT). The aim of this study was to determine the association of Ala589Ser polymorphism of WNK4 gene with essential hypertensive patients in Malaysia. WNK4 gene polymorphism was specified utilizing mutagenically separated polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method in 320 subjects including 163 cases and 157 controls. Close relation between Ala589Ser polymorphism and elevated systolic and diastolic blood pressure (SBP and DBP) was recognized. Sociodemographic factors including body mass index (BMI), age, the level of fasting blood sugar (FBS), low density lipoprotein (LDL), and triglyceride (TG) in the cases and healthy subjects exhibited strong differences (p < 0.05). The distribution of allele frequency and genotype of WNK4 gene Ala589Ser polymorphism showed significant differences (p < 0.05) between EHT subjects with or without type 2 diabetes mellitus (T2DM) and normotensive subjects, statistically. The WNK4 gene variation influences significantly blood pressure increase. Ala589Ser probably has effects on the enzymic activity leading to enhanced predisposition to the disorder.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Ghodsian N,Ismail P,Ahmadloo S,Heidari F,Haghvirdizadeh P,Ataollahi Eshkoor S,Etemad Adoi
10.1155/2016/8219543subject
Has Abstractpub_date
2016-01-01 00:00:00pages
8219543eissn
2314-6745issn
2314-6753journal_volume
2016pub_type
杂志文章abstract:BACKGROUND:Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a negative regulator of natural and adaptive immunity. The role of TIPE2 in type 2 diabetes mellitus (T2DM) remains unknown, although TIPE2 plays key roles in preserving inflammatory homeostasis. METHODS:TIPE2 expression was measured b...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/4802319
更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
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更新日期:2019-11-11 00:00:00
abstract:Purpose:Pancreatic stone protein/regenerating protein I (PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detected in the pancreas. Recent studies revealed increased serum PSP/REG Iα) is a secretory protein mainly detec...
journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2020-03-23 00:00:00
abstract::Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten. Aims. To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring. Methods. Nonobese diabetic mice were divided into 7 groups to receive c...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3047574
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/524517
更新日期:2014-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/254529
更新日期:2013-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/2789209
更新日期:2020-03-09 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/8839376
更新日期:2020-12-15 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/846807
更新日期:2015-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/379287
更新日期:2015-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/4742952
更新日期:2020-11-18 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/2562759
更新日期:2017-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3295747
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/3426878
更新日期:2019-11-16 00:00:00
abstract::Advanced glycation end products (AGEs) are major inflammatory mediators in diabetes, affecting atherosclerosis progression via macrophages. Metformin slows diabetic atherosclerosis progression through mechanisms that remain to be fully elucidated. The present study of murine bone marrow derived macrophages showed that...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/4847812
更新日期:2016-01-01 00:00:00
abstract::The haptoglobin (Hp) genotype (1-1 and 2-2) is a major determinant of nephropathy progression in diabetes mellitus patients. Hp 2-2 diabetic mice have impaired Hb clearance and increased iron deposits and oxidative stress in the proximal tubules (PCT), leading to increased renal injury. However, the precise mechanism ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/7163652
更新日期:2018-09-03 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/972431
更新日期:2014-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/4243053
更新日期:2020-07-21 00:00:00
abstract::Sodium meta-arsenite (SA) is implicated in the regulation of hepatic gluconeogenesis-related genes in vitro; however, the effects in vivo have not been studied. We investigated whether SA has antidiabetic effects in a type 2 diabetic mouse model. Diabetic db/db mice were orally intubated with SA (10 mg kg(-1) body wei...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/961732
更新日期:2014-01-01 00:00:00
abstract::The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle. However, no significant glycogen stores are detected in normal kidneys, but diabetic subjects present a characteristic renal histopathological feature resulting f...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/5697970
更新日期:2018-05-29 00:00:00
abstract::Diabetes mellitus is a chronic disease prevalence of which is high and continually growing. Cardiovascular disease continues to be the leading cause of death in patients with T2DM. The prevention of cardiovascular complications and the cardiovascular safety of treatments should be a primary objective when selecting tr...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/4020492
更新日期:2018-04-02 00:00:00
abstract::Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β -catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/848679
更新日期:2013-01-01 00:00:00
abstract::We investigated the correlation between obestatin and metabolic parameters and carotid intima-media thickness (IMT) in plasma of patients with type 2 diabetes mellitus (T2DM). We collected 103 patients aged from 60 to 83 years (69.26 ± 5.83 years) form January, 2007 to May, 2009. All patients were divided into normal ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/563919
更新日期:2013-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2020-11-24 00:00:00
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journal_title:Journal of diabetes research
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes research
pub_type: 临床试验,杂志文章
doi:10.1155/2016/3906425
更新日期:2016-01-01 00:00:00