Association of pulse pressure with serum TNF-α and neutrophil count in the elderly.

Abstract:

AIMS:Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. METHODS:Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of whom had hypertension. RESULTS:Systolic blood pressure (standardized β, 0.775), log tumor necrosis factor-α (TNF-α, standardized β, 0.110), age (standardized β, 0.140), and neutrophil count (standardized β, 0.114) emerged as determinants of PP independent of high-sensitivity C-reactive protein, interleukin-6, monocyte count, plasminogen activator inhibitor-1, homeostasis model assessment of insulin resistance, HDL-cholesterol, and adiponectin (R(2) = 0.772). CONCLUSIONS:The present studies have demonstrated an independent association of higher PP with higher TNF-α, a marker of insulin resistance, and neutrophil count in community-living elderly women and suggest that insulin resistance and chronic low-grade inflammation may in part be responsible for the association between high PP and incident type 2 diabetes found in elderly patients with hypertension.

journal_name

J Diabetes Res

authors

Yamada E,Takeuchi M,Kurata M,Kazumi T,Fukuo K

doi

10.1155/2014/972431

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

972431

eissn

2314-6745

issn

2314-6753

journal_volume

2014

pub_type

杂志文章
  • Effects of Probiotic Supplement in Pregnant Women with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    abstract:Background:Previous studies showed that probiotics could improve glycemic control and attenuate some of the adverse effects of type 2 diabetes. However, whether the effects are generalizable to gestational diabetes mellitus (GDM) remains uncertain. Objective:We conducted a systematic review and meta-analysis to evalua...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,meta分析

    doi:10.1155/2019/5364730

    authors: Zhang J,Ma S,Wu S,Guo C,Long S,Tan H

    更新日期:2019-09-05 00:00:00

  • Implementation of a Diabetes Educator Care Model to Reduce Paediatric Admission for Diabetic Ketoacidosis.

    abstract::Introduction. Diabetic Ketoacidosis (DKA) is a serious complication that can be life-threatening. Management of DKA needs admission in a specialized center and imposes major constraints on hospital resources. Aim. We plan to study the impact of adapting a diabetes-educator care model on reducing the frequency of hospi...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/3917806

    authors: Deeb A,Yousef H,Abdelrahman L,Tomy M,Suliman S,Attia S,Al Suwaidi H

    更新日期:2016-01-01 00:00:00

  • Impact of Real-Time Continuous Glucose Monitoring Use on Glucose Variability and Endothelial Function in Adolescents with Type 1 Diabetes: New Technology--New Possibility to Decrease Cardiovascular Risk?

    abstract::Children with type 1 diabetes (T1DM) are the high-risk group of accelerated atherosclerosis. Real-time continuous glucose monitoring (RT-CGM) provides possibilities for the detection of glycaemic variability, newly recognized cardiovascular risk factor. The aim of the study was to assess the usefulness of RT-CGM as an...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/4385312

    authors: Jamiołkowska M,Jamiołkowska I,Łuczyński W,Tołwińska J,Bossowski A,Głowińska Olszewska B

    更新日期:2016-01-01 00:00:00

  • The Challenges of Electronic Health Records and Diabetes Electronic Prescribing: Implications for Safety Net Care for Diverse Populations.

    abstract::Widespread electronic health record (EHR) implementation creates new challenges in the diabetes care of complex and diverse populations, including safe medication prescribing for patients with limited health literacy and limited English proficiency. This review highlights how the EHR electronic prescribing transformat...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,评审

    doi:10.1155/2017/8983237

    authors: Ratanawongsa N,Chan LL,Fouts MM,Murphy EJ

    更新日期:2017-01-01 00:00:00

  • The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

    abstract::Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM pa...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2016/5928726

    authors: Zhang X,Sun J,Han W,Jiang Y,Peng S,Shan Z,Teng W

    更新日期:2016-01-01 00:00:00

  • Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6.

    abstract::Mitogen inducible gene-6 (Mig-6) is a feedback inhibitor of epidermal growth factor receptor (EGFR) signaling pathway. The liver-specific knockout mice of the Mig-6 gene (Mig-6 d/d ) showed hepatomegaly and increased hypercholesterolemia. In this study, the biomarkers of i...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/1632061

    authors: Park BK,Lee EA,Kim HY,Lee JC,Kim KS,Jeong WH,Kim KY,Ku BJ,Rhee SD

    更新日期:2016-01-01 00:00:00

  • Potent Oral Hypoglycemic Agents for Microvascular Complication: Sodium-Glucose Cotransporter 2 Inhibitors for Diabetic Retinopathy.

    abstract::The purpose of this study was to investigate the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on the progression of diabetic retinopathy (DR) in patients with type 2 diabetes. The medical records of 21 type 2 diabetic patients who used a SGLT2i and 71 patients with sulfonylurea (control) were reviewed...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2018/6807219

    authors: Cho EH,Park SJ,Han S,Song JH,Lee K,Chung YR

    更新日期:2018-12-05 00:00:00

  • Characteristics and determinants of partial remission in children with type 1 diabetes using the insulin-dose-adjusted A1C definition.

    abstract::To evaluate the characteristics and determinants of partial remission (PR) in Belgian children with type 1 diabetes (T1D), we analyzed records of 242 children from our center. Clinical and biological features were collected at diagnosis and during follow-up. PR was defined using the insulin-dose-adjusted A1C definitio...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2014/851378

    authors: Pecheur A,Barrea T,Vandooren V,Beauloye V,Robert A,Lysy PA

    更新日期:2014-01-01 00:00:00

  • The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain.

    abstract::Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients. A multifaceted treatment approach can include nutritional supplements with antioxidant properties such as 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC). This prospective, randomized, sing...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2016/8294805

    authors: Al-Saber F,Aldosari W,Alselaiti M,Khalfan H,Kaladari A,Khan G,Harb G,Rehani R,Kudo S,Koda A,Tanaka T,Nakajima M,Darwish A

    更新日期:2016-01-01 00:00:00

  • Effects of Negative Pressure Wound Therapy on Levels of Angiopoetin-2 and Other Selected Circulating Signaling Molecules in Patients with Diabetic Foot Ulcer.

    abstract:Background and Aims:Diabetic foot ulcers (DFUs) are linked to amputations and premature deaths. Negative pressure wound therapy (NPWT) has been used for DFUs. The mechanism of NPWT's action may be associated with its influence on circulating molecules. We assessed NPWT's effect on the plasma levels of angiopoietin-2 (A...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2019/1756798

    authors: Hohendorff J,Drozdz A,Borys S,Ludwig-Slomczynska AH,Kiec-Wilk B,Stepien EL,Malecki MT

    更新日期:2019-10-28 00:00:00

  • Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses.

    abstract::Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. T...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,评审

    doi:10.1155/2016/6264149

    authors: Aravindhan V,Madhumitha H

    更新日期:2016-01-01 00:00:00

  • To Explore the Pathogenesis of Vascular Lesion of Type 2 Diabetes Mellitus Based on the PI3K/Akt Signaling Pathway.

    abstract:Background:Type 2 diabetes mellitus (T2DM) has become a chronic disease, serious harm to human health. Complications of the blood pipe are the main cause of disability and death in diabetic patients, including vascular lesions that directly affects the prognosis of patients with diabetes and survival. This study was to...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2019/4650906

    authors: Gao JR,Qin XJ,Fang ZH,Li-Shan,Han LP,Hui-Jiang,Guo MF,Jiang NN

    更新日期:2019-04-17 00:00:00

  • Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis.

    abstract:OBJECTIVE:To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. METHODS:A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nond...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,meta分析

    doi:10.1155/2016/6194750

    authors: Li S,Liu D,Li L,Li Y,Li Q,An Z,Sun X,Tian H

    更新日期:2016-01-01 00:00:00

  • The effect of chromium picolinate supplementation on the pancreas and macroangiopathy in type II diabetes mellitus rats.

    abstract:PURPOSE:The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats. METHODS:The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ). The rats were randomly divided into 5 groups (ten rats ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2014/717219

    authors: Huang S,Peng W,Jiang X,Shao K,Xia L,Tang Y,Qiu J

    更新日期:2014-01-01 00:00:00

  • CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.

    abstract:Objective:To evaluate the role of CCAAT/enhancer-binding protein β (C/EBP β (C/EBP. Methods:Rats with OIR were exposed to alternating hypoxic and hyperopic conditions for 14 days. Then, the rats with OIR were assigned randomly to groups that received intravitreal injections of either shRNA lentiviral particles targeti...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/2789209

    authors: Li T,Cai X,Wang X,Zhang X,Zhang H,Xu B,Li S,Hu J,Wu Q

    更新日期:2020-03-09 00:00:00

  • The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice.

    abstract::The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle. However, no significant glycogen stores are detected in normal kidneys, but diabetic subjects present a characteristic renal histopathological feature resulting f...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2018/5697970

    authors: Bertinat R,Westermeier F,Silva P,Gatica R,Oliveira JM,Nualart F,Gomis R,Yáñez AJ

    更新日期:2018-05-29 00:00:00

  • Analysis of Inflammatory Mediators in Prediabetes and Newly Diagnosed Type 2 Diabetes Patients.

    abstract::This study evaluated the inflammatory markers in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). Inflammatory markers levels were analyzed using one-way analysis of covariance and the association with prediabetes or T2DM risks was examined by logistic regression models. Our data showed increased level...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/7965317

    authors: Wang Z,Shen XH,Feng WM,Ye GF,Qiu W,Li B

    更新日期:2016-01-01 00:00:00

  • Nutrient induced type 2 and chemical induced type 1 experimental diabetes differently modulate gastric GLP-1 receptor expression.

    abstract::T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2D...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2015/561353

    authors: Bloch O,Broide E,Ben-Yehudah G,Cantrell D,Shirin H,Rapoport MJ

    更新日期:2015-01-01 00:00:00

  • Expression of Dual-Specificity Phosphatase 9 in Placenta and Its Relationship with Gestational Diabetes Mellitus.

    abstract:Introduction:The aim of the present study was to examine placental levels of DUSP9 mRNA and protein and to investigate the potential role of DUSP9 in the development of gestational diabetes mellitus (GDM). Methods:Placental tissues from pregnant women with GDM (n = 17) and normal healthy pregnant women (n = 16) were c...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2019/1963178

    authors: Wei Q,Pu X,Zhang L,Xu Y,Duan M,Wang Y

    更新日期:2019-10-20 00:00:00

  • Corrigendum to "Vitamin D-Binding Protein Clearance Ratio Is Significantly Associated with Glycemic Status and Diabetes Complications in a Predominantly Vitamin D-Deficient Population".

    abstract::[This corrects the article DOI: 10.1155/2018/6239158.]. ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,已发布勘误

    doi:10.1155/2018/3016723

    authors: Abdella NA,Mojiminiyi OA

    更新日期:2018-10-22 00:00:00

  • Differences in the Clinical and Hematological Characteristics of COVID-19 Patients with and without Type 2 Diabetes.

    abstract:Objective:To examine whether comorbidity with type 2 diabetes (T2D) affects the clinical and hematological parameters of coronavirus disease 2019 (COVID-19) patients. Methods:We retrospectively investigated the clinical, imaging, and laboratory characteristics of patients with confirmed COVID-19 who were hospitalized ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/1038585

    authors: Sun Y,Zhao R,Hu Z,Wang W,Wang S,Gao L,Fei J,Jian X,Li Y,Zheng H,Hou X,Chen L

    更新日期:2020-12-02 00:00:00

  • Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus.

    abstract::Oxidative stress is enhanced by various mechanisms. Serum oxidized low-density lipoprotein (LDL) is a useful prognostic marker in diabetic patients with coronary artery disease. To examine the effects of Theracurmin®, a highly absorbable curcumin preparation, on glucose tolerance, adipocytokines, and oxidized LDL, we ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2019/8208237

    authors: Funamoto M,Shimizu K,Sunagawa Y,Katanasaka Y,Miyazaki Y,Kakeya H,Yamakage H,Satoh-Asahara N,Wada H,Hasegawa K,Morimoto T

    更新日期:2019-11-23 00:00:00

  • The LDL Receptor-Related Protein 1: At the Crossroads of Lipoprotein Metabolism and Insulin Signaling.

    abstract::The metabolic syndrome is an escalating worldwide public health concern. Defined by a combination of physiological, metabolic, and biochemical factors, the metabolic syndrome is used as a clinical guideline to identify individuals with a higher risk for type 2 diabetes and cardiovascular disease. Although risk factors...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,评审

    doi:10.1155/2017/8356537

    authors: Au DT,Strickland DK,Muratoglu SC

    更新日期:2017-01-01 00:00:00

  • Prospective Randomized Controlled Study of Hemostatic Efficacy with Kaolin-Impregnated Dressings in Diabetic Foot Ulcers Taking Anticoagulants Undergoing Debridement in an Outpatient Clinic.

    abstract:Background:The effective hemostasis after minor debridement in an outpatient clinic is important and essential. This study is aimed at evaluating the hemostatic efficacy and safety of the kaolin-impregnated dressing for diabetic foot ulcer patient who take an anticoagulant. Methods:A prospective, randomized, clinical ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2019/9316380

    authors: Hwang YG,Lee JW,Won EA,Han SH

    更新日期:2019-11-11 00:00:00

  • Application of Metabolomics to Study Effects of Bariatric Surgery.

    abstract::Bariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and similarly, it shows great...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,评审

    doi:10.1155/2018/6270875

    authors: Samczuk P,Ciborowski M,Kretowski A

    更新日期:2018-03-11 00:00:00

  • Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes.

    abstract::Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4 + and CD8 ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,评审

    doi:10.1155/2020/4106518

    authors: Sun L,Xi S,He G,Li Z,Gang X,Sun C,Guo W,Wang G

    更新日期:2020-07-30 00:00:00

  • Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring.

    abstract::Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten. Aims. To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring. Methods. Nonobese diabetic mice were divided into 7 groups to receive c...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2016/3047574

    authors: Antvorskov JC,Josefsen K,Haupt-Jorgensen M,Fundova P,Funda DP,Buschard K

    更新日期:2016-01-01 00:00:00

  • Cod-Liver Oil Improves Metabolic Indices and hs-CRP Levels in Gestational Diabetes Mellitus Patients: A Double-Blind Randomized Controlled Trial.

    abstract:Objective:To investigate the effects of cod-liver oil on metabolic status and high-sensitivity C-reactive protein (hs-CRP) in patients with gestational diabetes mellitus (GDM). Methods:This study was a randomized, double-blinded, placebo-controlled trial with the allocation ratio of 1 : 1. The contents of EPA and DHA ...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2019/7074042

    authors: Yang S,Lin R,Si L,Li Z,Jian W,Yu Q,Jia Y

    更新日期:2019-12-28 00:00:00

  • Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling.

    abstract:Aims:The purpose of the present research is to investigate the effects of the VHL protein antagonist, VH298, on functional activities of fibroblasts and vascular endothelial cells and the effects on the wound healing process in a streptozotocin-induced hyperglycaemic rat model. Methods:HIF-1α and hydroxy-HIF-1α protei...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2019/1897174

    authors: Qiu S,Jia Y,Sun Y,Han P,Xu J,Wen G,Chai Y

    更新日期:2019-02-17 00:00:00

  • Influence of Metabolic Parameters and Treatment Method on OCT Angiography Results in Children with Type 1 Diabetes.

    abstract:Aim:To evaluate the influence of metabolic parameters and the treatment method in children with type 1 diabetes (T1D) on the optical coherence tomography angiography (OCTA) results as early markers of diabetic retinopathy (DR). Material and Methods. This prospective study enrolled 175 consecutive children with T1D. OCT...

    journal_title:Journal of diabetes research

    pub_type: 杂志文章

    doi:10.1155/2020/4742952

    authors: Wysocka-Mincewicz M,Baszyńska-Wilk M,Gołębiewska J,Olechowski A,Byczyńska A,Hautz W,Szalecki M

    更新日期:2020-11-18 00:00:00