New Diagnostic and Therapeutic Approaches for Preventing the Progression of Diabetic Retinopathy.

abstract：:The metabolic syndrome is an escalating worldwide public health concern. Defined by a combination of physiological, metabolic, and biochemical factors, the metabolic syndrome is used as a clinical guideline to identify individuals with a higher risk for type 2 diabetes and cardiovascular disease. Although risk factors...

journal_title：Journal of diabetes research

authors： Au DT,Strickland DK,Muratoglu SC

更新日期：2017-01-01 00:00:00

abstract：:Objective. Diabetic nephropathy is a life-threatening complication in patients with long-standing diabetes. Hemodynamic, inflammatory, and metabolic factors are considered as developmental factors for diabetic nephropathy. In this study, we evaluated whether pharmacological interventions with salicylate, compared to p...

journal_title：Journal of diabetes research

authors： Abouzed TK,Munesue S,Harashima A,Masuo Y,Kato Y,Khailo K,Yamamoto H,Yamamoto Y

更新日期：2016-01-01 00:00:00

abstract：Introduction:Studies have shown increased urine excretion of vitamin D-binding protein (VDBP) in patients with diabetic nephropathy (DN) resulting from postulated mechanisms linked to renal tubular damage. In this study, we evaluate the utility of VDBP clearance ratio as a novel determinant of glycemic status, DN, and ...

journal_title：Journal of diabetes research

authors： Abdella NA,Mojiminiyi OA

更新日期：2018-05-20 00:00:00

abstract：:Background/Aims. Subclinical atherosclerosis and long-term glycemic variability have been reported to predict incident chronic kidney disease (CKD) in the general population. However, these associations have not been investigated in patients with type 2 diabetes with preserved kidney function. Methods. We prospectivel...

journal_title：Journal of diabetes research

authors： Takenouchi A,Tsuboi A,Kurata M,Fukuo K,Kazumi T

更新日期：2016-01-01 00:00:00

abstract：:Angiotensin-(1-7) [Ang-(1-7)] may have beneficial effects in diabetes mellitus-induced erectile dysfunction (DMIED) but its molecular actions in the diabetic corpus cavernosum (CC) are not known. We characterized the effects of diabetes and/or chronic in vivo administration of Ang-(1-7) on vascular reactivity in the r...

journal_title：Journal of diabetes research

authors： Yousif MH,Makki B,El-Hashim AZ,Akhtar S,Benter IF

更新日期：2014-01-01 00:00:00

abstract：:Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. However, the role of inflammation in the pathogenesis of DR is not completely understood. This is an observational clinical research enrolling 80 type II diabetic patients who had undergone cataract surgeries eith...

journal_title：Journal of diabetes research

authors： Feng S,Yu H,Yu Y,Geng Y,Li D,Yang C,Lv Q,Lu L,Liu T,Li G,Yuan L

更新日期：2018-04-04 00:00:00

abstract：BACKGROUND:Intestinal dysfunction in the ob/ob mouse model of diabetes mimics that seen clinically. METHODS:We determined the effects of a 4-week genistein diet (600 mg genistein/kg food) on intestinal function (contractility, morphology, AChR, and motility) in female ob/ob and lean mice. RESULTS:Contractility of the...

journal_title：Journal of diabetes research

authors： Schacht S,Masood F,Catmull S,Dolan R,Altabtabaee R,Grow W,Al-Nakkash L

更新日期：2017-01-01 00:00:00

abstract：Background:Diabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide. Due to the increasing prevalence and various complications, diabetes brings about a huge financial burden to DM patients. Nowadays, more and more studies reveal the relationship between diseases and gut microbial c...

journal_title：Journal of diabetes research

authors： Zhao X,Zhang Y,Guo R,Yu W,Zhang F,Wu F,Shang J

更新日期：2020-11-11 00:00:00

abstract：:We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health ...

journal_title：Journal of diabetes research

authors： van Vugt M,de Wit M,Sieverink F,Roelofsen Y,Hendriks SH,Bilo HJ,Snoek FJ

更新日期：2016-01-01 00:00:00

abstract：:The objective of this study was to assess the effects of exogenously expressed proinsulin on the biological characters of a hematopoietic stem cell line (HSC) and erythroid myeloid lymphoid (EML) cells and explore new strategies for cell therapy for type I diabetes. EML cells were transduced with lentivirus particles ...

journal_title：Journal of diabetes research

authors： Han Y,Liu T,Zou Y,Ji L,Li Y,Li J,Wang J,Chen G,Chen J,Chen L,Ye Z

更新日期：2017-01-01 00:00:00

abstract：:The early growth response- (Egr-) 1 has been found to play a key role in organ fibrosis. Metformin has been shown to be effective in attenuating renal tubular epithelial-to-mesenchymal transition (EMT), which is involved in renal fibrosis. However, it is unknown whether metformin improves EMT via inhibiting Egr-1. In ...

journal_title：Journal of diabetes research

authors： Guan M,Li W,Xu L,Zeng Y,Wang D,Zheng Z,Lyv F,Xue Y

更新日期：2018-06-27 00:00:00

abstract：:Background. The feasibility of digital health programs to prevent and manage diabetes in low-income patients has not been adequately explored. Methods. Researchers collaborated with a digital health company to adapt a diabetes prevention program for low-income prediabetes patients at a large safety net clinic. We cond...

journal_title：Journal of diabetes research

authors： Fontil V,McDermott K,Tieu L,Rios C,Gibson E,Sweet CC,Payne M,Lyles CR

更新日期：2016-01-01 00:00:00

abstract：Background:T2DM may cause increased levels of oxidative stress and cardiac apoptosis through elevated blood glucose. The present study investigated the effects of Lactobacillus plantarum (L. plantarum) as a probiotic strain and inulin as a prebiotic supplement on cardiac oxidative stress and apoptotic markers in type 2...

journal_title：Journal of diabetes research

authors： Sefidgari-Abrasi S,Karimi P,Roshangar L,Morshedi M,Bavafa-Valenlia K,Saghafi-Asl M,Mohiti S,Rahimiyan-Heravan M

更新日期：2020-05-15 00:00:00

abstract：:The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...

journal_title：Journal of diabetes research

authors： Chen GP,Zhang XQ,Wu T,Li L,Han J,Du CQ

更新日期：2015-01-01 00:00:00

abstract：:Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by progressive glomerular sclerosis and tubulointerstitial fibrosis. However, the underlying mechanisms involved in DN remain to be elucidated. We explored changes in the transcriptional profile in spontaneous type 2 diabetic db/...

journal_title：Journal of diabetes research

authors： Zhang H,Zhao T,Li Z,Yan M,Zhao H,Zhu B,Li P

更新日期：2017-01-01 00:00:00

abstract：:To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be recapitulated in the mouse, we compared C57BL/6J mice fed a Western-style diet (WD) to weight-matched genetically obese leptin receptor-deficient mice (db/db). All mice were monitored for changes in body composition, glycemia, and t...

journal_title：Journal of diabetes research

authors： Burke SJ,Batdorf HM,Burk DH,Noland RC,Eder AE,Boulos MS,Karlstad MD,Collier JJ

更新日期：2017-01-01 00:00:00

abstract：:Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascu...

journal_title：Journal of diabetes research

authors： Dahan I,Farber E,Thauho N,Nakhoul N,Francis A,Awawde M,Levy AP,Kim-Shapiro DB,Basu S,Nakhoul F

更新日期：2015-01-01 00:00:00

abstract：Purpose:Because thyroid hormones from the maternal thyroid glands are known to influence the growth, development, and metabolic functioning of offspring, we used a rat model to preliminarily investigate the effects of maternal hypothyroidism on glucose metabolism, pancreas cell proliferation, and insulin production in ...

journal_title：Journal of diabetes research

authors： Liu Z,Chen Y,Chen G,Mao X,Wei X,Li X,Xu Y,Jiang F,Wang K,Liu C

更新日期：2019-02-21 00:00:00

abstract：:Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. T...

journal_title：Journal of diabetes research

authors： Aravindhan V,Madhumitha H

更新日期：2016-01-01 00:00:00

abstract：Introduction:Diabetes mellitus type 1 and type 2 are linked to higher prevalence and occurrences of depression. Internet-based depression- and diabetes-specific cognitive behavioral therapies (CBT) can be effective in reducing depressive symptom severity and diabetes-related emotional distress. The aim of the study was...

journal_title：Journal of diabetes research

authors： Schlicker S,Weisel KK,Buntrock C,Berking M,Nobis S,Lehr D,Baumeister H,Snoek FJ,Riper H,Ebert DD

更新日期：2019-05-14 00:00:00

abstract：AIMS:This study assesses the impact of using an AP-system at home on fear of hypoglycaemia. In addition, satisfaction and acceptance of the new technology are evaluated. METHODS:In a multicentre, multinational study of 75 patients using the MD-Logic AP during four consecutive nights in home setting 59 of them (aged 10...

journal_title：Journal of diabetes research

authors： Ziegler C,Liberman A,Nimri R,Muller I,Klemenčič S,Bratina N,Bläsig S,Remus K,Phillip M,Battelino T,Kordonouri O,Danne T,Lange K

更新日期：2015-01-01 00:00:00

abstract：:Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in ...

journal_title：Journal of diabetes research

authors： Watanabe M,Katayama A,Kagawa H,Ogawa D,Wada J

更新日期：2016-01-01 00:00:00

abstract：Background:Previous studies showed that probiotics could improve glycemic control and attenuate some of the adverse effects of type 2 diabetes. However, whether the effects are generalizable to gestational diabetes mellitus (GDM) remains uncertain. Objective:We conducted a systematic review and meta-analysis to evalua...

journal_title：Journal of diabetes research

authors： Zhang J,Ma S,Wu S,Guo C,Long S,Tan H

更新日期：2019-09-05 00:00:00

abstract：:Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactio...

journal_title：Journal of diabetes research

authors： Haghvirdizadeh P,Mohamed Z,Abdullah NA,Haghvirdizadeh P,Haerian MS,Haerian BS

更新日期：2015-01-01 00:00:00

abstract：:Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of diabetes mellitus (DM). The state of persistent hyperglycemia leads to an increase in the production of cytosolic and mitochondrial reactive oxygen species (ROS) and favors deregulation of the antioxidant defenses that are capable...

journal_title：Journal of diabetes research

authors： Sifuentes-Franco S,Pacheco-Moisés FP,Rodríguez-Carrizalez AD,Miranda-Díaz AG

更新日期：2017-01-01 00:00:00

abstract：Objective:The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes. Methods:Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital. ACPR was...

journal_title：Journal of diabetes research

authors： Shen Y,Si Y,Lu J,Ma X,Zhang L,Mo Y,Lu W,Zhu W,Bao Y,Hu G,Zhou J

更新日期：2020-07-21 00:00:00

abstract：Objectives:Tetrahydrobiopterin (BH4) pathway that included generation of neopterin (Neop), biopterin (Biop), and nitric oxide (NO) is altered in type 2 diabetes (T2D). The aim of this study was to assess the biomarkers of BH4 pathway in noninfected DFUs and to relate these levels to the variables of diabetes as well as...

journal_title：Journal of diabetes research

authors： Al-Nimer M,Ratha R,Mahwi T

更新日期：2019-11-16 00:00:00

abstract：Background:Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein. Objective:To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D....

journal_title：Journal of diabetes research

authors： Chisalita SI,Ludvigsson J

更新日期：2018-03-20 00:00:00

abstract：Objective:Few studies have examined whether maternal 25(OH)D deficiency and gestational diabetes mellitus (GDM) jointly affect fetal growth. We aimed to examine the separate and combined effects of maternal 25(OH)D deficiency and GDM on trajectories of fetal growth. Methods:We established a birth cohort (2016-2017) wi...

journal_title：Journal of diabetes research

authors： Liu Z,Liu H,Xu X,Luo S,Liu J,Jin C,Han N,Wang HJ

更新日期：2020-03-30 00:00:00

abstract：:We investigated the correlation between obestatin and metabolic parameters and carotid intima-media thickness (IMT) in plasma of patients with type 2 diabetes mellitus (T2DM). We collected 103 patients aged from 60 to 83 years (69.26 ± 5.83 years) form January, 2007 to May, 2009. All patients were divided into normal ...

journal_title：Journal of diabetes research

authors： Gu PY,Kang DM,Wang WD,Chen Y,Zhao ZH,Zheng H,Ye SD

更新日期：2013-01-01 00:00:00