Abstract:
AIM:To evaluate an agreement in identifying dysglycemia between fasting plasma glucose (FPG) and the 2 hr postprandial glucose tolerance test (OGTT) in a population with high risk of diabetes. METHODS:A total of 6,884 individuals aged 35-65 years recruited for a community-based diabetes prevention program were tested for prediabetes including impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), and diabetes. The agreement was assessed by Kappa statistics. Logistic regression was used to examine factors associated with missed prediabetes and diabetes by FPG. RESULTS:A total of 2671 (38.8%) individuals with prediabetes were identified. The prevalence of prediabetes identified by FPG and OGTT was 32.2% and 22.3%, respectively. The proportions of diabetes classified by OGTT were two times higher than those identified by FPG (11.0% versus 5.4%, resp.). The Kappa statistics for agreement of both tests was 0.55. Overall, FPG missed 46.3% of all prediabetes and 54.7% of all diabetes cases. Prediabetes was more likely to be missed by FPG among female, people aged <45 yrs, and those without family history of diabetes. CONCLUSION:The detection of prediabetes and diabetes using FPG only may miss half of the cases. Benefit of adding OGTT to FPG in some specific groups should be confirmed.
journal_name
J Diabetes Resjournal_title
Journal of diabetes researchauthors
Aekplakorn W,Tantayotai V,Numsangkul S,Sripho W,Tatsato N,Burapasiriwat T,Pipatsart R,Sansom P,Luckanajantachote P,Chawarokorn P,Thanonghan A,Lakhamkaew W,Mungkung A,Boonkean R,Chantapoon C,Kungsri M,Luanseng K,Chaiyajidoi
10.1155/2015/396505subject
Has Abstractpub_date
2015-01-01 00:00:00pages
396505eissn
2314-6745issn
2314-6753journal_volume
2015pub_type
杂志文章abstract::Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by progressive glomerular sclerosis and tubulointerstitial fibrosis. However, the underlying mechanisms involved in DN remain to be elucidated. We explored changes in the transcriptional profile in spontaneous type 2 diabetic db/...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/8391253
更新日期:2017-01-01 00:00:00
abstract::Introduction. Diabetic Ketoacidosis (DKA) is a serious complication that can be life-threatening. Management of DKA needs admission in a specialized center and imposes major constraints on hospital resources. Aim. We plan to study the impact of adapting a diabetes-educator care model on reducing the frequency of hospi...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3917806
更新日期:2016-01-01 00:00:00
abstract::With-no-lysine (K) Kinase-4 (WNK4) consisted of unique serine and threonine protein kinases, genetically associated with an autosomal dominant form of hypertension. Argumentative consequences have lately arisen on the association of specific single nucleotide polymorphisms of WNK4 gene and essential hypertension (EHT)...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8219543
更新日期:2016-01-01 00:00:00
abstract::Widespread electronic health record (EHR) implementation creates new challenges in the diabetes care of complex and diverse populations, including safe medication prescribing for patients with limited health literacy and limited English proficiency. This review highlights how the EHR electronic prescribing transformat...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2017/8983237
更新日期:2017-01-01 00:00:00
abstract:Introduction:The aim of the present study was to examine placental levels of DUSP9 mRNA and protein and to investigate the potential role of DUSP9 in the development of gestational diabetes mellitus (GDM). Methods:Placental tissues from pregnant women with GDM (n = 17) and normal healthy pregnant women (n = 16) were c...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2019/1963178
更新日期:2019-10-20 00:00:00
abstract::Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness. The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/5263798
更新日期:2016-01-01 00:00:00
abstract::Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM pa...
journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/5928726
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Puerarin is a natural flavonoid isolated from the TCM lobed kudzuvine root. This study investigated the effect and mechanisms of puerarin on diabetic aorta in rats. METHODS:Streptozotocin- (STZ-) induced diabetic rats were administered with puerarin for 3 weeks. Levels of serum insulin (INS), PGE2, endotheli...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8541520
更新日期:2016-01-01 00:00:00
abstract::Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic β-cells, we investigated their role in the control of insulin secretion and glucose homeostasis. In this study, we conf...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3142175
更新日期:2016-01-01 00:00:00
abstract::Background. The feasibility of digital health programs to prevent and manage diabetes in low-income patients has not been adequately explored. Methods. Researchers collaborated with a digital health company to adapt a diabetes prevention program for low-income prediabetes patients at a large safety net clinic. We cond...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8472391
更新日期:2016-01-01 00:00:00
abstract:Objective:The objective of this study is to investigate the relationship between time in range (TIR), a new metric of continuous glucose monitoring (CGM) and cardiovascular autonomic neuropathy (CAN) in individuals with type 2 diabetes mellitus (T2DM). Methods:A total of 349 individuals with T2DM were enrolled in this...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2020/5817074
更新日期:2020-02-06 00:00:00
abstract::Advanced glycation end products (AGEs) are major inflammatory mediators in diabetes, affecting atherosclerosis progression via macrophages. Metformin slows diabetic atherosclerosis progression through mechanisms that remain to be fully elucidated. The present study of murine bone marrow derived macrophages showed that...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/4847812
更新日期:2016-01-01 00:00:00
abstract::Aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 isozymes. They are present in various organs and involved in metabolizing aldehydes that are biologically generated. For instance, ALDH2, a cardiac mitochondrial ALDH isozyme, is known to detoxify 4-hydroxy-2-nonenal, a reactive aldehyde produced upon lipid...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1390861
更新日期:2016-01-01 00:00:00
abstract::Type 1 diabetes mellitus (T1DM) is a long-term and chronic autoimmune disorder, in which the immune system attacks the pancreatic β-cells. Both adaptive and innate immune systems are involved in T1DM development. Both B-cells and T-cells, including CD4 + and CD8 ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2020/4106518
更新日期:2020-07-30 00:00:00
abstract::The aim of this study is to evaluate the effects of regular moderate exercise training initiated previously or after induction of diabetes mellitus on renal oxidative stress and inflammation in STZ-induced diabetic female rats. For this purpose, Wistar rats were divided into five groups: sedentary control (SC), traine...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2018/6170352
更新日期:2018-03-29 00:00:00
abstract::Insulin resistance, which plays a central role in the pathogenesis of type 2 diabetes (T2D), is an early indicator that heralds the occurrence of T2D. It is imperative to understand the metabolic changes that occur at the cellular level in the early stages of insulin resistance. The objective of this study was to dete...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/102054
更新日期:2015-01-01 00:00:00
abstract::A growing body of evidence suggests yogic practices may benefit adults with type 2 diabetes (DM2). In this systematic review, we evaluate available evidence from prospective controlled trials regarding the effects of yoga-based programs on specific health outcomes pertinent to DM2 management. To identify qualifying st...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/6979370
更新日期:2016-01-01 00:00:00
abstract:Background:Previous studies showed that probiotics could improve glycemic control and attenuate some of the adverse effects of type 2 diabetes. However, whether the effects are generalizable to gestational diabetes mellitus (GDM) remains uncertain. Objective:We conducted a systematic review and meta-analysis to evalua...
journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析
doi:10.1155/2019/5364730
更新日期:2019-09-05 00:00:00
abstract:AIMS:Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM. METHODS:55 euthyroid patients were enrolle...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2014/128014
更新日期:2014-01-01 00:00:00
abstract::Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy rema...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/485759
更新日期:2015-01-01 00:00:00
abstract::The hypoalbuminuric effect of sulodexide (SDX) on diabetic kidney disease (DKD) was suggested by some clinical trials but was denied by the Collaborative Study Group. In this study, the diabetic rats were treated with SDX either from week 0 to 24 or from week 13 to 24. We found that 24-week treatment significantly dec...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/4989847
更新日期:2017-01-01 00:00:00
abstract::Aims. Dipeptidyl-peptidase IV inhibitors (DPP-4i) are among the most popular oral antidiabetic agents. However, the effects of DPP-4i on diabetic nephropathy are not well-established. The aim of this study was to determine the renoprotective effects of DPP-4i, using albuminuria and glomerular filtration rate (GFR) as ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1423191
更新日期:2016-01-01 00:00:00
abstract::Children with type 1 diabetes (T1DM) are the high-risk group of accelerated atherosclerosis. Real-time continuous glucose monitoring (RT-CGM) provides possibilities for the detection of glycaemic variability, newly recognized cardiovascular risk factor. The aim of the study was to assess the usefulness of RT-CGM as an...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/4385312
更新日期:2016-01-01 00:00:00
abstract::Statin therapy improves lipid profiles and reduces vascular inflammation, but its effects on central arterial stiffness in type 2 diabetes are unclear. The aim of this study was to determine whether statin therapy reduces central arterial stiffness, in a dose-dependent manner, in male patients with type 2 diabetes. Fi...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/846807
更新日期:2015-01-01 00:00:00
abstract:Objective:To investigate the effects of cod-liver oil on metabolic status and high-sensitivity C-reactive protein (hs-CRP) in patients with gestational diabetes mellitus (GDM). Methods:This study was a randomized, double-blinded, placebo-controlled trial with the allocation ratio of 1 : 1. The contents of EPA and DHA ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/7074042
更新日期:2019-12-28 00:00:00
abstract::Glucokinase (GK) plays a critical role in the control of whole-body glucose homeostasis. We investigated the possible effects of a novel glucokinase activator (GKA), HMS5552, to the GK in rats with type 2 diabetes mellitus (T2DM). Male Sprague-Dawley (SD) rats were divided into four groups: control group, diabetic gro...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/5812607
更新日期:2017-01-01 00:00:00
abstract::Gastric emptying and glycemic control pathways are closely interrelated processes. Gastric chyme is transferred into the duodenum with velocities depending on its solid or liquid state, as well as on its caloric and nutritional composition. Once nutrients enter the intestine, the secretion of incretins (hormonal produ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2018/1736959
更新日期:2018-10-03 00:00:00
abstract::The objective of this study was to assess the effects of exogenously expressed proinsulin on the biological characters of a hematopoietic stem cell line (HSC) and erythroid myeloid lymphoid (EML) cells and explore new strategies for cell therapy for type I diabetes. EML cells were transduced with lentivirus particles ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2017/5649191
更新日期:2017-01-01 00:00:00
abstract::Immune and inflammatory pathways play a central role in the pathogenesis of diabetic liver injury. Celastrol is a potent immunosuppressive and anti-inflammatory agent. So far, there is no evidence regarding the mechanism of innate immune alterations of celastrol on diabetic liver injury in type 2 diabetic animal model...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2641248
更新日期:2016-01-01 00:00:00
abstract::Germinated brown rice (GBR) is rich in bioactive compounds, which confer GBR with many functional properties. Evidence of its hypocholesterolemic effects is emerging, but the exact mechanisms of action and bioactive compounds involved have not been fully documented. Using type 2 diabetic rats, we studied the effects o...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2013/134694
更新日期:2013-01-01 00:00:00