Abstract:
:A latent tuberculosis infection (LTBI) prevalence survey was conducted using tuberculin skin test (TST) and Quantiferon test (QFT) in 1218 healthcare workers (HCWs) in Medellín, Colombia. In order to improve the prevalence estimates, a latent class model was built using a Bayesian approach with informative priors on the sensitivity and specificity of the TST. The proportion of concordant results (TST+,QFT+) was 41% and the discordant results contributed 27%. The marginal estimate of the prevalence P(LTBI+) was 62·1% [95% credible interval (CrI) 53·0-68·2]. The probability of LTBI+ given positive results for both tests was 99·6% (95% CrI 98·1-99·9). Sensitivity was 88·5 for TST and 74·3 for QFT, and specificity was 87·8 for TST and 97·6 for QFT. A high LTBI prevalence was found in HCWs with time-accumulated exposure in hospitals that lack control plans. In a context of intermediate tuberculosis (TB) incidence it is recommended to use only one test (either QFT or TST) in prevalence surveys or as pre-employment tests. Results will be useful to help implement TB infection control plans in hospitals where HCWs may be repeatedly exposed to unnoticed TB patients, and to inform the design of TB control policies.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Ochoa J,León AL,Ramírez IC,Lopera CM,Bernal E,Arbeláez MPdoi
10.1017/S0950268816003150subject
Has Abstractpub_date
2017-04-01 00:00:00pages
1095-1106issue
6eissn
0950-2688issn
1469-4409pii
S0950268816003150journal_volume
145pub_type
杂志文章abstract::The phenotypic and genotypic profiles of the V. cholerae strains causing the Mozambican 1997-8 epidemic were characterized to provide a reference for comparison with other epidemic strains. A total of 75 strains of V. cholerae O1 isolated in different provinces, were analysed. Strains were characterized by PCR for det...
journal_title:Epidemiology and infection
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journal_title:Epidemiology and infection
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journal_title:Epidemiology and infection
pub_type: 杂志文章,随机对照试验
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journal_title:Epidemiology and infection
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journal_title:Epidemiology and infection
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journal_title:Epidemiology and infection
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journal_title:Epidemiology and infection
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journal_title:Epidemiology and infection
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