A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections.

Abstract:

:Vitamin D has been shown to be an important immune system regulator. Vitamin D insufficiency during winter may cause increased susceptibility to upper respiratory tract infections (URIs). To determine whether vitamin D supplementation during the winter season prevents or decreases URI symptoms, 162 adults were randomized to receive 50 microg vitamin D3 (2000 IU) daily or matching placebo for 12 weeks. A bi-weekly questionnaire was used to record the incidence and severity of URI symptoms. There was no difference in the incidence of URIs between the vitamin D and placebo groups (48 URIs vs. 50 URIs, respectively, P=0.57). There was no difference in the duration or severity of URI symptoms between the vitamin D and placebo groups [5.4+/-4.8 days vs. 5.3+/-3.1 days, respectively, P=0.86 (95% CI for the difference in duration -1.8 to 2.1)]. The mean 25-hydroxyvitamin D level at baseline was similar in both groups (64.3+/-25.4 nmol/l in the vitamin D group; 63.0+/-25.8 nmol/l in the placebo group; n.s.). After 12 weeks, 25-hydroxyvitamin D levels increased significantly to 88.5+/-23.2 nmol/l in the vitamin D group, whereas there was no change in vitamin D levels in the placebo group. There was no benefit of vitamin D3 supplementation in decreasing the incidence or severity of symptomatic URIs during winter. Further studies are needed to determine the role of vitamin D in infection.

journal_name

Epidemiol Infect

authors

Li-Ng M,Aloia JF,Pollack S,Cunha BA,Mikhail M,Yeh J,Berbari N

doi

10.1017/S0950268809002404

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1396-404

issue

10

eissn

0950-2688

issn

1469-4409

pii

S0950268809002404

journal_volume

137

pub_type

杂志文章,随机对照试验
  • Uncommon aetiological agents of catheter-related bloodstream infections.

    abstract::The clinical and microbiological characteristics of catheter-related bloodstream infection (CR-BSI) due to uncommon microorganisms was assessed in a retrospective case-control study over a 9-year period in a tertiary teaching hospital. Uncommon microorganisms were defined as those representing <0·5% of all CR-BSI. Dia...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268814001435

    authors: Reigadas E,Rodríguez-Créixems M,Sánchez-Carrillo C,Martín-Rabadán P,Bouza E

    更新日期:2015-03-01 00:00:00

  • Modelling the transmission of airborne infections in enclosed spaces.

    abstract::The Wells-Riley equation for modelling airborne infection in indoor environments is incorporated into an SEIR epidemic model with a short incubation period to simulate the transmission dynamics of airborne infectious diseases in ventilated rooms. The model enables the effect of environmental factors such as the ventil...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268806005875

    authors: Noakes CJ,Beggs CB,Sleigh PA,Kerr KG

    更新日期:2006-10-01 00:00:00

  • Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya.

    abstract::Demographic and epidemiological field data were used in a deterministic model to describe dog rabies transmission in Machakos District, Kenya and to predict the impact of potential vaccination strategies for its control. The basic reproduction number (R0) was estimated to be 2.44 (1.52-3.36, 95% confidence limits). Th...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268802006957

    authors: Kitala PM,McDermott JJ,Coleman PG,Dye C

    更新日期:2002-08-01 00:00:00

  • Intestinal colonization of broiler chickens by Campylobacter spp. in an experimental infection study.

    abstract::Consumption of poultry meat is considered as one of the main sources of human campylobacteriosis, and there is clearly a need for new surveillance and control measures based on quantitative data on Campylobacter spp. colonization dynamics in broiler chickens. We conducted four experimental infection trials, using four...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268814003239

    authors: Bahrndorff S,Garcia AB,Vigre H,Nauta M,Heegaard PM,Madsen M,Hoorfar J,Hald B

    更新日期:2015-08-01 00:00:00

  • The use of sorbitol-MacConkey agar in conjunction with a specific antiserum for the detection of Vero cytotoxin-producing strains of Escherichia coli O 157.

    abstract::Using DNA probes specific for the genes encoding Vero cytotoxins 1 and 2 in hybridization experiments on faecal samples, Vero cytotoxin-producing Escherichia coli (VTEC) of serogroup O 157 were detected in 21 of 63 cases of haemorrhagic colitis, 9 of 31 cases of non-bloody diarrhoea and 14 of 68 cases of haemolytic ur...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800054261

    authors: Kleanthous H,Fry NK,Smith HR,Gross RJ,Rowe B

    更新日期:1988-10-01 00:00:00

  • Farm-specific lineages of methicillin-resistant Staphylococcus aureus clonal complex 398 in Danish pig farms.

    abstract::The objective of this study was to investigate the genetic diversity of methicillin-resistant Staphylococcus aureus (MRSA) clonal complex (CC) 398 using pulsed-field gel electrophoresis (PFGE). Dust and pigs at five age groups were sampled in six Danish MRSA-positive pig farms. MRSA CC398 was isolated from 284 of the ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268811002391

    authors: Espinosa-Gongora C,Larsen J,Moodley A,Nielsen JP,Skov RL,Andreasen M,Guardabassi L

    更新日期:2012-10-01 00:00:00

  • Comparative study of visual inspections and microbiological sampling in premises manufacturing and selling high-risk foods.

    abstract::The possible relationship between the results of a microbiological sampling programme and visual inspections carried out in local food-manufacturing premises was examined. Using five main parameters - overall appearance, personal hygiene, risk of contamination, temperature control, and training and education - a visua...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800030880

    authors: Tebbutt GM,Southwell JM

    更新日期:1989-12-01 00:00:00

  • Space-time patterns of Campylobacter spp. colonization in broiler flocks, 2002-2006.

    abstract::This study was performed to investigate space-time patterns of Campylobacter spp. colonization in broiler flocks in Norway. Data on the Campylobacter spp. status at the time of slaughter of 16 054 broiler flocks from 580 farms between 2002 and 2006 was included in the study. Spatial relative risk maps together with ma...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268810000051

    authors: Jonsson ME,Norström M,Sandberg M,Ersbøll AK,Hofshagen M

    更新日期:2010-09-01 00:00:00

  • The epidemiology of bat rabies in New York State, 1988-92.

    abstract::In 1993 New York and Texas each reported a human rabies case traced to a rare variant of rabies virus found in an uncommon species of bat. This study examined the epidemiology of bat rabies in New York State. Demographic, species, and animal-contact information for bats submitted for rabies testing from 1988-92 was an...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800068515

    authors: Childs JE,Trimarchi CV,Krebs JW

    更新日期:1994-12-01 00:00:00

  • A national case-control study of risk factors for listeriosis in Australia.

    abstract::Listeriosis is a foodborne disease associated with significant mortality. This study attempts to identify risk factors for sporadic listeriosis in Australia. Information on underlying illnesses was obtained from cases' treating doctors and other risk factors were elicited from the patient or a surrogate. We attempted ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268810000944

    authors: Dalton CB,Merritt TD,Unicomb LE,Kirk MD,Stafford RJ,Lalor K,OzFoodNet Working Group.

    更新日期:2011-03-01 00:00:00

  • Indirect protection obtained by Haemophilus influenzae type b vaccination: analysis in a structured population model.

    abstract::We used a structured population model to study factors determining the magnitude of indirect protection in Haemophilus influenzae type b (Hib) vaccination. On a simulation platform mimicking the population of Finland, a Hib transmission and immunity model, including cross-reactive bacterial encounters, was formulated....

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s095026880400250x

    authors: Leino T,Takala T,Auranen K,Mäkelä PH,Takala AK

    更新日期:2004-10-01 00:00:00

  • Excess mortality monitoring in England and Wales during the influenza A(H1N1) 2009 pandemic.

    abstract::We present the results from a novel surveillance system for detecting excess all-cause mortality by age group in England and Wales developed during the pandemic influenza A(H1N1) 2009 period from April 2009 to March 2010. A Poisson regression model was fitted to age-specific mortality data from 1999 to 2008 and used t...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268811000410

    authors: Hardelid P,Andrews N,Pebody R

    更新日期:2011-09-01 00:00:00

  • Application of ribotyping and IS200 fingerprinting to distinguish the five Salmonella serotype O6,7:c:1,5 groups: Choleraesuis sensu stricto, Choleraesuis var. Kunzendorf, Choleraesuis var. Decatur, Paratyphi C, and Typhisuis.

    abstract::Sixty-seven strains of the five described Salmonella serotypes having antigens 6,7:c:1,5, that is S. enterica serotype Choleraesuis sensu stricto, Choleraesuis var. Kunzendorf, Choleraesuis var. Decatur, Paratyphi C, and Typhisuis, were examined for 16S rrn profile ribotype, presence of IS200 and phenotypic characters...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268899002654

    authors: Uzzau S,Hovi M,Stocker BA

    更新日期:1999-08-01 00:00:00

  • Lack of response of INT-407 cells to the presence of non-culturable Campylobacter jejuni.

    abstract::Many contradictory articles on the infectivity of non-culturable Campylobacter jejuni can be found. We studied the effect of non-culturable C. jejuni in an in vitro assay. To prevent the potential effect of a few culturable bacteria in the non-culturable suspension, INT-407 cells, which mimic the outer cell layer in t...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268807000040

    authors: Verhoeff-Bakkenes L,Hazeleger WC,Zwietering MH,De Jonge R

    更新日期:2008-10-01 00:00:00

  • Characterization of a novel international clonal complex (CC32) of Acinetobacter baumannii with epidemic potential.

    abstract::Twelve non-replicate Acinetobacter baumannii isolates from five European hospitals, Kuwait, and the US military healthcare system collected between 1980 and 2005 revealed a new clone, CC32. These included representative isolates of outbreaks/cross-infections. Antimicrobial susceptibility and carbapenem-resistant genet...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268813002288

    authors: Da Silva GJ,Van Der Reijden T,Domingues S,Mendonça N,Petersen K,Dijkshoorn L

    更新日期:2014-07-01 00:00:00

  • Modelling food safety and economic consequences of surveillance and control strategies for Salmonella in pigs and pork.

    abstract::Targets for maximum acceptable levels of Salmonella in pigs and pork are to be decided. A stochastic simulation model accounting for herd and abattoir information was used to evaluate food safety and economic consequences of different surveillance and control strategies, based among others on Danish surveillance data....

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268810001767

    authors: Baptista FM,Halasa T,Alban L,Nielsen LR

    更新日期:2011-05-01 00:00:00

  • Outbreak of hospital-acquired gastroenteritis and invasive infection caused by Listeria monocytogenes, Finland, 2012.

    abstract::During one week in July 2012, two patients from the same ward at the municipal hospital in Vaasa, Finland, were diagnosed with septicaemia caused by Listeria monocytogenes. An outbreak investigation revealed eight concomitant cases of febrile gastroenteritis caused by L. monocytogenes on the same ward. Median age of t...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268815002563

    authors: Jacks A,Pihlajasaari A,Vahe M,Myntti A,Kaukoranta SS,Elomaa N,Salmenlinna S,Rantala L,Lahti K,Huusko S,Kuusi M,Siitonen A,Rimhanen-Finne R

    更新日期:2016-10-01 00:00:00

  • Outbreak of Listeria monocytogenes infections linked to a pasteurized ice cream product served to hospitalized patients.

    abstract::Two cases of hospital-acquired listeriosis were linked to a commercially produced, pasteurized ice cream mix. Manufacturers should implement safety measures from the Food Safety Modernization Act to minimize the risk of Listeria contamination. Dietary guidelines for persons at high risk of listeriosis may need revisio...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268815003039

    authors: Rietberg K,Lloyd J,Melius B,Wyman P,Treadwell R,Olson G,Kang MG,Duchin JS

    更新日期:2016-10-01 00:00:00

  • Test characteristics of the tuberculin skin test and post-mortem examination for bovine tuberculosis diagnosis in cattle in Northern Ireland estimated by Bayesian latent class analysis with adjustments for covariates.

    abstract::The single intradermal comparative cervical tuberculin (SICCT) test and post-mortem examination are the main diagnostic tools for bovine tuberculosis (bTB) in cattle in the British Isles. Latent class modelling is often used to estimate the bTB test characteristics due to the absence of a gold standard. However, the r...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268819000888

    authors: O'Hagan MJH,Ni H,Menzies FD,Pascual-Linaza AV,Georgaki A,Stegeman JA

    更新日期:2019-01-01 00:00:00

  • Outcomes of hospitalized patients with bacteraemic and non-bacteraemic community-acquired pneumonia caused by Streptococcus pneumoniae.

    abstract::In contrast to bacteraemic pneumococcal community-acquired pneumonia (CAP), there is a paucity of data on the clinical characteristics and outcomes of non-bacteraemic pneumococcal CAP. This retrospective study compared the outcome of hospitalized patients with bacteraemic and non-bacteraemic pneumococcal CAP treated a...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268810002402

    authors: Lin SH,Lai CC,Tan CK,Liao WH,Hsueh PR

    更新日期:2011-09-01 00:00:00

  • Increase in paratyphoid fever cases in Japanese travellers returning from Cambodia in 2013.

    abstract::In 2013, an unusual increase of paratyphoid fever cases in travellers returning from Cambodia was reported in Japan. From December 2012 to September 2013, 18 cases of Salmonella Paratyphi A infection were identified. Microbiological analyses revealed that most isolates had the same clonal identity, although the epidem...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268815001648

    authors: Saitoh T,Morita M,Shimada T,Izumiya H,Kanayama A,Oishi K,Ohnishi M,Sunagawa T

    更新日期:2016-02-01 00:00:00

  • Burden of community-onset bloodstream infection: a population-based assessment.

    abstract::Although community-onset bloodstream infection (BSI) is recognized to be a major cause of morbidity and mortality, there is a paucity of population-based studies defining its overall burden. We conducted population-based laboratory surveillance for all community-onset BSI in the Calgary Health Region during 2000-2004....

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268806007631

    authors: Laupland KB,Gregson DB,Flemons WW,Hawkins D,Ross T,Church DL

    更新日期:2007-08-01 00:00:00

  • Temporally distinct Escherichia coli 0157 outbreaks associated with alfalfa sprouts linked to a common seed source--Colorado and Minnesota, 2003.

    abstract::Escherichia coli O157 outbreaks were identified in Minnesota in February 2003 involving seven persons and in Colorado in July 2003 involving 13 persons. Case isolates from the two states had matching pulsed-field gel electrophoresis (PFGE) patterns. Independent case-control studies linked infections in each outbreak w...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268804003589

    authors: Ferguson DD,Scheftel J,Cronquist A,Smith K,Woo-Ming A,Anderson E,Knutsen J,De AK,Gershman K

    更新日期:2005-06-01 00:00:00

  • High intensities of population movement were associated with high incidence of COVID-19 during the pandemic.

    abstract::Increased population movements and increased mobility made it possible for severe acute respiratory syndrome coronavirus 2, which is mainly spread by respiratory droplets, to spread faster and more easily. This study tracked and analysed the development of the coronavirus 2019 (COVID-19) outbreak in the top 100 cities...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268820001703

    authors: Yang H,Chen D,Jiang Q,Yuan Z

    更新日期:2020-08-03 00:00:00

  • The epidemiology of hepatitis A in Rio de Janeiro: environmental and domestic risk factors.

    abstract::A serological study of hepatitis A was carried out in low-income areas scheduled for a major sanitation programme in Rio de Janeiro, Brazil. Blood spots were collected by finger puncture and transported on filter paper, and total antibodies to hepatitis A virus were detected by ELISA. Households were also interviewed ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268801005945

    authors: Almeida LM,Werneck GL,Cairncross S,Coeli CM,Costa MC,Coletty PE

    更新日期:2001-10-01 00:00:00

  • What might the future bring? COVID-19 planning considerations for faculty and universities.

    abstract::This paper applies a scenario planning approach, to outline some current uncertainties related to COVID-19 and what they might mean for plausible futures for which we should prepare, and to identify factors that we as individual faculty members and university institutions should be considering now, when planning for t...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268820000898

    authors: Majowicz SE

    更新日期:2020-04-29 00:00:00

  • Prospective study of the incidence of diarrhoea and prevalence of bacterial pathogens in a cohort of Vietnamese children along the Red River.

    abstract::We prospectively studied diarrhoea incidence among 1655 children < 5 years of age in northern Vietnam for 1 year using primarily passive surveillance. Standard culture methods were used to detect bacterial pathogens. Overall 2160 cases occurred (13 cases/child per year). Peak rates of diarrhoea occurred in children < ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268801005933

    authors: Isenbarger DW,Hien BT,Ha HT,Ha TT,Bodhidatta L,Pang LW,Cam PD

    更新日期:2001-10-01 00:00:00

  • Multiple sites of exposure in an outbreak of ornithosis in workers at a poultry abattoir and farm.

    abstract::Cases of ornithosis amongst workers on a rural duck abattoir and farm were notified from late 2003 to health authorities in Victoria, Australia. In May 2004 we conducted a serological survey to identify the extent of exposure to Chlamydophila psittaci amongst workers and a case control study to identify high-risk work...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S095026880700790X

    authors: Tiong A,Vu T,Counahan M,Leydon J,Tallis G,Lambert S

    更新日期:2007-10-01 00:00:00

  • Early-life environment influencing susceptibility to cytomegalovirus infection: evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins.

    abstract::Human cytomegalovirus (CMV) is a common herpesvirus establishing lifelong persisting infection, which has been implicated in immunosenescence and mortality in the elderly. Little is known about how and when susceptibility to CMV infection is determined. We measured CMV seroprevalence in two genetically informative coh...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268811001397

    authors: Mortensen LH,Maier AB,Slagbom PE,Pawelec G,Derhovanessian E,Petersen I,Jahn G,Westendorp RG,Christensen K

    更新日期:2012-05-01 00:00:00

  • A comparison of gastroenteritis in a general practice-based study and a community-based study.

    abstract::We compared gastroenteritis cases that consulted a general practitioner (GP) with those who did not in a community-based study and also with those in a GP-based study. We aimed to identify factors associated with consultation, and with inclusion of cases by GPs, and secondly to study the effects on the frequency of de...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268801006082

    authors: de Wit MA,Kortbeek LM,Koopmans MP,de Jager CJ,Wannet WJ,Bartelds AI,van Duynhoven YT

    更新日期:2001-12-01 00:00:00