Impaired health status and increased incidence of diseases in Toxoplasma-seropositive subjects - an explorative cross-sectional study.

Abstract:

:The global seroprevalence of latent toxoplasmosis is estimated to be higher than 30%. The presence of slowly dividing parasites in tissue cysts located mainly in immunoprivileged organs was long considered asymptomatic. Recently, many studies have shown that latent Toxoplasma infections could have serious impacts on human health. Here we ran a cross-sectional study in a population of 1486 volunteers. The results showed that 333 infected subjects scored worse than 1153 controls in 28 of 29 health-related variables. Similarly, they reported higher rates of 77 of a list of 134 disorders reported by at least 10 participants of the study. Toxoplasmosis was associated most strongly with musculoskeletal (τ = 0·107, P < 0·0005), followed by neurological (τ = 0·088, P < 0·0005), immune (τ = 0·085, p < 0·0005), metabolic (τ = 0·079, P < 0·0005), respiratory (τ = 0·068, P = 0·0001), allergic (τ = 0·053, P = 0·004), digestive system (τ = 0·052, P = 0·004) and mental health disorders (τ = 0·050, P = 0·008). Results of the present cohort study, along with the previous data from many case-control studies or ecological studies suggest that latent toxoplasmosis represents a large and so far underrated public health problem.

journal_name

Parasitology

journal_title

Parasitology

authors

Flegr J,Escudero DQ

doi

10.1017/S0031182016001785

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1974-1989

issue

14

eissn

0031-1820

issn

1469-8161

pii

S0031182016001785

journal_volume

143

pub_type

杂志文章
  • Enzyme variation in T. brucei ssp. II. Evidence for T. b. rhodesiense being a set of variants of T. b. brucei.

    abstract::A collection of stocks of Trypanosoma brucei rhodesiense isolated in Kenya have been examined for electrophoretic variation in 20 enzymes. The results obtained have been analysed in order to determine whether these trypanosomes are diploid and undergo mating and to determine the genetic distance between T. b. rhodesie...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000049040

    authors: Tait A,Barry JD,Wink R,Sanderson A,Crowe JS

    更新日期:1985-02-01 00:00:00

  • Molecular characterization of 5S ribosomal RNA genes and transcripts in the protozoan parasite Leishmania major.

    abstract::Eukaryotic 5S rRNA, synthesized by RNA polymerase III (Pol III), is an essential component of the large ribosomal subunit. Most organisms contain hundreds of 5S rRNA genes organized into tandem arrays. However, the genome of the protozoan parasite Leishmania major contains only 11 copies of the 5S rRNA gene, which are...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182016001712

    authors: Moreno-Campos R,Florencio-Martínez LE,Nepomuceno-Mejía T,Rojas-Sánchez S,Vélez-Ramírez DE,Padilla-Mejía NE,Figueroa-Angulo E,Manning-Cela R,Martínez-Calvillo S

    更新日期:2016-12-01 00:00:00

  • Consequences of reduced umbilical and increased foetal cerebral flow during malaria crisis on foetal behaviour.

    abstract::The objectives of this study were (a) to evaluate the sensitivity and specificity of foetal Doppler indices for the prediction of abnormal foetal heart rate (aFHR) at delivery after malaria crisis and (b) to test Doppler parameters against crisis duration for predicting aFHR. Every day during the malaria crisis, the u...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:

    authors: Arbeille P,Carles G,Georgescu M,Tobal N,Herault S,Bousquet F,Perrotin F

    更新日期:2003-06-01 00:00:00

  • Selection and evolution of virulence in bacteria: an ecumenical excursion and modest suggestion.

    abstract::Why do parasites kill their hosts? During this past decade, research in three different areas; evolutionary ecology, medical microbiology, and population genetics has provided theory and data that address this and related questions of selection and the evolution and maintenance of parasite virulence. A general theory ...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182000073054

    authors: Levin BR,Svanborg Edén C

    更新日期:1990-01-01 00:00:00

  • Age, acquired immunity and the risk of visceral leishmaniasis: a prospective study in Iran.

    abstract::In order to investigate the phenomenon of age-related immunity to visceral leishmaniasis, a 1 year prospective survey was carried out on 5671 people in a Leishmania infantum focus in north-west Iran. The average incidence rate of infection since 1985 was 2.8%/year with all ages equally at risk. One in 13 infections in...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182099004680

    authors: Davies CR,Mazloumi Gavgani AS

    更新日期:1999-09-01 00:00:00

  • The attachment of Schistosoma mansoni cercariae to human skin cells.

    abstract::Most of our knowledge about the process of penetration of skin, by cercariae of Schistosoma mansoni, has been gained from studies carried out in vivo with laboratory animals. Human skin is significantly different from that of other animals but there are obvious practical difficulties in directly studying attachment an...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200100885x

    authors: Khammo N,Bartlett A,Clothier RH,Whitfield PJ

    更新日期:2002-01-01 00:00:00

  • Expression of LPG and GP63 by different developmental stages of Leishmania major in the sandfly Phlebotomus papatasi.

    abstract::Development and forward migration of Leishmania parasites in the sandfly gut is accompanied by morphological transformation to highly motile, non-dividing 'metacyclic' forms. Previous studies in vitro have demonstrated that this metacyclogenesis is associated with developmentally regulated changes in expression of two...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000060522

    authors: Davies CR,Cooper AM,Peacock C,Lane RP,Blackwell JM

    更新日期:1990-12-01 00:00:00

  • Ammonia-induced cellular and immunological changes in juvenile Cyprinus carpio infected with the blood fluke Sanguinicola inermis.

    abstract::Immunological and structural changes in the thymus and pronephros of Cyprinus carpio infected with the blood fluke, Sanguinicola inermis for 30 days, and exposed to 0.5 mg NH4+/1 for 48 and 168 h were investigated. Ultrastructural observations revealed cell disruption and highly vacuolated cytoplasm in the thymus. Of ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001007260

    authors: Schuwerack PM,Lewis JW,Hoole D,Morley NJ

    更新日期:2001-03-01 00:00:00

  • Characterization of an atypical antigen from Sarcoptes scabiei containing an MADF domain.

    abstract::We have cloned a cDNA encoding a novel antigen from a Sarcoptes scabiei (Acari) cDNA library by immunoscreening with sera from S. scabiei-infected dogs. The antigen is encoded by a 2,157 bp mRNA with a predicted open reading frame of 719 amino acids (molecular weight 79 kDa). Our sequence analysis identified the prese...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182005008747

    authors: Ljunggren EL,Bergström K,Morrison DA,Mattsson JG

    更新日期:2006-01-01 00:00:00

  • Host-parasite relationship between congenital Toxoplasma infection and mouse brain: role of small vessels.

    abstract::Small vessels showing inflammatory cell infiltrates were invariably observed in the vicinity of intact Toxoplasma tissue cysts within the brains of mice congenitally infected with the protozoan. Lymphocytes were observed in intimate contact with the luminal aspect of the endothelium, penetrating into the thickened bas...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000063873

    authors: Sims TA,Hay J

    更新日期:1995-02-01 00:00:00

  • Gill monogenean communities (Platyhelminthes, Monogenea, Dactylogyridae) of butterflyfishes from tropical Indo-West Pacific Islands.

    abstract::We studied the monogenean communities of 34 species of butterflyfish from the tropical Indo-West Pacific, identifying 13 dactylogyrid species (including two species that are presently undescribed). Monogenean assemblages differed significantly between host species in terms of taxonomic structure, intensity and prevale...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182016001463

    authors: Reverter M,Cutmore SC,Bray R,Cribb TH,Sasal P

    更新日期:2016-10-01 00:00:00

  • Infections with Eimeria maxima and Eimeria acervulina in the fowl: effect of previous infection with the heterologous organism on oocyst production.

    abstract::Judged by oocyst production, infections with Eimeria acervulina in birds immunized with E. maxima were consistently higher than in birds which had not been immunized. Oocyst production of E. maxima in birds previously infected with E. acervulina was greater, in three out of four experiments, than in control chickens,...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000049726

    authors: Rose ME

    更新日期:1975-04-01 00:00:00

  • Detection of viruses in livestock.

    abstract::Diseases caused by viruses are a constant and major problem for livestock production world wide. The diseases range from highly contagious acute forms with high mortality, to chronic disabling diseases with an insidious effect on production. Such diseases cannot be regarded as static in nature due to the highly mutabl...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182099004199

    authors: Crowther JR

    更新日期:1998-01-01 00:00:00

  • Genetic structure of Trypanosoma cruzi populations from Argentina estimated from enzyme polymorphism.

    abstract::Isolates of Trypanosoma cruzi from human patients, domestic and sylvatic animals and vector insects were obtained in different areas of Argentina. Electrophoretic patterns of enzymes from extracts of 95 isolates were analysed. On the basis of zymograms providing information on 10 loci, 12 zymodemes are described accor...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000067755

    authors: de Luca D'oro GM,Gardenal CN,Perret B,Crisci JV,Montamat EE

    更新日期:1993-11-01 00:00:00

  • In vitro isolation of Plasmodium knowlesi merozoites using polycarbonate sieves.

    abstract::A culture chamber fitted with a polycarbonate sieve has been used to isolate Plasmodium knowlesi merozoites as they are released from schizonts. A 3 mum pore-size sieve allows passage of normal erythrocytes and red cells containing rings and trophozoites and can be used to concentrate schizonts from a mixed cell popul...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000047235

    authors: Dennis ED,Mitchell GH,Butcher GA,Cohen S

    更新日期:1975-12-01 00:00:00

  • Availability of caecal habitat as a density-dependent limit on survivorship of Leptorhynchoides thecatus in green sunfish, Lepomis cyanellus.

    abstract::Distribution of Leptorhynchoides thecatus (Acanthocephala: Rhadinorhynchidae) among the pyloric caeca and the relationship between site and rate of maturation were studied in laboratory infections of 10, 25 and 40 cystacanths fed to green sunfish, Lepomis cyanellus. After 1 week fish fed at each intensity had signific...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000061539

    authors: Ewald JA,Nickol BB

    更新日期:1989-06-01 00:00:00

  • RNA-interference methods for gene-knockdown in the sea louse, Lepeophtheirus salmonis: studies on a putative prostaglandin E synthase.

    abstract::Harnessing the full utility of extensive gene sequences recently available for the economically important sea louse, Lepeophtheirus salmonis, requires the adaptation of modern molecular biology approaches to this non-model organism. Using a putative microsomal prostaglandin E synthase type-2 (PGES2) as a candidate gen...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182009990357

    authors: Campbell EM,Pert CC,Bowman AS

    更新日期:2009-07-01 00:00:00

  • Hymenolepis nana: the fine structure of the embryonic envelopes.

    abstract::The fine structure of the envelopes surrounding hatched and unhatched oncospheres of Hymenolepis nana has been investigated by transmission and scanning electron microscopy (SEM), together with light microscope histochemical observations of JB-4 embedded material. The oncosphere is surrounded by 3 layers--the capsule,...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000066968

    authors: Fairweather I,Threadgold LT

    更新日期:1981-06-01 00:00:00

  • Alternative oxidase inhibitors as antiparasitic agents against scuticociliatosis.

    abstract::Philasterides dicentrarchi causes a severe disease in turbot, and at present there are no drugs available to treat infected fish. We have previously demonstrated that, in addition to the classical respiratory pathway, P. dicentrarchi possesses an alternative mitochondrial respiratory pathway that is cyanide-insensitiv...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182014000572

    authors: Mallo N,Lamas J,Leiro JM

    更新日期:2014-09-01 00:00:00

  • Mesocestoides corti intracranial infection as a murine model for neurocysticercosis.

    abstract::Neurocysticercosis (NCC) is the most common parasitic disease of the central nervous system (CNS) caused by the larval form of the tapeworm Taenia solium. NCC has a long asymptomatic period with little or no inflammation, and the sequential progression to symptomatic NCC depends upon the intense inflammation associate...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182009991971

    authors: Alvarez JI,Mishra BB,Gundra UM,Mishra PK,Teale JM

    更新日期:2010-03-01 00:00:00

  • Molecular characterizations of three distinct Babesia gibsoni rhoptry-associated protein-1s (RAP-1s).

    abstract::Three cDNAs encoding rhoptry-associated protein 1 (RAP-1) homologues were found in the Babesia gibsoni EST database. Based on similarities to BgRAP-1a, which was identified previously by serological screening of a cDNA merozoite library, the two new genes were designated BgRAP-1b (33.7%) and BgRAP-1c (57%). Mice antis...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S003118200999045X

    authors: Terkawi MA,Amornthep A,Ooka H,Aboge G,Jia H,Goo YK,Nelson B,Yamagishi J,Nishikawa Y,Igarashi I,Kawazu SI,Fujisaki K,Xuan X

    更新日期:2009-09-01 00:00:00

  • Hydrological modelling of snail dispersal patterns in Msambweni, Kenya and potential resurgence of Schistosoma haematobium transmission.

    abstract::Urinary schistosomiasis is an important source of human morbidity in Msambweni, Kenya, where the intermediate host snail, Bulinus nasutus is found in ponds and water pools. In the past, aquatic habitats in the area have been studied separately; however, recent collections of B. nasutus snails and shells indicated that...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006001594

    authors: Clennon JA,King CH,Muchiri EM,Kitron U

    更新日期:2007-05-01 00:00:00

  • The reproductive effort of Lepeophtheirus pectoralis (Copepoda: Caligidae): insights into the egg production strategy of parasitic copepods.

    abstract::The reproductive effort of Lepeophtheirus pectoralis (Müller O. F., 1776), a caligid copepod, which is commonly found infecting the European flounder, Platichthys flesus (Linnaeus, 1758), is studied in detail for the first time. Seasonal variation in body dimensions and reproductive effort are analysed. Data for 120 o...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182015001493

    authors: Frade DG,Santos MJ,Cavaleiro FI

    更新日期:2016-01-01 00:00:00

  • Non-homogenized ITS regions in the parasitic nematode Cooperia oncophora.

    abstract::Here, the validity of the assumption of concerted evolution of ribosomal regions in larval and adult Cooperia oncophora was assessed. In each of 4 individuals of this parasitic nematode, at least 78% of the sequences comprised different ITS variants. This implies that concerted evolution is not acting, which is corrob...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182004005499

    authors: Mes TH,Cornelissen AW

    更新日期:2004-08-01 00:00:00

  • Purification of a 64 kDa antigen from Trypanosoma evansi that exhibits cross-reactivity with Trypanosoma vivax.

    abstract::Trypanosoma evansi and Trypanosoma vivax are the most extensively distributed trypanosomes responsible for diseases in livestock. Western blot and indirect immunofluorescence assays revealed a high immunological cross-reaction between these two parasites. An antigen with an apparent molecular mass of 64 kDa (p64), whi...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001001214

    authors: Uzcanga G,Mendoza M,Aso PM,Bubis J

    更新日期:2002-03-01 00:00:00

  • Nematode Hsp90: highly conserved but functionally diverse.

    abstract::Nematodes are amongst the most successful and abundant organisms on the planet with approximately 30 000 species described, although the actual number of species is estimated to be one million or more. Despite sharing a relatively simple and invariant body plan, there is considerable diversity within the phylum. Nemat...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182014000304

    authors: Gillan V,Devaney E

    更新日期:2014-08-01 00:00:00

  • The role of Plasmodium knowlesi in the history of malaria research.

    abstract::In recent years, a malaria infection of humans in South East Asia, originally diagnosed as a known human-infecting species, Plasmodium malariae, has been identified as a simian parasite, Plasmodium knowlesi. This species had been subject to considerable investigation in monkeys since the 1930s. With the development of...

    journal_title:Parasitology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1017/S0031182016001888

    authors: Butcher GA,Mitchell GH

    更新日期:2018-01-01 00:00:00

  • Modulation of host cell receptors: a mechanism for the survival of malaria parasites.

    abstract::Intra-erythrocytic stages of malaria parasites can alter the surface of their host cells and release toxins which induce the production of cytokines, which in turn can up- or down-regulate the expression of adhesion receptors on the surface of microvascular endothelial cells. New adhesion receptors on endothelial cell...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182097002345

    authors: Hommel M

    更新日期:1997-01-01 00:00:00

  • The ecology of host-finding behaviour and parasite transmission: past and future perspectives.

    abstract::Host location by parasites can be achieved by either active or passive mechanisms. In spite of their significance, the efficacy of these methods has been little researched. High fecundity in parasites is discussed in terms of the role it plays in dispersal and transmission. Some concepts developed by mainstream behavi...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182000085061

    authors: Rea JG,Irwin SW

    更新日期:1994-01-01 00:00:00

  • Echinococcus granulosus: intraspecific genetic variation assessed by a DNA repetitive element.

    abstract::A 186 bp Echinococcus granulosus-specific repetitive element, TREg, was used to assess genetic variation between strains. In G7 genotype (pig strain) it has the characteristics of a satellite DNA element with a copy number of 23000 per haploid genome. Analysis, by sequencing of TREg monomers, showed a great degree of ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182001008575

    authors: Rosenzvit MC,Canova SG,Kamenetzky L,Guarnera EA

    更新日期:2001-10-01 00:00:00