Mesocestoides corti intracranial infection as a murine model for neurocysticercosis.

Abstract:

:Neurocysticercosis (NCC) is the most common parasitic disease of the central nervous system (CNS) caused by the larval form of the tapeworm Taenia solium. NCC has a long asymptomatic period with little or no inflammation, and the sequential progression to symptomatic NCC depends upon the intense inflammation associated with degeneration of larvae. The mechanisms involved in these progressive events are difficult to study in human patients. Thus it was necessary to develop an experimental model that replicated NCC. In this review, we describe studies of a murine model of NCC in terms of the release/secretion of parasite antigens, immune responses elicited within the CNS environment and subsequent pathogenesis. In particular, the kinetics of leukocyte subsets infiltrating into the brain are discussed in the context of disruption of the CNS barriers at distinct anatomical sites and the mechanisms contributing to these processes. In addition, production of various inflammatory mediators and the mechanisms involved in their induction by the Toll-like receptor signaling pathway are described. Overall, the knowledge gained from the mouse model of NCC has provided new insights for understanding the kinetics of events contributing to different stages of NCC and should aid in the formulation of more effective therapeutic approaches.

journal_name

Parasitology

journal_title

Parasitology

authors

Alvarez JI,Mishra BB,Gundra UM,Mishra PK,Teale JM

doi

10.1017/S0031182009991971

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

359-72

issue

3

eissn

0031-1820

issn

1469-8161

pii

S0031182009991971

journal_volume

137

pub_type

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