Modulation of host cell receptors: a mechanism for the survival of malaria parasites.

abstract：:Following cloning of Leishmania (L.) amazonensis kinetoplast DNA two recombinant clones were identified: one specific for L. (L.) amazonensis and the other specific for L. (L.) amazonensis and closely related isolates. DNA sequences from these clones were compared with those of other kinetoplastids and oligonucleotide...

journal_title：Parasitology

authors： Eresh S,McCallum SM,Barker DC

更新日期：1994-11-01 00:00:00

abstract：:The efficiency of treatment of human infections with the unicellular eukaryotic pathogens such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates from nosocomial fungemia in critically ill, immunosuppressed or post-cancer patients often exceed 50%. A set of six systemic clinical azol...

journal_title：Parasitology

authors： Lepesheva GI,Friggeri L,Waterman MR

更新日期：2018-12-01 00:00:00

abstract：:The phenotypic activity of two 5-nitroindazolinones, i.e. 2-benzyl-1-propyl (22) and 2-benzyl-1-butyl (24) derivatives, previously proposed as anti-Trypanosoma cruzi prototypes, was presently assayed on bloodstream trypomastigotes (BT) of the moderately drug-resistant Y strain. Further exploration of putative targets ...

journal_title：Parasitology

authors： Fonseca-Berzal C,DA Silva CF,Menna-Barreto RF,Batista MM,Escario JA,Arán VJ,Gómez-Barrio A,Soeiro Mde N

更新日期：2016-09-01 00:00:00

abstract：:Cryptosporidium parvum is composed of multiple subtypes, which appear to be zoonotic or anthroponotic. Therefore, in order to understand the molecular epidemiology of this species and to control the zoonotic transmission, it is essential to identify the isolates at the subtype level. In the present study, 60.2% of 103...

journal_title：Parasitology

authors： Misic Z,Abe N

更新日期：2007-03-01 00:00:00

abstract：:The public health significance of hookworm disease is briefly reviewed. The latest evidence confirms that blood loss caused by the worms' feeding activity in the gut is a contributing factor in the development of poor iron status leading to iron-deficiency anaemia. The World Health Organization has identified adolesce...

journal_title：Parasitology

authors： Crompton DW

更新日期：2000-01-01 00:00:00

abstract：:The genomes of more than 20 helminths have now been sequenced. Here we perform a meta-analysis of all sequenced genomes of nematodes and Platyhelminthes, and attempt to address the question of what are the defining characteristics of helminth genomes. We find that parasitic worms lack systems for surface antigenic var...

journal_title：Parasitology

authors： Zarowiecki M,Berriman M

更新日期：2015-02-01 00:00:00

abstract：:The biological parameters which generate seasonal fluctuations in the size of populations of Caryophyllaeus laticeps are examined in detail. A mathematical model is formulated to describe the dynamics of the adult parasite within the fish host Abramis brama, and the predictions of the model are compared with observed ...

journal_title：Parasitology

authors： Anderson RM

更新日期：1976-06-01 00:00:00

abstract：:Many different drug-resistant lines of rodent malaria are available as screening models. It is obligatory to screen new compounds for antimalarial activity against a series of resistant lines in order to identify a compound with potential for the treatment of multi-drug resistant (MDR) malaria infections. Instead of u...

journal_title：Parasitology

authors： Tripathi R,Dhawan S,Dutta GP

更新日期：2005-09-01 00:00:00

abstract：:Blood examination by microhaematocrit and haemoculture of 459 snakes belonging to 37 species revealed 2.4% trypanosome prevalence in species of Viperidae (Crotalus durissus and Bothrops jararaca) and Colubridae (Pseudoboa nigra). Trypanosome cultures from C. durissus and P. nigra were behaviourally and morphologically...

journal_title：Parasitology

authors： Viola LB,Campaner M,Takata CS,Ferreira RC,Rodrigues AC,Freitas RA,Duarte MR,Grego KF,Barrett TV,Camargo EP,Teixeira MM

更新日期：2008-04-01 00:00:00

abstract：:Distribution of Leptorhynchoides thecatus (Acanthocephala: Rhadinorhynchidae) among the pyloric caeca and the relationship between site and rate of maturation were studied in laboratory infections of 10, 25 and 40 cystacanths fed to green sunfish, Lepomis cyanellus. After 1 week fish fed at each intensity had signific...

journal_title：Parasitology

authors： Ewald JA,Nickol BB

更新日期：1989-06-01 00:00:00

abstract：:The mechanism by which Giardia lamblia exerts its pathogenicity is likely to be multifactorial. A 58 kDa enterotoxin was purified and characterized from the excretory-secretory product (ESP) of the parasite (Kaur et al. 2001). In the present study an attempt has been made to elucidate the mechanism of action of the ES...

journal_title：Parasitology

authors： Shant J,Ghosh S,Bhattacharyya S,Ganguly NK,Majumdar S

更新日期：2004-10-01 00:00:00

abstract：:This study assessed the role of historical processes on the geographic isolation, molecular evolution, and morphological diversification of host-parasite populations from the southern Brazilian coast. Adult specimens of Scleromystax barbatus and Scleromystax macropterus were collected from the sub-basin of the Nhundia...

journal_title：Parasitology

authors： Bueno-Silva M,Boeger WA

更新日期：2019-09-01 00:00:00

abstract：:During the course of Schistosoma mansoni murine infection there is a dramatic increase of some immunoglobulins and S. mansoni-specific antibodies. The most substantial response is initiated after 40 days of infection and results in a prolonged increase of total IgG1, IgM and IgA. The maximum increase is respectively 2...

journal_title：Parasitology

authors： Bout D,Rousseaux R,Carlier Y,Capron A

更新日期：1980-04-01 00:00:00

abstract：:A metabolic pathway known as the mannitol cycle has been identified in Eimerian parasites. The pathway is a shunt off of the glycolytic pathway at fructose-6-phosphate (F6P). Two enzymes convert F6P to mannitol and two other enzymes are responsible for converting mannitol back to F6P when it is utilized. Although the ...

journal_title：Parasitology

authors： Schmatz DM

更新日期：1997-01-01 00:00:00

abstract：:If parasitic infection is a driving force in female mate choice, then females should preferentially select parasite-free males. The role of infection on female mate choice in mammals was assessed using a 3-chambered apparatus. A female CD-1 mouse was allowed to choose between 2 tethered male mice, 1 uninfected and 1 i...

journal_title：Parasitology

authors： Ehman KD,Scott ME

更新日期：2002-11-01 00:00:00

abstract：:A double antibody sandwich ELISA technique has been developed for detection of antigens of African trypanosomes present in the sera of infected mammals. The assay uses a high titre, high affinity rabbit antiserum made to purified membranes of procyclic trypanosomes as "capture" reagent and a mixture of three biotin-la...

journal_title：Parasitology

authors： Liu MK,Pearson TW

更新日期：1987-10-01 00:00:00

abstract：:Infection of intermediate hosts with eggs of taeniid parasites results in a larval infestation known as cysticercosis. A number of studies have indicated that cysticercosis is associated with immunosuppression, although little is known about the mechanisms involved. In the present study, mice infected with the larvae ...

journal_title：Parasitology

authors： Villa OF,Kuhn RE

更新日期：1996-06-01 00:00:00

abstract：:The effects of dietary urea supplementation and of a 10-week trickle infection regime, simulating chronic exposure to Haemonchus contortus, on the zymogenic population of the abomasa of Hampshire Down lambs was examined. At necropsy a variety of parameters including plasma pepsinogen concentration, the wet weights of ...

journal_title：Parasitology

authors： Scott I,Stear MJ,Irvine J,Dick A,Wallace DS,McKellar QA

更新日期：1998-06-01 00:00:00

abstract：:Many clinically useful antibacterial drugs have intracellular target sites. Therefore, in order to reach their targets, these compounds must be able to cross bacterial outer and cytoplasmic membranes. Considerable information is available on the mechanisms by which antibiotics cross bacterial membranes and, in many ca...

journal_title：Parasitology

authors： Chopra I

更新日期：1988-01-01 00:00:00

abstract：:Giardia lamblia localize and multiply in the small intestine and may cause acute or chronic diarrhoea with malabsorption of fat, protein and other nutrients. Abnormal pancreatic function has been documented in giardiasis and trophozoites directly inhibit pancreatic lipase activity in vitro. The aim of this study was t...

journal_title：Parasitology

authors： Seow F,Katelaris P,Ngu M

更新日期：1993-04-01 00:00:00

abstract：:Protective immunity against larval Taenia crassiceps has been shown to rely on T cells; however, the roles of the specific subsets of T cells during infection are not known. To investigate a possible role for gamma delta T cells, this study investigated larval infection in delta-chain knock-out C57BL/6 (deltaKO) and w...

journal_title：Parasitology

authors： Toenjes SA,Spolski RJ,Mooney KA,Kuhn RE

更新日期：1999-10-01 00:00:00

abstract：:cDNA-AFLP (cDNA-Amplified Fragment Length Polymorphism)-based strategy has been used to identify levamisole (LEV) resistance markers in the nematode Haemonchus contortus. Transcript profiles of adult nematodes from two LEV-resistant and two susceptible isolates were compared. Among the 17 280 transcript-derived fragme...

journal_title：Parasitology

authors： Neveu C,Charvet C,Fauvin A,Cortet J,Castagnone-Sereno P,Cabaret J

更新日期：2007-01-01 00:00:00

abstract：:Sequence comparisons have recently shown that the Schistosoma mansoni protein Sm32 is similar to asparaginyl endoproteinases, a novel family of cysteine proteinases, of which the legumains from legumes are the best characterized. By synthesizing and employing fluorogenic peptide substrates for the specific detection o...

journal_title：Parasitology

authors： Dalton JP,Hola-Jamriska L,Brindley PJ

更新日期：1995-12-01 00:00:00

abstract：:Although the rumen fluke, Calicophoron daubneyi is now very common and widespread throughout Western Europe, reports of clinical cases are still rare. This study explores the epidemiological background to a severe rumen fluke outbreak in 6-month-old heifers on a dairy farm in Ireland. Sequence analysis of the cytochro...

journal_title：Parasitology

authors： O'Shaughnessy J,Garcia-Campos A,McAloon CG,Fagan S,de Waal T,McElroy M,Casey M,Good B,Mulcahy G,Fagan J,Murphy D,Zintl A

更新日期：2018-06-01 00:00:00

abstract：:Neospora caninum causes economical impact in cattle-raising farms since it is implicated as the major cause of bovine abortions. Although infection by the parasite has been widely described in mammals, the role of birds in its life-cycle is still obscure. Therefore, this work aimed to evaluate the infection by N. cani...

journal_title：Parasitology

authors： Furuta PI,Mineo TW,Carrasco AO,Godoy GS,Pinto AA,Machado RZ

更新日期：2007-12-01 00:00:00

abstract：:The host-parasite relationship is exquisitely specific. In exploiting the host niche, a variety of helminth parasites have been shown to directly manipulate their hosts' immune responses. We assessed the ability of a whole-worm extract of Hymenolepis diminuta to modulate immune cell activation. Immune cells isolated f...

journal_title：Parasitology

authors： Wang A,McKay DM

更新日期：2005-05-01 00:00:00

abstract：:As more facts emerge regarding the ways in which E. multilocularis-derived molecules trigger the host immune response and modulate the host-parasite interplay, it becomes possible to envisage how the parasite can survive and proliferate in its intermediate host, while in other hosts it dies out. Through effects on cel...

journal_title：Parasitology

authors： Mejri N,Hemphill A,Gottstein B

更新日期：2010-03-01 00:00:00

abstract：:The ultrastructure of the formation of the first-stage cuticle within the egg of Trichostrongylus colubriformis is described. The first indication of cuticle formation was the formation of the epicuticle external to the epidermal plasma membrane. This becomes thickened to form the epicuticle of the fully formed cuticl...

journal_title：Parasitology

authors： Wharton DA,Bone LW

更新日期：1988-12-01 00:00:00

abstract：:African sleeping sickness is a parasitic disease transmitted through the bites of tsetse flies of the genus Glossina. We constructed mechanistic models for the basic reproduction number, R0, of Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, respectively the causative agents of West and East African h...

journal_title：Parasitology

authors： Davis S,Aksoy S,Galvani A

更新日期：2011-04-01 00:00:00

abstract：:The development of microgamonts was studied in the small intestine of a 2-day-old cat after oral inoculation with 10(7) bradyzoites of Sarcocystis hirsuta. The cat was given bradyzoites in 2 doses at 2 h apart and killed 4 h later. Gamonts were seen in parasitophorous vacuoles of goblet cells in the epithelium of the ...

journal_title：Parasitology

authors： Dubey JP

更新日期：1983-02-01 00:00:00