Molecular mechanisms involved in the transport of antibiotics into bacteria.

abstract：:Theileria-free waterbuck (Kobus defassa) born in captivity were successfully infected with Theileria parva sporozoites derived from ticks infected by feeding on African buffalo (Syncerus caffer). All waterbuck underwent mild infections with the development of sporadic schizont and piroplasm parasitosis when inoculated...

journal_title：Parasitology

authors： Stagg DA,Bishop RP,Morzaria SP,Shaw MK,Wesonga D,Orinda GO,Grootenhuis JG,Molyneux DH,Young AS

更新日期：1994-06-01 00:00:00

abstract：:The SICA[-] or non-agglutinable phenotype of Plasmodium knowlesi schizont-infected erythrocytes has been defined serologically but not biochemically. Similarly, non-cloned SICA[+] or agglutinable parasites have been shown serologically to express SICA or variant antigen(s) but the number and nature of such antigens ha...

journal_title：Parasitology

authors： Howard RJ,Barnwell JW

更新日期：1985-10-01 00:00:00

abstract：:The primary immune response to infection with Heligmosomoides polygyrus was studied in mice differing in response phenotype (fast-SWR, intermediate-NIH, slow-CBA). Marked IgG1 and IgE but not IgG2a antibody responses were detected in infected mice and the former were more intense in fast compared with slow responder s...

journal_title：Parasitology

authors： Wahid FN,Behnke JM,Grencis RK,Else KJ,Ben-Smith AW

更新日期：1994-05-01 00:00:00

abstract：:To recognize the stage conversion of Toxoplasma gondii between tachyzoite and bradyzoite in live host cells, a transgenic T. gondii line, which expressed stage-specific red and green fluorescence, was constructed. T. gondii PLK strain tachyzoites were stably transformed with genes encoding red fluorescent protein (DsR...

journal_title：Parasitology

authors： Unno A,Suzuki K,Batanova T,Cha SY,Jang HK,Kitoh K,Takashima Y

更新日期：2009-05-01 00:00:00

abstract：:High throughput technologies continue to develop in response to the challenges set by the genome projects. This article discusses how the techniques of both high throughput screening (HTS) and synthesis can influence research in parasitology. Examples of the use of targeted and phenotype-based HTS using unbiased compo...

journal_title：Parasitology

authors： Morgan RE,Westwood NJ

更新日期：2004-01-01 00:00:00

abstract：:Neospora caninum is a cyst-forming parasite that causes abortion in cattle. Despite this parasite's ubiquitous distribution and wide host range, the number of N. caninum isolates obtained to date is limited. In vitro isolation of the parasite is arduous and often unsuccessful. In addition, most isolates have been obta...

journal_title：Parasitology

authors： Regidor-Cerrillo J,Gómez-Bautista M,Pereira-Bueno J,Aduriz G,Navarro-Lozano V,Risco-Castillo V,Férnandez-García A,Pedraza-Díaz S,Ortega-Mora LM

更新日期：2008-12-01 00:00:00

abstract：:A comparison has been made of the responses of random-bred CFLP and inbred NIH mice to infection with Trichuris muris. Random-bred mice showed greater variation in worm burdens and less uniformity in worm expulsion. Irradiation prior to infection reduced variation, but did not increase the mean level of infection abov...

journal_title：Parasitology

authors： Wakelin D

更新日期：1975-08-01 00:00:00

abstract：:Neospora caninum is the causative agent of bovine neosporosis. A N. caninum cytoplasmic dynein LC8 light chain (NcDYNLL) protein was characterized in this study. Cytoplasmic dyneins, including DYNLLs, belong to the microtubule minus-end-directed motor proteins and are involved in many cellular processes. Previous micr...

journal_title：Parasitology

authors： Cao L,Fetterer R,Qu G,Zhang X,Tuo W

更新日期：2018-12-18 00:00:00

abstract：:Digenean parasites infecting four Cominella whelk species (C. glandiformis, C. adspersa, C. maculosa and C. virgata), which inhabit New Zealand's intertidal zone, were analysed using molecular techniques. Mitochondrial 16S and cytochrome oxidase 1 (COI) and nuclear rDNA ITS1 sequences were used to infer phylogenetic r...

journal_title：Parasitology

authors： Donald KM,Spencer HG

更新日期：2016-08-01 00:00:00

abstract：:The isolation of 2 genomic clones has allowed us to further characterize a Schistosoma mansoni serine protease designated SmSP1. The deduced amino acid sequence (248aa) considered as a 'light chain' encoding the active site, presents significant homologies with mouse plasma kallikrein and human factor I light chain. T...

journal_title：Parasitology

authors： Cocude C,Pierrot C,Cêtre C,Fontaine J,Godin C,Capron A,Khalife J

更新日期：1999-04-01 00:00:00

abstract：:Seroprevalence data illustrate that human exposure to Toxocara is frequent. Environmental contamination with Toxocara spp. eggs is assumed to be the best indicator of human exposure, but increased risk of exposure has also been associated with many other factors. Reported associations are inconsistent, however, and th...

journal_title：Parasitology

authors： Kanobana K,Devleesschauwer B,Polman K,Speybroeck N

更新日期：2013-07-01 00:00:00

abstract：:Studies of the kinetics of adenosine transport were carried out on the P1 and P2 transporters of drug-sensitive Trypanosoma evansi and its cloned derivative, resistant to the melaminophenyl arsenical Mel CY. Characterization of adenosine uptake was made by estimation of the maximum concentration taken up at time infin...

journal_title：Parasitology

authors： Suswam EA,Ross CA,Martin RJ

更新日期：2003-12-01 00:00:00

abstract：:The importance of host heterogeneity in generating aggregation was investigated using Heligmosomoides polygyrus (Nematoda) in laboratory mice. Parameters of infection were compared between inbred and outbred mice, between primary and challenge infection protocols, and between gavage and natural exposure protocols, to ...

journal_title：Parasitology

authors： Tanguay GV,Scott ME

更新日期：1992-06-01 00:00:00

abstract：:Artificially transformed schistosomula of Schistosoma mansoni develop a consistent but small protection against the lethal effects of antibody plus complement when cultured for 24 h in a chemically defined medium. In contrast, they become rapidly resistant to antibody plus complement, when cultured in the presence of ...

journal_title：Parasitology

authors： Tavares CA,Soares RC,Coelho PM,Gazzinelli G

更新日期：1978-10-01 00:00:00

abstract：:The community structure of monogeneans on the gills of a catfish Pimelodus albicans, in the Río de la Plata, was studied and compared with previous findings on P. maulatus. Six Monogenea species belonging to 3 genera were found: Demidospermus majusculus Kritsky & Gutiérrez, 1998; Demidospermus armostus Kritsky & Gutié...

journal_title：Parasitology

authors： Gutiérrez PA

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Unravelling the determinants of parasite life-history traits in natural settings is complex. Here, we deciphered the relationships between biotic, abiotic factors and the variation in 4 life-history traits (body size, egg presence, egg number and egg size) in the fish ectoparasite Tracheliastes polycolpus. We...

journal_title：Parasitology

authors： Loot G,Poulet N,Brosse S,Tudesque L,Thomas F,Blanchet S

更新日期：2011-06-01 00:00:00

abstract：:Freshwater snails of the Bulinus forskalii group are one of four Bulinus species complexes responsible for the transmission of schistosomes in Africa and adjacent regions. The species status of these conchologically variable and widely distributed planorbids remains unclear, and parasite compatibility varies considera...

journal_title：Parasitology

authors： Jones CS,Rollinson D,Mimpfoundi R,Ouma J,Kariuki HC,Noble LR

更新日期：2001-01-01 00:00:00

abstract：:The sequence of appearance of specific lytic activity against more than 20 variable antigen types (VATs) of Trypanosoma vivax in the serum of 27 animals belonging to 5 species has been examined. For each host species there was a characteristic course of infection, with differences in height and duration of parasitaemi...

journal_title：Parasitology

authors： Barry JD

更新日期：1986-02-01 00:00:00

abstract：:BALB/c mice were characterized as more resistant to infection with Heligmosomoides polygyrus (Nematoda) than C57BL/6 mice based on lower establishment and survival during a primary infection and stronger protection induced by an immunizing regime. It was hypothesized, therefore, that C57BL/6 mice would be more heavily...

journal_title：Parasitology

authors： Scott ME

更新日期：1991-12-01 00:00:00

abstract：:There has been an enormous growth in the development of biotechnological applications, where advances in the techniques of microelectronic fabrication and the technologies of miniaturization and integration in semiconductor industries are being applied to the production of Laboratory-on-a-Chip devices. The aim of this...

journal_title：Parasitology

authors： Talary MS,Burt JP,Pethig R

更新日期：1998-01-01 00:00:00

abstract：:In recent years, through a national programme for schistosomiasis control, this infection has been eliminated from Iran. The aim of this study was to report the process of significant decrease of urogenital schistosomiasis in southwestern Iran. During national programme surveillance for urogenital schistosomiasis cont...

journal_title：Parasitology

authors： Khademvatan S,Salmanzadeh S,Foroutan-Rad M,Ghomeshi M

更新日期：2016-09-01 00:00:00

abstract：:In light of the low success rate of target-based genomics and HTS (High Throughput Screening) approaches in anti-infective drug discovery, in silico structure-based drug design (SBDD) is becoming increasingly prominent at the forefront of drug discovery. In silico SBDD can be used to identify novel enzyme inhibitors r...

journal_title：Parasitology

authors： Cunningham F,McPhillie MJ,Johnson AP,Fishwick CW

更新日期：2014-01-01 00:00:00

abstract：:Th2-biased inflammation with eosinophilia and IgE production is a hallmark of helminth infections. It is pronounced in hyperreactive onchocerciasis patients ('sowda' or 'local form'), who efficiently kill microfilariae resulting in severe dermatitis and lymphadenitis. In contrast, hyporeactive patients ('generalised f...

journal_title：Parasitology

authors： Korten S,Hoerauf A,Kaifi JT,Büttner DW

更新日期：2011-01-01 00:00:00

abstract：:A time-course study was conducted to resolve discrepancies in the literature and better define aspects of the Eimeria maxima life cycle such, as sites of development and both morphology and number of asexual stages. Broiler chickens were inoculated orally with five million E. maxima oocysts (APU1), and were necropsied...

journal_title：Parasitology

authors： Dubey JP,Jenkins MC

更新日期：2018-07-01 00:00:00

abstract：:The nematode-trapping fungus Arthrobotrys oligospora traps and invades all the free-living juvenile stages of the trichostrongyle nematode Trichostrongylus colubriformis. The processes of capture and invasion of the 1st-stage juveniles are described using differential interference contrast optics and 3-D reconstructio...

journal_title：Parasitology

authors： Murray DS,Wharton DA

更新日期：1990-08-01 00:00:00

abstract：:The free radical nitric oxide (NO) is a neuronal messenger which is synthesized from L-arginine and O2 by nitric oxide synthase (NOS). In the synthesis NO and L-citrulline are produced in a stoichiometric 1:1 relation. The activity of NOS was analysed in homogenates of the rat tapeworm Hymenolepis diminuta by measurin...

journal_title：Parasitology

authors： Terenina NB,Onufriev MV,Gulyaeva NV,Lindholm AM,Gustafsson MK

更新日期：2000-01-01 00:00:00

abstract：:A striking feature of toxoplasmic seroconversion is the prominent and early IgM response to a low molecular weight antigen of 4-5 kDa. Two different monoclonal antibodies directed against the 4-5 kDa antigen have been generated and used to characterize this molecule. Using these monoclonal antibodies, we could demonst...

journal_title：Parasitology

authors： Tomavo S,Couvreur G,Leriche MA,Sadak A,Achbarou A,Fortier B,Dubremetz JF

更新日期：1994-02-01 00:00:00

abstract：:Syphacia stroma (von Linstow, 1884) Morgan, 1932 and Syphacia frederici Roman, 1945 are oxyurid nematodes that parasitize two murid rodents, Apodemus sylvaticus and Apodemus flavicollis, on the European mainland. Only S. stroma has been recorded previously in Apodemus spp. from the British Isles. Despite the paucity o...

journal_title：Parasitology

authors： Stewart A,Lowe A,Smales L,Bajer A,Bradley J,Dwużnik D,Franssen F,Griffith J,Stuart P,Turner C,Zaleśny G,Behnke JM

更新日期：2018-03-01 00:00:00

abstract：:A number of authors have demonstrated that the schistosomicidal compound, Praziquantel (Pzq), depends for its action upon the immune status of the host (Sabah et al. 1985; Brindley & Sher, 1987; Doenhoff et al. 1987). We have attempted to define the synergistic interaction between immuno- and chemotherapy further, usi...

journal_title：Parasitology

authors： Piper KP,Mott RF,Hockley DJ,McLaren DJ

更新日期：1991-10-01 00:00:00

abstract：:Expression of metalloprotease activities during metacyclogenesis of a series of strains and clones of Trypanosoma cruzi was investigated using SDS-polyacrylamide gel electrophoresis with a range of different co-polymerized proteolytic substrates. A complex pattern of metalloprotease expression, with considerable quant...

journal_title：Parasitology

authors： Lowndes CM,Bonaldo MC,Thomaz N,Goldenberg S

更新日期：1996-04-01 00:00:00