Abstract:
:The importance of host heterogeneity in generating aggregation was investigated using Heligmosomoides polygyrus (Nematoda) in laboratory mice. Parameters of infection were compared between inbred and outbred mice, between primary and challenge infection protocols, and between gavage and natural exposure protocols, to investigate the relative effects of innate resistance, acquired resistance and behaviour, respectively. Heterogeneity in acquired resistance was identified as the most consistent factor leading to variability and aggregation of H. polygyrus numbers in mice. This hypothesis was supported in two experiments where groups of mice did not develop resistance to challenge infection (use of certain inbred strains of mice and immunosuppression with corticosteroids in the drinking water) and where variability in worm numbers after the challenge infection was comparable with that after the primary infection. Heterogeneity in host behaviour, particularly in behaviours enhancing skin contact with larvae, also was associated with increased heterogeneity in worm burden, though not as consistently as heterogeneity in acquired resistance. Surprisingly, worm burdens were not more variable in outbred compared with inbred mice. Our data suggest that the relative contributions of innate resistance, acquired resistance and behaviour in generating variable worm burdens are likely to vary spatially and temporally.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Tanguay GV,Scott MEdoi
10.1017/s0031182000063782subject
Has Abstractpub_date
1992-06-01 00:00:00pages
519-29eissn
0031-1820issn
1469-8161journal_volume
104 ( Pt 3)pub_type
杂志文章相关文献
PARASITOLOGY文献大全abstract::Sodium fluoride (NaF) is an anion that has been previously shown to block the moulting process of Ascaris suum larvae. This study describes moulting and development-specific protein expression profiles of A. suum lung-stage L3 (AsLL3) following NaF exposure. AsLL3s cultured in the presence or absence of NaF were prepa...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182006000576
更新日期:2006-10-01 00:00:00
abstract::The effect of the parasitic swimbladder nematode, Anguillicola crassus, on the physiological status of wild European eels (Anguilla anguilla) was investigated during an 18 month survey (February 1995 until September 1996), and compared with that of wild uninfected eels collected over the same time-period. Despite the ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182099005314
更新日期:2000-02-01 00:00:00
abstract::A beta-1,3-glucan-binding lectin from the penetration glands of Diplostomum pseudospathaceum cercariae was isolated by affinity chromatography using yeast glucan and curdlan as affinity matrices. Further purification to homogeneity was performed by cation-exchange chromatography. The protein migrated as a double band ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182003003305
更新日期:2003-07-01 00:00:00
abstract::The glycogen stores of adult Schistosoma mansoni worms could be labelled by incubation of the worms, after an initial reduction of their glycogen content, in the presence of [6-14C]glucose. Subsequent breakdown of the labelled glycogen by the parasite revealed that glycogen was degraded to lactate and carbon dioxide. ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000059692
更新日期:1989-02-01 00:00:00
abstract::Experiments to investigate the metabolism of glycine, L-glutamic acid and L-aspartic acid by Moniliformis moniliformis were carried out by incubating adult worms aerobically for 3 h at 37 degrees C in Tyrode's solution containing either [U-14C]glycine, L-[U-14C]glutamic acid, L-[U-14C]aspartic acid or L-[4-14C]asparti...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000055876
更新日期:1987-06-01 00:00:00
abstract::Ultrastructural investigations (SEM, TEM) combined with lectin-binding analysis, have revealed concurrent modifications in tegumentary structure and surface glycoconjugates during the establishment and differentiation of Echinococcus multilocularis metacestodes in jirds. The laminated layer, which is amorphous and ric...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s003118200006087x
更新日期:1992-02-01 00:00:00
abstract::Humans and other hosts acquire Toxoplasma gondii infection by ingesting tissue cysts in undercooked meat, or by food or drink contaminated with oocysts. Currently, there is no vaccine to prevent clinical disease due this parasite in humans, although, various T. gondii vaccine candidates are being developed. Mice are g...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182011001673
更新日期:2012-01-01 00:00:00
abstract::Neospora caninum is an Apicomplexan protozoan that has the dog as a definitive host and cattle (among other animals) as intermediate hosts. It causes encephalopathy in dogs and abortion in cows, with significant loss in worldwide livestock. As any Apicomplexan, the parasite invades the cells using proteins contained i...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182010001290
更新日期:2011-03-01 00:00:00
abstract::The molecular phylogeny and morphology of the oxyuroid nematode genus Aspiculuris from voles and house mice has been examined. Worms collected from Myodes glareolus in Poland, Eire and the UK are identified as Aspiculuris tianjinensis, previously known only from China, while worms from Mus musculus from a range of loc...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182015000864
更新日期:2015-10-01 00:00:00
abstract::A cDNA clone codifying ribosomal protein L25 was isolated from a Leishmania braziliensis cDNA gene library. The alignment of the amino acid sequence deduced from this gene with other proteins revealed that this protein is related to the L23/25 rihosomal protein family. This is so because this protein shows, in its C-t...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182002001804
更新日期:2002-07-01 00:00:00
abstract::Syphacia stroma (von Linstow, 1884) Morgan, 1932 and Syphacia frederici Roman, 1945 are oxyurid nematodes that parasitize two murid rodents, Apodemus sylvaticus and Apodemus flavicollis, on the European mainland. Only S. stroma has been recorded previously in Apodemus spp. from the British Isles. Despite the paucity o...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182017001470
更新日期:2018-03-01 00:00:00
abstract::Pinewood nematode, Bursaphelenchus xylophilus, a pine parasitic nematode, poses a serious threat to its host pine forests globally. When dispersal-stage larvae 4 (dauer, DL4) of B. xylophilus enters the new pine, it moults into propagative adult (dauer recovery) and reproduces quickly to kill the host pine. Here, we f...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182019001264
更新日期:2020-01-01 00:00:00
abstract::In previous studies, ultrastructural observations revealed a large number of gap junctions (GJs) in the neck and immature proglottid tissues of Taenia solium tapeworms. In these helminths, cytoplasmic glycogen sacs are connected by numerous discrete GJs to other cells throughout the maturing strobilar tissue. Disconti...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182008004629
更新日期:2008-08-01 00:00:00
abstract::Investigations were carried out into the properties and localization of chitin synthase (EC 2.4.1.16) in connection with the formation of Ascaris suum egg-shells. The chitin synthase of eggs exhibited properties very similar to those found in other chitin-synthesizing organisms. It was stimulated by the presence of AT...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000063575
更新日期:1986-02-01 00:00:00
abstract::A polymorphic set of 14 kDa excretory-secretory (E-S) antigen-encoding cDNAs, with similarity to a previously characterized 15 kDa E-S antigen of Haemonchus contortus, was cloned from Cooperia punctata. Five cDNAs encoding predicted proteins of 70-80% identity were sequenced. Genomic analyses of individuals proved the...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182001008770
更新日期:2001-12-01 00:00:00
abstract::Sera from goats and cattle that were infected with two Trypanosoma vivax clones (ILDat 1.2 and ILDat 2.1) derived from different stocks were analysed for antibody activity against the variable surface glycoproteins (VSGs) of the infecting clones by enzyme-linked immune assays (ELISA) and immune lysis. To obtain purifi...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000060157
更新日期:1990-02-01 00:00:00
abstract::American trypanosamiasis occurs in nature as a sylvatic cycle, where Trypanosoma cruzi interacts with wild triatomines and mammalian reservoirs, such as marsupials, rodents, armadillos and other animals. Due to difficulties in trying to isolate T. cruzi stocks from the sylvatic cycle, very few studies have been perfor...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182098003709
更新日期:1999-02-01 00:00:00
abstract::Avian malaria is a mosquito-borne disease caused by Plasmodium spp. protozoa. Although these parasites have been extensively studied in North America and Eurasia, knowledge on the diversity of Plasmodium, its vectors and avian hosts in Africa is scarce. In this study, we report on natural malarial infections in free-r...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182020000566
更新日期:2020-08-01 00:00:00
abstract::Nematodes represent one of the most abundant and species-rich groups of animals on the planet, with parasitic species causing chronic, debilitating infections in both livestock and humans worldwide. The prevalence and success of the nematodes is a direct consequence of the exceptionally protective properties of their ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182010001113
更新日期:2011-02-01 00:00:00
abstract::In theory, the age at which maturation occurs in parasitic nematodes is inversely related to pre-maturational mortality rate, and cross-species data on mammalian nematodes are consistent with this prediction. Immunity is a major source of parasite mortality and parasites stand to gain sizeable fitness benefits through...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182003003998
更新日期:2003-11-01 00:00:00
abstract::n order to investigate the dynamics of Septin4 (Sept4) expression and its function in the formation of fibrotic livers in mice infected with Schistosoma japonicum, we constructed the mouse model of S. japonicum egg-induced liver fibrosis for 24 weeks. Immunohistochemical staining, qRT-PCR and Western blot were used to...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182011000667
更新日期:2011-07-01 00:00:00
abstract::Merocyanin 540 (Mc540) is a fluorescent compound which is thought to bind to membranes in which there are substantial amounts of lipid in the lipid-crystalline phase. It is shown here to be of value in detecting the transformation by both mechanical and skin-penetration methods of the cercaria to the schistosomulum. T...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000081671
更新日期:1988-02-01 00:00:00
abstract::The ultrastructure of the formation of the first-stage cuticle within the egg of Trichostrongylus colubriformis is described. The first indication of cuticle formation was the formation of the epicuticle external to the epidermal plasma membrane. This becomes thickened to form the epicuticle of the fully formed cuticl...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000058868
更新日期:1988-12-01 00:00:00
abstract::Antibodies against the retrovirus envelope glycoprotein (gp70) of mouse xenotropic retrovirus, BALB virus 2 (Bv2) reacted with the adult worms of Schistosoma japonicum and S. mansoni. This reaction was completely inhibited after adsorption of the antibodies with virions of retrovirus. The reactive schistosome antigen ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000060996
更新日期:1989-08-01 00:00:00
abstract::The ribosomal RNA (rRNA) gene units of Schistosoma mansoni and S. rodhaini, of the lateral spined egg group, have been studied. The schistosome rRNA gene unit consists of a regular interspersion of the two genes encoding the large and small rRNA units with two spacers. The large spacer is not transcribed while the sma...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000059709
更新日期:1989-02-01 00:00:00
abstract::The group of haemosporidian parasites is of general interest to basic and applied science, since several species infect mammals, leading to malaria and associated disease symptoms. Although the great majority of haemosporidian parasites appear in bird hosts, as in the case of Leucocytozoon buteonis, there is little ge...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/S0031182012000972
更新日期:2012-10-01 00:00:00
abstract::Responses to Taenia taeniaeformis infection were studied in mice with severe combined immunodeficiency (scid), which lack functional T and B lymphocytes. In the early phase of infection, accumulation of polymorphonuclear leucocytes (PML) occurred around the larvae in the liver of scid mice and their immunocompetent co...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000061825
更新日期:1992-04-01 00:00:00
abstract::The surface morphology of fixed ovarian balls from female Moniliformis dubius, agd 12, 18, 26, 28, 42, 77, 105 and 118 days, has been examined by means of scanning electron microscopy. The appearance of the surface has been found to be variable between ovarian balls from worms of the same and different ages. Some part...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182000056146
更新日期:1980-10-01 00:00:00
abstract::Stability of trichostrogylid populations indicates that some form of density-dependent regulation occurs which could act through fecundity. We present evidence for intraspecific density-dependent effects in 1 of 2, dominant, abomasal nematodes species (Ostertagia gruehneri) of Svalbard reindeer (Rangifer tarandus plat...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182001007818
更新日期:2001-06-01 00:00:00
abstract::A 186 bp Echinococcus granulosus-specific repetitive element, TREg, was used to assess genetic variation between strains. In G7 genotype (pig strain) it has the characteristics of a satellite DNA element with a copy number of 23000 per haploid genome. Analysis, by sequencing of TREg monomers, showed a great degree of ...
journal_title:Parasitology
pub_type: 杂志文章
doi:10.1017/s0031182001008575
更新日期:2001-10-01 00:00:00