Abstract:
:n order to investigate the dynamics of Septin4 (Sept4) expression and its function in the formation of fibrotic livers in mice infected with Schistosoma japonicum, we constructed the mouse model of S. japonicum egg-induced liver fibrosis for 24 weeks. Immunohistochemical staining, qRT-PCR and Western blot were used to detect the expression of Sept4 and α-smooth muscle actin (α-SMA). We found Sept4 localized in the perisinusoidal space where hepatic stellate cells (HSCs) distribute in the periphery of circumoval granulomas and the portal venule. The expression of Sept4 and α-SMA had a similar significant tendency of an up-regulation to a peak at 12 weeks post-infection (p.i.) followed by a down-regulation. At 24 weeks p.i. both were at a low level. These results suggest that Sept4 and α-SMA may interact together in HSCs. Based on this evidence, we hypothesize that Sept4 seems to be involved in the formation of inflammatory granulomata and subsequent liver fibrosis by regulating HSCs activation.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Duan YN,Qian HY,Qin YW,Zhu DD,He XX,Zhou Q,Yang YN,Bao J,Feng JR,Sun W,Chen JLdoi
10.1017/S0031182011000667subject
Has Abstractpub_date
2011-07-01 00:00:00pages
1003-10issue
8eissn
0031-1820issn
1469-8161pii
S0031182011000667journal_volume
138pub_type
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