Abstract:
:In theory, the age at which maturation occurs in parasitic nematodes is inversely related to pre-maturational mortality rate, and cross-species data on mammalian nematodes are consistent with this prediction. Immunity is a major source of parasite mortality and parasites stand to gain sizeable fitness benefits through short-term adjustments of maturation time in response to variation in immune-mediated mortality. The effects of thymus-dependent immune responses on maturation in the nematode parasites Strongyloides ratti and Nippostrongylus brasiliensis were investigated using congenitally thymus-deficient (nude) rats. As compared with worms in normal rats, reproductive maturity of parasites (presence of eggs in utero) in nude rats occurred later in S. ratti but earlier in N. brasiliensis. Immune-mediated differences in maturation time were not associated with differences in worm length. Thymus-dependent immunity had no effect on prematurational mortality. Results are discussed in relation to theoretical expectations and possible explanations for the observed patterns in parasite maturation.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Guinnee MA,Gemmill AW,Chan BH,Viney ME,Read AFdoi
10.1017/s0031182003003998subject
Has Abstractpub_date
2003-11-01 00:00:00pages
507-12issue
Pt 5eissn
0031-1820issn
1469-8161journal_volume
127pub_type
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