The role of Plasmodium knowlesi in the history of malaria research.

Abstract:

:In recent years, a malaria infection of humans in South East Asia, originally diagnosed as a known human-infecting species, Plasmodium malariae, has been identified as a simian parasite, Plasmodium knowlesi. This species had been subject to considerable investigation in monkeys since the 1930s. With the development of continuous culture of the erythrocytic stages of the human malarial parasite, Plasmodium falciparum in 1976, the emphasis in research shifted away from knowlesi. However, its importance as a human pathogen has provoked a renewed interest in P. knowlesi, not least because it too can be maintained in continuous culture and thus provides an experimental model. In fact, this parasite species has a long history in malaria research, and the purpose of this chapter is to outline approximately the first 50 years of this history.

journal_name

Parasitology

journal_title

Parasitology

authors

Butcher GA,Mitchell GH

doi

10.1017/S0031182016001888

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

6-17

issue

1

eissn

0031-1820

issn

1469-8161

pii

S0031182016001888

journal_volume

145

pub_type

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