Abstract:
:In South America, visceral leishmaniasis is frequently caused by Leishmania infantum and, at an unknown frequency, by Leishmania amazonensis. Therefore, mixed infections with these organisms are possible. Mixed infections might affect the clinical course, immune response, diagnosis, treatment and epidemiology of the disease. Here we describe the clinical course of mixed infections with L. amazonensis and L. infantum in a hamster model. We show that mixed infections are associated with more severe clinical disease than infection with L. amazonensis or L. infantum alone. In spleens with mixed infections, L. infantum outcompeted L. amazonensis in the tissue, but not in culture from tissue. We found increased levels of IgG in animals infected with L. infantum. Although more than 30 bands were revealed in a Western blot, the highest immunogenicity was observed with proteins having molecular masses of 95 and 90 kDa, whereas proteins with molecular masses of lower than 50 kDa were reactive frequently with serum from hamsters infected with L. amazonensis, and proteins with molecular masses of 80 and 70 kDa were reactive only with serum from hamsters infected with L. infantum. This finding has important implications regarding the biology of Leishmania and humoral immune responses to infections with these organisms.
journal_name
Parasitologyjournal_title
Parasitologyauthors
DE Lima Celeste JL,Venuto Moura AP,França-Silva JC,Matos DE Sousa G,Oliveira Silva S,Norma Melo M,Luiz Tafuri W,Carvalho Souza C,Monteiro DE Andrade Hdoi
10.1017/S0031182017000464subject
Has Abstractpub_date
2017-08-01 00:00:00pages
1191-1202issue
9eissn
0031-1820issn
1469-8161pii
S0031182017000464journal_volume
144pub_type
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