Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections.

Abstract:

:We studied infection dynamics of Plasmodium chabaudi in mice infected with 3 genetically distinct clones--1 less virulent than the other 2--either on their own or in mixtures. During the acute phase of infection, total numbers of asexual parasites in mixed-clone infections were equal to those produced by the 3 clones alone, suggesting strong in-host competition among clones. During the chronic phase of the infection, mixed-clone infections produced more asexual parasites than single-clone infections, suggesting lower levels of competition than during the acute phase, and indicating that a genetically diverse infection is harder to control by the host immune system. Transmission potential over the whole course of infection was lower from mixed-clone infections than from the average of the 3 single-clone infections. These results suggest that in-host competition reduces both growth rate and probability of transmission for individual parasite clones.

journal_name

Parasitology

journal_title

Parasitology

authors

De Roode JC,Read AF,Chan BH,Mackinnon MJ

doi

10.1017/s0031182003004001

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

411-8

issue

Pt 5

eissn

0031-1820

issn

1469-8161

journal_volume

127

pub_type

杂志文章
  • Quantitative modelling and prediction of development times of the free-living stages of Ostertagia ostertagi under controlled and field conditions.

    abstract::The development of the free-living stages of Ostertagia ostertagi incubated at constant temperatures from 5 to 27 degrees C and in dung pats in the field was observed. The death rates were adequately described by a single exponential functional and the distribution of times for development by a delayed gamma density f...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000061886

    authors: Young RR,Nicholson RM,Tweedie RL,Schuh HJ

    更新日期:1980-12-01 00:00:00

  • Hymenolepis diminuta: metacestode-induced reduction in the synthesis of the yolk protein, vitellogenin, in the fat body of Tenebrio molitor.

    abstract::Vitellogenin synthesis by the fat body has been monitored using in vitro culture and immunoprecipitation. This system was found to be efficient for measuring vitellogenin production in both non-infected Tenebrio molitor and those infected with Hymenolepis diminuta. In fat bodies from infected beetles, vitellogenin pro...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000066658

    authors: Webb TJ,Hurd H

    更新日期:1996-04-01 00:00:00

  • Plasmodium vivax Duffy binding protein: a modular evolutionary proposal.

    abstract::The population of malaria-causing parasites is characterized by great genetic diversity. Knowledge of the polymorphism generation mechanism is a central issue for developing effective vaccines against malaria and understanding the parasite population structure. Plasmodium vivax genetic diversity has been explained in ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182003004773

    authors: Martinez P,Suarez CF,Cardenas PP,Patarroyo MA

    更新日期:2004-04-01 00:00:00

  • Malaria, quinine and red cell lysis.

    abstract::An hypothesis is presented to explain the red cell lysis which accompanies an acute malarial infection, as well as the mode of action of certain schizonticidal drugs in the quinoline and acridine series. Quinine and a number of other antimalarial drugs have been found to counteract the inhibition by protein of fatty a...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200004662x

    authors: Laser H,Kemp P,Miller N,Lander D,Klein R

    更新日期:1975-10-01 00:00:00

  • Development of a strategy for the identification of surface proteins in the pathogenic microsporidian Nosema bombycis.

    abstract::Parasite-host interactions mediated by cell surface proteins have been implicated as a critical step in infections caused by the microsporidian Nosema bombycis. Such cell surface proteins are considered as promising diagnostic markers and targets for drug development. However, little research has specifically addresse...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182015000190

    authors: Zhao W,Hao Y,Wang L,Zhou Z,Li Z

    更新日期:2015-06-01 00:00:00

  • Dynamic interaction between CD4+ T cells and parasitic helminths: mathematical models of heterogeneity in outcome.

    abstract::Potential mechanisms of immunoregulation have been investigated for the capacity to generate heterogeneity in the outcome of infection with helminth parasites. We have developed a mathematical model of the interaction between T cell and parasite populations, based on the assumption that activation of a Th1 CD4+ T cell...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000074692

    authors: Schweitzer AN,Anderson RM

    更新日期:1992-12-01 00:00:00

  • Apparent tolerance of Plasmodium falciparum in infants in a highly endemic area.

    abstract::The incidence of fever among infants in the village of Idete in the Morogoro region of Tanzania was analyzed in relation to densities of Plasmodium falciparum parasites in the peripheral blood. Parasite densities in both fever cases and in asymptomatic infants, were compared and a Bayesian non-parametric mixture decom...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182099005211

    authors: Vounatsou P,Smith T,Kitua AY,Alonso PL,Tanner M

    更新日期:2000-01-01 00:00:00

  • Direct molecular identification of Trypanosoma cruzi discrete typing units in domestic and peridomestic Triatoma infestans and Triatoma sordida from the Argentine Chaco.

    abstract::We assessed the distribution of Trypanosoma cruzi Discrete Typing Units (DTUs) in domestic and peridomestic Triatoma infestans and Triatoma sordida specimens collected in a well-defined rural area in Pampa del Indio, northeastern Argentina. Microscopically-positive bugs were randomly selected with a multi-level sampli...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182012000856

    authors: Maffey L,Cardinal MV,Ordóñez-Krasnowski PC,Lanati LA,Lauricella MA,Schijman AG,Gürtler RE

    更新日期:2012-10-01 00:00:00

  • Repeated infection of cats with Brugia pahangi: parasitological observations.

    abstract::Cats were repeatedly inoculated with infective larvae of Brugia pahangi. On parasitological grounds they could be divided into 5 groups. Group I--most cats (some 70%) became microfilaraemic (mf+) and retained high levels of microfilariae (mf) in their blood for over 2 years. In some Group I cats mf counts stabilized a...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000063666

    authors: Denham DA,Medeiros F,Baldwin C,Kumar H,Midwinter IC,Birch DW,Smail A

    更新日期:1992-06-01 00:00:00

  • Glomerular disease associated with Polysporoplasma sparis (Myxozoa) infections in cultured gilthead sea bream, Sparus aurata L. (Pisces: Teleostei).

    abstract::Polysporoplasma sparis infection was studied in gilthead sea bream from different mariculture systems of the Spanish coasts. Culture conditions influenced the infection dynamics, as the parasite appeared only in semi-intensive cultures and was not found in intensive closed systems nor in open ones. No clear seasonal p...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182098003758

    authors: Palenzuela O,Alvarez-Pellitero P,Sitjà-Bobadilla A

    更新日期:1999-03-01 00:00:00

  • Heligmosomoides polygyrus (Nematoda): susceptible and resistant strains of mice are indistinguishable following natural infection.

    abstract::BALB/c mice were characterized as more resistant to infection with Heligmosomoides polygyrus (Nematoda) than C57BL/6 mice based on lower establishment and survival during a primary infection and stronger protection induced by an immunizing regime. It was hypothesized, therefore, that C57BL/6 mice would be more heavily...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000059953

    authors: Scott ME

    更新日期:1991-12-01 00:00:00

  • Glasgow encounters with tropical diseases.

    abstract::The period 1875-1925 was remarkable in the history of parasitology mainly for the elucidation of the life cycles of parasites causing important parasitic diseases and the incrimination of vectors in their transmission. These discoveries were made by a small number of scientists working in the tropics a number of whom ...

    journal_title:Parasitology

    pub_type: 社论,历史文章

    doi:10.1017/S0031182017000956

    authors: Cox FEG

    更新日期:2017-10-01 00:00:00

  • The effect of dietary sainfoin ( Onobrychis viciifolia) on local cellular responses to Trichostrongylus colubriformis in sheep.

    abstract::The effect of sainfoin (Onobrychis viciifolia) hay consumption on the pathophysiology and local cellular responses of growing lambs during infection with Trichostrongylus colubriformis was investigated. Thirty-two lambs, 16 weeks of age, were allocated to 1 of 4 treatment groups (n=8) that were offered either grass (G...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182008004563

    authors: Ríos-de Alvarez L,Greer AW,Jackson F,Athanasiadou S,Kyriazakis I,Huntley JF

    更新日期:2008-08-01 00:00:00

  • Individual and combined effects of cadmium and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the humoral immune response in European eel (Anguilla anguilla) experimentally infected with larvae of Anguillicola crassus (Nematoda).

    abstract::The individual and combined effects of cadmium (Cd) and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the antibody response of fish against metazoan parasites were tested. Eels experimentally infected with the swim bladder nematode Anguillicola crassus were exposed to sublethal concentrations of Cd and PCB 126. Cd was ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200300475x

    authors: Sures B,Knopf K

    更新日期:2004-04-01 00:00:00

  • Characterization of the Neospora caninum NcROP40 and NcROP2Fam-1 rhoptry proteins during the tachyzoite lytic cycle.

    abstract::Virulence factors from the ROP2-family have been extensively studied in Toxoplasma gondii, but in the closely related Neospora caninum only NcROP2Fam-1 has been partially characterized to date. NcROP40 is a member of this family and was found to be more abundantly expressed in virulent isolates. Both NcROP2Fam-1 and N...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182015001511

    authors: Pastor-Fernández I,Regidor-Cerrillo J,Jiménez-Ruiz E,Álvarez-García G,Marugán-Hernández V,Hemphill A,Ortega-Mora LM

    更新日期:2016-01-01 00:00:00

  • Electron microscopy of Eimeria acervulina macrogametogony and oocyst wall formation.

    abstract::Macrogametogony and the formation of the oocyst wall has been examined in Eimeria acervulina. Macrogametes develop within a parasitophorous vacuole. Within the cytoplasm can be observed wall-forming bodies of Type I (WFBI) and Type II (WFBII), a nucleus, mitochondria, canaliculi and polysaccharide granules. WFBII are ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000001074

    authors: Pittilo RM,Ball SJ

    更新日期:1984-08-01 00:00:00

  • Philasterides dicentrarchi (Ciliophora:Scuticociliatida) expresses surface immobilization antigens that probably induce protective immune responses in turbot.

    abstract::Philasterides dicentrarchi is a histophagous ciliate causing systemic scuticociliatosis in cultured turbot. This study demonstrates that turbot which survive this disease have serum antibodies that recognize ciliary antigens of this ciliate in ELISA and immobilize/agglutinate the ciliate in vitro. Mouse sera raised ag...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182002002688

    authors: Iglesias R,Paramá A,Alvarez MF,Leiro J,Ubeira FM,Sanmartín ML

    更新日期:2003-02-01 00:00:00

  • Phylogeny of Trypanosoma ( Megatrypanum ) theileri and related trypanosomes reveals lineages of isolates associated with artiodactyl hosts diverging on SSU and ITS ribosomal sequences.

    abstract::SSU ribosomal sequences of trypanosomes from Brazilian cattle and water buffalo were used to infer phylogenetic relationships between non-pathogenic T. theileri and allied species parasitic in artiodactyls. T. theileri trypanosomes from distinct geographical regions in Brazil and from other countries were tightly clus...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182005008929

    authors: Rodrigues AC,Paiva F,Campaner M,Stevens JR,Noyes HA,Teixeira MM

    更新日期:2006-02-01 00:00:00

  • Loss of behavioural dominance in male mice infected with Trichinella spiralis.

    abstract::Trichinella spiralis infections may lead to the loss of behavioural dominance among male mice. Reversals of dominance order first appear at the time when newborn larvae are released into the circulation of the host. The duration of dominance reversals bears no relationship to the number of muscle larvae harboured. ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:

    authors: Rau ME

    更新日期:1984-04-01 00:00:00

  • Investigating the epidemiology of heartwater (Cowdria ruminantium infection) by means of a transmission dynamics model.

    abstract::A mathematical model of the transmission dynamics of Cowdria ruminantium by the ixodid tick Amblyomma hebraeum in the bovine host is developed and used to investigate the epidemiology of heartwater across a range of vector challenge. The processes described are supported by empirical data. The pattern of outcome measu...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182098002790

    authors: O'Callaghan CJ,Medley GF,Peter TF,Perry BD

    更新日期:1998-07-01 00:00:00

  • Molecular characterization of Cystoisospora belli and unizoite tissue cyst in patients with Acquired Immunodeficiency Syndrome.

    abstract::Cystoisospora belli is a coccidian protozoan that can cause chronic diarrhoea, acalculous cholecystitis and cholangiopathy in AIDS patients. We applied molecular methods to identify Cystoisospora at species level in AIDS patients presenting with and without the presence of unizoites in lamina propria. Coprological and...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182010001253

    authors: Velásquez JN,Osvaldo GA,Di Risio C,Etchart C,Chertcoff AV,Perissé GE,Carnevale S

    更新日期:2011-03-01 00:00:00

  • Behaviour and development of Elasmosoma sp. (Neoneurinae: Braconidae: Hymenoptera), an endoparasite of Formica ants (Formicidae: Hymenoptera).

    abstract::The behaviour and development of Elasmosoma sp., near pergandei Ashm. (Neoneurinae: Braconidae: Hymenoptera), a parasite of the ant, Formica obscuriventris clivia Creighton, was studied in a coastal sand dune habitat in central Oregon over a 2-year period. Female wasps oviposited into the abdomen of major worker ants ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182004004809

    authors: Poinar G Jr

    更新日期:2004-05-01 00:00:00

  • Resistance towards monensin is proposed to be acquired in a Toxoplasma gondii model by reduced invasion and egress activities, in addition to increased intracellular replication.

    abstract::Monensin (Mon) is an anticoccidial polyether ionophore widely used to control coccidiosis. The extensive use of polyether ionophores on poultry farms resulted in widespread resistance, but the underlying resistance mechanisms are unknown in detail. For analysing the mode of action by which resistance against polyether...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182017001512

    authors: Thabet A,Schmidt J,Baumann S,Honscha W,VON Bergen M,Daugschies A,Bangoura B

    更新日期:2018-03-01 00:00:00

  • Re-evaluation of the life cycle of Eimeria maxima Tyzzer, 1929 in chickens (Gallus domesticus).

    abstract::A time-course study was conducted to resolve discrepancies in the literature and better define aspects of the Eimeria maxima life cycle such, as sites of development and both morphology and number of asexual stages. Broiler chickens were inoculated orally with five million E. maxima oocysts (APU1), and were necropsied...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182017002153

    authors: Dubey JP,Jenkins MC

    更新日期:2018-07-01 00:00:00

  • Apis mellifera venom induces different cell death pathways in Trypanosoma cruzi.

    abstract::Chagas disease chemotherapy is based on drugs that exhibit toxic effects and have limited efficacy, such as Benznidazole. Therefore, research into new chemotherapeutic agents from natural sources needs to be exploited. Apis mellifera venom consists of many biologically active molecules and has been reported to exhibit...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182012000790

    authors: Adade CM,Chagas GS,Souto-Padrón T

    更新日期:2012-09-01 00:00:00

  • Age, acquired immunity and the risk of visceral leishmaniasis: a prospective study in Iran.

    abstract::In order to investigate the phenomenon of age-related immunity to visceral leishmaniasis, a 1 year prospective survey was carried out on 5671 people in a Leishmania infantum focus in north-west Iran. The average incidence rate of infection since 1985 was 2.8%/year with all ages equally at risk. One in 13 infections in...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182099004680

    authors: Davies CR,Mazloumi Gavgani AS

    更新日期:1999-09-01 00:00:00

  • Characterization of two cDNAs encoding cysteine proteinases from the soybean cyst nematode Heterodera glycines.

    abstract::Two cDNAs encoding cysteine proteinases were isolated from a cDNA library constructed from feeding females of Heterodera glycines. The library was screened with a cysteine proteinase gene fragment originally amplified from cDNA of H. glycines. Database searches predict that 1 cDNA (hgcp-I) encodes a cathepsin L-like p...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:

    authors: Urwin PE,Lilley CJ,McPherson MJ,Atkinson HJ

    更新日期:1997-06-01 00:00:00

  • The recruitment of mast cells, exclusively of the mucosal phenotype, into granulomatous lesions caused by the pentastomid parasite Porocephalus crotali: recruitment is irrespective of site.

    abstract::Adults of the porocephalid pentastomid Porocephalus crotali infect the lung of rattlesnake definitive hosts and larvae develop in rat intermediate hosts. In the latter, nymphs encyst within a variety of tissue sites (commonly abdominal fat bodies and lungs) and each becomes the focus of an eosinophilic granuloma. From...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000074801

    authors: McHardy P,Riley J,Huntley JF

    更新日期:1993-01-01 00:00:00

  • The effect of drugs on the cell cycle of Giardia intestinalis.

    abstract::Flow cytometric analysis of the binucleated protozoan parasite Giardia intestinalis gave DNA histograms with a broad G1 peak and a definable G2 + M peak with twice the DNA content of G1. Twenty-four hour treatment with metronidazole arrested cell cycle progression of susceptible trophozoites in the G2 + M phase, but h...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000059047

    authors: Hoyne GF,Boreham PF,Parsons PG,Ward C,Biggs B

    更新日期:1989-12-01 00:00:00

  • Immunological relationships during primary infection with Heligmosomoides polygyrus: Th2 cytokines and primary response phenotype.

    abstract::The primary immune response to infection with Heligmosomoides polygyrus was studied in mice differing in response phenotype (fast-SWR, intermediate-NIH, slow-CBA). Marked IgG1 and IgE but not IgG2a antibody responses were detected in infected mice and the former were more intense in fast compared with slow responder s...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000076022

    authors: Wahid FN,Behnke JM,Grencis RK,Else KJ,Ben-Smith AW

    更新日期:1994-05-01 00:00:00