Abstract:
:We studied infection dynamics of Plasmodium chabaudi in mice infected with 3 genetically distinct clones--1 less virulent than the other 2--either on their own or in mixtures. During the acute phase of infection, total numbers of asexual parasites in mixed-clone infections were equal to those produced by the 3 clones alone, suggesting strong in-host competition among clones. During the chronic phase of the infection, mixed-clone infections produced more asexual parasites than single-clone infections, suggesting lower levels of competition than during the acute phase, and indicating that a genetically diverse infection is harder to control by the host immune system. Transmission potential over the whole course of infection was lower from mixed-clone infections than from the average of the 3 single-clone infections. These results suggest that in-host competition reduces both growth rate and probability of transmission for individual parasite clones.
journal_name
Parasitologyjournal_title
Parasitologyauthors
De Roode JC,Read AF,Chan BH,Mackinnon MJdoi
10.1017/s0031182003004001subject
Has Abstractpub_date
2003-11-01 00:00:00pages
411-8issue
Pt 5eissn
0031-1820issn
1469-8161journal_volume
127pub_type
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