Abstract:
:An hypothesis is presented to explain the red cell lysis which accompanies an acute malarial infection, as well as the mode of action of certain schizonticidal drugs in the quinoline and acridine series. Quinine and a number of other antimalarial drugs have been found to counteract the inhibition by protein of fatty acid-induced lysis, when tested in an in vitro system. It is suggested that these schizonticides exert their chemotherapeutic effect by inducing the premature lysis of the parasitized red cell, as a result of relieving the inhibition by protein of haemolysis.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Laser H,Kemp P,Miller N,Lander D,Klein Rdoi
10.1017/s003118200004662xsubject
Has Abstractpub_date
1975-10-01 00:00:00pages
167-81issue
2eissn
0031-1820issn
1469-8161journal_volume
71pub_type
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