Malaria, quinine and red cell lysis.

Abstract:

:An hypothesis is presented to explain the red cell lysis which accompanies an acute malarial infection, as well as the mode of action of certain schizonticidal drugs in the quinoline and acridine series. Quinine and a number of other antimalarial drugs have been found to counteract the inhibition by protein of fatty acid-induced lysis, when tested in an in vitro system. It is suggested that these schizonticides exert their chemotherapeutic effect by inducing the premature lysis of the parasitized red cell, as a result of relieving the inhibition by protein of haemolysis.

journal_name

Parasitology

journal_title

Parasitology

authors

Laser H,Kemp P,Miller N,Lander D,Klein R

doi

10.1017/s003118200004662x

subject

Has Abstract

pub_date

1975-10-01 00:00:00

pages

167-81

issue

2

eissn

0031-1820

issn

1469-8161

journal_volume

71

pub_type

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