Malarial parasites and antioxidant nutrients.

Abstract:

:Susceptibility to oxidative stress is a well-established feature of the malarial parasite. Pharmacologists have taken advantage of this property to design highly effective pro-oxidant antimalarial drugs. Less well appreciated is the fact that nutritional manipulation of host oxidative stress status by dietary means can have a profound effect on the growth of the parasite. In particular, rapid induction of vitamin E deficiency in mice by feeding highly unsaturated fatty acids (fish oil) strongly suppresses plasmodial growth. Likewise, the status of other antioxidant nutrients (e.g., riboflavin or vitamin C) may also influence the course of malarial infection under certain conditions. A combined nutritional pharmacology approach may offer some promise in controlling malaria.

journal_name

Parasitology

journal_title

Parasitology

authors

Levander OA,Ager AL Jr

doi

10.1017/s0031182000075533

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

S95-106

eissn

0031-1820

issn

1469-8161

journal_volume

107 Suppl

pub_type

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