Abstract:
:Susceptibility to oxidative stress is a well-established feature of the malarial parasite. Pharmacologists have taken advantage of this property to design highly effective pro-oxidant antimalarial drugs. Less well appreciated is the fact that nutritional manipulation of host oxidative stress status by dietary means can have a profound effect on the growth of the parasite. In particular, rapid induction of vitamin E deficiency in mice by feeding highly unsaturated fatty acids (fish oil) strongly suppresses plasmodial growth. Likewise, the status of other antioxidant nutrients (e.g., riboflavin or vitamin C) may also influence the course of malarial infection under certain conditions. A combined nutritional pharmacology approach may offer some promise in controlling malaria.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Levander OA,Ager AL Jrdoi
10.1017/s0031182000075533subject
Has Abstractpub_date
1993-01-01 00:00:00pages
S95-106eissn
0031-1820issn
1469-8161journal_volume
107 Supplpub_type
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