Glucose transport in Acanthocheilonema viteae.

Abstract:

:The uptake of glucose by Acanthocheilonema viteae was studied in vitro. The process was selective for the D-isomer and saturatable with a Km of 2 mM. The rate of glucose transport/utilization was inhibited by 2-deoxyglucose, mannose, 5-thioglucose and dipyridamole but, unlike mammalian systems, was not impaired by cytochalasin B, phloretin, phloridzin, 3-O-methylglucose and 4,6-ethylideneglucose. A potential chemotherapeutic advantage of selectively inhibiting filarial glucose transport exists for the following reasons. (1) The glucose transporter present in A. viteae was shown to be different from the one present in some mammalian systems. (2) Incubation under glucose-free conditions led to glycogen depletion, loss of motility and worm death. (3) Worms maintained in vitro for more than 18 h without glucose did not survive when implanted into gerbils.

journal_name

Parasitology

journal_title

Parasitology

authors

Hayes DJ,Selwood DL

doi

10.1017/s0031182000063307

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

249-55

eissn

0031-1820

issn

1469-8161

journal_volume

101 Pt 2

pub_type

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