Abstract:
:The dynamic interaction of cells of the immune system with other cells, antigens and secreted factors determines the nature of an immune response. The response of individual cells is governed by the sequence of intracellular signalling events triggered following the association of cell surface molecules during cell-cell contact or the detection of soluble molecules of host or pathogen origin. In this review we will first outline the general principles of intracellular signal transduction. We will then describe the signalling pathways triggered following the recognition of antigen, as well as the detection of cytokines, and discuss how the signalling pathways activated regulate the effector response.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Goodridge HS,Harnett MMdoi
10.1017/S0031182005008115subject
Has Abstractpub_date
2005-01-01 00:00:00pages
S3-9eissn
0031-1820issn
1469-8161pii
S0031182005008115journal_volume
130 Supplpub_type
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