Small RNAs in parasitic nematodes - forms and functions.

Abstract:

:Small RNAs are important regulators of gene expression. They were first identified in Caenorhabditis elegans, but it is now apparent that the main small RNA silencing pathways are functionally conserved across diverse organisms. Availability of genome data for an increasing number of parasitic nematodes has enabled bioinformatic identification of small RNA sequences. Expression of these in different lifecycle stages is revealed by small RNA sequencing and microarray analysis. In this review we describe what is known of the three main small RNA classes in parasitic nematodes - microRNAs (miRNAs), Piwi-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) - and their proposed functions. miRNAs regulate development in C. elegans and the temporal expression of parasitic nematode miRNAs suggest modulation of target gene levels as parasites develop within the host. miRNAs are also present in extracellular vesicles released by nematodes in vitro, and in plasma from infected hosts, suggesting potential regulation of host gene expression. Roles of piRNAs and siRNAs in suppressing target genes, including transposable elements, are also reviewed. Recent successes in RNAi-mediated gene silencing, and application of small RNA inhibitors and mimics will continue to advance understanding of small RNA functions within the parasite and at the host-parasite interface.

journal_name

Parasitology

journal_title

Parasitology

authors

Britton C,Laing R,Devaney E

doi

10.1017/S0031182019001689

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

855-864

issue

8

eissn

0031-1820

issn

1469-8161

pii

S0031182019001689

journal_volume

147

pub_type

杂志文章
  • Trophic relationship between the invasive parasitic copepod Mytilicola orientalis and its native blue mussel (Mytilus edulis) host.

    abstract::Invasive parasites can spill over to new hosts in invaded ecosystems with often unpredictable trophic relationships in the newly arising parasite-host interactions. In European seas, the intestinal copepod Mytilicola orientalis was co-introduced with Pacific oysters (Magallana gigas) and spilled over to native blue mu...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182017001779

    authors: Goedknegt MA,Shoesmith D,Jung AS,Luttikhuizen PC,van der Meer J,Philippart CJM,van der Veer HW,Thieltges DW

    更新日期:2018-05-01 00:00:00

  • Genetic control of immune responses to parasites: immunity to Trichuris muris in inbred and random-bred strains of mice.

    abstract::A comparison has been made of the responses of random-bred CFLP and inbred NIH mice to infection with Trichuris muris. Random-bred mice showed greater variation in worm burdens and less uniformity in worm expulsion. Irradiation prior to infection reduced variation, but did not increase the mean level of infection abov...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000053142

    authors: Wakelin D

    更新日期:1975-08-01 00:00:00

  • CYP51 as drug targets for fungi and protozoan parasites: past, present and future.

    abstract::The efficiency of treatment of human infections with the unicellular eukaryotic pathogens such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates from nosocomial fungemia in critically ill, immunosuppressed or post-cancer patients often exceed 50%. A set of six systemic clinical azol...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182018000562

    authors: Lepesheva GI,Friggeri L,Waterman MR

    更新日期:2018-12-01 00:00:00

  • Evidence that primary infection of Charollais sheep with Toxoplasma gondii may not prevent foetal infection and abortion in subsequent lambings.

    abstract::A study carried out on a sheep farm examined whether Toxoplasma gondii foetal infection and associated abortion occur in successive lambings. We identified 29 ewes that gave birth to lambs on at least 2 successive years over our study period, 2000-2003. Tissue samples from the progeny of these ewes were analysed by PC...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182007003721

    authors: Morley EK,Williams RH,Hughes JM,Thomasson D,Terry RS,Duncanson P,Smith JE,Hide G

    更新日期:2008-02-01 00:00:00

  • Diversity and distribution of Blastocystis sp. subtypes in non-human primates.

    abstract::Blastocystis SSU-rDNA sequence data from 317 captive and free-living non-human primates (NHPs) representing 30 genera of apes, Old and New World (OW and NW) monkeys and prosimians were analysed to investigate subtype (ST) and allele distribution among hosts. Excluding 20 mixed ST infections, 27% of the sequences belon...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182013000255

    authors: Alfellani MA,Jacob AS,Perea NO,Krecek RC,Taner-Mulla D,Verweij JJ,Levecke B,Tannich E,Clark CG,Stensvold CR

    更新日期:2013-07-01 00:00:00

  • A panel of antigens of muscle larvae of Trichinella spiralis and T. pseudospiralis as revealed by two-dimensional western blot and immunoelectron microscopy.

    abstract::This study characterized antigens of Trichinella spiralis and T. pseudospiralis muscle larvae recognized by mice infected with the worms. Two-dimensional (2-D) Western blot analysis revealed some profile of antigenic peptides including: (1) molecular weight (MW); (2) isoelectric points (pI), (3) reactivity to well-def...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182099004187

    authors: Wu Z,Nagano I,Takahashi Y

    更新日期:1999-06-01 00:00:00

  • In vitro isolation of Plasmodium knowlesi merozoites using polycarbonate sieves.

    abstract::A culture chamber fitted with a polycarbonate sieve has been used to isolate Plasmodium knowlesi merozoites as they are released from schizonts. A 3 mum pore-size sieve allows passage of normal erythrocytes and red cells containing rings and trophozoites and can be used to concentrate schizonts from a mixed cell popul...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000047235

    authors: Dennis ED,Mitchell GH,Butcher GA,Cohen S

    更新日期:1975-12-01 00:00:00

  • Natural Lyme disease cycles maintained via sheep by co-feeding ticks.

    abstract::We present observational and experimental evidence that cycles of the Lyme disease spirochaete, Borrelia burgdorferi s.l., can be maintained by sheep in the virtual absence of alternative hosts. A 2-year field study in upland moorland habitats of northwest UK established that sheep feed up to 80% of larval, > 99% of n...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182097001868

    authors: Ogden NH,Nuttall PA,Randolph SE

    更新日期:1997-12-01 00:00:00

  • Leg structure explains host site preference in bat flies (Diptera: Streblidae) parasitizing neotropical bats (Chiroptera: Phyllostomidae).

    abstract::Bat flies (Streblidae) are diverse, obligate blood-feeding insects and probably the most conspicuous ectoparasites of bats. They show preferences for specific body regions on their host bat, which are reflected in behavioural characteristics. In this study, we corroborate the categorization of bat flies into three eco...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182018000318

    authors: Hiller T,Honner B,Page RA,Tschapka M

    更新日期:2018-09-01 00:00:00

  • Distinctive histopathology and modulation of cytokine production during oral and intraperitoneal Trypanosoma cruzi Y strain infection.

    abstract::Acute Chagas disease outbreaks are related to the consumption of food or drink contaminated by triatomine feces, thus making oral infection an important route of transmission. Both vector-borne and oral infections trigger important cardiac manifestations in the host that are related to a dysregulated immune response. ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182013002059

    authors: Kuehn CC,Oliveira LG,Miranda MA,Prado JC

    更新日期:2014-06-01 00:00:00

  • Allosteric control of pyrimidine transport in Hymenolepis diminuta: an unusual kinetic isotope effect.

    abstract::A thymine-uracil transport system is present in the plasma membrane brush-border of the tapeworm, Hymenolepis diminuta. The relation between initial uptake and substrate concentration of either thymine or uracil was sigmoidal when 2-14C-labelled substrates were used. In contrast, absorption kinetics of methyl-14C- and...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000052641

    authors: Uglem GL,Dupre RK,Harley JP

    更新日期:1983-10-01 00:00:00

  • Magnetic resonance imaging in dogs with neuroangiostrongyliasis (rat lungworm disease).

    abstract::The magnetic resonance imaging (MRI) appearance of the brain and spinal cord in humans with neuroangiostrongyliasis (NA) due to Angiostrongylus cantonensis infection has been well reported. Equivalent studies in animals are lacking. This case series describes clinical and MRI findings in 11 dogs with presumptively or ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182020001742

    authors: Wun MK,Malik R,Yu J,Chow KE,Lau M,Podadera JM,Webster N,Lee R,Šlapeta J,Davies S

    更新日期:2020-09-21 00:00:00

  • Estimating phylogenetic relationships despite discordant gene trees across loci: the species tree of a diverse species group of feather mites (Acari: Proctophyllodidae).

    abstract::With the increased availability of multilocus sequence data, the lack of concordance of gene trees estimated for independent loci has focused attention on both the biological processes producing the discord and the methodologies used to estimate phylogenetic relationships. What has emerged is a suite of new analytical...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S003118201100031X

    authors: Knowles LL,Klimov PB

    更新日期:2011-11-01 00:00:00

  • Unusual cryptosporidiosis cases in Swedish patients: extended molecular characterization of Cryptosporidium viatorum and Cryptosporidium chipmunk genotype I.

    abstract::Most human cases of cryptosporidiosis are caused by Cryptosporidium parvum or Cryptosporidium hominis, but the use of molecular diagnostic methods has revealed that several other less common species or genotypes can also be involved. Here, we describe two unusual causes of cryptosporidiosis, one being the recently des...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S003118201300084X

    authors: Lebbad M,Beser J,Insulander M,Karlsson L,Mattsson JG,Svenungsson B,Axén C

    更新日期:2013-12-01 00:00:00

  • The virus infecting the parasitoid Leptopilina boulardi exerts a specific action on superparasitism behaviour.

    abstract::Parasites often induce behavioural changes in their host. However, it is not necessarily easy to determine whether these changes are representative of an adaptation of the parasite (parasite manipulation), an adaptive response of the host or a side-effect of infection. In a solitary parasitoid of Drosophila larvae (Le...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182006009930

    authors: Varaldi J,Petit S,Boulétreau M,Fleury F

    更新日期:2006-06-01 00:00:00

  • Cytochemical studies on nuclear DNA of four eucoccidian parasites, Isospora (Toxoplasma) gondii, Eimeria tenella, Sarcocystis cruzi and Plasmodium berghei.

    abstract::Feulgen-pararosaniline (SO2) staining was performed on stages in the life-cycle of Isospora (Toxoplasma) gondii, Eimeria tenella, Sarcocystis cruzi and Plasmodium berghei. The fluorescence emission of the stained DNA in nuclei of these stages was examined and compared with absorption microscopy measurements at 560 nm ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000054305

    authors: Cornelissen AW,Overdulve JP,Van der Ploeg M

    更新日期:1984-02-01 00:00:00

  • Transcriptome analysis during the process of in vitro differentiation of Leishmania donovani using genomic microarrays.

    abstract::Leishmania donovani causes visceral disease (kala-azar), a major health problem throughout the tropics with 500 000 new cases every year. Leishmania differentiates from the promastigote to the amastigote form to establish infection in a mammalian host. To understand the process of differentiation, we assessed the glob...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S003118200700296X

    authors: Srividya G,Duncan R,Sharma P,Raju BV,Nakhasi HL,Salotra P

    更新日期:2007-10-01 00:00:00

  • Can Wolbachia modulate the fecundity costs of Plasmodium in mosquitoes?

    abstract::Vertically transmitted parasites (VTPs) such as Wolbachia are expected not only to minimize the damage they inflict on their hosts, but also to protect their hosts against the damaging effects of coinfecting parasites. By modifying the fitness costs of the infection, VTPs can therefore play an important role in the ev...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182017001330

    authors: Zélé F,Denoyelle J,Duron O,Rivero A

    更新日期:2018-05-01 00:00:00

  • Solo Schistocephalus solidus tapeworms are nasty.

    abstract::Trophically transmitted parasites must trade-off own growth on one hand and energy drain from the intermediate host on the other hand, since killing the host before transmission to the next host is a dead end for both parasites and hosts. This challenge becomes especially intriguing when multiple parasites find themse...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182016000676

    authors: Nordeide JT,Matos F

    更新日期:2016-09-01 00:00:00

  • Glucose-restriction increases Trichomonas vaginalis cellular damage towards HeLa cells and proteolytic activity of cysteine proteinases (CPs), such as TvCP2.

    abstract::Trichomonas vaginalis induces cellular damage to the host cells (cytotoxicity) through the proteolytic activity of multiple proteinases of the cysteine type (CPs). Some CPs are modulated by environmental factors such as iron, zinc, polyamines, etc. Thus, the goal of this study was to assess the effect of glucose on T....

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182019000209

    authors: Miranda-Ozuna JFT,Rivera-Rivas LA,Cárdenas-Guerra RE,Hernández-García MS,Rodríguez-Cruz S,González-Robles A,Chavez-Munguía B,Arroyo R

    更新日期:2019-08-01 00:00:00

  • Aggravation of pathogenesis mediated by ochratoxin A in mice infected with Trypanosoma brucei rhodesiense.

    abstract::Mice fed 1.5 mg ochratoxin A (OTA) per kg body weight and infected with Trypanosoma brucei rhodesiense were compared with trypanosome-infected placebo-fed and uninfected OTA-fed controls. Uninfected OTA-fed mice showed fever, lethargy, facial and eyelid oedemas, mild hepatitis and nephritis, and high survival. Infecte...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182008005386

    authors: Kibugu JK,Ngeranwa JJ,Makumi JN,Gathumbi JK,Kagira JM,Mwangi JN,Muchiri MW,Mdachi RE

    更新日期:2009-03-01 00:00:00

  • The formation of surface membrane vesicles from schistosomula of Schistosoma mansoni.

    abstract::Intact surface membrane vesicles were obtained and purified from the schistosomula of Schistosoma mansoni. The method of preparation of the vesicles involved treating the schistosomula in a buffered high salt medium for 1 h at 4 degrees C (Step 1), and then for 1 h at 25-37 degrees C (Step 2). Vesicles were formed fro...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000056717

    authors: Kusel JR,Gazzinelli G,Colley DG,de Souza CP,Cordeiro MN

    更新日期:1984-12-01 00:00:00

  • Impact of number of isoenzyme loci on the robustness of intraspecific phylogenies using multilocus enzyme electrophoresis: consequences for typing of Trypanosoma cruzi.

    abstract::Thirty-one stocks of Trypanosoma cruzi, the agent of Chagas disease, representative of the genetic variability of the 2 principal lineages, that subdivide T. cruzi, were selected on the basis of previous multilocus enzyme electrophoresis analysis using 21 loci. Analyses were performed with lower numbers of loci to exp...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182003003573

    authors: Breniere SF,Barnabe C,Bosseno MF,Tibayrenc M

    更新日期:2003-09-01 00:00:00

  • Comparative recruitment, morphology and reproduction of a generalist trematode, Dicrocoelium dendriticum, in three species of host.

    abstract::Epidemiological rate parameters of host generalist parasites are difficult to estimate, especially in cases where variation in parasite performance can be attributed to host species. Such cases are likely common for generalist parasites of sympatric grazing mammals. In this study, we combined data from experimental ex...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182015000621

    authors: Beck MA,Goater CP,Colwell DD

    更新日期:2015-09-01 00:00:00

  • Quantitative modelling and prediction of development times of the free-living stages of Ostertagia ostertagi under controlled and field conditions.

    abstract::The development of the free-living stages of Ostertagia ostertagi incubated at constant temperatures from 5 to 27 degrees C and in dung pats in the field was observed. The death rates were adequately described by a single exponential functional and the distribution of times for development by a delayed gamma density f...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000061886

    authors: Young RR,Nicholson RM,Tweedie RL,Schuh HJ

    更新日期:1980-12-01 00:00:00

  • Induction of the prophenoloxidase-activating system of Simulium (Diptera: Simuliidae) following Onchocerca (Nematoda: Filarioidea) infection.

    abstract::Trials were carried out to study the humoral immune response of blackflies to filariae following infection using the intrathoracic injection technique. An induced 66 kDa protein was abundant in the haemolymph of the European species Simulium ornatum following infection with bovine Onchocerca lienalis. This protein was...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000076538

    authors: Hagen HE,Grunewald J,Ham PJ

    更新日期:1994-12-01 00:00:00

  • Widespread infection of the Eastern red-spotted newt (Notophthalmus viridescens) by a new species of Amphibiocystidium, a genus of fungus-like mesomycetozoan parasites not previously reported in North America.

    abstract::Given the worldwide decline of amphibian populations due to emerging infectious diseases, it is imperative that we identify and address the causative agents. Many of the pathogens recently implicated in amphibian mortality and morbidity have been fungal or members of a poorly understood group of fungus-like protists, ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182007003708

    authors: Raffel TR,Bommarito T,Barry DS,Witiak SM,Shackelton LA

    更新日期:2008-02-01 00:00:00

  • Identification of a Nosema bombycis (Microsporidia) spore wall protein corresponding to spore phagocytosis.

    abstract::Life-cycle stages of the microsporidia Nosema bombycis, the pathogen causing silkworm pebrine, were separated and purified by an improved method of Percoll-gradient centrifugation. Soluble protein fractions of late sporoblasts (spore precursor cells) and mature spores were analysed by two-dimensional polyacrylamide ge...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182011000801

    authors: Cai S,Lu X,Qiu H,Li M,Feng Z

    更新日期:2011-08-01 00:00:00

  • Pathophysiology of parasitic infections.

    abstract::Parasites can have a wide range of pathophysiological effects on the host. This review describes those associated with some parasites of major importance in man and animals. Haemoprotozoan diseases such as trypanosomiasis and malaria are primarily associated with anaemia. Such anaemias have a complex aetiology involvi...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182000085814

    authors: Holmes PH

    更新日期:1987-01-01 00:00:00

  • Changes in adenosine transport associated with melaminophenyl arsenical (Mel CY) resistance in Trypanosoma evansi: down-regulation and affinity changes of the P2 transporter.

    abstract::Studies of the kinetics of adenosine transport were carried out on the P1 and P2 transporters of drug-sensitive Trypanosoma evansi and its cloned derivative, resistant to the melaminophenyl arsenical Mel CY. Characterization of adenosine uptake was made by estimation of the maximum concentration taken up at time infin...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200300413x

    authors: Suswam EA,Ross CA,Martin RJ

    更新日期:2003-12-01 00:00:00