Pathophysiology of parasitic infections.

Abstract:

:Parasites can have a wide range of pathophysiological effects on the host. This review describes those associated with some parasites of major importance in man and animals. Haemoprotozoan diseases such as trypanosomiasis and malaria are primarily associated with anaemia. Such anaemias have a complex aetiology involving various mechanisms responsible for red cell destruction as well as possible defects in red cell production. In addition to these haematological effects these diseases are associated with marked disturbances in heart function and the nervous, immune and urinary systems. The other major groups of parasitic diseases are those associated with the gastrointestinal tract. The most advanced studies have been conducted on the pathophysiology of gastrointestinal nematode parasites of sheep and have revealed significant effects on feed intake, gastrointestinal function, and protein and energy metabolism. Similar studies have yet to be conducted in other hosts and parasitic diseases. There is also a need to examine in greater detail the factors which can modulate pathophysiological responses by the host to parasitic infections.

journal_name

Parasitology

journal_title

Parasitology

authors

Holmes PH

doi

10.1017/s0031182000085814

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

S29-51

eissn

0031-1820

issn

1469-8161

journal_volume

94 Suppl

pub_type

杂志文章,评审
  • Aggravation of pathogenesis mediated by ochratoxin A in mice infected with Trypanosoma brucei rhodesiense.

    abstract::Mice fed 1.5 mg ochratoxin A (OTA) per kg body weight and infected with Trypanosoma brucei rhodesiense were compared with trypanosome-infected placebo-fed and uninfected OTA-fed controls. Uninfected OTA-fed mice showed fever, lethargy, facial and eyelid oedemas, mild hepatitis and nephritis, and high survival. Infecte...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182008005386

    authors: Kibugu JK,Ngeranwa JJ,Makumi JN,Gathumbi JK,Kagira JM,Mwangi JN,Muchiri MW,Mdachi RE

    更新日期:2009-03-01 00:00:00

  • Immunocytochemical demonstration of neuropeptides in the nervous system of the liver fluke, Fasciola hepatica (Trematoda, Digenea).

    abstract::The localization and distribution of neuropeptides in the nervous system of the liver fluke, Fasciola hepatica at different stages in the development of the adult fluke have been determined by an indirect immunofluorescence technique, using antisera to 19 vertebrate peptides and the invertebrate neuropeptide, FMRFamid...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000062132

    authors: Magee RM,Fairweather I,Johnston CF,Halton DW,Shaw C

    更新日期:1989-04-01 00:00:00

  • Mice infected with the larvae of Taenia crassiceps exhibit a Th2-like immune response with concomitant anergy and downregulation of Th1-associated phenomena.

    abstract::Infection of intermediate hosts with eggs of taeniid parasites results in a larval infestation known as cysticercosis. A number of studies have indicated that cysticercosis is associated with immunosuppression, although little is known about the mechanisms involved. In the present study, mice infected with the larvae ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000066142

    authors: Villa OF,Kuhn RE

    更新日期:1996-06-01 00:00:00

  • Anthelmintic activity of plants against gastrointestinal nematodes of goats: a review.

    abstract::The gastrointestinal nematodes (GIN) stand out as an important cause of disease in small ruminant, especially on goat farm. Widespread resistance to synthetic anthelminthics has stimulated the research for alternative strategies of parasite control, including the use of medicinal plants. The present work summarizes th...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182019000672

    authors: Oliveira Santos F,Ponce Morais Cerqueira A,Branco A,José Moreira Batatinha M,Borges Botura M

    更新日期:2019-09-01 00:00:00

  • A genetic investigation of virulence in a rodent malaria parasite.

    abstract::The genetic basis of virulence in a line (YM) of Plasmodium yoelii yoelii was investigated in a cross with a mild line (A/C). The blood forms of the virulent line developed extensively in mature erythrocytes of mice, causing death of the host within 7 days; infections with the mild line were normally restricted to ret...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000048484

    authors: Walliker D,Sanderson A,Yoeli M,Hargreaves BJ

    更新日期:1976-04-01 00:00:00

  • Alpha 2 giardin is an assemblage A-specific protein of human infective Giardia duodenalis.

    abstract::Of the 7 genetic assemblages of the parasite Giardia duodenalis only 2 (A and B) are known to cause infections in humans. These assemblages have been characterized in detail at the genomic level but few studies have examined differences in the proteins expressed. Employing one and two-dimensional PAGE we have identifi...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182008004988

    authors: Steuart RF,O'Handley R,Lipscombe RJ,Lock RA,Thompson RC

    更新日期:2008-12-01 00:00:00

  • Mechanisms underlying reduced expulsion of a murine nematode infection during protein deficiency.

    abstract::Balb/c mice infected with the gastrointestinal nematode Heligmosomoides bakeri were fed protein sufficient (PS, 24%) or deficient (PD, 3%) diets to investigate whether diet, infection or dose of larval challenge (0, 100 or 200 larvae) influenced gut pathophysiology and inflammation. Among the PS mice, worms were more ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182007003617

    authors: Tu T,Koski KG,Scott ME

    更新日期:2008-01-01 00:00:00

  • Modelling the influence of host community composition in a sylvatic Trypanosoma cruzi system.

    abstract::Species composition of wild reservoir hosts can influence the transmission and maintenance of multi-host vector borne pathogens. The 'pace of life' hypothesis proposes that the life history strategy of reservoir hosts can influence pathogen transmission of vector borne generalist pathogens. We use empirical data to pa...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182017001287

    authors: Erazo D,Cordovez J,Cabrera C,Calzada JE,Saldaña A,Gottdenker NL

    更新日期:2017-12-01 00:00:00

  • Apparent tolerance of Plasmodium falciparum in infants in a highly endemic area.

    abstract::The incidence of fever among infants in the village of Idete in the Morogoro region of Tanzania was analyzed in relation to densities of Plasmodium falciparum parasites in the peripheral blood. Parasite densities in both fever cases and in asymptomatic infants, were compared and a Bayesian non-parametric mixture decom...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182099005211

    authors: Vounatsou P,Smith T,Kitua AY,Alonso PL,Tanner M

    更新日期:2000-01-01 00:00:00

  • Phylogenetic relationships of the family Campulidae (Trematoda) based on 18S rRNA sequences.

    abstract::Traditionally, the family Campulidae has been associated either with the family Fasciolidae, parasites of ruminants, or the Acanthocolpidae, parasites of fishes, based on morphological similarities. Since morphology does not seem to resolve clearly the problem of the relationships of campulids, we have used the sequen...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182098003126

    authors: Fernandez M,Littlewood DT,Latorre A,Raga JA,Rollinson D

    更新日期:1998-10-01 00:00:00

  • Eimeria tenella in chickens: development of resistance to quinolone anticoccidial drugs.

    abstract::The development of drug resistance by the present Houghton strain of Eimeria tenella to the quinolones, methyl benzoquate and buquinolate, was found to take place after a single experimental passage. The development of resistance was independent of drug selection pressure and showed cross resistance to other quinolone...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000053130

    authors: Chapman HD

    更新日期:1975-08-01 00:00:00

  • Bartonella species in bat flies (Diptera: Nycteribiidae) from western Africa.

    abstract::Bat flies are obligate ectoparasites of bats and it has been hypothesized that they may be involved in the transmission of Bartonella species between bats. A survey was conducted to identify whether Cyclopodia greefi greefi (Diptera: Nycteribiidae) collected from Ghana and 2 islands in the Gulf of Guinea harbour Barto...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182011002113

    authors: Billeter SA,Hayman DT,Peel AJ,Baker K,Wood JL,Cunningham A,Suu-Ire R,Dittmar K,Kosoy MY

    更新日期:2012-03-01 00:00:00

  • Comparative recruitment, morphology and reproduction of a generalist trematode, Dicrocoelium dendriticum, in three species of host.

    abstract::Epidemiological rate parameters of host generalist parasites are difficult to estimate, especially in cases where variation in parasite performance can be attributed to host species. Such cases are likely common for generalist parasites of sympatric grazing mammals. In this study, we combined data from experimental ex...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182015000621

    authors: Beck MA,Goater CP,Colwell DD

    更新日期:2015-09-01 00:00:00

  • Malaria--a neglected disease?

    abstract::In situations where malaria eradication is not an option in the foreseeable future the emphasis must be on the control of morbidity and mortality due to malaria. Under such circumstances drawing a distinction between malarial parasitization and malarial disease may be important for workers in both field and laboratory...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182000075247

    authors: Marsh K

    更新日期:1992-01-01 00:00:00

  • Classical transmitters and their receptors in flatworms.

    abstract::The flatworm nervous system employs a wide repertoire of neuroactive substances, including small chemical messengers, the so called classical transmitters, and several types of neuropeptides. A large body of research accumulated over four decades has provided a wealth of information on the tissue localization and effe...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182005008565

    authors: Ribeiro P,El-Shehabi F,Patocka N

    更新日期:2005-01-01 00:00:00

  • Optimization of the in vitro feeding of Rhipicephalus appendiculatus nymphae for the transmission of Theileria parva.

    abstract::An apparatus for artificial feeding of Rhipicephalus appendiculatus nymphae was modified to improve feeding performance. Heparinized blood was supplied above a treated artificial membrane while the ticks attached below on its undersurface. The feeding apparatus was incubated at 37 degrees C in an atmosphere of 3% CO2 ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000065963

    authors: Waladde SM,Young AS,Mwaura SN,Njihia GN,Mwakima FN

    更新日期:1995-11-01 00:00:00

  • Phylogeny of snake trypanosomes inferred by SSU rDNA sequences, their possible transmission by phlebotomines, and taxonomic appraisal by molecular, cross-infection and morphological analysis.

    abstract::Blood examination by microhaematocrit and haemoculture of 459 snakes belonging to 37 species revealed 2.4% trypanosome prevalence in species of Viperidae (Crotalus durissus and Bothrops jararaca) and Colubridae (Pseudoboa nigra). Trypanosome cultures from C. durissus and P. nigra were behaviourally and morphologically...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182008004253

    authors: Viola LB,Campaner M,Takata CS,Ferreira RC,Rodrigues AC,Freitas RA,Duarte MR,Grego KF,Barrett TV,Camargo EP,Teixeira MM

    更新日期:2008-04-01 00:00:00

  • Comparative analysis of ITS1 nucleotide sequence reveals distinct genetic difference between Brugia malayi from Northeast Borneo and Thailand.

    abstract::Brugia malayi is one of the parasitic worms which causes lymphatic filariasis in humans. Its geographical distribution includes a large part of Asia. Despite its wide distribution, very little is known about the genetic variation and molecular epidemiology of this species. In this study, the internal transcribed space...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182012001242

    authors: Fong MY,Noordin R,Lau YL,Cheong FW,Yunus MH,Idris ZM

    更新日期:2013-01-01 00:00:00

  • Parasite-host relationships during the development of Eimeria dispersa Tyzzer 1929, in the turkey (Meleagris gallopavo gallopavo) with a description of intestinal intra-epithelial leucocytes.

    abstract::An electron microscopical study was made on the development of Eimeria dispersa in the small intestine of the domestic turkey. Turkey poults, 10-14 days of age, were inoculated with oocysts and pieces of intestinal tissue were fixed at intervals between 3.5 and 114 h after inoculation. Sporozoites were occasionally se...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000051611

    authors: Millard BJ,Lawn AM

    更新日期:1982-02-01 00:00:00

  • Axenic cultivation and partial characterization of Leishmania braziliensis amastigote-like stages.

    abstract::Leishmania braziliensis strain M2903 was adapted for growth and serially maintained as amastigotes at 34 degrees C in modified UM-54 medium, with growth curves exhibiting typical log and stationary phases. In late passages, amastigote growth took place in the absence of supplementary haemin and was unaffected when the...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118209700214x

    authors: Balanco JM,Pral EM,da Silva S,Bijovsky AT,Mortara RA,Alfieri SC

    更新日期:1998-02-01 00:00:00

  • Changes in the zymogenic cell populations of the abomasa of sheep infected with Haemonchus contortus.

    abstract::The effects of dietary urea supplementation and of a 10-week trickle infection regime, simulating chronic exposure to Haemonchus contortus, on the zymogenic population of the abomasa of Hampshire Down lambs was examined. At necropsy a variety of parameters including plasma pepsinogen concentration, the wet weights of ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182098002704

    authors: Scott I,Stear MJ,Irvine J,Dick A,Wallace DS,McKellar QA

    更新日期:1998-06-01 00:00:00

  • Depletion of the ozone layer: consequences for non-infectious human diseases.

    abstract::Stratospheric ozone depletion threatens to increase exposure to ultraviolet (UV) radiation which is known to be a factor in a number of diseases. There is little doubt that cumulative exposure to UV radiation is important in the aetiology of non-melanoma skin cancers. Evidence is also strong for a link with cutaneous ...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182000086108

    authors: Bentham G

    更新日期:1993-01-01 00:00:00

  • A comparative analysis of various developmental stages of Schistosoma mansoni with respect to their protein composition.

    abstract::The protein composition of Schistosoma mansoni was analysed by electrophoresis in polyacrylamide slab gel in the presence of sodium dodecyl sulphate. A high degree of identity existed between protein patterns obtain from immature and adult parasites of the two sexes. Some stage-and sex-specific components were indenti...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200005188x

    authors: Ruppel A,Cioli D

    更新日期:1977-12-01 00:00:00

  • Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines.

    abstract::The extent of sequence diversity among the genes encoding 10 antigens (Tp1-10) known to be recognized by CD8+ T lymphocytes from cattle immune to Theileria parva was analysed. The sequences were derived from parasites in 23 buffalo-derived cell lines, three cattle-derived isolates and one cloned cell line obtained fro...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182018000264

    authors: Sitt T,Pelle R,Chepkwony M,Morrison WI,Toye P

    更新日期:2018-09-01 00:00:00

  • Four new species of KudoaMeglitsch, 1947 (Myxosporea: Multivalvulida) from Australia with recommendations for species descriptions in the Kudoidae.

    abstract::Kudoid parasites are significant pathogens of marine fish. In the past, specific identification has been difficult due to a paucity of detailed morphological and biological information provided in the original description of some species. However, the introduction of DNA analysis has dramatically improved diagnosis. F...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182009991557

    authors: Burger MA,Adlard RD

    更新日期:2010-04-01 00:00:00

  • Quantitative characterization, classification and reconstruction of oocyst shapes of Eimeria species from cattle.

    abstract::This study reports on morphological variability of Eimeria species, which may be given either by drawings or as quantitative data. The drawings may be used to facilitate identification by eye of 'unknown' Eimeria specimens, whereas quantitative data may serve as a reference set for identification by multivariate stati...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118209700187x

    authors: Sommer C

    更新日期:1998-01-01 00:00:00

  • Schistosoma mansoni: changes in elemental composition in relation to the age and sexual status of the worms.

    abstract::Changes during development in the elemental contents (Ca, P, K, Mg and S) of male and female Schistosoma mansoni from both mixed and single sex infections have been measured for the first time. In mixed infections, there is a significant difference between the calcium content of male and female worms; female worms hav...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000050630

    authors: Shaw MK,Erasmus DA

    更新日期:1983-06-01 00:00:00

  • Proteomics at the schistosome-mammalian host interface: any prospects for diagnostics or vaccines?

    abstract::Since 2004 there has been a remarkable increment in our knowledge of the proteins and glycans that reside at, or are released from the surfaces of schistosomes in the mammalian host. Initial characterization of the soluble proteome permits distinctions to be made between the parasite secretome and its necrotome. The p...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182012000339

    authors: Wilson RA

    更新日期:2012-08-01 00:00:00

  • Protease inhibitors and haemagglutinins associated with resistance to the protozoan parasite, Perkinsus marinus, in the Pacific oyster, Crassostrea gigas.

    abstract::Perkinsus marinus is a protozoan responsible for dramatic mortality in the Eastern oyster, Crassostrea virginica, but not in the Pacific oyster, C. gigas. To understand the host-parasite relationship, we inoculated P. marinus trophozoites into the shell cavity of C. gigas and measured, over 2 months, (i) intensity of ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182002002135

    authors: Romestand B,Corbier F,Roch P

    更新日期:2002-10-01 00:00:00

  • Detection of circulating trypanosomal antigens by double antibody ELISA using antibodies to procyclic trypanosomes.

    abstract::A double antibody sandwich ELISA technique has been developed for detection of antigens of African trypanosomes present in the sera of infected mammals. The assay uses a high titre, high affinity rabbit antiserum made to purified membranes of procyclic trypanosomes as "capture" reagent and a mixture of three biotin-la...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000057735

    authors: Liu MK,Pearson TW

    更新日期:1987-10-01 00:00:00