Classical transmitters and their receptors in flatworms.

Abstract:

:The flatworm nervous system employs a wide repertoire of neuroactive substances, including small chemical messengers, the so called classical transmitters, and several types of neuropeptides. A large body of research accumulated over four decades has provided a wealth of information on the tissue localization and effects of these substances, their biochemistry and, recently, their molecular modes of action in all major classes of flatworms. This evidence will be reviewed, with particular emphasis on the small (classical) transmitters and the receptors that mediate their effects. One of the themes that will emerge from this discussion is that classical transmitters regulate core activities such as movement, metabolism and transport, and thus are essential for survival of the organism. In addition, the evidence shows that flatworms have multiple neurotransmitter receptors, many with unusual pharmacological features, which make them particularly attractive as drug targets. Understanding the molecular basis of these distinctive properties, and developing new, more specific receptor agonists and antagonists will undoubtedly become a major challenge in future research.

journal_name

Parasitology

journal_title

Parasitology

authors

Ribeiro P,El-Shehabi F,Patocka N

doi

10.1017/S0031182005008565

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

S19-40

eissn

0031-1820

issn

1469-8161

pii

S0031182005008565

journal_volume

131 Suppl

pub_type

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