Insights on adaptive and innate immunity in canine leishmaniosis.

Abstract:

:Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neglected tropical disease and the complex immune responses associated with Leishmania species makes therapeutic treatments and vaccine development challenging for both dogs and humans. In this review, we summarize innate and adaptive immune responses associated with L. infantum infection in dogs, and we discuss the problems associated with the disease as well as potential solutions and the future direction of required research to help control the parasite.

journal_name

Parasitology

journal_title

Parasitology

authors

Hosein S,Blake DP,Solano-Gallego L

doi

10.1017/S003118201600055X

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

95-115

issue

1

eissn

0031-1820

issn

1469-8161

pii

S003118201600055X

journal_volume

144

pub_type

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