Abstract:
:Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neglected tropical disease and the complex immune responses associated with Leishmania species makes therapeutic treatments and vaccine development challenging for both dogs and humans. In this review, we summarize innate and adaptive immune responses associated with L. infantum infection in dogs, and we discuss the problems associated with the disease as well as potential solutions and the future direction of required research to help control the parasite.
journal_name
Parasitologyjournal_title
Parasitologyauthors
Hosein S,Blake DP,Solano-Gallego Ldoi
10.1017/S003118201600055Xsubject
Has Abstractpub_date
2017-01-01 00:00:00pages
95-115issue
1eissn
0031-1820issn
1469-8161pii
S003118201600055Xjournal_volume
144pub_type
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