Induction of immunity in sheep to Fasciola hepatica with mimotopes of cathepsin L selected from a phage display library.

abstract：:Serology is an important tool for the diagnosis of alveolar echinococcosis (AE) in humans. In order to improve serodiagnostic performance, we have developed an in vitro-produced Echinococcus mulilocularis metacestode vesicle fluid (EmVF) antigen for application in an immunoblot assay. Immunoblot analysis of EmVF revea...

journal_title：Parasitology

authors： Müller N,Frei E,Nuñez S,Gottstein B

更新日期：2007-06-01 00:00:00

abstract：:Human strongyloidiasis is a serious disease mostly attributable to Strongyloides stercoralis and to a lesser extent Strongyloides fuelleborni, a parasite mainly of non-human primates. The role of animals as reservoirs of human-infecting Strongyloides is ill-defined, and whether dogs are a source of human infection is ...

journal_title：Parasitology

authors： Barratt JLN,Sapp SGH

更新日期：2020-09-01 00:00:00

abstract：:The efficiency of treatment of human infections with the unicellular eukaryotic pathogens such as fungi and protozoa remains deeply unsatisfactory. For example, the mortality rates from nosocomial fungemia in critically ill, immunosuppressed or post-cancer patients often exceed 50%. A set of six systemic clinical azol...

journal_title：Parasitology

authors： Lepesheva GI,Friggeri L,Waterman MR

更新日期：2018-12-01 00:00:00

abstract：:In light of the low success rate of target-based genomics and HTS (High Throughput Screening) approaches in anti-infective drug discovery, in silico structure-based drug design (SBDD) is becoming increasingly prominent at the forefront of drug discovery. In silico SBDD can be used to identify novel enzyme inhibitors r...

journal_title：Parasitology

authors： Cunningham F,McPhillie MJ,Johnson AP,Fishwick CW

更新日期：2014-01-01 00:00:00

abstract：:We investigated intestinal trichomonads in western lowland gorillas, central chimpanzees and humans cohabiting the forest ecosystem of Dzanga-Sangha Protected Area in Central African Republic, using the internal transcribed spacer (ITS) region and SSU rRNA gene sequences. Trichomonads belonging to the genus Tetratrich...

journal_title：Parasitology

authors： Petrželková KJ,Smejkalová P,Céza V,Pafčo B,Shutt-Phillips KA,Todd A,Jirků-Pomajbíková K,Benavides J,Modrý D,Čepička I

更新日期：2020-02-01 00:00:00

abstract：:The fine structure of the envelopes surrounding hatched and unhatched oncospheres of Hymenolepis nana has been investigated by transmission and scanning electron microscopy (SEM), together with light microscope histochemical observations of JB-4 embedded material. The oncosphere is surrounded by 3 layers--the capsule,...

journal_title：Parasitology

authors： Fairweather I,Threadgold LT

更新日期：1981-06-01 00:00:00

abstract：:Schistosoma mansoni egg counts by faecal examination vary considerably and are not very sensitive, so prevalences are underestimated. The distribution of egg counts can adequately be described by a stochastic model which distinguishes variation in counts between persons and variation in repeated counts within a person...

journal_title：Parasitology

authors： De Vlas SJ,Engels D,Rabello AL,Oostburg BF,Van Lieshout L,Polderman AM,Van Oortmarssen GJ,Habbema JD,Gryseels B

更新日期：1997-02-01 00:00:00

abstract：:Sexual size dimorphism (SSD) in mammals reveals the extent of sexual selection, which may in turn explain why males are often more infected by parasites than females and that parasites may contribute to the association between SSD and male-biased mortality. Here, we investigated the relationship between SSD in small m...

journal_title：Parasitology

authors： Morand S,De Bellocq JG,Stanko M,Miklisová D

更新日期：2004-10-01 00:00:00

abstract：:Avian malaria is a vector transmitted disease caused by Plasmodium and recent studies suggest that variation in its prevalence across avian hosts is correlated with a variety of ecological traits. Here we examine the relationship between prevalence and diversity of Plasmodium lineages in southeastern Amazonia and: (1)...

journal_title：Parasitology

authors： Fecchio A,Ellis VA,Bell JA,Andretti CB,D'Horta FM,Silva AM,Tkach VV,Weckstein JD

更新日期：2017-07-01 00:00:00

abstract：:The relationships between populations of the Deer Mouse (Peromyscus maniculatus) and the White-footed Mouse (P. leucopus) and their respective Cuterebra parasites were examined. Population genetic structure of hosts and parasites was inferred using cytochrome oxidase mitochondrial sequences of specimens from 7 populat...

journal_title：Parasitology

authors： Noel S,Angers B,Lapointe FJ

更新日期：2005-08-01 00:00:00

abstract：:The ultrastructure of the formation of the first-stage cuticle within the egg of Trichostrongylus colubriformis is described. The first indication of cuticle formation was the formation of the epicuticle external to the epidermal plasma membrane. This becomes thickened to form the epicuticle of the fully formed cuticl...

journal_title：Parasitology

authors： Wharton DA,Bone LW

更新日期：1988-12-01 00:00:00

abstract：:RNA extracted from purified parasites of Plasmodium knowlesi was fractionated using agarose gel electrophoresis. Preparations from para sites grown both in vivo and in vitro contained species of RNA with sedimentation coefficients of 4-0S, 5-0S, 16-6S, 24-2S, 31-4S, 38-0S and 48-3S. There was less RNA present in paras...

journal_title：Parasitology

authors： Trigg PI,Shakespeare PG,Burt SJ,Kyd SI

更新日期：1975-10-01 00:00:00

abstract：:Quinine (QN) and quinidine (QND) have been commonly used as effective and affordable antimalarials for over many years. Quinine primarily is used for severe malaria treatment. However, plasmodia resistance to these drugs and poor patient compliance limits their administration to the patients. The declining sensitivity...

journal_title：Parasitology

authors： Pandey SK,Dwivedi H,Singh S,Siddiqui WA,Tripathi R

更新日期：2013-03-01 00:00:00

abstract：:Cyst fluid (CF) of Taenia solium metacestode (TsM) is an important source of serodiagnostic antigens. We have investigated the molecular characteristics of the 120 kDa protein complex in TsM CF purified by fast performance liquid chromatography. The structure of the purified protein was characterized by a variety of p...

journal_title：Parasitology

authors： Lee EG,Bae YA,Jeong YT,Chung JY,Je EY,Kim SH,Na BK,Ju JW,Kim TS,Ma L,Cho SY,Kong Y

更新日期：2005-12-01 00:00:00

abstract：:A cross-sectional sero-epidemiological study was performed in Magoda, Tanzania, an area where malaria is holoendemic. Blood samples were collected from children (1-4 years) and tested for IgG antibody reactivity against 2 recombinant protein fragments of Plasmodium falciparum Rhoptry-Associated Protein-1 (rRAP-1). The...

journal_title：Parasitology

authors： Alifrangis M,Lemnge MM,Moon R,Theisen M,Bygbjerg I,Ridley RG,Jakobsen PH

更新日期：1999-10-01 00:00:00

abstract：:African sleeping sickness is a parasitic disease transmitted through the bites of tsetse flies of the genus Glossina. We constructed mechanistic models for the basic reproduction number, R0, of Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, respectively the causative agents of West and East African h...

journal_title：Parasitology

authors： Davis S,Aksoy S,Galvani A

更新日期：2011-04-01 00:00:00

abstract：:Nitric oxide (NO) produced by cytokine-activated macrophages is reported to be cytotoxic against the helminth Schistosoma mansoni, although this is a controversial issue. Previous work in our laboratory identified a fraction of S. mansoni soluble adult worm antigenic preparation (SWAP), named PIII, able to elicit sign...

journal_title：Parasitology

authors： Oliveira DM,Silva-Teixeira DN,Gustavson S,Oliveira SM,Goes AM

更新日期：2000-04-01 00:00:00

abstract：:A new histozoic species of myxosporean was found to infect the gill filaments, gut, kidney and liver of the freshwater teleost Leporinus friderici, collected from the estuarine region of the Amazon, near the city of Belém, Brazil. The plasmodia show asynchronous development, at any one time composed of mature spores a...

journal_title：Parasitology

authors： Casal G,Matos E,Azevedo C

更新日期：2003-04-01 00:00:00

abstract：:An animal's social behaviour both influences and changes in response to its parasites. Here we consider these bidirectional links between host social behaviours and parasite infection, both those that occur from ecological vs evolutionary processes. First, we review how social behaviours of individuals and groups infl...

journal_title：Parasitology

authors： Hawley DM,Gibson AK,Townsend AK,Craft ME,Stephenson JF

更新日期：2020-10-23 00:00:00

abstract：:Acetylcholinesterase (AChE) is present in all stages of the life-cycle of schistosomes and is located in muscle and on the surface of the parasite. Metrifonate is a drug that inhibits AChE. We compared the AChEs from three schistosome species (Schistosoma mansoni, Schistosoma haematobium and Schistosoma bovis) that ha...

journal_title：Parasitology

authors： Camacho M,Tarrab-Hazdai R,Espinoza B,Arnon R,Agnew A

更新日期：1994-02-01 00:00:00

abstract：:The occurrence of multiple-clone Plasmodium falciparum haploid blood-stage infections is a pre-requisite for cross-fertilization and genetic exchange at the diploid stage in the mosquito. Using monoclonal antibodies against 3 polymorphic blood-stage antigens, a method of two-colour differential immunofluorescence allo...

journal_title：Parasitology

authors： Conway DJ,Greenwood BM,McBride JS

更新日期：1991-08-01 00:00:00

abstract：:Within the genus Cryptosporidium 2 lineages have evolved, one adapted to the acid environment of the stomach and abomasum, the other comprising parasites that multiply in the small intestine. We tested whether the release of sporozoites from oocysts, a process known as excystation, is triggered by conditions which mim...

journal_title：Parasitology

authors： Widmer G,Klein P,Bonilla R

更新日期：2007-10-01 00:00:00

abstract：:The kinetoplastid parasite Trypanosoma brucei causes African trypanosomiasis in both humans and animals. Infections place a significant health and economic burden on developing nations in sub-Saharan Africa, but few effective anti-parasitic treatments are currently available. Hence, there is an urgent need to identify...

journal_title：Parasitology

authors： Dickie EA,Young SA,Smith TK

更新日期：2019-04-01 00:00:00

abstract：:The interactions in vivo between Plasmodium berghei sporozoites and Kupffer cells in rat livers were studied by transmission electron microscopy. By 10 and 15 min after inoculation, sporozoites were both free in the liver sinusoids and inside endocytotic vacuoles of the Kupffer cells. The latter cells were very active...

journal_title：Parasitology

authors： Meis JF,Verhave JP,Jap PH,Meuwissen JH

更新日期：1983-04-01 00:00:00

abstract：:This study describes morphological changes during capsule formation of Trichinella spiralis with emphasis on nuclei within the capsule. The nuclei of the pre-existing muscle cell may become hypertrophied or degrade soon after the entrance of newborn larvae. Cytoplasm associated with these hypertrophied nuclei was baso...

journal_title：Parasitology

authors： Matsuo A,Wu Z,Nagano I,Takahashi Y

更新日期：2000-08-01 00:00:00

abstract：:In previous studies, ultrastructural observations revealed a large number of gap junctions (GJs) in the neck and immature proglottid tissues of Taenia solium tapeworms. In these helminths, cytoplasmic glycogen sacs are connected by numerous discrete GJs to other cells throughout the maturing strobilar tissue. Disconti...

journal_title：Parasitology

authors： Zurabian R,Landa A,Robert L,Willms K

更新日期：2008-08-01 00:00:00

abstract：:An ultrastructural study has been performed on radiation-attenuated parasites fixed in situ during their extended stay in the lungs. At day 7 post-infection all parasites were located within blood vessels. In contrast to normally migrating parasites, at days 13 and 21 post-infection the majority of radiation-attenuate...

journal_title：Parasitology

authors： Mastin A,Bickle QD,Wilson RA

更新日期：1985-08-01 00:00:00

abstract：:Bloodstream forms of Trypanosoma congolense (2 clones: ILNat3.1 and IL3000, and 4 stocks: IL2079, IL2466, IL3266 and CP-81) were continuously cultivated in vitro at 34-36 degrees C in the absence of feeder cell layers, using HMI-93 medium which was modified from Iscove's modified Dulbecco's MEM (Flow Laboratories, Irv...

journal_title：Parasitology

authors： Hirumi H,Hirumi K

更新日期：1991-04-01 00:00:00

abstract：:The radiation-attenuated schistosome vaccine induces a high level of protective immunity in rodents. In order to assess its potential relevance to man, we have tested its efficacy in the non-human primate Papio anubis. A vaccination regime consisting of 3 exposures of approximately 9000 cercariae irradiated with 30 or...

journal_title：Parasitology

authors： Yole DS,Pemberton R,Reid GD,Wilson RA

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Unravelling the determinants of parasite life-history traits in natural settings is complex. Here, we deciphered the relationships between biotic, abiotic factors and the variation in 4 life-history traits (body size, egg presence, egg number and egg size) in the fish ectoparasite Tracheliastes polycolpus. We...

journal_title：Parasitology

authors： Loot G,Poulet N,Brosse S,Tudesque L,Thomas F,Blanchet S

更新日期：2011-06-01 00:00:00