Alpha 2 giardin is an assemblage A-specific protein of human infective Giardia duodenalis.

Abstract:

:Of the 7 genetic assemblages of the parasite Giardia duodenalis only 2 (A and B) are known to cause infections in humans. These assemblages have been characterized in detail at the genomic level but few studies have examined differences in the proteins expressed. Employing one and two-dimensional PAGE we have identified an assemblage A-specific protein of human infective G. duodenalis; alpha 2 giardin. The protein difference was evident using both electrophoretic techniques. Alpha 2 giardin is known to be a structural protein and associates with the caudal flagella and the plasma membrane; however, its exact function is unknown. Although several proteins unique to assemblage B were also observed, we were unable to identify these proteins due to a lack of genomic data available for assemblage B isolates. Together, these proteins represent distinct phenotypic differences between the human infective assemblages of G. duodenalis and support the need to revise the taxonomy of this parasite.

journal_name

Parasitology

journal_title

Parasitology

authors

Steuart RF,O'Handley R,Lipscombe RJ,Lock RA,Thompson RC

doi

10.1017/S0031182008004988

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

1621-7

issue

14

eissn

0031-1820

issn

1469-8161

pii

S0031182008004988

journal_volume

135

pub_type

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