CYP51 as drug targets for fungi and protozoan parasites: past, present and future.

abstract：:Expression of metalloprotease activities during metacyclogenesis of a series of strains and clones of Trypanosoma cruzi was investigated using SDS-polyacrylamide gel electrophoresis with a range of different co-polymerized proteolytic substrates. A complex pattern of metalloprotease expression, with considerable quant...

journal_title：Parasitology

authors： Lowndes CM,Bonaldo MC,Thomaz N,Goldenberg S

更新日期：1996-04-01 00:00:00

abstract：:Pinewood nematode, Bursaphelenchus xylophilus, a pine parasitic nematode, poses a serious threat to its host pine forests globally. When dispersal-stage larvae 4 (dauer, DL4) of B. xylophilus enters the new pine, it moults into propagative adult (dauer recovery) and reproduces quickly to kill the host pine. Here, we f...

journal_title：Parasitology

authors： Zhang W,Li Y,Pan L,Wang X,Feng Y,Zhang X

更新日期：2020-01-01 00:00:00

abstract：:Cod (Gadus morhua), an important fish species in the Baltic Sea, is the paratenic host for many parasite species, including the zoonotic nematodes, Anisakis sp. and Contracaecum osculatum. We aimed to identify which invertebrate species (found in situ in the fish stomach) are responsible for infection of cod with zoon...

journal_title：Parasitology

authors： Pawlak J,Nadolna-Ałtyn K,Szostakowska B,Pachur M,Bańkowska A,Podolska M

更新日期：2019-11-01 00:00:00

abstract：:Plerocercoids of the pseudophyllidean cestode Schistocephalus solidus infect the three-spined stickleback Gasterosteus aculeatus, with important consequences for the biology of host fish. Techniques for culturing the parasite in vitro and generating infective stages that can be used to infect sticklebacks experimental...

journal_title：Parasitology

authors： Barber I,Scharsack JP

更新日期：2010-03-01 00:00:00

abstract：:We have determined the molar content of guanine + cytosine (GC content) of DNA of the filarial nematode (Brugia malayi, Brugia pahangi and Dirofilaria imitis) and of the free-living soil nematodes Caenorhabditis elegans and have analysed the DNA for the presence of methylcytosine. Two independent methods, thermal dena...

journal_title：Parasitology

authors： Rothstein N,Stoller TJ,Rajan TV

更新日期：1988-08-01 00:00:00

abstract：:Phylogenetic relationships among Trypanosoma rangeli isolates from man, wild mammals and triatomine bugs from widespread geographical origin were inferred by comparison of the small subunit of ribosomal gene sequences. The phylogenetic trees indicated that the subgenus Herpetosoma is polyphyletic and strongly supporte...

journal_title：Parasitology

authors： Da Silva FM,Noyes H,Campaner M,Junqueira AC,Coura JR,Añez N,Shaw JJ,Stevens JR,Teixeira MM

更新日期：2004-11-01 00:00:00

abstract：:DNA barcoding is now a common tool in parasitology and epidemiology, which require good methods for identification not only of parasites and pathogens but vectors and reservoirs. This special issue presents some advances and challenges in barcoding of microbes, parasites, and their vectors and reservoirs. DNA barcodin...

journal_title：Parasitology

authors： Morand S

更新日期：2018-04-01 00:00:00

abstract：:A field trial was conducted to evaluate the potential of the nematode-destroying fungus Duddingtonia flagrans to control free-living stages of horse strongyles. In late Spring 2 groups of horses (yearlings) with mixed infections of strongyles were allowed to contaminate 2 equal-sized pastures. One of the groups (F) re...

journal_title：Parasitology

authors： Larsen M,Nansen P,Grøndahl C,Thamsborg SM,Grønvold J,Wolstrup J,Henriksen SA,Monrad J

更新日期：1996-07-01 00:00:00

abstract：:Bat flies are obligate ectoparasites of bats and it has been hypothesized that they may be involved in the transmission of Bartonella species between bats. A survey was conducted to identify whether Cyclopodia greefi greefi (Diptera: Nycteribiidae) collected from Ghana and 2 islands in the Gulf of Guinea harbour Barto...

journal_title：Parasitology

authors： Billeter SA,Hayman DT,Peel AJ,Baker K,Wood JL,Cunningham A,Suu-Ire R,Dittmar K,Kosoy MY

更新日期：2012-03-01 00:00:00

abstract：:To test the homogeneity of 18S sequences within Trypanosoma cruzi, riboprint profiles were separated by temperature gradient gel electrophoresis (TGGE). Upon interpretation of melting curves of fragments within a riboprint profile, there appeared to be two 18S sequence types within each stock examined. Two similar typ...

journal_title：Parasitology

authors： Stothard JR,Frame IA,Carrasco HJ,Miles MA

更新日期：1998-09-01 00:00:00

abstract：:Biodiversity loss may increase the risk of infectious disease in a phenomenon known as the dilution effect. Circumstances that increase the likelihood of disease dilution are: (i) when hosts vary in their competence, and (ii) when communities disassemble predictably, such that the least competent hosts are the most li...

journal_title：Parasitology

authors： Stewart Merrill TE,Johnson PTJ

更新日期：2020-09-01 00:00:00

abstract：:We studied the pattern of infection and the inter-annual variation and individual factors affecting the infection of 2 species of nasopharyngeal bot flies, Cephenemyia auribarbis and Pharyngomyia picta (Diptera: Oestridae), in a population of Iberian red deer (Cervus elaphus hispanicus) from south central Spain (10 an...

journal_title：Parasitology

authors： Vicente J,Fierro Y,Martínez M,Gortázar C

更新日期：2004-09-01 00:00:00

abstract：:Population genetics of multi-host pathogens offers great potential for the understanding of their complex epidemiology but care must be taken to ensure that the sampling procedure does not bias estimates of population indices. The transfer of material to laboratory passage, in particular, runs the risk of bottleneckin...

journal_title：Parasitology

authors： Shrivastava J,Gower CM,Balolong E Jr,Wang TP,Qian BZ,Webster JP

更新日期：2005-11-01 00:00:00

abstract：:The gastrointestinal nematode Heligmosomoides polygyrus bakeri shows enhanced survival in mice with colitis. As the antibody response plays an important role in antiparasitic immunity, antibodies against male and female L4 H. polygyrus were examined in mice with and without colitis. Levels of specific antibodies in th...

journal_title：Parasitology

authors： Maruszewska-Cheruiyot M,Donskow-Łysoniewska K,Krawczak K,Szewczak L,Joachimiak E,Doligalska M

更新日期：2020-11-01 00:00:00

abstract：:Since 2004 there has been a remarkable increment in our knowledge of the proteins and glycans that reside at, or are released from the surfaces of schistosomes in the mammalian host. Initial characterization of the soluble proteome permits distinctions to be made between the parasite secretome and its necrotome. The p...

journal_title：Parasitology

authors： Wilson RA

更新日期：2012-08-01 00:00:00

abstract：:An M13 phage random 12-mers peptide library was used to screen cathepsin L mimotopes of Fasciola hepatica and to evaluate their immunogenicity in sheep. Seven clones showed positive reactivity to a rabbit anti-cathepsin L1/L2 antiserum in ELISA, and their amino acid sequences deduced by DNA sequencing were tentatively...

journal_title：Parasitology

authors： Villa-Mancera A,Quiroz-Romero H,Correa D,Ibarra F,Reyes-Pérez M,Reyes-Vivas H,López-Velázquez G,Gazarian K,Gazarian T,Alonso RA

更新日期：2008-10-01 00:00:00

abstract：:Vertically transmitted parasites (VTPs) such as Wolbachia are expected not only to minimize the damage they inflict on their hosts, but also to protect their hosts against the damaging effects of coinfecting parasites. By modifying the fitness costs of the infection, VTPs can therefore play an important role in the ev...

journal_title：Parasitology

authors： Zélé F,Denoyelle J,Duron O,Rivero A

更新日期：2018-05-01 00:00:00

abstract：:The diversity and prevalence of malaria parasites of the genera Plasmodium and Haemoproteus were determined in the globally-threatened Aquatic Warbler Acrocephalus paludicola. Birds were sampled during migration in Portugal and at the wintering quarters in Senegal and parasites were detected using molecular methods. O...

journal_title：Parasitology

authors： Neto JM,Pérez-Rodríguez A,Haase M,Flade M,Bensch S

更新日期：2015-08-01 00:00:00

abstract：:Giardia lamblia localize and multiply in the small intestine and may cause acute or chronic diarrhoea with malabsorption of fat, protein and other nutrients. Abnormal pancreatic function has been documented in giardiasis and trophozoites directly inhibit pancreatic lipase activity in vitro. The aim of this study was t...

journal_title：Parasitology

authors： Seow F,Katelaris P,Ngu M

更新日期：1993-04-01 00:00:00

abstract：:Understanding the origin of invasive parasites and ecological transmission barriers on the distribution of mosquito-borne pathogens is enriched by molecular phylogenetic approaches now that large databases are becoming available. Here we assess the biogeographical relationships among haemosporidian blood parasites and...

journal_title：Parasitology

authors： Baillie SM,Brunton DH

更新日期：2011-12-01 00:00:00

abstract：:Neospora caninum causes economical impact in cattle-raising farms since it is implicated as the major cause of bovine abortions. Although infection by the parasite has been widely described in mammals, the role of birds in its life-cycle is still obscure. Therefore, this work aimed to evaluate the infection by N. cani...

journal_title：Parasitology

authors： Furuta PI,Mineo TW,Carrasco AO,Godoy GS,Pinto AA,Machado RZ

更新日期：2007-12-01 00:00:00

abstract：:Depending on the extent of evolutionary divergence among parent taxa, hybrids may suffer from a breakdown of co-adapted genes or may conversely exhibit vigour due to the heterosis effect, which confers advantages to increased genetic diversity. That last mechanism could explain the success of hybrids when hybridizatio...

journal_title：Parasitology

authors： Planade B,Lena JP,Li H,Plenet S,Guegan JF,Thomas F,Hurtrez-Bousses S,Renaud F,Joly P

更新日期：2009-08-01 00:00:00

abstract：:Philasterides dicentrarchi causes a severe disease in turbot, and at present there are no drugs available to treat infected fish. We have previously demonstrated that, in addition to the classical respiratory pathway, P. dicentrarchi possesses an alternative mitochondrial respiratory pathway that is cyanide-insensitiv...

journal_title：Parasitology

authors： Mallo N,Lamas J,Leiro JM

更新日期：2014-09-01 00:00:00

abstract：:Schizont-infected red blood cells (SI-RBC) from Plasmodium berghei-infected mice contain between 2 and 10 times as much sialic acid as uninfected RBC from the same blood (99-550 micrograms/10(10) RBC versus 33-65 micrograms/10(10) RBC). Total RBC samples from infected animals containing up to 63% ring- and trophozoite...

journal_title：Parasitology

authors： Howard RJ,Seeley DC Jr,Kao V,Wember M,Schauer R

更新日期：1986-06-01 00:00:00

abstract：:We tested whether the prevalence of ticks can be predicted reliably from a simple epidemiological model that takes into account only mean abundance and its variance. We used data on the abundance and distribution of larvae and nymphs of 2 ixodid ticks parasitic on small mammals (Apodemus agrarius, Apodemus flavicollis...

journal_title：Parasitology

authors： Stanko M,Krasnov BR,Miklisova D,Morand S

更新日期：2007-01-01 00:00:00

abstract：:Trichomonas vaginalis induces cellular damage to the host cells (cytotoxicity) through the proteolytic activity of multiple proteinases of the cysteine type (CPs). Some CPs are modulated by environmental factors such as iron, zinc, polyamines, etc. Thus, the goal of this study was to assess the effect of glucose on T....

journal_title：Parasitology

authors： Miranda-Ozuna JFT,Rivera-Rivas LA,Cárdenas-Guerra RE,Hernández-García MS,Rodríguez-Cruz S,González-Robles A,Chavez-Munguía B,Arroyo R

更新日期：2019-08-01 00:00:00

abstract：:Anti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigenic variation of the parasite surface coat has been considered the major obstacle in the development...

journal_title：Parasitology

authors： Magez S,Caljon G,Tran T,Stijlemans B,Radwanska M

更新日期：2010-12-01 00:00:00

abstract：:Quinine (QN) and quinidine (QND) have been commonly used as effective and affordable antimalarials for over many years. Quinine primarily is used for severe malaria treatment. However, plasmodia resistance to these drugs and poor patient compliance limits their administration to the patients. The declining sensitivity...

journal_title：Parasitology

authors： Pandey SK,Dwivedi H,Singh S,Siddiqui WA,Tripathi R

更新日期：2013-03-01 00:00:00

abstract：:The twin concepts of zooprophylaxis and the dilution effect originated with vector-borne diseases (malaria), were driven forward by studies on Lyme borreliosis and have now developed into the mantra "biodiversity protects against disease". The basic idea is that by diluting the assemblage of transmission-competent hos...

journal_title：Parasitology

authors： Randolph SE,Dobson AD

更新日期：2012-06-01 00:00:00

abstract：:Susceptability of Ascaridia galli to benzimidazole (BZ) was investigated using faecal egg count reduction test (FECRT), in ovo larval development test (LDT) and genetic markers (mutations at codons 167, 198 and 200 of β-tubulin gene). Six flocks (F1-F6) of a commercial laying hen farm with different number of exposure...

journal_title：Parasitology

authors： Tarbiat B,Jansson DS,Tydén E,Höglund J

更新日期：2017-09-01 00:00:00